Latest news with #Pantoprazole
NDTV
5 days ago
- Health
- NDTV
Centre Flags Carcinogen Fears On Acidity Medicine Ranitidine, Orders Probe
New Delhi: The Central Drugs Standard Control Organisation (CDSCO) has directed all state and union territory drug regulators to ensure manufacturers of Ranitidine -- a commonly used acidity medicine --monitor NDMA levels, a potentially cancer-causing impurity, in both the active pharmaceutical ingredient (API) and formulations of the drug. The CDSCO has also suggested reducing the shelf life as a precautionary step. The move comes from the Drugs Controller General of India (DCGI), Dr Rajeev Singh Raghuvanshi, following a recommendation by the Drugs Technical Advisory Board (DTAB) during its 92nd meeting on April 28, 2025. The Board reviewed a report submitted by an expert committee constituted in December last year to study the impurity concerns around Ranitidine. Based on this, DTAB has called for a larger committee to examine all aspects of the issue, including storage conditions that may contribute to NDMA formation. In addition, the Board recommended that the Indian Council of Medical Research (ICMR) conduct a study to further assess the long-term safety of Ranitidine in light of NDMA presence. Manufacturers have now been told to adopt risk-based measures, such as limiting shelf life, modifying storage recommendations, and enhancing NDMA testing protocols across their supply chains. "Ranitidine falls in the Group 2A carcinogen category, according to the International Agency for Research on Cancer (IARC), which implies that it is a probable human carcinogen. It should not be continued in prescription when there are safer alternatives such as Famotidine and Pantoprazole available," said Dr Abhishek Shankar, Oncologist, AIIMS Delhi. NDMA is classified as a probable human carcinogen, and its presence in medications has triggered global regulatory scrutiny over recent years. Ranitidine, commonly prescribed for acid reflux and ulcers, was withdrawn from several markets, including the US, after alarmingly high levels of NDMA were found in some samples. "Ranitidine was commonly prescribed in the past. Its usage has reduced in most metro cities, but it is still prescribed in Tier 1 or 2 cities, particularly at primary healthcare centres. In my knowledge, the drug has been known to have NDMA impurities; the FDA has also ruled out the use of this drug in large doses. The DGCI needs to set prescribed limits for NDMA levels in this drug," said Dr Lohit Chauhan, Gastroenterologist at Max Dwarka.
India Today
02-07-2025
- India Today
Shefali Jeriwala death: Forensic tests underway, cause of death still unclear
Actor Shefali Jariwala's death is still a mystery as the panel of the five forensic doctors at Cooper hospital who performed post-mortem or autopsy on her body reserved their opinion on the cause of death. They have sent samples for post-mortem histology and the preserved viscera for chemical analysis to Kalina Forensic Science Laboratory (FSL).Speaking to India Today TV, police officials, privy to the investigations, said that histopathology is done only in cases where the cause of death is not clear during the autopsy and also if the viscera have been preserved for chemical analysis. Once both the evaluations are completed and the report is submitted by FSL, the cause of death will be per open source information, histopathological after-death report, or post-mortem histology, is primarily done to determine the cause and manner of death when it's not readily apparent from a macroscopic (external and gross internal) examination during an autopsy. It involves examining tissue samples under a microscope to identify subtle changes or specific disease processes that may have contributed to or caused the of histopathology in post-mortem examinations: Determining cause and manner of death:When the cause of death isn't clear after a standard autopsy, histology can reveal microscopic evidence of disease, injury, or other conditions that might have led to the macroscopic findings:Histology can confirm and refine diagnoses made during the gross autopsy, providing a more detailed understanding of the pathological subtle or microscopic pathology:advertisementSome diseases or injuries have microscopic characteristics that are only visible under a microscope, such as myocarditis (inflammation of the heart muscle) or amniotic fluid chemical analysis of viscera will help find if there was any kind of poison or toxins in the body which led to the fatality or sudden cardiac arrest leading to Jariwala's last momentsPolice officials have found CCTV footage of Jariwala's room and have accessed the footage. As per police officials, Jariwala was fasting the whole day as there was puja at her residence that day, but after 8:30 pm, she had some stale fried rice which was brought a day ago and then kept in the fridge. The fried rice was heated, and after, she felt uneasy and acidic - so she had a tablet of 40 mg of Pantoprazole and 30 mg of Domperidone. During the day, she reportedly got a vial of anti-ageing medication that was administered by a medical professional at her per police officials, her uneasiness grew after 10:15 pm and at around 10:30 pm she collapsed. Her body started trembling, after which the house staff alerted her husband, Parag Tyagi, who had taken their dog out for a walk. Parag immediately rushed upstairs, and in his statement to the police, he said that he could feel the pulse of Shefali when he went back upstairs, after which they rushed her to Bellevue hospital in Andheri the Bellevue hospital, Shefali was declared dead before admission and her family was told to take the body to Cooper hospital. Police officials received the call at 11:30 pm, and they reached the hospital at 11:45 pm."We checked the house and found two boxes of medication which consisted of Glutathione injections, Vitamin-C pills and some other medication at the house. We checked the dustbin and collected packets of food and injections. We checked the dustbin and collected food packets, wrappers, medication packets and vials from it. We also learnt that many of those medications were not prescribed or had been prescribed long back. She was taking medicines herself for anti-ageing and skin glow," an officer told India Today."CCTV footage from the house has been analysed, statements of family members and the person who had administered the vial that day have been taken. As of now, no foul play has come to light or been alleged by anyone. "But, we are taking all possible measures as per procedure to ascertain the cause of death," said an officer privy to the officers spoke to the forensic doctors at the Cooper hospital, and they suspected that the death could be due to a sudden major drop in blood pressure which led to cardiac arrest. The cause of her death and cause of the sudden drop in blood pressure could be due to multiple reasons, which are fasting, self-medication during fasting or even the stale food she had that evening.- EndsMust Watch
Time of India
25-06-2025
- Business
- Time of India
Haffkine to quiz 2 pharmaceutical firms for selling it ‘blacklisted' medicines for government hospitals in Maharashtra
Mumbai: Haffkine Bio-Pharmaceuticals procurement cell will be seeking explanations from two pharmaceutical firms after it came to light that medicines ordered for govt hospitals across the state in Feb had been declared "not of standard quality" and blacklisted by Employees' State Insurance Corporation (ESIC) just two months earlier. In Dec, ESIC issued a circular blacklisting specific drugs from seven pharmaceutical companies, citing test results that found these medicines to be of substandard quality and directing that no further orders be placed with them. However, Haffkine Bio-Pharmaceuticals placed large supply orders with two of the listed firms. This resulted in the procurement of nearly 21.9 lakh vials of Pantoprazole 40mg/10ml injection worth Rs 2.5 crore from Galpha Laboratories Ltd, and 88,650 tablets of Vildagliptin 50mg, along with Metformin Hydrochloride 1000mg worth nearly Rs 12.6 lakh, from Bajaj Healthcare Ltd. Pantoprazole is used to treat acid-related stomach issues such as ulcers and acid reflux, while Vildagliptin with Metformin is prescribed to manage type 2 diabetes by controlling blood sugar levels. Although Haffkine is no longer the primary authority for medicine procurement, it was granted permission to utilise the remaining Rs 131.6 crore to restock medicines at state-run hospitals through a Govt Resolution (GR). by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Memperdagangkan CFD Emas dengan salah satu spread terendah? IC Markets Mendaftar "The procurement process must be based on ESIC rate contracts as received on the e-Aushadhi platform," the GR stated. You Can Also Check: Mumbai AQI | Weather in Mumbai | Bank Holidays in Mumbai | Public Holidays in Mumbai A senior official at the procurement cell confirmed that they are looking into the matter. "We have been orally informed by ESIC that the issue pertained to specific batches. Nevertheless, we have sought written responses from the companies as well as from ESIC. These will be submitted to higher authorities, and payments to the companies will be withheld until a reasonable explanation is provided," the official said, but did not provide the amount of payments to be withheld. Abhay Pandey, of the All Food and Drug Licence Holders Foundation, who flagged the issue with medical education department officials, alleged that the existing rate contract was arbitrarily selected by Haffkine without verifying the blacklisting status of the companies or conducting additional tests on the medicines. Haffkine officials did not respond when asked whether random sampling of the procured products was conducted in accordance with the GR. Dr Shashi Kolnoorkar, state ESIC director (Medical), said the blacklisting order came from the Delhi headquarters and that appropriate action had been taken at the time. When asked whether the blacklisting applied to specific batches or constituted a complete ban on the medicines in question, he referred the query to the ESIC head office. Attempts were made to reach Dr Neeta Garbiyal, deputy medical commissioner at the ESIC head office, who had signed the blacklist circular, but she was unavailable for comment. File pic
Yahoo
14-04-2025
- Yahoo
Inmate accused of trying to rape two nurses while at Mount Nittany in State College
STATE COLLEGE, Pa. (WTAJ) — A State College inmate was arrested Friday for allegedly trying to rape two nurses at Mount Nittany Medical Center. Conner C. Patterson, 26, was charged with two counts of attempted rape and indecent assault and three counts of assault with deadly force. His bail was denied, citing his being homeless and for violent crimes against nursing staff. According to the criminal complaint, State College police were called to Mount Nittany on Wellness Way at 9:06 a.m. April 11, in regard to an assault of two nurses. While speaking with one of the victims, police were told Patterson was in a room and made a comment about needing sex. Roughly 20 minutes later, Patterson left the room, grabbed a nurse by the hair and dragged them back into the room, according to a victim's account with police. She went on to say Patterson pushed her against the bed and tried to pull her pants down. Thwarted State College school attack meant to coincide with Columbine anniversary Charging documents show that a second nurse heard the first one yelling for Patterson to get off of him and she hit an emergency button to alert security before running into the room to help. The second victim claimed Patterson pushed her against a wall and pulled her pants down. That's when hospital security showed up to step in. The Director of Emergency Services told police that as they tried to subdue Patterson, he pushed them against a wall, causing neck and shoulder pain, the complaint was in Centre County Prison awaiting criminal proceedings in a robbery case from March when he allegedly tried to steal a $3.50 can of beer from a State College store. He was then found to have a prescription bottle of Pantoprazole with someone else's name on it. That person told police she didn't know Patterson and she just noticed the bottle missing, a previous complaint reads. A preliminary hearing on the attempted rape charges is scheduled for April 16. Copyright 2025 Nexstar Media, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.
