31-05-2025
Extremely rare tumour removed from 12-year-old's brain in Vadodara
Vadodara: In a medical breakthrough that may be the first of its kind globally, doctors at Vadodara's SSG Hospital and Baroda Medical College successfully removed an exceptionally rare tumour — angiomyxofibromatous — from the brain of a 12-year-old girl.
What makes this case extraordinary is that such a tumour has never before been reported in the brain, and is so rare that it isn't even included in the current World Health Organization (WHO) classification of nervous system tumours. Worldwide, angiomyxofibromatous tumours are known to occur in the genital region of adult females, making this diagnosis in the posterior fossa (a small space at the back of the skull and houses some critical structures of the central nervous system) unprecedented.
Dr Parth Modi, from the Department of Neurosurgery at SSG Hospital, said the girl presented last year with persistent headaches, dizziness and vomiting, but had no prior health issues. "Her physical examination didn't reveal any neurological deficits. However, MRI and CT scans showed a 5 cm tumour in the posterior fossa region," he explained.
Given the tumour's critical location, the surgical team had to proceed with extreme caution.
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"This was a high-risk procedure due to the potential for bleeding," Dr Modi said. The surgery — sub-occipital craniotomy and tumour excision via the telovelar approach — was carried out by Dr Modi, Dr Amey Patankar, Dr Ankit Shah and Dr Vinay Rohra. Remarkably, the girl was discharged within a week of the surgery.
However, the mystery deepened post-surgery when the biopsy initially yielded inconclusive results. The sample was then sent to the National Institute of Mental Health and Neurosciences (NIMHANS) in Bengaluru — a WHO-affiliated premier institute — where the tumour was finally identified as angiomyxofibromatous.
"Given the unprecedented nature of this case—being the first reported instance of such a tumour in the brain of a child — we decided to formally document it," said Dr Modi. The case was reviewed by renowned neurosurgeons from Japan and South Korea, and was recently published in the Asian Journal of Neurosurgery.
While angiomyxofibromatous tumours are typically benign, the exact behaviour of this tumour in the brain remains unknown.
"We're closely monitoring her for any signs of recurrence," Dr Modi added.
For now, the news is hopeful. The girl has resumed school and is once again playing with her friends.
BOX
Angiomyxofibromatous tumour: Angiomyxofibromatous tumours are soft tissue tumours that have, until now, been reported only in the genital region of adult females. Although typically benign, their behaviour within the brain remains unknown due to the rarity of such occurrences.
Vadodara: In a medical breakthrough that may be the first of its kind globally, doctors at Vadodara's SSG Hospital and Baroda Medical College successfully removed an exceptionally rare tumour — angiomyxofibromatous — from the brain of a 12-year-old girl.
What makes this case extraordinary is that such a tumour has never before been reported in the brain, and is so rare that it isn't even included in the current World Health Organization (WHO) classification of nervous system tumours.
Worldwide, angiomyxofibromatous tumours are known to occur in the genital region of adult females, making this diagnosis in the posterior fossa (a small space at the back of the skull and houses some critical structures of the central nervous system) unprecedented.
Dr Parth Modi, from the Department of Neurosurgery at SSG Hospital, said the girl presented last year with persistent headaches, dizziness and vomiting, but had no prior health issues.
"Her physical examination didn't reveal any neurological deficits. However, MRI and CT scans showed a 5 cm tumour in the posterior fossa region," he explained.
Given the tumour's critical location, the surgical team had to proceed with extreme caution. "This was a high-risk procedure due to the potential for bleeding," Dr Modi said. The surgery — sub-occipital craniotomy and tumour excision via the telovelar approach — was carried out by Dr Modi, Dr Amey Patankar, Dr Ankit Shah and Dr Vinay Rohra.
Remarkably, the girl was discharged within a week of the surgery.
However, the mystery deepened post-surgery when the biopsy initially yielded inconclusive results. The sample was then sent to the National Institute of Mental Health and Neurosciences (NIMHANS) in Bengaluru — a WHO-affiliated premier institute — where the tumour was finally identified as angiomyxofibromatous.
"Given the unprecedented nature of this case—being the first reported instance of such a tumour in the brain of a child — we decided to formally document it," said Dr Modi.
The case was reviewed by renowned neurosurgeons from Japan and South Korea, and was recently published in the Asian Journal of Neurosurgery.
While angiomyxofibromatous tumours are typically benign, the exact behaviour of this tumour in the brain remains unknown. "We're closely monitoring her for any signs of recurrence," Dr Modi added.
For now, the news is hopeful. The girl has resumed school and is once again playing with her friends.
BOX
Angiomyxofibromatous tumour: Angiomyxofibromatous tumours are soft tissue tumours that have, until now, been reported only in the genital region of adult females. Although typically benign, their behaviour within the brain remains unknown due to the rarity of such occurrences.