Latest news with #Pavlovian
Business Wire
5 days ago
- Health
- Business Wire
Enveric Biosciences Lead Drug Candidate EB-003 Demonstrates Positive Effects in Preclinical Model of Post-Traumatic Stress Disorder (PTSD)
BUSINESS WIRE)-- Enveric Biosciences (NASDAQ: ENVB) ('Enveric' or the 'Company'), a biotechnology company dedicated to the development of novel neuroplastogenic small-molecule therapeutics for the treatment of psychiatric and neurological disorders, today announced positive results in a preclinical, exposure-based therapeutic model for post-traumatic stress disorder (PTSD). In fear conditioned mice, oral administration of EB-003 significantly decreased context-induced freezing behavior when measured one-hour post-dose (p < 0.05) indicating a positive therapeutic effect with extinction of contextual fear after a single dose. These results were in line with the therapeutic effects observed with MDMA, which was used as a positive control in this study. MDMA is a psychedelic controlled substance that has demonstrated clinical benefit in the treatment of PTSD in human trials, although it is not approved by the FDA. The pairing of electrical shock stimulus with a controlled environment generates context-based traumatic memories leading to freezing behaviors when the subject is re-exposed to the same environment. This well-established translational rodent model, performed by a third-party lab, is designed to induce a potent, trauma-related state of fear using a Pavlovian association paradigm. 'Only a few medications have been approved by the FDA for the treatment of PTSD, including the serotonin reuptake inhibitors (SSRIs) paroxetine and sertraline,' said Joseph Tucker, Ph.D., CEO and Director of Enveric. 'Only 20% to 30% of PTSD patients experience full remission with these drugs and it takes two to three weeks of SSRI administration before clinical and neuronal benefits become apparent. Clearly, there is enormous unmet need in PTSD, which has yet to be addressed with meaningful innovation.' Dr. Tucker added: 'Research has implicated impaired hippocampal neuroplasticity as key underlying features of patients struggling with PTSD. We are very encouraged that a single dose of our lead neuroplastogen, EB-003, facilitated rapid fear extinction in mice.' In light of this new data, EB-003, a next-generation neuroplastogen that may enhance hippocampal neuroplasticity without causing hallucinations, has the potential to significantly improve treatment outcomes for this chronic and debilitating mental health condition, representing a major opportunity in an underserved market. About Enveric Biosciences Enveric Biosciences (NASDAQ: ENVB) is a biotechnology company dedicated to the development of novel neuroplastogenic small-molecule therapeutics for the treatment of psychiatric and neurological disorders. Leveraging its unique discovery and development Psybrary™ platform, which houses proprietary information on the use and development of existing and novel molecules for specific mental health indications, Enveric seeks to develop a robust intellectual property portfolio of novel drug candidates. Enveric's lead molecule, EB-003, is a potential first-in-class neuroplastogen designed to promote neuroplasticity, without inducing hallucinations, in patients suffering from difficult-to-address mental health disorders. Enveric is focused on advancing EB-003 towards clinical trials for the treatment of neuropsychiatric disorders while out-licensing other novel, patented Psybrary™ platform drug candidates to third-party licensees advancing non-competitive market strategies for patient care. Enveric is headquartered in Naples, FL with offices in Cambridge, MA and Calgary, AB Canada. For more information, please visit Forward-Looking Statements This press release contains forward-looking statements and forward-looking information within the meaning of applicable securities laws. These statements relate to future events or future performance. All statements other than statements of historical fact may be forward-looking statements or information. Generally, forward-looking statements and information may be identified by the use of forward-looking terminology such as "plans," "expects" or "does not expect," "proposes," "budgets," "explores," "schedules," "seeks," "estimates," "forecasts," "intends," "anticipates" or "does not anticipate," or "believes," or variations of such words and phrases, or by the use of words or phrases which state that certain actions, events or results may, could, should, would, or might occur or be achieved. Forward-looking statements may include statements regarding beliefs, plans, expectations, or intentions regarding the future and are based on the beliefs of management as well as assumptions made by and information currently available to management. Actual results could differ materially from those contemplated by the forward-looking statements as a result of certain factors, including, but not limited to, the ability of Enveric to: finalize and submit its IND filing to the U.S. Food and Drug Administration; carry out successful clinical programs; achieve the value creation contemplated by technical developments; avoid delays in planned clinical trials; establish that potential products are efficacious or safe in preclinical or clinical trials; establish or maintain collaborations for the development of therapeutic candidates; obtain appropriate or necessary governmental approvals to market potential products; obtain future funding for product development and working capital on commercially reasonable terms; scale-up manufacture of product candidates; respond to changes in the size and nature of competitors; hire and retain key executives and scientists; secure and enforce legal rights related to Enveric's products, including patent protection; identify and pursue alternative routes to capture value from its research and development pipeline assets; continue as a going concern; and manage its future growth effectively. A discussion of these and other factors, including risks and uncertainties with respect to Enveric, is set forth in Enveric's filings with the Securities and Exchange Commission, including Enveric's Annual Report on Form 10-K and its Quarterly Reports on Form 10-Q. Enveric disclaims any intention or obligation to revise any forward-looking statements, whether as a result of new information, future events or otherwise, except as required by law.
Winnipeg Free Press
12-07-2025
- Entertainment
- Winnipeg Free Press
Best bubbles for your buck
Opinion For those of us whose desert island wine would be sparkling (what else would you drink with desert island oysters?), the sound of a cork popping out of a bottle of bubbly is practically Pavlovian: our heads snap in the direction of the sound, our mouths start watering. We sparkling wine lovers don't need a special occasion to crack a bottle of bubbly, although I've had a couple reasons to pop open some Champagne this year, with my daughter turning 18 in January and then graduating high school in June. But since I can't afford the good stuff year-round, I test drove six more affordable bubblies recently, some serviceable and ready for your favourite fizzy cocktail, and others truly tasty on their own and ideal for serving well chilled during summer patio season (air quality permitting). And if you really need a reason to crack open some sparkling wine this weekend, how about this: today (July 12) is apparently International Cava Day. You know what to do. uncorked@ @bensigurdson Segura Viudas NV Brut Cava (Guarda, Spain — $19.99, Liquor Marts and beyond) Like most cavas, the Segura's a blend of Macabeo, Parellada and Xarel-lo grapes, made in the traditional method of fermentation in the bottle. It's very pale straw in colour, and offers green apple skin, chalk, lemon zest, floral and subtle saline notes aromatically. It's light-bodied and mainly dry, with lively effervescence ramping up the citrus and chalky notes, keeping things lean and (slightly) green, while the white peach and tart apple notes add some depth of flavour. The 12 per cent alcohol seems just right. 3.5/5 Jeio Belstar NV Vaporetto No. 8 Prosecco (Veneto, Italy — $26.99, The Winehouse) Made from the Glera grape (as are most proseccos), this pale straw-coloured bubbly offers floral, chalky, red apple, crisp peach and lemon candy notes on the nose. It's dry and light-bodied, with medium acidity that comes with peach, red apple, lemon zest, melon and a subtle chalky note. Decent on its own, with a bit more complexity than your typical prosecco. Available at The Winehouse. 3/5 Doña Dominga NV Brut Sparkling (Colchagua Valley, Chile — around $17, private wine stores) This lively bubbly from Chile's Colchagua Valley is made from 100 per cent Chardonnay; it's pale straw in colour and offers fresh pear and peach aromas, secondary chalky and lemon notes and a subtle herbacious component. It's light-plus bodied and bone dry, with racy acidity and effervescence delivering crunchy red apple, peach, lemon rind and subtle toasty, nutty notes before the medium-length finish (it's 12.5 per cent alcohol). A very good bubbly for the price; available at Ellement Wine + Spirits and The Pourium. 4/5 Yes Way NV Rosé Bubbles (France — $19.99, Liquor Marts and beyond) A blend of Grenache, Cinsault and Muscat grapes grown in southern France, this sparkling rosé is made in the Charmat method, where the bubbles are added while the wine's still in tanks. It's pale pinkish-orange in colour, and aromatically brings simple peach, pear and strawberry candy notes on the nose. It's light-bodied and slightly off-dry, with fizzy effervescence bringing cheerful peach candy, lemon zest and red apple flavours. A good candidate for fizzy cocktails. 3/5 Henry of Pelham Family Estate NV Cuvée Catharine (Niagara Peninsula, Ont. — $33.99, Liquor Marts and beyond) A blend of Chardonnay and Pinot Noir made in the traditional method, this Niagara bubbly is pale straw in appearance and offers beautiful bread dough, chalky, herbal, red apple skin and lemon aromas, with hints of toasted nut and lime adding depth. It's a light-plus-bodied, bone-dry sparkling, delivering up-front bread dough, nutty, lemon zest, green apple skin and chalky flavours, with vibrant bubbles and acidity and great length (thanks in part to the 12 per cent alcohol). Better than some entry-level French Champagnes that sells for twice the price or more. 5/5 Ben SigurdsonLiterary editor, drinks writer Ben Sigurdson is the Free Press's literary editor and drinks writer. He graduated with a master of arts degree in English from the University of Manitoba in 2005, the same year he began writing Uncorked, the weekly Free Press drinks column. He joined the Free Press full time in 2013 as a copy editor before being appointed literary editor in 2014. Read more about Ben. In addition to providing opinions and analysis on wine and drinks, Ben oversees a team of freelance book reviewers and produces content for the arts and life section, all of which is reviewed by the Free Press's editing team before being posted online or published in print. It's part of the Free Press's tradition, since 1872, of producing reliable independent journalism. Read more about Free Press's history and mandate, and learn how our newsroom operates. Our newsroom depends on a growing audience of readers to power our journalism. If you are not a paid reader, please consider becoming a subscriber. Our newsroom depends on its audience of readers to power our journalism. Thank you for your support.
Spectator
03-07-2025
- Politics
- Spectator
Rachel Reeves, Winston Churchill and a short history of crying in politics
The scenes of a tearful Rachel Reeves are all anyone is likely to remember from yesterday's Prime Minister's Questions. The Chancellor wept openly, her expression distraught; it was difficult to watch. The death of Princess Diana and the extraordinary outpourings of public grief that followed marked the end of stiff-upper-lip Britain. Vestiges remain, however, and we still become uncomfortable at the sight of the prominent and powerful brought to tears. It triggers a Pavlovian response in much the same way that the mention of religion in polite company has our toes scrunching in our shoes, as we try to dig a hole to escape the awkwardness. In fact, the tearful politician has been with us for some time. Andrew Roberts notes that Winston Churchill's 'astonishing lachrymosity could be unleashed at minor moments as well as on great occasions, especially if martial music was involved'. Examples included tearing up on a visit to an East End air raid shelter during the Blitz, while singing 'O God Our Help In Ages Past' with FDR aboard the USS Augusta, and after watching historical drama That Hamilton Woman (Alexander Korda, 1941). For Brits over a certain age, a defining political memory will be Margaret Thatcher's tear-stained exit from Number 10. Her voice trembled as she announced: 'Ladies and gentlemen, we're leaving Downing Street for the last time,' but the brave face gave way once she was bundled into the back of the car that would carry her away from power. A camera flash penetrated the tinted windows and revealed the haunted eyes and clasped lip of a commander betrayed by her own infantrymen. Twenty-nine years later, Theresa May trod the same cobbled steps to fall on her own sword, though much like her predecessor the mortal wounds had been delivered by the daggers of her own colleagues. May held up longer than Thatcher but began to waver when she spoke of 'the job that it has been the honour of my life to hold' and there was a pronounced crack in her timbre at mention of being 'the second female prime minister'. But it was in the final words of her statement, when she expressed her 'enormous and enduring gratitude', that her composure crumbled, so that she closed several octaves higher, on 'serve the country that I love', and you could feel her heart ache with each syllable. While Thatcher's tears elicited schadenfreude from her enemies on the left, May's sniffles evoked a little more sympathy due to the sheer impossibility of the feat she had taken on: getting Brexit through an anti-Brexit parliament and a soft Brexit through a hard Brexit party. There was markedly less sympathy for Matt Hancock during his lachrymose tenure as health secretary, epitomised by his choking up while discussing the Covid vaccine rollout on Good Morning Britain. Hancock's Kleenex moments became so prolific that they were mocked by Spitting Image and even had Good Morning Britain questioning how sincere the waterworks were. Public lamentations by the political classes aren't just a British phenomenon. Even less sympathetic than Hancock is Japanese lawmaker Ryutaro Nonomura, who went viral in 2014 for bawling hysterically in a press conference called to rebut allegations that he had fraudulently claimed expenses. He was later convicted of misusing public funds, and is now a relationship guru and host of 'Ryutaro Nonomura's Love Story Channel'. (I'm not making this up.) Hillary Clinton choked up during a televised reading of the presidential victory speech she never got to give in 2016, an act of such solipsism you can appreciate why the American people opted for the reality TV sociopath instead. Former Republican House Speaker John Boehner bleated so often — when he was sworn in, when he met the Pope, when he had a conversation with the prime minister of Estonia — that blubbing is his principal legacy. Edmund Muskie, a serious contender for the Democrat presidential nomination in 1972, was thought to have sunk his chances when a speech in New Hampshire defending his wife from criticism of her lifestyle opened the floodgates. Other leaders manage to snot up but retain their dignity in the long run. Israeli prime minister Menachem Begin famously sobbed during a radio broadcast on the Altalena affair while Australians recall Bob Hawke being overcome during a speech describing the horrors of the Tiananmen Square massacre. Politics is an unforgiving business. One of Hawke's successors, Julia Gillard, remembers a phone call from another former PM, the eternally blunt Paul Keating, the day after she was deposed in a party room coup. 'We all get taken out in a box, love,' came the voice on the other end of the line. It was intended as a consolation. Yet the brute realities and sudden betrayals that await all who walk the corridors of power are of little interest to the voters. They don't have warm and fuzzy feelings for Chancellors at the best of times, and certainly not in times of economic hardship. Our upper lips might not be so stiff anymore but they curl in cruelty when a politician blubbers. Whatever the source of Rachel Reeves' sorrows, the political and media classes will be far more sympathetic than the voters. Whether her anguish is personal or political, most hearts across the country have already hardened against her. Many MPs and journalists will find that hard to believe — what if some terrible family loss is involved? — but as in so many things proximity to Westminster is distance from the voters, and the voters are not merely angry but contemptuous towards this government. A little more graciousness would benefit us all, a recognition of life's difficulties and complexities, even just a fleeting pang of empathy for our common human frailty, but don't count on it in this case. If the Chancellor had any idea just how thoroughly the public loathes her and her colleagues, she really would weep.
Miami Herald
01-07-2025
- Science
- Miami Herald
Ancient boomerang found in Poland challenges beliefs on early human settlement
New technology has revealed that an ancient mammoth tusk boomerang discovered in Poland in 1985 is significantly older than archaeologists initially believed. The artifact, discovered in Podhale Obłazowa Cave, was estimated to be between 30,000 and 23,000 years old and believed to originate from Pavlovian culture, according to a June 28 news release from Science in Poland. Thanks to DNA and isotopic analyses, researchers have confirmed the artifact may be up to 42,000 years old, predating the oldest known Aboriginal boomerang by tens of thousands of years, according to a study published June 25 in the journal PLOS One and Australian archaeological records. The new finding makes the mammoth ivory boomerang the oldest ever discovered in Europe and possibly the world, according to the study. 'While today the boomerang is commonly associated with Aboriginal culture in Australia, historical evidence suggests its use across different continents,' researchers said. The boomerang, measuring about 28 inches long, flies but does not return to the thrower, similar to some Aboriginal boomerang designs, experts said. It bears 'notable wear and polish' indicating frequent handling. The artifact was found alongside a bone from a human thumb, a Conus shell, pendants made from arctic fox teeth, stone artifacts and boulders intentionally moved into the cave, suggesting it may have been used in a 'shamanistic ritual,' according to experts. Researchers said no ivory fragments were found at the site, so the boomerang must have been carved somewhere else and taken to Obłazowa Cave, 'underscoring its special status.' The age of the ivory boomerang and other artifacts also challenges beliefs that no one permanently lived in what is now Central Europe during that time, according to researchers. Until now, many experts believed Homo sapiens did not settle in the region until after 35,000 B.C., leaving it 'uninhabited for millennia following Neanderthal extinction.' The new findings provide evidence of sustained human settlement during the Early Aurignacian — a culture associated with the first modern humans, according to the study. The research team included Sahra Talamo, Nicole Casaccia, Michael P. Richards, Lukas Wacker, Laura Tassoni, Adam Nadachowski, Anna Kraszewska, Magda Kowal, Jakub Skłucki, Christopher Barrington, Monica Kelly, Frankie Tait, Mia Williams, Carla Figus, Antonino Vazzana, Ginevra Di Bernardo, Matteo Romandini, Giovanni Di Domenico, Stefano Benazzi, Cristina Malegori, Giorgia Sciutto, Paolo Oliveri, Jean-Jacques Hublin, Mateja Hajdinjak, Pontus Skoglund, Andrea Picin and Paweł Valde‑Nowak. Obłazowa Cave is about a 60-mile drive south from Krakow. Google Translate was used to translate the news release from Science in Poland.
Extra.ie
24-06-2025
- Entertainment
- Extra.ie
Mark McCabe on Maniac 2000: 'Nobody really knew what to make of it'
2025 marks the silver jubilee of Ireland's unofficial national anthem – Mark McCabe's 'Maniac 2000' – The essential classic club track that every Irish person has shaken their booty to. Even if you think you haven't, trust me, you have. For 25 years, the song has been blasted out at discos, clubs, pubs, weddings and sporting events – usually at night's end, summoning delirious dancers to the dance floor at every shindig, blowout and jamboree like a Pavlovian klaxon. Therefore, it is beyond bizarre that the song has never been available on streaming platforms… until now. Spending 10 weeks at Number 1 in 2000, 'Maniac 2000' overtook All Saints, Madonna and Backstreet Boys while preventing Westlife from getting their fifth consecutive number one. It was a nationwide phenomenon. And what makes it more incredible is the fact that it was created with no budget and released on a tiny indie label. A quarter of a century ago, the music industry landscape was completely different to what it is today. Napster was only in its infancy, streaming platforms such as Spotify were still light years away, and everyone bought CDs or cassettes. Such was the climate into which 'Maniac 2000' was released. It was an underdog, produced guerrilla style, at a time when grandiose production was in the ascendant. Mark McCabe, an affable chap and great company, sets the scene. 'That time was very much Westlife at their peak,' he recalls. 'Well, maybe not at their peak, but they were the next thing after Take That and Boyzone. There was a lot of manufactured pop around, bands like Steps and S Club, stuff like that. It was all heavily controlled by the major record labels.' However, there was also a vibrant rave culture. Across a hive of venues – The Asylum, Ormond Multimedia Centre, Temple of Sound, The Kitchen, Switch, RíRa, The Pod, Colombia Mills and Temple Theatre – Dublin was buzzing to the sound of the dance underground. Mark occupied a sonic territory somewhere between those two polarities. He reflects on cutting his teeth at raves, such as Awesome and Obsession at the RDS. 'I just loved the atmosphere,' he enthuses. 'The lasers, the smoke machines, the lights and the show that they put on. I had been involved in doing my own little discos and stuff like that, but it was the scale of what they were doing that really appealed to me. And I liked the music. I liked the fact that it was not five guys playing instruments. 'It was one or two guys, and they were generating this music electronically. The Prodigy's 'Charly' was the first track that I ever bought. That was my awakening to it, because it sounded so different to everything else. And then there were things like Kicks Like A Mule's 'The Bouncer', which has this vocal hook, which is super simple, and that also appealed to me.' McCabe became an avid listener to pirate station Pulse FM, which, pre-internet, along with Club FM, was where people discovered new dance tracks. 'Pulse appealed to me a little bit more,' Mark explains, 'because it was slightly more commercial. I got in touch with them and asked if I could come and see the studio, and went out to Clontarf. I got on really well with the guys that were running it, and they gave me a show. I ended up being the station manager and programming it.' That shows some moxie. McCabe was still a teenager. On top of that, then, he created the fifth biggest selling Irish single of all time. His views on 'Maniac 2000' are not entirely what you might expect, however. 'My peers,' he explains, 'the Billy Scurrys, the Johnny Moys and all of those people, it just wouldn't have been their thing. This was my first dance release. All my heroes, the guys whose tunes I had grown up listening to, and who I worked for in the Ormond Multimedia Centre, doing sound, they were going, 'What the heck is this?' So I was embarrassed. 'Nobody really knew what to make of it. I think as a result of that, there was no chance of me having a credible DJ career or being respected in that scene, even though I managed to get signed to Danny Tenaglia's label, Twisted, which was super-cool. So, on one side I was doing cool, incredible things, but then on the other, I was the guy that did this 'Maniac' track.' The origins of 'Maniac 2000' emerged in the early '80s via Michael Sembello of Flashdance soundtrack fame. Fast forward to 1995 when Irish act 4 Rhythm released their own version of the song, which spawned a remix by Irish duo Sound Crowd, McCabe, like many other Dublin DJs at the time (including co-writer Al Gibbs), was drawn to the 'Maniac' instrumental and, as a party piece, would throw different raps over it. 'The first version, the demo, was aired on Pulse FM from a gig that was in the Temple Theatre,' says Mark. 'And that's how people got to know it. It was literally, on the night we hit record, whatever came out of my mouth – that was it. Then we started playing it on Pulse, and that's the version that stuck. We went back and recorded it in the Clontarf Cricket Club at an under-18 gig, and that was the final version.' Initially, the popularity of the track was gauged by the number of people phoning in to Pulse FM.'People just kept on requesting it,' Mark smiles, 'and then they went into Billy Murray at Abbey Discs, and said, 'Can we buy this?' So I signed to him. It went in at No.2 for the first week and then spent 10 weeks at No.1.' 'Maniac 2000' took on a life of its own. But it was not the door-opener it should have been for Mark… 'There was a side of me,' Mark explains, 'that was going, 'Okay, I want to be a superstar DJ. I want to be one of those cool DJs'. So, on one side I had 'Maniac', and then on the other, I was doing shows on 2FM, playing new trance or tribal house. And at that time, it didn't make sense for 'Maniac' to fit with that. It was just so different, so that's where I really struggled. 'Obviously, the 'Maniac' people were far outnumbering the 2FM audience at the shows. I think I did it for about four or five years, and then I thought, 'It's just not for me, it doesn't make sense'. I found it really difficult to go and do shows, because I was thinking, 'Oh man, I've got to do 'Maniac'. It's not going to make sense, playing all these tunes and then suddenly going into 'Maniac'. 'I went to work for RTÉ and had my own studio where I started to record bands, orchestras, choirs, you name it. So, I got back to doing the technical side of things. Then I got the opportunity to set up the RTÉ digital station. I brought Pulse with me, and we set up 2XM, which was the indie station.' Mark McCabe. Copyright Abigail Ring/ And that was that, until McCabe unleashed 'Maniac 2000' once again at Electric Picnic 2015, and the crowd went insane. 'I really didn't expect anything at all,' Mark laughs. 'It turned out to be this sort of awakening, where I got to see it for what it was – it was just people really enjoying it. They were having a good time with it and I felt it was my duty to give people what they want! Now it makes sense. I can play a show and everything works together. 'A lot of dance music now is reworks of stuff from the '90s and noughties. Playing the Picnic last year, there were people from 13 to 60, and the younger kids knew a lot of the reworks. And then the older people obviously knew the original. Now it's nothing but joy, it's so much fun.' 'Maniac 2000', the underdog with the heart of a lion, is relishing its second act, with McCabe playing massive gigs and even selling out the 3Arena in March of this year. 'People were showing up for the fact that it was 25 years of 'Maniac',' he notes. 'So it was very personal, because I knew that everybody there had an appreciation for 'Maniac 2000'. That was really special.' • The 25th anniversary edition of 'Maniac 2000' is streaming now on all platforms.
