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Health Line
01-07-2025
- Health
- Health Line
Can Vitamin E Help Hepatic Steosis (Fatty Liver)?
Vitamin E is a fat-soluble vitamin that may have antioxidant and anti-inflammatory properties that may benefit some people with liver disease. But research is inconclusive. Steatotic liver disease (SLD), previously known as fatty liver disease (FLD), refers to a group of conditions in which excessive fat builds up in the liver. Some liver fat is normal, but excess liver fat could impact liver function and lead to serious complications. There are two types of SLD. These have been renamed in 2023 by global liver societies to help reduce stigma and more accurately reflect the underlying causes of these conditions: Metabolic dysfunction-associated steatotic liver disease (MASLD): This condition involves a buildup of fat in the liver, but it causes little to no inflammation or liver damage. It used to be called nonalcoholic fatty liver disease (NAFLD). Metabolic dysfunction-associated steatohepatitis (MASH): This is a more severe type of fatty liver disease involving liver inflammation and other changes, such as cirrhosis (scarring). It used to be called non-alcoholic-associated steatohepatitis (NASH). According to the American Association for the Study of Liver Diseases (AASLD) Guidelines and the American Diabetes Association (ADA), vitamin E supplements may be beneficial for certain people with MASLD and MASH. However, the Food and Drug Administration (FDA) has not approved vitamin E supplements for treating SLD, and not all studies fully support their purported benefits. It's important to work with a doctor to develop the best treatment plan for you. Keep reading to learn more about the possible benefits of vitamin E for SLD and how much to take. What are the benefits of vitamin E for fatty liver disease? Vitamin E is a fat-soluble compound known for its antioxidant properties. These compounds help neutralize free radicals, which can cause oxidative damage to various cells in the body, such as hepatocytes (liver cells). According to the AASLD, vitamin E supplementation may also help in the treatment of MASH by: reducing levels of the enzyme aminotransferase, a marker of liver damage protecting liver cells from inflammation reducing cellular ballooning, which is when liver cells get bigger and appear large and round, like balloons preventing the buildup of fat and fat-induced damage Furthermore, a 2020 review also found that vitamin E supplementation may help reduce liver fibrosis (scarring) in adults and children living with MASH. How much vitamin E should you take? There are no official guidelines on how much vitamin E to take for hepatic steosis (fatty liver). Research suggests that a daily dosage of 400 to 800 International Units (IU) (180 to 360 milligrams) taken for 3 to 24 months may help relieve inflammation in people with SLD. This can be taken as a single dose or divided into two doses. Some studies also found that vitamin E may contribute to slowing down liver scarring and other complications when taken in combination with other supplements and medications, including: Vitamin C: 500 mg per day Pioglitazone: 45 mg per day Ursodeoxycholic acid (UDCA): 12 to 15 mg per kilogram of bodyweight per day Despite these findings, however, it's important to note that none of these medications and supplements are FDA-approved for treating SLD, and other research has found mixed results. A healthcare professional can help develop the best treatment plan for you, which may include a combination of lifestyle, dietary, and medical treatments. Who should take vitamin E? Researchers are still trying to determine who might benefit from taking vitamin E supplements for SLD. The AASLD notes that vitamin E supplementation may benefit people with MASH who don't have diabetes. A 2021 review found similar recommendations, but also suggests that a combination of vitamin E and pioglitazone may be beneficial for people with MASH and type 2 diabetes. The ADA and AASLD conclude that vitamin E supplementation for SLD should be considered on an individual basis. As such, it's best to work with a healthcare professional to help decide whether vitamin E is right for you. What are the possible side effects of vitamin E? Researchers are still trying to understand the possible side effects of vitamin E supplementation for SLD. According to a 2024 review, the following side effects have been reported across various studies: diarrhea constipation nausea upper respiratory infection sinusitis bronchitis arrhythmia cataract gastroenteritis gout syncope (fainting) The AASLD notes that vitamin E supplementation may also be linked to prostate cancer and stroke, but the evidence is inconclusive. More research is needed to understand the possible side effects of vitamin E supplementation. Other natural remedies There's currently no cure or specific medical treatment for SLD. Lifestyle and dietary changes are considered the primary treatment for SLD and other liver conditions. If you're living with MASLD or MASH, the following natural remedies may help manage your condition: maintaining a healthy-for-you weight eating a well-balanced diet of nutrient-dense whole foods exercising regularly managing other health conditions, such as diabetes, high cholesterol, and stress trying some herbal remedies, such as turmeric, ginger, and garlic A healthcare professional could help develop an appropriate treatment plan for you. The bottom line Steatotic liver disease refers to metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), two conditions in which excessive fat builds up in the liver. Some healthcare organizations and researchers have found that vitamin E supplementation may help improve markers of liver disease, reduce oxidative stress, and reduce liver inflammation. However, the research is inconclusive, and more studies are needed.
Time of India
23-06-2025
- Time of India
School bus operators block RTO (Rural) office over new tracking device mandate
1 2 Nagpur: School bus owners on Monday morning blocked the entry of the Regional Transport Office (Nagpur Rural) on Kamptee Road, stalling operations to protest what they called arbitrary and unlawful directives mandating the reinstallation of vehicle tracking systems. The agitation, coinciding with the reopening of schools in the city, raised concerns over a looming transport crisis for students. As warned, the members of Nagpur Mahanagar Parwana Bus Association and bus owners reportedly parked school buses inside the rural RTO premises, blocking its entry and exit. Operators alleged that despite having functional Vehicle Location Tracking (VLT) systems and Secure Layer Devices (SLD) installed in their buses, the RTO is forcing them to replace them with new 16-digit VLT-compliant devices. They also claim they are being made to pay for two years of service upfront, even though the fitness certificate issued by the department is valid only for the same duration. Association president Shailesh Pande said many VLT devices installed barely two years ago are now blocked without valid reason. They claim the circular mandating new devices has no backing under the Motor Vehicles Act and is designed to benefit a few private vendors. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like 5 Books Warren Buffett Wants You to Read In 2025 Blinkist: Warren Buffett's Reading List Undo Another major point of contention is that the central monitoring system, meant to track the vehicles and alert authorities in emergencies, is not operational. "We are being forced to install these costly devices, but the system that's supposed to monitor them doesn't even exist," said protester Virendra Dubey. "What's the use of an SOS button if there's no one to respond? This is nothing but a formality to fill someone's pockets. " Dubey also said several functional older devices have been blacklisted arbitrarily. "They want us to install new systems again, without any change in safety features. This reeks of corruption," he said. A senior transport official, however, defended the move, saying the VLT mandate is as per govt order aimed at students' safety. "Fitness certificates can only be issued if the VLT system is active and valid for the entire fitness period — two years. The system doesn't accept partial or one-year validity," the official said adding, "We are aware of the technical issues and have referred the matter to higher authorities. " On June 12, operators submitted a formal complaint to RTO Vijay Chavhan, also marking it to the transport commissioner in Mumbai. With no action taken, they launched the blockade on Monday. "If the department continues to ignore us, we will escalate the protest and shut down other RTO offices too," said a spokesperson for the protesters adding, "The govt will be responsible for any disruption in school transport." # How the VLT system works Vehicle Location Tracking systems are GPS-enabled tracking devices designed to ensure real-time monitoring of school buses. Each device comes with an emergency SOS button. In case of an accident or emergency, pressing the button is supposed to immediately alert both the transport and police departments through a central monitoring platform. The device also helps in tracking the vehicle's live location, enhancing child safety during school commutes.
The Sun
14-06-2025
- Automotive
- The Sun
PBEM backs MOT's plan for driver database, speed limiters on heavy vehicles
KUALA LUMPUR: The Malaysia Express Bus Operators Association (PBEM) has expressed support for the Transport Ministry's (MOT) proposal to introduce a new driver database system and mandate the installation of speed limitation devices (SLD) on all heavy vehicles, including express and tour buses. PBEM chairman Mohamad Nazri Md Yusof said the database would help operators recruit better-qualified drivers by screening applicants based on clean employment and traffic records, while avoiding those with poor discipline or frequent offences. 'With this system, bus operators can reduce recruitment time and costs, monitor drivers more efficiently, and identify those needing further training. It will also enhance the company's reputation by helping to prevent accidents caused by driver negligence,' he said in a statement today. He added that PBEM strongly supports making SLD installation a mandatory operational requirement, complementing the existing GPS tracking systems. Mohamad Nazri noted that speeding remains a major cause of fatal road accidents, and the use of SLDs can serve as a critical safety measure. 'Installing SLDs in each bus' electronic control unit (ECU), with specifications that prevent tampering or deactivation, would effectively stop drivers from exceeding speed limits,' he said. Mohamad Nazri reaffirmed PBEM's commitment to supporting the government's efforts to improve public transport, especially in enhancing the safety of express bus operations. He also urged PBEM members not to focus solely on profits, but to prioritise the safety of passengers and drivers by strictly complying with all relevant laws, regulations, and licensing conditions.
The Sun
14-06-2025
- Automotive
- The Sun
PBEM backs new driver database, speed limit devices
KUALA LUMPUR: The Malaysia Express Bus Operators Association (PBEM) has expressed support for the Transport Ministry's (MOT) proposal to introduce a new driver database system and mandate the installation of speed limitation devices (SLD) on all heavy vehicles, including express and tour buses. PBEM chairman Mohamad Nazri Md Yusof said the database would help operators recruit better-qualified drivers by screening applicants based on clean employment and traffic records, while avoiding those with poor discipline or frequent offences. 'With this system, bus operators can reduce recruitment time and costs, monitor drivers more efficiently, and identify those needing further training. It will also enhance the company's reputation by helping to prevent accidents caused by driver negligence,' he said in a statement today. He added that PBEM strongly supports making SLD installation a mandatory operational requirement, complementing the existing GPS tracking systems. Mohamad Nazri noted that speeding remains a major cause of fatal road accidents, and the use of SLDs can serve as a critical safety measure. 'Installing SLDs in each bus' electronic control unit (ECU), with specifications that prevent tampering or deactivation, would effectively stop drivers from exceeding speed limits,' he said. Mohamad Nazri reaffirmed PBEM's commitment to supporting the government's efforts to improve public transport, especially in enhancing the safety of express bus operations. He also urged PBEM members not to focus solely on profits, but to prioritise the safety of passengers and drivers by strictly complying with all relevant laws, regulations, and licensing conditions.
Sinar Daily
13-06-2025
- Business
- Sinar Daily
FRU fatal crash: Lorry company owner to face court action
Transport Minister Anthony Loke said that the Road Transport Department (JPJ) will take action against the company. 13 Jun 2025 05:08pm Transport Minister Anthony Loke said that the Road Transport Department (JPJ) will take action against the company. - Bernama photo SHAH ALAM - The owner of the lorry company linked to the fatal crash involving a Federal Reserve Unit (FRU) vehicle on Jalan Chikus-Sungai Lampam in Teluk Intan last month, will be taken to court. Transport Minister Anthony Loke said that the Road Transport Department (JPJ) will take action against the company. Anthony Loke - Bernama file photo "Firstly, the operator's licence has been revoked. Secondly, legal action will be taken against the company owner in court through JPJ,' he told reporters at a press conference after officiating the Speed Limitation Device (SLD) for commercial vehicles' implementation, at Scania (Malaysia) Sdn Bhd. Loke added that the families of the victims could also pursue civil action against the company, to seek damages and compensation. The tragic accident occurred at 8.54 am on May 13, when a Federal Reserve Unit (FRU) lorry collided with a tipper lorry, which had allegedly veered into the opposite lane. The crash claimed the lives of nine FRU members, and left nine others injured. In another development, Loke said the decision to return the authority to regulate tourism transport, particularly involving tour buses, to the Ministry of Tourism, Arts and Culture (MOTAC) is subject to Cabinet approval and he has no objection to the move, noting that the matter has been raised over the past two years. "MOTAC had previously prepared a Cabinet Memorandum (MJM) and submitted it to the Ministry of Transport (MOT) even before the recent incident involving Universiti Pendidikan Sultan Idris (UPSI) students,' Loke said. "I want to stress that this issue is not a response to the tragedy. I've told the Tourism, Arts and Culture Minister Datuk Seri Tiong King Sing that I have no objection to returning the regulatory authority, provided that the safety of sightseeing buses can be guaranteed. I'm more than happy to hand it back, but ultimately, the decision lies with the Cabinet,' he added. Last Wednesday, MOTAC, in a statement, called for the return of tourism transport regulatory authority to the ministry, following the fatal bus crash in Gerik, Perak, on Monday, which claimed the lives of 15 UPSI students. MOTAC described the tragedy not only as a devastating incident, but also exposed deep issues within in the current tourism transport safety system. Meanwhile, Loke said that the bus operators' association should inform the ministry and enforcement authorities, if they have any evidence or information regarding the alleged long-standing practice of leasing bus permits. He added that, if the association had cooperated by providing such information earlier, the government could have taken appropriate measures to address the issue, and possibly prevent the recent fatal accident. "Everyone is talking about permit leasing, but where is the evidence? The association should have assisted the MOT... they should have blacklisted or publicly exposed the company's actions, to help clean up the industry,' he said. In the early Monday morning incident, 15 Universiti Pendidikan Sultan Idris (UPSI) students were killed, when the bus they were travelling in overturned at KM53, East-West Highway (JRTB), near Tasik Banding, Gerik. - BERNAMA More Like This
