Latest news with #STORM
Business Wire
16-06-2025
- Business
- Business Wire
Quiver Bioscience Appoints Graham Dempsey, PhD as Chief Executive Officer to Lead Scaling of AI-Driven CNS Platform and Advance Lead Program into the Clinic
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Quiver Bioscience ('Quiver'), a discovery technology and therapeutics company advancing programs for treatment of serious central nervous system (CNS) disorders and chronic pain, announced the appointment of co-founder Graham Dempsey, PhD as Chief Executive Officer. Dr. Dempsey assumes the CEO role after more than a decade of scientific and operational leadership at Quiver, most recently serving as Quiver's Chief Scientific Officer, directing the planning and execution of all scientific, medical, engineering and AI/machine learning activities at the company. This appointment comes as Quiver aims to advance its lead program into the clinic, an antisense oligonucleotide (ASO) targeting Na v 1.7 for the treatment of chronic pain, while scaling its CNS-focused AI-driven drug discovery platform to accelerate a portfolio of therapeutic programs. Paul Roma, Quiver co-founder and interim CEO will transition to Chairman of the Board of Directors. 'We're excited by the potential of our genetic medicine strategy and platform to unlock this important target towards creating a transformative product for patients suffering from chronic neuropathic pain," said Dr. Dempsey Share Dr. Dempsey has successfully led the development and rapid evolution of the company's technology platforms since the company's inception, as well as its first small molecule and antisense oligonucleotide therapeutic programs, resulting in several foundational patents and peer-reviewed publications. He has also led more than a dozen pharma collaborations and the execution of several grants from non-dilutive funding sources such as the NIH SBIR Programs and CNS Foundations. Dr. Dempsey holds a B.A. in biochemistry (Roy and Diana Vagelos Scholar) and biophysics from the University of Pennsylvania and a Ph.D. in biophysics from Harvard Medical School, where he co-invented novel fluorescence-based imaging platforms for investigating biological systems and was part of the team that developed the super-resolution imaging technique called stochastic optical reconstruction microscopy (STORM) that was subsequently commercialized by Nikon Instruments. Dr. Dempsey serves on the Scientific Advisory Board of the Dan Lewis Foundation for Brain Regeneration Research and the editorial board of Molecular Therapy Nucleic Acids. Under Dr. Dempsey's leadership, Quiver will advance their lead asset, an ASO targeting the genetically validated pain target Na v 1.7, a voltage gated sodium channel implicated in several neuropathic pain disorders, through IND and early clinical studies. 'Despite the longstanding promise of Nav1.7 as a target for pain, it has remained elusive for drug developers. We're excited by the potential of our genetic medicine strategy and platform to unlock this important target towards creating a transformative product for patients suffering from chronic neuropathic pain,' said Dr. Dempsey. Quiver's Na v 1.7 ASO is expected to deliver durable relief for chronic pain while overcoming limitations of other Na v -targeted small molecules currently under development and recently approved. Quiver's strong data package demonstrates the efficacy of Na v 1.7 ASOs in rescuing pain phenotypes in in vitro and in vivo models with a favorable CNS tolerability profile. The ASO program is approaching development candidate selection in 2025 and is expected to begin critical IND enabling studies shortly thereafter. Quiver is also scaling their human-centric AI-driven novel CNS drug discovery platform with in silico models of target, efficacy and toxicity prediction, and is further bolstering a pipeline of fast-follower programs in pain, neurodevelopmental disorders, and other diseases of the CNS including the advancement of its UBE3A -targeting ASO for the neurodevelopmental disorder, chromosome 15q duplication syndrome (Dup15q) to IND. The company will be attending the BIO International Convention in Boston this week to showcase their programs and platform. About Quiver Bioscience Quiver Bioscience is a technology-driven company established to create transformational medicines for the brain while simultaneously uncovering new biology and novel, effective drug targets. Using advanced single-cell imaging and multi-omics, we are building the world's most information-rich neuronal insight map via our "Genomic Positioning System." Our approach integrates cutting-edge scalable human models, state-of-the-art technology and proprietary engineering, and learning and surrogate AI/ML models to identify novel therapeutic targets and the best candidate molecules to deliver new and meaningful therapeutics to patients. For more information, including partnerships and publications describing application of Quiver's GPS to drug discovery, visit or follow us on LinkedIn.
Malay Mail
06-06-2025
- General
- Malay Mail
Teen missing in Melaka forest while searching for cows found weak but safe after 32 hours
KUALA LUMPUR, June 6 — A 15-year-old boy with a learning disability who went missing while looking for cattle in a forested area near Kampung Permatang Pasir, Alai, was found safe early this morning after more than 32 hours. According to the New Straits Times, Muhamad Aidil Asyraf Fadli was found lying in the undergrowth behind a house about 600 metres from the Fire and Rescue Department's control post at 2.08am. 'He was given initial treatment by medical personnel at the scene before being handed over to the police for further action,' said Melaka Fire and Rescue Department public relations officer Mohd Hafidzatullah Rashid. He said the victim was found in a weak state and unable to move, and the search and rescue (SAR) operation was officially called off at 3.52am. The operation had earlier been suspended at 7pm yesterday after a search over a 2.4-hectare area yielded no leads. A total of 31 personnel were involved in the SAR effort, including 14 members from the Special Tactical Operation and Rescue Team of Malaysia (STORM), five policemen and four Civil Defence Force personnel. Villagers also assisted in the search, along with three sniffer dogs — two from the Fire and Rescue Department and one from the police. 'The operation was divided into four sectors and expanded to include riverbanks, with aerial monitoring conducted using a Fire and Rescue Department drone,' said Hafidzatullah. He added that SAR teams also drained two artificial ponds during the search. Meanwhile, Melaka Tengah deputy police chief Superintendent Halim Abas confirmed that Muhamad Aidil is currently receiving treatment at the Emergency Department of Melaka Hospital and is in stable condition.
Time of India
23-04-2025
- Automotive
- Time of India
Demand grows for racing fuel, IOCL expects surge in export
Vadodara: When superbikes roared down the tracks at the Asia Road Racing Championship 2024 in Thailand, few knew the fuel behind that raw power came from Gujarat. Indian Oil Corporation Ltd's Gujarat Refinery in Vadodara played a crucial role in the international event by supplying its high-performance STORM racing fuel — the first of its kind produced in India. "We began manufacturing racing fuel about a year and a half ago in response to growing demand. Until then, this fuel had to be imported, as no one in India was producing it," said Biplob Biswas, executive director and head of the Gujarat Refinery. "Apart from Thailand, our STORM fuel has also been used at two other racing events in India." Officials added that while a few more orders are in the pipeline, the majority of the racing fuel is currently exported. "We are considering supplying to western markets as well, but for now, production is based on confirmed orders," Biswas told TOI on Wednesday. In addition to racing fuel, Gujarat Refinery has also made strides in aviation energy, producing and exporting AVGAS 100 LL — a fuel that was previously imported. IndianOil has shipped AVGAS to Papua New Guinea, Sri Lanka, and Indonesia, and it is also used by the Indian armed forces. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Google Brain Co-Founder Andrew Ng, Recommends: Read These 5 Books And Turn Your Life Around Blinkist: Andrew Ng's Reading List Undo The refinery is now eyeing a broader role in the petrochemical sector through its Petrochemical and Lube Integration Project (LuPech). "With a projected investment of Rs 17,825 crore, LuPech will boost the refinery's capacity from 13.7 MMTPA (million metric tonnes per annum) to 18 MMTPA," Biswas said, outlining the refinery's ambitions of becoming a key petrochemical hub.
