Latest news with #Saeed
Time of India
8 hours ago
- Lifestyle
- Time of India
UAE farmer showcases unique 4kg homegrown organic mango variety at Khorfakkan Festival
Live Events (You can now subscribe to our (You can now subscribe to our Economic Times WhatsApp channel UAE farmer Saeed Al Maeli took everyone by surprise at the Mango Festival in Khorfakkan after he showed mangoes weighing nearly four kilogrammes, which he grew on his farms in Fujairah. The mangoes left even the seasoned cultivators baffled. However, they do not taste as sweet as the ones found in fruit four-kilogramme fruit is called Malda mango . It is slightly tangy and works well for pickles and curries, according to Khaleej Times. He sold these mangoes for Dh25 and says people come looking for them every about the Malda mangoes, Saeed called them 'unique' and said that this variety came out after years of careful hybrid cultivation, mixing cuttings and seeds from different trees. 'Not everything succeeds. But when it works, the result is something unique. This nearly 4 kg mango is one of those outcomes,' he said, according to Khaleej further asserted that the fruit does not catch the attention of the buyers for its sweetness but for its size and look. The other factor that he highlighted was how well it works in traditional dishes. 'It's not something you find in regular markets,' he said. He also stated that families buy it to make chutneys, pickles, or mango curry, and some people even come just to see his farms in Fujairah, Saeed grows over 35 varieties of mangoes, and he has hundreds of trees spread across his land. Saeed, who says that he started farming out of interest, also grows tomatoes, papayas, figs, dragon fruit, and other seasonal fruits. His ability to grow mangoes through most of the year makes him stand out from the crowd, as this is something many people don't expect to hear about farms in the near his stall at the festival, where he displayed the heavy Malda mango, Saeed said that people stop and ask, Is this real?.At festivals like the Khorfakkan Mango Festival , many farmers like Saeed get access to local residents, tourists, and restaurant owners looking for organic produce, which allows them to sell directly and build a connection with the buyers. 'They ask questions; they want to know how it's grown, whether it's organic, what we use – it builds trust,' he agree that the interest in UAE-grown mangoes is increasing. And as more people try these home-grown fruits, it's giving local farmers a platform to grow and experiment. In Saeed's case it's quite simple. 'Mango farming is not just about selling fruit,' he said. 'It's about making something with your own hands, something that grows from the land you live on.'
Express Tribune
06-06-2025
- Express Tribune
Sania Saeed talks hierarchy of abuse
Veteran television and theatre actor Sania Saeed recently appeared on The Rafay Mahmood Podcast and spoke about a myriad of topics including the cold-blooded murder of the 17-year-old influencer Sana Yousaf. 'Everyday, I wake up with the news of women dying,' said a visibly emotional Saeed. 'There's fatigue even in our compassion. How much more can we take?' 'This was just one girl, and even one is too much. How can we, as a society, permit that even one child is subjected to such assault and violence?' she added. Rationalising injustice The host Mahmood pinpointed Saeed's statement about fatigue and the society mislabelling it as resilience. Asked if she sees any such resilience in the society, Saeed noted how it's our way of rationalising and moving on with our lives. 'The logical part of your brain keeps saying that you have no other choice.' Saeed seemed to be holding back tears at this point, clearly affected by the tragedy. 'You carry a heavy heart, but to move on, to keep working, you rationalise it. You try to understand why and how it happened, where this all came from.' Saeed spoke about how the influencer was not involved in any controversies either; she 'was an innocent kid posting cute videos about restaurants and all.' She was 'following traditions, refusing unwanted advances exactly like we want our children to do. Isn't that what we teach our girls?' The Joyland actor said this is the point she wants to present to those who criticise and oppose women's rights, Aurat March and slogans like 'Mera Jism, Meri Marzi'. 'When people respond aggressively, accuse and abuse without thinking, just to defend their privilege, this is what we are talking about.' At this point, the host mentioned the state of our society is such that when journalist Fasi Zaka wrote a prayer for the deceased, users abused him in the comments and said that she deserved it. He brought up tackling such extreme mentality prevalent in the society where you can't even say a prayer for a murder victim. Saeed questioned this instinctive hatred for women that causes such extreme reactions. 'This girl could have been a religious person posting religious videos and it wouldn't have been any different. If there's any small thing, anything that you don't like about a woman, you get this incredibly extreme response. Where does this stem from?' Cry for help The artist shared her theory about this deep aggression. 'I feel like this relates to the way we have raised our men. We have raised weak men who are not equipped to understand anything and are not emotionally intelligent. This may seem like an anti-women attitude, but it's a cry for help for our boys too. How can a person be so enraged in an instant?' She continued, 'We teach our daughters to rely on their brothers, fathers, husbands. They will protect you. But if they are so volatile, how can you rely on them? If they can't make right decisions in their lives and lose control so fast, how can I put my life in their hands?' Mahmood then quotes Ali Gul Pir saying that it's a constant struggle for everyone, especially men, to not become a product of their circumstance. Saeed agreed and emphasised that it was a joint struggle. 'This cannot be separate. If we don't play up our strengths, there will be issues like we are seeing today. We have undermined women so much. Everyday, we hear such news. Every woman you meet has a story. And class is not even a factor in it. But at the end of the day, it's a joint struggle. If we don't fight it together, it won't work.' Emotional repression The host expanded upon the idea and cited Swiss psychologist Carl Jung's work saying that most of the violence that exists in the world is because man is unable to tell his own story. Jung's theory about unresolved inner conflicts leading to external issues pointed the conversation towards the mental and emotional repression that leads to this violence. Even Saeed added to the point about how this repression leads you to oppress others. 'How can you think if I give them some space, they will take over mine as well? How incapable do you think yourself to be?' Later in the conversation, she spoke about the hierarchy of oppression and abuse, citing an example of kids committing cruel acts against animals. 'You have to imagine what must have happened with those kids if they are so comfortable abusing animals? It's a hierarchy. Class abuses gender. Gender abuses the supposedly weaker gender. Then they continue it based on age and so on. At this point, it doesn't matter if someone is weak or not. What is this psyche of abusing instead of helping the one who you perceive as weak?' She pointed out how they take pleasure in abusing someone or even witnessing it. 'I want to know what they went through to become such psychopaths? We have created them too. Go look at the abused children in the hospitals, look at how teachers strike kids in classrooms, you will see the ground realities [of this inherent violence].' Throughout the podcast, the conversation steered toward multiple topics including women's rights, justice and Saeed's acclaimed work in film and the drama and the lessons she's learned in her life and career. Have something to add to the story? Share it in the comments below.
Express Tribune
03-06-2025
- Entertainment
- Express Tribune
Saeed proud of weightlifter Sybil Sohail's gold medal
Farhan Saeed, former frontman of the renowned Pakistani band Jal and now a singer-songwriter and actor, took to Instagram to publicly express his pride after Sybil Sohail became the first Pakistani woman to win the gold medal at the Asian Weightlifting Masters Championship in Doha, Qatar. In a simple Instagram Story, Saeed tagged Sohail herself and wrote, "Proud moment. Congratulations." Adding a Pakistani flag emoji at the end of his short but sweet message to lock in his national pride, Saeed's simple message captured the essence of the country's joy and pride in Sohail's achievement. This was not the first time Saeed has used his social media platform to highlight Pakistani sporting excellence. When javelin thrower Arshad Nadeem clinched gold at the Asian Athletics Championship by defeating a strong Indian contender in the men's javelin final in May, Saeed took to Instagram Story to extend his congratulations on the historic victory. Sohail, 31, competed in the 59kg weight category in Doha. She lifted a total of 95kg — 40kg in the snatch and 55kg in the clean and jerk — to secure her place at the top of the podium. This gold medal marked not only her debut in international weightlifting but also a significant milestone for Pakistani women in strength sports. Previously a decorated powerlifter, Sohail holds titles such as Commonwealth Powerlifting Champion and Asian Commonwealth Powerlifting Champion. Transitioning to weightlifting, she set out with a clear ambition: to raise Pakistan's flag at major Asian events. "I aim to make my country proud, make my family proud. We have sacrificed a lot for the sport, but I need to make sure that all of that effort and dedication pays off," Sohail told The Express Tribune in Doha.
Time of India
02-06-2025
- Time of India
Truck cleaner, over 50 goats killed in Khargone accident
Khargone: A truck cleaner and over 50 goats were killed on Monday when a truck full of goats, being transported to Hyderabad, met with an accident in Mengaon police station area of Khargone district. Mengaon police station in-charge, Pankaj Tiwari said that a truck full of goats, while trying to overtake, collided with a cement-laden truck parked on the Khargone-Indore road. The cement-laden truck had broke down due to mechanical fault. Due to the accident, 50 of the 180 goats stuffed brutally in the truck, died on the spot. The primary reason for the goats' death is said to be suffocation. He said that the cleaner of the truck, Sadiq Qureshi, 25, a resident of Indore, was badly injured. He succumbed to his injuries on the way to Indore. The truck driver, Saeed, was also injured. The goats were being taken to Hyderabad from Neemuch for sacrifice during Eid al-Adha (Bakrid) festival. He said that a case was registered on Monday evening against the truck driver and the truck owner for cruelly loading the goats. Truck driver Saeed mentioned that 60 goats died and some goats were taken away by the villagers as well.
Yahoo
02-06-2025
- Business
- Yahoo
KAHR Bio Announces Positive Phase 2 Results of DSP107 in Combination with anti-PD-L1 in Colorectal Cancer
- Findings presented in an oral presentation at the 2025 ASCO Annual Meeting - DSP107 in combination with atezolizumab in 3rd line microsatellite stable colorectal cancer (MSS-CRC) patients elicits anti-tumor activity and extends survival including in patients with liver metastases MODI'IN, Israel, June 2, 2025 /PRNewswire/ -- KAHR, a clinical-stage biotech company developing DSP107, a first-in-class bi-specific 4-1BB T-cell engager that activates innate and adaptive immunity to treat solid tumors, today announced positive results from the Phase 2 dose expansion cohort of DSP107 in combination with atezolizumab (Tecentriq®), an anti-PD-L1 cancer immunotherapy, in patients with 3rd line microsatellite stable metastatic colorectal cancer (MSS-CRC). In addition to its favorable safety profile, the combination has shown anti-tumor activity and extended survival including in patients with liver metastases. The results were presented in an oral presentation by Anwaar Saeed, MD, Associate Professor of Medicine, University of Pittsburgh Medical Center and Director, Gastrointestinal Disease Center, UPMC Hillman Cancer Center at the American Society of Clinical Oncology (ASCO) 2025 Annual Meeting, May 30 – June 3, 2025, in Chicago, IL. "Colorectal cancer, the second largest cause of cancer deaths worldwide, is considered a 'cold' tumor that usually does not elicit an efficient immune response," said Dr. Saeed. "This immunotherapy combination showed durable results in MSS-CRC patients. Not only is the median survival of DSP107 with atezolizumab longer than current standard treatments, it is also very well tolerated by patients, without the severe, sometimes life-threatening side effects of chemotherapy in such advanced lines of treatment. Importantly, the majority of patients in the combination cohort had active liver metastases and the activity and survival benefit were also seen in these patients, who are very difficult to treat, suggesting that DSP107 in combination with a PD1/PD-L1 checkpoint inhibitor may become an effective immunotherapy treatment option for this patient population." Yaron Pereg, Ph.D., Chief Executive Officer of KAHR, said, "We are extremely encouraged by the dose expansion data, showing objective responses and extended survival in response to DSP107 in combination with atezolizumab in patients with 3rd line MSS-CRC. We look forward to initiating a Phase 2b, randomized, controlled study to confirm these promising efficacy signals. In addition, we expect data in 2026 from a Phase 2 dose expansion cohort in Non-small Cell Lung Cancer (NSCLC), the leading cause of cancer deaths worldwide." Results from the completed dose expansion cohort show that DSP107 monotherapy and combination treatment with atezolizumab were well tolerated with no dose limiting toxicities. The median OS from the efficacy-evaluable patients who received DSP107 monotherapy (n=19) and combination therapy with atezolizumab (n=21) has not been reached, but currently (May 2025 cutoff) stands at 8.1 and 17 months, respectively. Disease control was demonstrated in 21% (monotherapy) and 62% (combination) of evaluable patients including a patient who achieved a complete response (> 2.5 years) and a patient with a deep (86% target lesion reduction) and durable (> 16 months) confirmed partial response and disappearance of pulmonary and hepatic metastases. Immunofluorescence analysis of baseline tumor biopsies demonstrated very high levels of CD47 expression, the DSP107 target, in all samples collected from liver metastases. The MSS-CRC dose expansion phase of the study was an open label, multi-center trial (NCT04440735) that enrolled patients with 3rd line MSS colorectal cancer patients, treated weekly with 10 mg/kg DSP107 infusions and atezolizumab (1200 mg) every three weeks, until disease progression. The primary objective was to determine the safety and tolerability of DSP107 in combination with atezolizumab. The secondary objective was to assess the preliminary efficacy of DSP107 in combination with atezolizumab. Presentation information: Abstract Title: Phase 2 dose expansion study of DSP107, a first-in-class bi-specific 4-1BB T-cell engager, with and without atezolizumab in metastatic MSS colorectal cancer patients. Abstract Number for Publication: 3517 About DSP107 KAHR's lead drug candidate, DSP107, is a first-in-class bi-specific 4-1BB T-cell engager utilizing CD47 overexpression as a tumor anchor. DSP107 binds to CD47 that cancer cells express on their cell surface. Once bound, DSP107 converts the CD47 signal, which cancer uses to camouflage itself from the innate immune system, into a 4-1BB signal, which attracts and activates adaptive immune cells, primarily cancer cytotoxic CD8 T-cells. In this way, DSP107 engages both parts of the immune system in a wholistic anti-cancer response. This is particularly relevant in colorectal cancer, where 70%+ of the metastatic patients have metastases in the liver, and where liver metastases highly express CD47 in response to first- and second-line chemotherapy treatments. Previous attempts to treat colorectal cancer with immunotherapy have failed as there is a lack of immune cells in the tumor. DSP107 is unique in that it takes advantage of CD47 expression to drive immune cells into the tumor. DSP107 is also being tested in Phase 2 expansion cohort in 2L/3L PD1-experienced NSCLC. About microsatellite stable metastatic colorectal cancer (MSS-CRC) Microsatellite stable metastatic colorectal cancer (MSS-CRC) is a subtype of colorectal cancer that lacks deficiencies in the DNA mismatch repair system, resulting in stable microsatellite regions within the genome. Unlike microsatellite instability-high (MSI-H) tumors, MSS-CRC exhibits lower tumor mutational burden and is less responsive to immunotherapy. MSS tumors represent the majority of colorectal cancer cases and are typically more challenging to treat. Standard treatment for metastatic MSS-CRC often involves a combination of chemotherapy, targeted therapy, and in select cases, surgical intervention. About KAHR KAHR develops novel, dual-targeting fusion protein therapeutics engineered to activate both the innate and adaptive immune systems simultaneously and localize that response in the tumor microenvironment. The Company is developing multifunctional fusion proteins that boost the immune systems' response to cancer. KAHR Bio was founded based on technology developed at the University of Pennsylvania and Thomas Jefferson University. For more information, please visit Media contact:Tsipi HaitovskyGlobal Media LiaisonKAHR +972-52-598-9892Tsipihai5@ View original content: SOURCE KAHR Medical Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
