Latest news with #Sail
Business Wire
02-06-2025
- Business
- Business Wire
Sail Biomedicines to Present New Preclinical Data on Malaria eRNA™ Vaccine Candidates at the 2025 Grand Challenges Annual Meeting
CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Sail Biomedicines, a Flagship Pioneering company and leader in RNA-based programmable medicines, today announced that it will present new preclinical data from its malaria vaccine program at the 2025 Grand Challenges Annual Meeting, taking place virtually June 1-4. The findings highlight the potential of Sail's Endless RNA™ (eRNA) platform to enable durable antigen expression and drive potent immune responses for protection from malaria challenge. "By engineering RNA for extended stability and translation, we are demonstrating the potential of Sail's eRNA platform to support the next generation of vaccines,' said Amy Espeseth, Ph.D., SVP, Head of Integrated Sciences at Sail Biomedicines. Share At the meeting, Sail will present new preclinical results demonstrating that its AI-driven design of eRNA vaccine candidates encoding a R21-based malaria antigen successfully formed virus-like particles with durable expression in vitro. In mouse immunogenicity studies, two doses of eRNA R21 vaccines generated robust anti-PfCSP antibody responses, with titers equal to and exceeding those reported for three doses of licensed malaria vaccines in published studies. In a mouse malaria challenge model, two doses of Sail's lead eRNA vaccine candidate substantially reduced liver parasite burden and achieved sterile protection in 53% of animals, suggesting a potential advantage over licensed malaria vaccines that are administered over three doses. 'These results demonstrate how Sail's eRNA platform can address key challenges in vaccine development, particularly by supporting more potent immune responses with a reduced dosing regimen,' said Amy Espeseth, Ph.D., SVP, Head of Integrated Sciences at Sail Biomedicines, who will be delivering the presentation. 'We believe that platforms like eRNA could play an important role in enabling more effective prevention of diseases like malaria.' Sail's malaria vaccine program, supported by funding from the Gates Foundation, focuses on optimizing the eRNA payload using AI to maximize antigen expression and durability of immune response. The vaccine candidates leverage Sail's proprietary Endless RNA format, which is engineered to resist degradation and extend translation, providing the opportunity for stronger, longer-lasting immune responses compared to conventional vaccine modalities. "By engineering RNA for extended stability and translation, we are demonstrating the potential of Sail's eRNA platform to support the next generation of vaccines,' said Dr. Espeseth. 'The manufacturability of eRNA coupled with its ability to generate robust immune responses supports its use as a vaccine platform for a wide range of infectious diseases." Collaborators at the Johns Hopkins Malaria Research Institute performed all challenge studies. About Sail Biomedicines Sail Biomedicines is pioneering the integrative design and deployment of fully programmable medicines to transform patient care. Sail's platform combines first-in-class programmable circular RNA technology (Endless RNA™ or eRNA™), and an industry-leading platform of programmable nanoparticles, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of generative AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering. For more, visit and follow us on X (@SailBiomeds) and LinkedIn. This research is based on work funded by the Gates Foundation. The findings and conclusions contained within are those of the authors and do not necessarily reflect positions or policies of the Gates Foundation.
News18
29-05-2025
- Business
- News18
SAIL Shares In Red Despite Q4 Net Profit Jumps 9x Sequentially To Rs 1,251 Cr, Dividend Announced
Last Updated: SAIL Share Price: The Board of Directors have recommended the Final Dividend @ Rs.1.60 /- per equity share of Rs.10/- each for the Financial Year 2024-25. Sail Share Price: Shares of Steel Authority of India Limited (Sail) traded in red at Rs 128.93 apiece with a dip of 0.023 per cent intraday on Thursday after a positive opening at Rs 131.75 apiece against the previous day close at Rs 128.96 apiece. The weakness in share price remained despite PSU declared a net profit of Rs 1,251 crore for the quarter ended March 31, 2025. It reflected a jump of 11 per cent year-on-year from Rs 1,125 crore in the corresponding quarter of the previous fiscal year. On a sequential basis, the steel major posted almost 9x gain from Rs 141.69 crore in Q3FY25. The rise in the profit of SAIL came due to improved performance across key steel plants and decrease in input costs. The company's earnings per share (EPS) also reflected this growth, rising to Rs 2.85 from Rs 0.30 in the previous quarter and Rs 2.45 a year ago. EBITDA for the quarter stood at approximately Rs 3,781 crore, slightly lower than Q4 FY24 but notably higher than Q3 FY25, showing an improvement of about 58% sequentially. EBITDA margin came in at 12.9%, dipping slightly year-on-year but improving significantly from 9.76% in the previous quarter. Net profit margin also saw an uptick to 4.02%, as compared to 3.62% in Q4 FY24 and just 0.51% in Q3 FY25, indicating better cost control and operational efficiency during the quarter. On Wednesday, shares of SAIL settled in green at Rs 128.80 apiece with a gain of 0.19 per cent on BSE. It opened at Rs 128.45 apiece, against the previous day close at Rs 128.55 apiece. For the financial year ended March 31, 2025 (FY25), Steel Authority of India Ltd (SAIL) posted a slight decline in its overall performance compared to the previous year. The company reported revenue of Rs 1,02,478 crore, down 2.7% from Rs 1,05,375 crore in FY24. Profit after tax (PAT) stood at Rs 2,148 crore, a drop of 21.4% year-on-year. As a result, earnings per share (EPS) fell to Rs 5.20 from Rs 6.62 in the previous year. EBITDA for FY25 was approximately Rs 11,764 crore, down around 4.2% from Rs 12,279 crore in FY24. The EBITDA margin saw a minor dip to 11.48%, compared to 11.65% last year. Net profit margin also came down to 2.10% from 2.59%, indicating some pressure on profitability despite a relatively stable operational performance. SAIL Dividend 2025 The Board of Directors have recommended the Final Dividend @ Rs.1.60 /- per equity share of Rs.10/- each for the Financial Year 2024-25 (16% of the paid up equity share capital of the Company). The said Final dividend for FY 2024-25 will be paid within 30 days from the date of approval by the Shareholders in the ensuing Annual General Meeting, the date of which will be intimated in due course. Disclaimer: The views and investment tips by experts in this report are their own and not those of the website or its management. Users are advised to check with certified experts before taking any investment decisions. First Published: May 29, 2025, 07:51 IST
News18
29-05-2025
- Business
- News18
SAIL Shares In Focus As Q4 Net Profit Jumps 9x Sequentially To Rs 1,251 Cr, Dividend Announced
Last Updated: SAIL Share Price: The Board of Directors have recommended the Final Dividend @ Rs.1.60 /- per equity share of Rs.10/- each for the Financial Year 2024-25. Sail Share Price: Shares of Steel Authority of India Limited (Sail) are in the spotlight after PSU declared a net profit of Rs 1,251 crore for the quarter ended March 31, 2025. It reflected a jump of 11 per cent year-on-year from Rs 1,125 crore in the corresponding quarter of the previous fiscal year. On a sequential basis, the steel major posted almost 9x gain from Rs 141.69 crore in Q3FY25. The rise in the profit of SAIL came due to improved performance across key steel plants and decrease in input costs. The company's earnings per share (EPS) also reflected this growth, rising to Rs 2.85 from Rs 0.30 in the previous quarter and Rs 2.45 a year ago. EBITDA for the quarter stood at approximately Rs 3,781 crore, slightly lower than Q4 FY24 but notably higher than Q3 FY25, showing an improvement of about 58% sequentially. EBITDA margin came in at 12.9%, dipping slightly year-on-year but improving significantly from 9.76% in the previous quarter. Net profit margin also saw an uptick to 4.02%, as compared to 3.62% in Q4 FY24 and just 0.51% in Q3 FY25, indicating better cost control and operational efficiency during the quarter. advetisement On Wednesday, shares of SAIL settled in green at Rs 128.80 apiece with a gain of 0.19 per cent on BSE. It opened at Rs 128.45 apiece, against the previous day close at Rs 128.55 apiece. For the financial year ended March 31, 2025 (FY25), Steel Authority of India Ltd (SAIL) posted a slight decline in its overall performance compared to the previous year. The company reported revenue of Rs 1,02,478 crore, down 2.7% from Rs 1,05,375 crore in FY24. Profit after tax (PAT) stood at Rs 2,148 crore, a drop of 21.4% year-on-year. As a result, earnings per share (EPS) fell to Rs 5.20 from Rs 6.62 in the previous year. EBITDA for FY25 was approximately Rs 11,764 crore, down around 4.2% from Rs 12,279 crore in FY24. The EBITDA margin saw a minor dip to 11.48%, compared to 11.65% last year. Net profit margin also came down to 2.10% from 2.59%, indicating some pressure on profitability despite a relatively stable operational performance. SAIL Dividend 2025 The Board of Directors have recommended the Final Dividend @ Rs.1.60 /- per equity share of Rs.10/- each for the Financial Year 2024-25 (16% of the paid up equity share capital of the Company). The said Final dividend for FY 2024-25 will be paid within 30 days from the date of approval by the Shareholders in the ensuing Annual General Meeting, the date of which will be intimated in due course. Disclaimer: The views and investment tips by experts in this report are their own and not those of the website or its management. Users are advised to check with certified experts before taking any investment decisions. Stay updated with all the latest news on the Stock Market, including market trends, Sensex and Nifty updates, top gainers and losers, and expert analysis. Get real-time insights, financial reports, and investment strategies—only on News18. First Published: May 29, 2025, 07:51 IST
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Business Standard
28-05-2025
- Business
- Business Standard
SAIL Q4 result: Net profit jumps 11% to ₹1,251 crore, dividend declared
State-run Steel Authority of India Limited (Sail) on Wednesday reported a consolidated net profit of ₹1,251 crore for the quarter ended March 31, 2025 (Q4FY25), marking an 11.1 per cent increase from ₹1,125.68 crore in the same quarter last year (Q4FY24). On a sequential basis, the steel major posted a significant gain from ₹141.69 crore in Q3FY25. The surge in profit can be attributed to improved performance across key steel plants, and decrease in input costs. However, the profit for Q3 declined sharply on account of increased expenses. "Amidst challenges posed by international tariffs and import pressures, which was present in the last quarter of FY25, our robust performance reflects our ability to navigate complexities while strengthening our position. The supporting government policies augur well for domestic steel demand and as we move forward, SAIL remains focused on innovation, cost optimization and planned future expansion in line with National Steel Policy," Sial chairman and MD, Amarendu Prakash, said. The PSU's revenue from operations stood at ₹29,316.14 crore in Q4FY25, up 4.9 per cent from ₹27,958.52 crore in the year-ago period. Compared to Q3FY25, revenue grew 19.7 per cent from ₹24,489.91 crore. Sail FY25 result For the entire year, Sail's consolidated net profit stood at ₹2,371.82 crore, down from ₹3,066.67 crore in FY24, marking a 22.7 per cent decline year-on-year. Meanwhile, the company's revenue from operations came in at ₹1,02,479.06 crore, marginally down from ₹1,05,378.33 crore recorded in FY24. Sail dividend announced SAIL's board of directors have also recommended a final dividend of ₹1.6 per share, subject to the approval of the shareholders. Shares of SAIL closed at ₹128.8 apiece on the BSE at the end of trading on Wednesday.
The Citizen
07-05-2025
- Entertainment
- The Citizen
Local jockeys good enough for world league
Riding excellence a highlight as KZN's new era dawns. It was a joyous occasion when the KwaZulu-Natal Champions Season cavalcade got rolling at Greyville at the weekend. It marked operator Gold Circle's first race meeting under the new ownership of Hollywood Sportsbook, the saviour of horse racing in the province. Appropriately, Gold Circle boss Michel Nairac, wearing his horse owner hat, led in a feature winner in the shape of the redoubtable Gladatorian. There were plenty of other positive aspects. For example, Justin Snaith declared the present three-year-old crop the best he'd seen – minutes after two of his star sophomores, Sail The Seas and Eight On Eighteen, had completed the Exacta in the WSB Guineas (Grade 2) and sounded a warning that the champion trainer's raiding party from Cape Town would be formidable opponents over the next few months. The excellence of jockeyship was another feature of the day. Muzi Yeni wins on Sail The Seas Local jocks have been guilty of all sorts of silly behaviour lately, but most of them remain, on the whole, very good riders of racehorses. As has been proven many times, South African jockeys can hold their own anywhere in the world and the best of them are the equal of anyone in a saddle. In the East Coast Cup over 2000m, underrated Serino Moodley showed off his good judgement of pace and conditions in bringing Mascherina from near the tail of the field, in heavy going, to win going away up the inside rail. Next, it was Sean Veale with a well-timed challenge on Gladatorian, nabbing highly rated See It Again in the last strides of the Drill Hall Stakes. Then champion jockey Richard Fourie was at his hard-driving best in landing the WSB Fillies Guineas on Mon Petit Cherie. Perhaps the ride of the day came from Muzi Yeni as he kept Sail The Seas sailing to hold off determined challenges from Eight On Eighteen and Cosmic Speed – two of the exemplars of Snaith's golden crop of three-year-olds. The wealth of talent in South African saddles was pulled into focus by the announcement of an international jockeys' super league that will start next year. The 12 riders signed for the new global competition are superstars: Frankie Dettori (Italy/UK/US), Ryan Moore (UK), William Buick (UK), James McDonald (New Zealand/Australia), Joao Moreira (Brazil/Japan/Australia), Zac Purton (Australia/Hong Kong), Christophe Lemaire (France/Japan), Mickael Barzalona (France), Yutaka Take (Japan), Irad Ortiz Jr (Puerto Rico/US), Flavien Prat (France/US), Vincent Ho (Hong Kong) Top SA jockeys South Africa, a relative global racing backwater, would not have expected representation in such company. Yet they wouldn't have been outclassed. The likes of Michael Roberts, Douglas Whyte and Jeff Lloyd flew the flag with honour in the past, while Luke Ferraris, Warren Kennedy and Ryan Munger are current emissaries. Organisers of the new league plan up to 10 fixtures of six-race contests, with Ascot and York in England, Leopardstown and the Curragh in Ireland and Longchamp and Chantilly in France mentioned as possible venues. 'The franchise-based league structure allows a range of commercial and investment opportunities to be progressed and we firmly believe the concept we've developed with our foundation jockeys can help revolutionise global horseracing in the coming years,' said Lachlan Fitt, one of the founders, adding that other jockeys will be drafted into the league as it develops. Female jockeys will probably be the first additions. South African racing fans wouldn't be deluded in thinking of their sole female rider Rachel Venniker as a candidate.
