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Hans India
2 days ago
- Health
- Hans India
IIT-BHU bioengineers develop nanoparticles to stop blood clotting
New Delhi: Biomedical engineers at the Indian Institute of Technology-BHU in Uttar Pradesh, have developed low-cost, and complex nanoparticles that can prevent clotting and act as an antidote to thrombotic disorders. The team focussed on the anticoagulation properties of potassium ferric oxalate nanoparticles (KFeOx-NPs) to develop the nanoparticles. Potassium is also known to be essential for the overall health of blood vessels and the heart. The nanoparticles were found to preserve human blood in a liquid state for 48 hours. The findings may be crucial for the safe collection and storage of blood for diagnosis and transfusion, said lead author Sudip Mukherjee, from the School of Biomedical Engineering at IIT (BHU). Using mice models, the team shows toxicity and biodistribution profiles and determines the safety and efficacy of nanoparticles. The nanoparticles were found to prevent clot formation in blood vessels in live mice, as well as halt thrombosis in mice. The team explained that the nanoparticles developed using KFeOx-NPs work by binding to calcium ions in the blood. It prevents the formation of fibrin -- the main protein that helps form blood clots. 'Intravenously injected KFeOx-NPs increased clotting time and thrombosis prevention in a mouse model, confirmed by ultrasound and the power Doppler images,' the researchers said. 'Coating catheters with KFeOx-NPs prevents clot formation with reduced protein attachment when incubated with blood, enhancing blood flow properties,' they added. According to researchers, KFeOx-NPs may also be deployed in biological applications. They noted that it may help boost the long-term prevention of blood clot formation and enhance the efficiency of medical devices. Notably, the nanoparticles also get easily dissolved in water and do not accumulate in fat tissues. In nanoparticle-coated catheters, the blood flow was better and fewer proteins stuck to the surface.
Time of India
06-05-2025
- Health
- Time of India
Breakthrough at IIT-BHU to help in prevention of blood clotting, thrombosis
Varanasi: A research team from Indian Institute of Technology (BHU) developed a novel material—Potassium Ferric Oxalate Nanoparticle (KFeOx-NPs)—that prevents blood coagulation and thrombosis without altering structure or properties of the blood. It aims to combat blood clot-related disorders such as strokes, heart attacks, pulmonary embolism, and deep vein thrombosis, the leading causes of mortality significant health challenges, a research team from IIT(BHU), led by Dr Sudip Mukherjee of the School of Biomedical Engineering, developed a novel material that effectively prevents blood coagulation and thrombosis without altering structure or properties of blood. Dr Mukherjee said blood clot-related disorders such as strokes, heart attacks, pulmonary embolism and deep vein thrombosis often arise from formation of dangerous blood clots that block veins or arteries, posing serious health India, incidence of venous thromboembolism (VTE) is estimated at 1–2 per 1,000 people annually, with even higher rates reported for pulmonary embolism (39–115 per 100,000) and deep vein thrombosis (53–162 per 100,000).Conventional anticoagulants like warfarin and heparin, while commonly used to treat or prevent clot formation, are often associated with side effects such as excessive bleeding, reduced bone density and potential birth defects. Similarly, in pathological settings, chemical anticoagulants like EDTA and sodium citrate used in blood collection tubes can lead to structural changes in blood cells over time, affecting diagnostic accuracy. The newly developed KFeOx-NPs offers a promising alternative. When tested on human blood samples, the material was successful in preventing clotting for up to 48 hours without affecting shape, size, or integrity of blood cells. The stability makes it highly suitable for clinical blood collection and storage. Furthermore, its efficacy was validated in a mouse model for thrombosis, where nanoparticles demonstrated ability to prevent clot formation in research findings were published in the reputed international journal ACS Applied Materials & Interfaces (ACS AMI), underscoring the scientific merit and global relevance of the work. A patent was also filed for the novel nanomaterial to protect the intellectual property and pave the way for future clinical translation."This innovative nanomaterial offers a safer and more effective approach to manage and prevent clot-related diseases. It also addresses limitations of current anticoagulants used in diagnostics," said Dr Mukherjee.
