Latest news with #TamerMohamed
Business Wire
2 days ago
- Health
- Business Wire
Aspect Biosystems Presents New Preclinical Data on Adrenal Bioprinted Tissue Therapeutics at ENDO 2025
VANCOUVER, British Columbia--(BUSINESS WIRE)--Aspect Biosystems, a biotechnology company pioneering the development of Bioprinted Tissue Therapeutics (BTTs) as a new category in regenerative medicine, today announced new preclinical data at ENDO 2025, the Endocrine Society's annual meeting held in San Francisco. The company presented an oral and poster presentation highlighting that Aspect's adrenal BTTs can restore adrenal function, following natural daily hormone rhythms and maintaining long-term performance in animal models of primary adrenal insufficiency. Primary adrenal insufficiency is a serious, life-threatening condition in which the adrenal glands fail to produce sufficient levels of essential hormones such as cortisol, a key regulator of the body's stress response. The current standard of care involves daily hormone replacement therapy, which does not fully replicate the body's natural circadian hormone rhythms and is associated with significant drug-related side effects. This can leave patients with a poor quality of life and at risk of ongoing health challenges, including potentially fatal adrenal crises. Aspect's adrenal BTTs were developed using the company's proprietary full-stack tissue therapeutic platform, which combines AI-powered bioprinting, computational design tools, therapeutic cells, and advanced biomaterials. In preclinical studies, adrenal BTTs containing human adrenal cells were implanted into adrenalectomized mice. These BTTs produced cortisol in response to adrenocorticotropic hormone (ACTH) stimulation—which is normally secreted from the brain—and followed the animals' natural circadian fluctuations in hormone levels. When exposed to high levels of injected ACTH, these mice demonstrated rapid increases in circulating cortisol, confirming that the adrenal BTTs were functionally responsive. In contrast, control animals receiving cell-free implants showed no significant cortisol levels and did not respond to ACTH stimulation. Importantly, adrenal BTTs remained functional in vivo throughout the study period of over six months and improved animal survival. 'Our research shows that Aspect's adrenal BTTs successfully replicate healthy human adrenal gland function by releasing cortisol in a pattern that follows the natural daily rhythms of hormone release and by responding appropriately to a stimulus that mimics a stress response,' said Sam Wadsworth, PhD, Chief Scientific Officer at Aspect Biosystems. 'These results demonstrate that our off-the-shelf, implantable cell therapy can work in harmony with the body's physiology and has real potential to serve as a functional cure for primary adrenal insufficiency." 'At Aspect, we're making breakthrough progress with our Bioprinted Tissue Therapeutics platform to restore complex biological functions across a range of serious endocrine and metabolic diseases,' said Tamer Mohamed, Chief Executive Officer of Aspect Biosystems. 'This latest advance in primary adrenal insufficiency, a rare and life-threatening condition with limited treatment options, showcases the potential of a bioengineered cell therapy to recreate natural hormone function and deliver a truly disease-modifying solution. This reflects our mission to develop regenerative medicines capable of achieving functional cures for patients with serious and underserved diseases.' About ENDO Hosted by the Endocrine Society, ENDO is the leading global meeting on endocrinology research and clinical care. The Endocrine Society is the world's oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions. Learn more at About Aspect Biosystems Aspect Biosystems is a biotechnology company pioneering the development of Bioprinted Tissue Therapeutics (BTTs) to transform how we treat some of the most elusive diseases. Aspect's BTTs are designed to replace, repair, or supplement biological function inside the body. Aspect is creating these next-generation cell therapies by applying its full-stack tissue therapeutic platform, which integrates proprietary AI-powered bioprinting technology, computational design tools, therapeutic cells, and advanced biomaterials. Aspect is advancing a pipeline of BTTs across multiple disease areas in the endocrine and metabolic space including diabetes, obesity, rare endocrine disorders, and liver disease. Aspect's pipeline development strategy involves both proprietary programs as well as strategic partnerships, including a collaboration with Novo Nordisk focused on diabetes and obesity. For more information, please visit and follow on LinkedIn.
Egypt Today
17-02-2025
- Business
- Egypt Today
IDSC monitors Egypt's tech effrorts in aircraft manufacturing, maintenance
Aircraft - file CAIRO - 17 February 2025: The Information and Decision Support Center (IDSC) of the Cabinet published a set of videos highlighting Egypt's leadership in the field of technical education specialized in aircraft maintenance and manufacturing. The videos were filmed within the first specialized school in the Middle East, which was established by the Arab Organization for Industrialization to qualify cadres capable of working at global rates. Major General Maged Mohamed Mahmoud, Director of the Arab Institute for Advanced Technology, revealed that the establishment of the school comes within the framework of the political leadership's interest in developing technical education, as its students were carefully selected through tests and personal interviews attended by the Chairman of the Arab Organization for Industrialization himself, in cooperation with the Ministry of Education. He explained that the teaching staff includes French experts in addition to Egyptian engineers, to ensure achieving the highest level of training and qualification. For his part, Tamer Mohamed, Director of the Arab Organization for Industrialization School for Applied Technology in the field of aircraft manufacturing, confirmed that the school aims to graduate a generation proficient in aircraft maintenance and manufacturing according to international standards, which enables it to meet the needs of the local market, and contribute to enhancing Egypt's capabilities in this field. He pointed out that the study requires a certain level of proficiency in the English language, as some specialized subjects are taught, such as aircraft manufacturing and maintenance, in addition to other cultural subjects, such as mathematics. Students also undergo rigorous admission tests, including an assessment of personality traits and emotional stability. He explained that students join the school after obtaining their preparatory certificate, as the minimum admission score last year was 240. They also undergo several tests prepared by the Ministry of Education and the school itself, to ensure the selection of the best elements. He added that the school provides intensive practical training in various types of aircraft maintenance, which has made it very popular with parents since the first academic year. In the same context, Mr. Safaa El-Din Farag, the school's senior English teacher, confirmed that the curricula are taught according to the latest educational methods, with a focus on practical training, away from traditional methods, to qualify students to work in local and international markets. During the meetings, the students expressed their pride in joining the school, as they confirmed that their passion for aircraft was the main motivation behind their choice of this field. They pointed out that the school is one of only three schools in the world, along with two schools in France and India. They also explained that they study a variety of subjects, including chemistry, English, national education, and Arabic, and that they aspire to complete their studies in colleges specialized in the field of aviation, to contribute to serving their country. For his part, Brigadier Engineer Hatem Mohamed, Director General of Technical Education at the Arab Organization for Industrialization, thanked Major General Staff Engineer Mokhtar Abdel Latif Mustafa, Chairman of the Organization, for his directives on the necessity of expanding the establishment of applied technology schools. He stressed that work is underway to establish a new applied technology school at the organization's headquarters in Heliopolis, to expand the scope of qualification in the field of aircraft manufacturing and maintenance. He pointed out that the raw materials needed by the French trainers are provided entirely from the local market, according to the required specifications, which contributes to reducing dependence on imports in hard currency, in implementation of the directives of the political leadership on the necessity of enhancing local manufacturing and supporting the national economy.
