Latest news with #UoH
Time of India
5 days ago
- Health
- Time of India
City startup incubated at UoH develops stem cell treatment for chronic liver failure
Hyderabad: A startup incubated at the University of Hyderabad (UoH) successfully tested a new treatment for chronic liver failure using stem cells. Called Tulsi-28X, the treatment is touted to be the first in the world by the firm to use a special combination of stem cells and natural healing particles called exosomes. These are taken from a part of the umbilical cord known as Wharton's Jelly. Although the concept was born in the US, the entire platform was developed in India by Tulsi Therapeutics after three years of rigorous research at ASPIRE-BioNEST, UoH's biotech incubator. "We have done trials on rats. All animals treated with Tulsi-28X showed reversal of liver fibrosis, indicating liver regeneration, resulting in zero deaths, compared to only 14% reversal and 43% deaths in the untreated control group," Dr Sairam Atluri, founder & CEO of Tulsi Therapeutics, told TOI. The preclinical trial was conducted in collaboration with Indiana University, US, and PGIMER, Chandigarh. He said that this treatment method can be a game-changer as it would give a new lease of life to those with liver failure and waiting for transplantation. "Right now, the only treatment for liver failure is transplant. However, there are not enough donors, the treatment is very expensive, and it comes with various complications. The medicine that we developed can be administered intravenously," added Atluri, and said he moved from the US to India to work on this idea and bring it to life. You Can Also Check: Hyderabad AQI | Weather in Hyderabad | Bank Holidays in Hyderabad | Public Holidays in Hyderabad The startup has applied to the Central Drugs Standard Control Organisation (CDSCO) for conducting human trials. "We are committed to developing world-class yet affordable regenerative solutions," said Dr Ravi Bonthala, chief scientific officer of the startup. "Our next step is to take Tulsi-28X into human clinical trials in collaboration with Nizam's Institute of Medical Sciences."
The Hindu
6 days ago
- Health
- The Hindu
University of Hyderabad incubated startup announces successful animal trials of stem cell therapy for liver failure
Tulsi Therapeutics, a startup incubated at ASPIRE-BioNEST,University of Hyderabad (UoH), has announced the world's first successful animal trial of a novel stem cell–exosome combination therapy for chronic liver failure. Chronic liver failure remains a serious public health concern in India, contributing to nearly 20% of global liver-related deaths. With transplantation being the only current treatment, investigational product - 'Tulsi-28X' represents a potential paradigm shift. It works by secreting regenerative proteins and growth factors, stimulating the repair of diseased liver tissue. 'We are committed to developing world-class yet affordable regenerative solutions. Our next step is to take Tulsi-28X into human clinical trials in collaboration with Nizam's Institute of Medical Sciences (NIMS),' said Tulsi Therapeutics chief scientific officer Ravi Bonthala. The preclinical trial, conducted in collaboration with global experts including Indiana University, (USA) Naga Chalasani and PGIMER, (Chandigarh) Ajay Duseja had demonstrated 100% of the animals treated with 'Tulsi-28x' showed reversal of liver fibrosis (indicating liver regeneration) resulting in zero deaths, compared to only 14% reversal (p<0.001) and 43% deaths (p<0.0066) in the untreated control group, according to a press release on Thursday. While conceptualized in the United States, the platform was entirely developed in India through three years of intensive research at ASPIRE-BioNEST. 'This is a significant milestone for India's biotech industry. ASPIRE-BioNEST provided a world-class platform that helped us translate our vision into scientific reality. While human trials are the next challenge, this study opens doors to a new class of biologics in liver disease,' said founder & CEO of Tulsi Therapeutics Sairam Atluri. Key results were presented at the AASLD 2024 Liver Conference in San Diego (US) and accepted for publication in the 'Journal of Regenerative Medicine'.The firm could also be the first biotech company developing dual stem cell–exosome biologic. It is said to be a first-in-class regenerative therapy derived from Wharton's Jelly mesenchymal stem cells and their native exosomes—a combination never before tested in any animal model worldwide. 'This milestone highlights how India's innovation ecosystem—anchored by institutions like the UoH and enabled by BIRAC and incubators like ASPIRE-BioNEST—is capable of delivering breakthrough global biotech products,' said Vice Chancellor B.J. Rao. 'The achievement is a proud moment for all of us at ASPIRE-BioNEST. It reflects our mission to nurture science-led innovation with real-world impact. it's incredibly fulfilling to see this ecosystem support a global-first breakthrough in regenerative medicine,'said CEO of ASPIRE-BioNEST Anil Kondreddy. ASPIRE-BioNEST supported by BIRAC, Department of Biotechnology, mentors early-stage biotech startups through infrastructure and funding access. It has supported more than 75 deep-tech life sciences startups and was recognized as 'Best Emerging Bio-Incubator' by BIRAC in 2021, added the release.
New Indian Express
13-07-2025
- Science
- New Indian Express
University of Hyderabad in the quest of climate-proof super grains
HYDERABAD: As climate change tightens its grip, threatening global food systems, a quiet revolution is taking root in the city. As the morning sun warms the red soil, millet plants sway gently in the breeze across the bustling University of Hyderabad (UoH) campus. On a one-acre experimental farm — a living lab — tucked within the research grounds, foxtail, kodo and other grains rustle in the wind. Guided by a young team of scientists, these ancient crops are being reimagined for a climate-stressed world. From tilling the soil to harvesting by hand, every step is carried out with care. Here, fieldwork meets genomics, where the sweat of the brow is matched by scientific precision, all in pursuit of developing climate-resilient, nutrient-rich grains. Leading this effort is Dr Mehanathan Muthamilarasan, who launched The Millet Lab in 2020 with a clear mission: to decode the genetic makeup of millets and enhance their natural resilience through cutting-edge gene editing. In India, the world's largest millet producer, this research couldn't be more timely. With droughts, soil degradation and salinity threatening food systems, millets may hold the key to ensuring nutritional security in the years to come. Dr Muthamilarasan notes a sharp contrast within the grass family: rice, wheat and millets may be botanical cousins, but when it comes to climate resilience, millets stand apart. Producing 1 kg of rice takes around 2,500 litres of water, compared to just 250 litres for the same amount of millets. Rather than pushing for a sudden shift away from rice, his team is working on a visionary solution: identifying climate-resilient genes in foxtail millet (korralu in Telugu) and transferring them into rice through genetic engineering. So far, they've mapped over 500 key genes that could help staple crops survive extreme environmental stress. Backed by the Department of Biotechnology (DBT) and the Anusandhan National Research Foundation (ANRF), the team recently identified a stress-associated protein gene in millets that enables the plant to endure extreme heat. This breakthrough could be pivotal in developing heat-tolerant crops, critical in an era of rising temperatures. Researcher Pooja Shukla, who works closely on the project, tells TNIE, 'We cultivate and study foxtail and kodo millets at our university farm.'
Time of India
12-07-2025
- Politics
- Time of India
Telangana govt moves HC to reopen Rohith Vemula case; bill to fight caste bias ready
Rohith Vemula HYDERABAD: Deputy chief minister Bhatti Vikramarka on Friday announced that Congress govt had approached the high court seeking a directive to reopen the Rohith Vemula case, vowing that those responsible for the PhD scholar's death "will not be spared. " The move comes nearly three months after leader of opposition in the Lok Sabha, Rahul Gandhi , wrote to chief minister A Revanth Reddy to enact a law against caste discrimination named after the 26-year-old Dalit student-activist from University of Hyderabad (UoH), who had died by suicide in Jan 2016. You Can Also Check: Hyderabad AQI | Weather in Hyderabad | Bank Holidays in Hyderabad | Public Holidays in Hyderabad Talking to reporters at the AICC headquarters in Delhi, alongside the party's SC cell chairman Rajendra Pal Gautam, Bhatti said state govt was working on the Rohith Vemula Act to provide legal safeguards against caste-based discrimination in higher education institutions. The draft bill has been sent to the law department for vetting, he said. Telangana police filed a closure report in the case last year, which gave a clean chit to all the accused, including current Telangana BJP chief N Ramchander Rao. Revanth, however, rejected the closure report and said the investigation was on. "The entire country hung its head in shame the day Rohith Vemula died. It is our responsibility to ensure such a tragedy never happens again," said Bhatti, who is also an alumnus of UoH. by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like American Investor Warren Buffett Recommends: 5 Books For Turning Your Life Around Blinkist: Warren Buffett's Reading List Undo He attacked BJP, accusing it of not only failing Dalit youth but also rewarding individuals named in the caste discrimination case linked to Rohith's death. "The then BJP MP Bandaru Dattatreya, MLC N Ramchander Rao and ABVP leader from UoH N Susheel Kumar - all named in the case - have been rewarded," he said. 'BJP rewarding those named in Rohith case' He demanded, 'Dattatreya was made governor, Ramchander is now BJP's Telangana president, and Susheel Kumar has been appointed as an assistant professor in a central university. The BJP should apologise unconditionally to the nation for this.' Bhatti alleged that a systematic campaign of pressure and harassment was mounted against Rohith and four other students, with interference coming from Union HRD (now education) ministry. According to him, Ramchander Rao allegedly pressured local police to file cases against the students, while the university's administration, under external pressure, expelled them from the hostel — which pushed Rohith to take the extreme step. Citing Rohith's suicide note and earlier petitions to university authorities, Bhatti said they reflected the deep despair faced by marginalised students. 'When Rohith wrote in a heartbreaking note that Dalit students should be given a rope along with admission—so that they can hang themselves—it shattered the conscience of the nation,' the deputy CM said. He recalled Rahul Gandhi had immediately visited the campus, met with student groups, and offered support to Rohith's mother, expressing solidarity with the cause of social justice. The deputy CM emphasised that the proposed Rohith Vemula Act would aim to institutionalise safeguards for Dalits, Adivasis, and other marginalised communities, especially in educational institutions. 'Rahul Gandhi's commitment gave hope to millions. This Act will translate that hope into legal protection,' he said. 'This is not just about one university or one student. It is about what kind of country we want to build. The govt's fundamental duty is to protect the dignity, rights, and lives of every citizen, especially those who have historically been denied of them,' he said.
Indian Express
09-07-2025
- General
- Indian Express
University of Hyderabad opens admissions for integrated PG courses, apply via UCET UG 2025 scores
The University of Hyderabad (UoH) has announced admissions for Integrated PG (I-PG) programmes for the academic year 2025–26. Eligible candidates can apply for admission based on their Common University Entrance Test for Undergraduate courses (CUET UG) 2025 scores. The application process will be entirely online. Candidates will be required to register and apply online on the official websites at and CUET Results: Admissions to these 20 PG programmes in IP University through CUET scores The following key dates have been announced for the I-PG admission cycle 2025: –Start of online applications: July 14 –Last date to apply: July 30 –Provisional selection and waitlist announcement: August 5 –Document verification and physical reporting: August 14 –Commencement of classes: August 18 –Display of vacant seats for waitlisted candidates: August 19 –Counselling for waitlisted candidates: August 28 'Recipe for failure': DU faculty petitions President over four-year UG programme Admissions to the Integrated PG programmes are open to candidates who have appeared in CUET UG 2025 and meet the specific eligibility criteria set by the University of Hyderabad. The integrated courses are ideal for students looking to pursue an advanced curriculum in sciences, social sciences, languages, and professional disciplines such as optometry and applied geology. CUET UG 2025 Results Out: Know admission process for DU, JNU, Jamia explained The University is offering 465 seats across multiple disciplines under the Integrated PG programme. Here's the detailed seat matrix by subject: For detailed guidelines, eligibility requirements, reservation policy and other information, candidates can go to the official website for most recently announced updates.
