Latest news with #VMS
Medscape
2 days ago
- Health
- Medscape
Does Elinzanetant Reduce VMS in Younger Patients?
Another phase 3 trial has demonstrated the effectiveness of the dual-neurokinin receptor antagonist elinzanetant in controlling hot flashes in women on adjuvant endocrine therapy for hormone receptor-positive (HR+) breast cancer. This time, the sample included younger and older patients with less frequent and severe episodes than patients in the previously published trials had experienced. 'Elinzanetant is the first neurokinin-targeted therapy to demonstrate efficacy in reducing vasomotor symptoms (VMS)' — otherwise known as hot flashes — 'in women with breast cancer,' Fatima Cardoso, MD, MSc, said as she presented results from the OASIS 4 trial at the breast cancer oral abstracts session at the American Society of Clinical Oncology (ASCO) 2025 annual meeting. 'The effect [of the hormone-free dual neurokinin-1 and -3 receptor antagonist] is rapid at week 1,' Cardoso said. 'It is sustained throughout the duration of the study. It is also well-tolerated, which supports its use long term.' Trial results were also published simultaneously in The New England Journal of Medicine . 'It is important to treat VSM because they can negatively impact quality of life and lead to women prematurely stopping their breast cancer treatment,' Cardoso, director of the breast cancer unit at the Champalimaud Cancer Center and president of the ABC Global Alliance in Lisbon, Portugal, told Medscape Medical News. VMS Reduction Advantage Sustained for 12 Weeks OASIS 4 enrolled 474 women aged 18-70 years who were receiving endocrine therapy for HR+ breast cancer or as prevention in those at high risk for breast cancer and had 35 or more moderate-to-severe vasomotor symptoms a week. The trial assigned 316 participants to receive elinzanetant 120 mg daily for 52 weeks and 148 to receive a placebo daily for 12 weeks followed by elinzanetant 120 mg daily for 40 weeks. The average daily VMS frequency was 11.4 in the elinzanetant group and 11.5 in the placebo group. All participants were evaluated for 4 weeks after a year of treatment. Reductions in frequency of VMS were observed after 1 week of treatment, Cardoso said. The mean daily number of episodes was reduced by four in the patients receiving elinzanetant and 1.8 in those receiving placebo. By week 4, the daily reductions in VMS were 6.5 and 3.0 in the two groups, respectively. By week 12, the patients receiving elinzanetant had almost twice the reduction in overall frequency of VMS: 7.8 vs 4.2 fewer average daily episodes than baseline, respectively. Cardoso also noted 'a substantial improvement' in reducing the severity of VMS in patients receiving elinzanetant. She characterized the safety profile of elinzanetant as favorable, during her interview with Medscape Medical News. 'Most side effects were mild, and the most common were headache, fatigue, and somnolence,' she said. 'Very low rates of serious side effects were seen.' During the placebo-controlled period, the rates of treatment-emergent adverse events (TEAEs) were 70% in the patients receiving elinzanetant and 62% in the placebo group. Fewer TEAEs were reported in both groups after the 12-week placebo period ended, she said. Elinzanetant 'was very well tolerated,' Cardoso said as she presented the results. 'Perhaps the best factor to say that it was well tolerated and efficacious is that over 90% of the patients decided to go into the 2-year extension phase.' How OASIS 4 Compares With Other Elinzanetant Trials The OASIS 4 results are consistent with other phase 3 trials of elinzanetant in women on adjuvant endocrine therapy with VMS, JoAnn Pinkerton, MD, director of midlife health at the University of Virginia in Charlottesville, Virginia, told Medscape Medical News. Pinkerton was principal investigator of the OASIS 2 randomized trial of elinzanetant in postmenopausal participants with more frequent and severe VMS symptoms than those in OASIS 4. 'It is worth noting that the treatment did not have any adverse effects on the endometrium, and there were no significant changes in bone density that were not expected due to aging,' Pinkerton said. OASIS 4 is significant because it enrolled patients from 90 international sites, including Europe and Canada, and well as women aged 18-70 years with 35 or more moderate-to-severe VMS a week while on tamoxifen or aromatase inhibitors, Pinkerton added. 'OASIS 4 showed significant relief in menopausal symptoms in women with breast cancer, precisely the population that needs an effective, Food and Drug Administration-approved medication to treat their bothersome menopausal symptoms,' Pinkerton said. The trial was funded by Bayer. Cardoso reported financial relationships with Amgen, Astellas Pharma, AstraZeneca, Bayer, Celgene, Daiichi Sankyo, Eisai, GE Healthcare, Genentech, Gilead Sciences, GlaxoSmithKline, IQVIA, Macrogenics, Merck Sharp & Dohme, Merus, Mundipharma, Mylan, Novartis, Pfizer, Pierre Fabre, Prime Oncology, Roche, Samsung Bioepis, Sanofi, Seagen, Teva and touchIME. Pinkerton reported having financial relationships with Bayer, Pfizer, and Merck.
Hamilton Spectator
3 days ago
- Business
- Hamilton Spectator
NexGold Announces Voting Results from its Annual and Special Meeting of Shareholders
TORONTO, June 26, 2025 (GLOBE NEWSWIRE) — NexGold Mining Corp. (TSXV: NEXG; OTCQX: NXGCF) ('NexGold' or the 'Company') is pleased to announce results from its 2025 Annual General and Special Meeting of Shareholders (the 'Meeting') held earlier today. A total of 50,604,879 common shares ('Shares') were voted in person or represented by proxy at the Meeting, representing approximately 32.11% of the votes attached to all the outstanding Shares as at the record date of the Meeting. Election of Directors At the Meeting, all nominees listed in the Company's management information circular dated May 12, 2025 were elected as directors of the Company to serve until the next annual meeting of shareholders or until their successors are elected or appointed. Shareholders present in person or represented by proxy at the Meeting voted as follows: Appointment of Auditors At the Meeting, PricewaterhouseCoopers LLP was appointed as auditors of the Company to hold office until the close of the next annual meeting of shareholders or until a successor is appointed and the Board was authorized to fix their remuneration, with the following results: Equity Incentive Plan At the Meeting, the Company's equity incentive plan was re-approved, with the following results: The report of voting results will be made available under the Company's profile on SEDAR+ at . About NexGold Mining Corp. NexGold Mining Corp. is a gold-focused company with assets in Canada and Alaska. NexGold's Goliath Gold Complex (which includes the Goliath, Goldlund and Miller deposits) is located in Northwestern Ontario and its Goldboro Gold Project is located in Nova Scotia. NexGold also owns several other projects throughout Canada, including the Weebigee-Sandy Lake Gold Project JV, and grassroots gold exploration property Gold Rock. In addition, NexGold holds a 100% interest in the high-grade Niblack copper-gold-zinc-silver VMS project, located adjacent to tidewater in southeast Alaska. NexGold is committed to inclusive, informed and meaningful dialogue with regional communities and Indigenous Nations throughout the life of all our Projects and on all aspects, including creating sustainable economic opportunities, providing safe workplaces, enhancing of social value, and promoting community wellbeing. Further details about NexGold, including a Prefeasibility Study for the Goliath Gold Complex and a Feasibility Study for the Goldboro Gold Project, are available under the Company's issuer profile on and on NexGold's website at . Contact: Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in the policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this news release. No stock exchange, securities commission or other regulatory authority has approved or disapproved the information contained herein.
Associated Press
3 days ago
- Business
- Associated Press
Blue Moon Awards Mining Contract for the Construction of the Portal and Exploration Decline for Its Blue Moon Mine in Mariposa County, California
TORONTO, June 26, 2025 (GLOBE NEWSWIRE) -- Blue Moon Metals Inc. ('Blue Moon' or the 'Company') (TSXV: MOON; OTCQB: BMOOF), is pleased to announce the award of a contract to Small Mine Development, L.L.C. ('SMD') for the construction of a portal and decline to enable underground mineral exploration activities at the Blue Moon volcanogenic massive sulphide ('VMS') deposit (the 'Project'), located in Mariposa County, California. This construction work represents a significant step forward for the Project's development, as the portal and decline will provide access for infill and exploration drilling, and allow for further studies and investigations related to geology, rock mechanics, underground mining conditions, and metallurgical test work and ultimately to a mine commercialization decision. Blue Moon undertook a formal request for proposal ('RFP') process (see April 15, 2025 news release) to select a mining contractor, from which several proposals were received. SMD ultimately provided a proposal that was consistent with the Company's Project objectives for Health & Safety, local employment, cost, schedule, and performance, making them a clear choice for the award of this contract. The CEO of Blue Moon, Christian Kargl-Simard stated: ' The award of this contract represents a major step forward in the development of the critical metals related Blue Moon Mine. The ability to access the orebody from underground will greatly accelerate the Company's plans towards a mine commercialization decision, and the minimal footprint at surface allows us to do so in a very responsible manner – both physically and environmentally. We are proud to have SMD as a partner on this significant milestone.' Execution planning and additional engineering work to support construction will commence immediately, followed by the start of portal development in Q3-Q4 of this year. The exploration decline is expected to be complete by Q3-2026 and will include an underground exploration drilling campaign along with the aforementioned additional study work. This initial construction work is expected to generate at least 20 local employment opportunities directly with the mine and through SMD and their subcontractors. The Company is committed to supporting the economic and social development of the local and regional communities. Qualified Persons The technical and scientific information of this news release has been reviewed and approved by Mr. Dustin Small, a non-Independent Qualified Person, as defined by NI 43-101. About Blue Moon Blue Moon is advancing 3 brownfield polymetallic projects, including the Nussir copper-gold-silver project in Norway, the NSG copper-zinc-gold-silver project in Norway and the Blue Moon zinc-gold-silver-copper project in the United States. All 3 projects are well located with existing local infrastructure including roads, power and historical infrastructure. Zinc and copper are currently on the USGS and EU list of metals critical to the global economy and national security. More information is available on the Company's website ( ). About Small Mine Development (SMD) Small Mine Development builds and operates America's underground mines. SMD's mission is to be the leader in safe, productive and innovative mining solutions. They specialize in underground, hardrock mining and advance projects from exploration, through engineering, development, production mining, and, ultimately, closure. For further information: Blue Moon Metals Inc. Christian Kargl-Simard CEO and Director Phone: (416) 230 3440 Email: [email protected] Neither TSX Venture Exchange nor its Regulation Services Provider (as that term is defined in policies of the TSX Venture Exchange) accepts responsibility for the adequacy or accuracy of this release. CAUTIONARYDISCLAIMER-FORWARDLOOKINGSTATEMENTS This news release includes 'forward-looking statements' and 'forward-looking information' within the meaning of applicable Canadian and U.S. securities laws. All statements included herein that address events or developments that we expect to occur in the future are forward-looking statements. Forward-looking information may in some cases be identified by words such as 'will', 'anticipates', 'expects', 'intends' and similar expressions suggesting future events or future performance. We caution that all forward-looking information is inherently subject to change and uncertainty and that actual results may differ materially from those expressed or implied by the forward-looking information. A number of risks, uncertainties and other factors could cause actual results and events to differ materially from those expressed or implied in the forward-looking information or could cause our current objectives, strategies and intentions to change. Accordingly, we warn investors to exercise caution when considering statements containing forward-looking information and that it would be unreasonable to rely on such statements as creating legal rights regarding our future results or plans. We cannot guarantee that any forward-looking information will materialize and you are cautioned not to place undue reliance on this forward-looking information. Any forward-looking information contained in this news release represents management's current expectations and are based on information currently available to management, and are subject to change after the date of this news release. We are under no obligation (and we expressly disclaim any such obligation) to update or alter any statements containing forward-looking information, the factors or assumptions underlying them, whether as a result of new information, future events or otherwise, except as required by law. All of the forward-looking information in this news release is qualified by the cautionary statements herein. Forward-looking information is provided herein for the purpose of giving information about the Project and its expected impact. Readers are cautioned that such information may not be appropriate for other purposes. A comprehensive discussion of other risks that impact Blue Moon can also be found in its public reports and filings which are available
Straits Times
6 days ago
- Business
- Straits Times
A $5 billion Hong Kong family office makes first crypto foray
HONG KONG - A money manager to some of Hong Kong's richest individuals will start investing in crypto, as more favourable regulations attract a wider array of investors to the digital-asset sector. VMS Group, a multifamily office with just under US$4 billion (S$5 billion) in assets under management, plans to allocate up to US$10 million to strategies run by decentralised-finance hedge fund Re7 Capital, said VMS managing partner Elton Cheung in an interview. He added that the size of the allocation hasn't been finalised. The decision is part of recent moves by VMS to diversify into more liquid investments, Mr Cheung said. The firm has largely focused on private equity and other longer-duration strategies since it was founded two decades ago. While those investments have performed well, such types of assets have become less liquid as more companies opt to stay private for longer, making it more difficult to exit, he said. VMS, which helps manage money for some of the city's billionaire families from property to conglomerates, runs funds that invest in various sectors including internet technology and pharmaceuticals. In 2023, it teamed up with a former executive from Chinese artificial-intelligence company SenseTime Group to look for early-stage investments in AI. Mr Cheung declined to identify VMS's clients. Digital assets, meanwhile, have been gaining in popularity since Donald Trump was elected to the White House in November with a pro-crypto agenda that he's since begun enacting. Bitcoin has rallied about 50 per cent since the election, and a blockbuster initial public offering by stablecoin issuer Circle Internet Group in June has added to the momentum. 'We thought this was the right time because of growing demand and because we see clearer legislative and government support from various jurisdictions, as well as large institutional support and endorsement,' Mr Cheung said. Moving into crypto Wealth managers are taking steps to accommodate rising crypto adoption among their clients. JPMorgan Chase & Co. plans to let wealth-management customers use some cryptocurrency-linked assets as collateral for loans, Bloomberg News reported this month. VMS opted to to make its crypto foray through Re7 rather than investing directly in tokens like Bitcoin to limit volatility, Mr Cheung said. Re7 uses a market-neutral strategy through which it earns yield by providing liquidity on decentralised exchanges and by lending stablecoins – while using hedging to mitigate price swings. Re7 has consistently generated double-digit yields since its inception in 2021, its founder Evgeny Gokhberg said in an interview, without providing exact figures. VMS has been also exploring partnerships with digital-asset payments and infrastructure projects, said Li Zhi who joined VMS in London in December 2023 to lead investing in this area. That includes studying whether it can integrate crypto-based payments at a Vietnam real estate project it currently operates as majority shareholder. 'There is very strong institutional and family interest in getting regulated digital asset exposure,' Mr Li said. 'We have seen the younger generation of families wanting to do something different.' BLOOMBERG Join ST's Telegram channel and get the latest breaking news delivered to you.
Business Times
6 days ago
- Business
- Business Times
A US$4 billion Hong Kong family office makes first crypto foray
A MONEY manager to some of Hong Kong's richest individuals will start investing in crypto, as more favourable regulations attract a wider array of investors to the digital-asset sector. VMS Group, a multifamily office with just under US$4 billion in assets under management, plans to allocate up to US$10 million to strategies run by decentralised-finance hedge fund Re7 Capital, said VMS managing partner Elton Cheung in an interview. He added that the size of the allocation hasn't been finalised. The decision is part of recent moves by VMS to diversify into more liquid investments, Cheung said. The firm has largely focused on private equity and other longer-duration strategies since it was founded two decades ago. While those investments have performed well, such types of assets have become less liquid as more companies opt to stay private for longer, making it more difficult to exit, he said. VMS, which helps manage money for some of the city's billionaire families from property to conglomerates, runs funds that invest in various sectors including internet technology and pharmaceuticals. In 2023, it teamed up with a former executive from Chinese artificial-intelligence company SenseTime Group to look for early-stage investments in AI. BT in your inbox Start and end each day with the latest news stories and analyses delivered straight to your inbox. Sign Up Sign Up Cheung declined to identify VMS's clients. Digital assets, meanwhile, have been gaining in popularity since Donald Trump was elected to the White House in November with a pro-crypto agenda that he's since begun enacting. Bitcoin has rallied about 50 per cent since the election, and a blockbuster initial public offering by stablecoin issuer Circle Internet Group this month has added to the momentum. 'We thought this was the right time because of growing demand and because we see clearer legislative and government support from various jurisdictions, as well as large institutional support and endorsement,' Cheung said. Moving into crypto Wealth managers are taking steps to accommodate rising crypto adoption among their clients. JPMorgan Chase & Co. plans to let wealth-management customers use some cryptocurrency-linked assets as collateral for loans, Bloomberg News reported this month. VMS opted to to make its crypto foray through Re7 rather than investing directly in tokens like Bitcoin to limit volatility, Cheung said. Re7 uses a market-neutral strategy through which it earns yield by providing liquidity on decentralised exchanges and by lending stablecoins — while using hedging to mitigate price swings. 'The reason investors keep coming back to crypto is the asymmetry of risk and return,' Re7 Capital founder Evgeny Gokhberg said in an interview. 'Typically, people think about asymmetry in crypto as 'lose it all or make a 100x'.' That's 'rarely a fit for a serious allocator with a reputation to lose.' Re7 has consistently generated double-digit yields since its inception in 2021, Gokhberg said without providing exact figures. VMS has been also exploring partnerships with digital-asset payments and infrastructure projects, said Zhi Li, who joined VMS in London in December 2023 to lead investing in this area. That includes studying whether it can integrate crypto-based payments at a Vietnam real estate project it currently operates as majority shareholder. 'There is very strong institutional and family interest in getting regulated digital asset exposure,' Li said. 'We have seen the younger generation of families wanting to do something different.' BLOOMBERG
