Latest news with #clenbuterol
Yahoo
02-07-2025
- Health
- Yahoo
Ozempic Alternative Ditches The Needle And One Major Side Effect
A drug that can be taken orally could soon rival the likes of Ozempic for treating type 2 diabetes and obesity, according to a new study. Although its efficacy hasn't yet been tested in humans, the compound could bypass some of the harmful side-effects associated with similar drugs. Unlike the famous family of GLP-1 receptor agonist drugs, this new candidate targets the β2-adrenergic receptor (β2AR). Drugs that do this aren't new: salbutamol (sold as Ventolin among other brand names) is widely prescribed for use in short stints to treat asthma and chronic obstructive pulmonary disease. Clenbuterol is also prescribed for asthma in some countries, though it's better known as a performance-enhancing drug, banned by the World Anti-Doping Agency for its anabolic effects. For more than a decade, scientists have been trying to find a way to harness the benefits of β2AR agonists, without setting off their harmful effects. They can stimulate skeletal muscle glucose uptake and burn fat, mimicking the effects of exercise – but they have been considered too risky for treating diabetes or obesity, because of their tendency to wreak havoc on the heart. Related: The body's β2-adrenergic receptors are coupled with G proteins, and when activated for long periods (by β2AR drugs, for instance), the G proteins set off a chain reaction which leads to cardiovascular problems. "That would lead to heart rate increases, systolic blood pressure increases, and, eventually, that over-sustained exposure would lead to increases in heart weight and cardiac hypertrophy," molecular biologist Shane Wright, from Karolinska Institute in Sweden, told Mar de Miguel of Bioworld. But a campaign led by scientists from the Karolinska Institute, Stockholm University, and the biotech company Atrogi AB has revealed a series of β2AR agonist molecules that can side-step the slippery slope triggered by the G proteins. By activating only specific pathways, one of these – dubbed 'compound 15' – seems less likely to cause those concerning side effects, though we won't know for sure until further clinical trials are carried out. Unlike GLP-1 receptor agonists like Ozempic, compound 15 doesn't suppress appetite or lead to muscle loss, which means it may be safer in that regard too. It's also much more user-friendly, as a drug that can be swallowed rather than injected. "The goal was to try to target this other action that this receptor has expressed in the skeletal muscle, not in the heart, where it is mediating glucose uptake as a very beneficial outlet for lowering blood glucose levels," Wright said. So far, the newly-designed drug has been tested in lab-grown cells, male mice, rats, beagles, and phase 1 clinical trials (which only test for safety, not efficacy) in healthy and type 2 diabetic men. "Lead candidates of the chemical series increased glucose tolerance in preclinical models of diabetes and obesity with little or no increase in contractile force, cardiac lesions, and cardiac hypertrophy," the authors report. They also reversed muscle atrophy induced by GLP-1 drugs. "Clinical evaluation demonstrated that our lead candidate was orally bioavailable and safe in both healthy volunteers and type 2 diabetics, underlining its therapeutic potential." Many more tests – and a catchier name – will be needed before compound 15 or its relatives are made available as an alternative to GLP-1 drugs. Phase 2 clinical trials are underway to see if the enhanced muscle growth, balanced glucose levels, and insulin sensitivity seen in animal tests hold up in human bodies. "A well-tolerated GRK2-biased agonist offers significant therapeutic potential beyond type 2 diabetes and obesity… like muscular dystrophy and sarcopenia," the authors add. The research was published in Cell. A Simple Change To Your Evening Routine Could Help You Exercise More 'Sky-High' Levels of Alzheimer's Protein Found in Newborns Alzheimer's Might Not Actually Be a Brain Disease, Says Expert
Reuters
25-06-2025
- Health
- Reuters
Cross-Country Skiing-German association calls for acquittal of Olympic champion Carl after positive test
June 25 (Reuters) - German cross-country skier Victoria Carl has tested positive for the banned substance clenbuterol, Germany's ski association (DSV) said on Wednesday, as they called for her acquittal saying there was no intention to deceive by the Olympic champion. Carl, who won gold in the team sprint and silver in the relay at the last Winter Olympics, tested positive in an out-of-competition doping control. The DSV say the substance was a component of a cough syrup prescribed by the German armed forces (Bundeswehr). The Bundeswehr explained that the wrong medicine was mistakenly delivered and the case was packed by untrained personnel. At the time of the acute illness, the Winter Military World Games, no alternative medicine was available. "From the point of view of the German Ski Association, this is an unfortunate isolated case that was caused by an unfortunate chain of organisational and medical circumstances," a DSV statement said. "But not by an intention of deception on the part of the athlete." The DSV is calling for a differentiated case-by-case examination, taking into account the medical emergency, the open communications of the athlete and the medical responsibility. "I was sick, had severe coughing fits and took the medication on doctor's orders," Carl said. "I disclosed everything. I wasn't aware that it contained a banned substance. I very much hope that the circumstances will be understood and assessed fairly." The National Anti-Doping Agency (NADA) has started proceedings and both the DSV and the Bundeswehr say they hope for a complete acquittal. Even a short-term ban could amount to Carl missing next year's Milano-Cortina Olympic Games, which take place from February 6-22.
CNA
25-06-2025
- Health
- CNA
Cross-Country Skiing-German association calls for acquittal of Olympic champion Carl after positive test
German cross-country skier Victoria Carl has tested positive for the banned substance clenbuterol, Germany's ski association (DSV) said on Wednesday, as they called for her acquittal saying there was no intention to deceive by the Olympic champion. Carl, who won gold in the team sprint and silver in the relay at the last Winter Olympics, tested positive in an out-of-competition doping control. The DSV say the substance was a component of a cough syrup prescribed by the German armed forces (Bundeswehr). The Bundeswehr explained that the wrong medicine was mistakenly delivered and the case was packed by untrained personnel. At the time of the acute illness, the Winter Military World Games, no alternative medicine was available. "From the point of view of the German Ski Association, this is an unfortunate isolated case that was caused by an unfortunate chain of organisational and medical circumstances," a DSV statement said. "But not by an intention of deception on the part of the athlete." The DSV is calling for a differentiated case-by-case examination, taking into account the medical emergency, the open communications of the athlete and the medical responsibility. "I was sick, had severe coughing fits and took the medication on doctor's orders," Carl said. "I disclosed everything. I wasn't aware that it contained a banned substance. I very much hope that the circumstances will be understood and assessed fairly." The National Anti-Doping Agency (NADA) has started proceedings and both the DSV and the Bundeswehr say they hope for a complete acquittal. Even a short-term ban could amount to Carl missing next year's Milano-Cortina Olympic Games, which take place from February 6-22.
Washington Post
25-06-2025
- Health
- Washington Post
German cross-country skier and Olympic champion Victoria Carl fails doping test
BERLIN — German cross-country skier Victoria Carl has tested positive for the banned substance clenbuterol, the German skiing association said Wednesday. The 29-year-old Carl, who won gold in the cross-country team sprint alongside Katharina Henning at the 2022 Beijing Olympics, failed the test after her final race at the Military World Games in March. She also finished second in the overall World Cup standings last season. The skiing association, known by its German acronym DSV, said Carl's positive test for clenbuterol arose after she was given the wrong cough syrup to treat acute spastic bronchitis by a German army doctor. 'This is a regrettable isolated incident that arose from an unfortunate combination of organizational and medical circumstances – not from any intent to deceive the athlete,' the DSV said. The DSV published a statement from the German army's medical service saying the skier was erroneously given the combination drug Spasmo Mucosolvan containing ambroxol and clenbuterol instead of Mucosolvan containing just ambroxol. Germany's National Anti-Doping Agency has initiated proceedings. The DSV and German army said they're hoping for the athlete's 'complete acquittal.' The 2026 Milan-Cortina Winter Games open on Feb. 6. ___ AP skiing:
Associated Press
25-06-2025
- Health
- Associated Press
German cross-country skier Victoria Carl fails doping test
BERLIN (AP) — German cross-country skier Victoria Carl has tested positive for the banned substance clenbuterol, the German skiing association said Wednesday. The 29-year-old Carl, who was second in the overall World Cup standings last season, failed the test after her final race at the Military World Games in March. The skiing association, known by its German acronym DSV, said Carl's positive test for clenbuterol arose after she was given the wrong cough syrup to treat acute spastic bronchitis by a German army doctor. 'This is a regrettable isolated incident that arose from an unfortunate combination of organizational and medical circumstances – not from any intent to deceive the athlete,' the DSV said. The DSV published a statement from the German army's medical service saying the skier was erroneously given the combination drug Spasmo Mucosolvan containing ambroxol and clenbuterol instead of Mucosolvan containing just ambroxol. Germany's National Anti-Doping Agency has initiated proceedings. The DSV and German army said they're hoping for the athlete's 'complete acquittal.' ___ AP skiing:
