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Business Wire
a day ago
- Business
- Business Wire
Neurogene Announces Registrational Trial Design for Embolden™ Study of NGN-401 Gene Therapy for Rett Syndrome
NEW YORK--(BUSINESS WIRE)--Neurogene Inc. (Nasdaq: NGNE), a clinical-stage company founded to bring life-changing genetic medicines to patients and families affected by rare neurological diseases, today announced details of Embolden™, the Company's registrational clinical trial designed to evaluate NGN-401 gene therapy for the treatment of females with Rett syndrome in participants ages 3 years and older. The Company has written agreement from the U.S. Food and Drug Administration (FDA) on key aspects of the registrational trial's design. 'We appreciate the partnership with the FDA as we aligned on the key elements of our NGN-401 registrational trial design, which will allow for rapid conversion of the current Phase 1/2 study to a pivotal trial,' said Rachel McMinn, Ph.D., Founder and Chief Executive Officer of Neurogene. 'We believe that the robust endpoint design, which was informed by key opinion leaders, caregiver input and primary market research with payors, will support NGN-401's best-in-class potential and provide key differentiating data critical to the Rett syndrome community and the future commercial success of NGN-401.' 'I appreciate the multi-domain approach across the clinical manifestations of Rett syndrome, and rigor in which the primary endpoint will be evaluated, including both the clinician perspective of improvement using the CGI-I scale with Rett syndrome anchors and videos to demonstrate gains of skills that are clinically meaningful for girls and women with Rett syndrome and their families,' said Elizabeth M. Berry-Kravis, M.D., Ph.D., Professor of Pediatrics, Neurological Sciences and Biochemistry at Rush University, and principal investigator in the NGN-401 clinical trial. 'Participants treated with NGN-401 have demonstrated increased independence, with both fine and gross motor function improvement, and gained the ability to better communicate wants, needs and choices. I have been impressed with the improvements observed in participants after NGN-401 administration, which have included global improvement in signs and symptoms of Rett syndrome and gains of multi-domain developmental milestones that would not be expected to occur spontaneously in the post-regression stage of Rett syndrome. Evaluating treatment effect in participants ages 3 and above in the registrational study will provide important insights on the potential benefits of NGN-401 in younger patients early in the course of this progressive disease.' Obtained Written Agreement from FDA on the Following Key Elements of Embolden Registrational Trial Design After Discussions Under the START Program Study Design: Open-label, single arm, baseline control (i.e., participants serving as their own control); N=18 proposed, subject to feedback from the FDA. Patient Population: Females ages ≥ 3 years with Rett syndrome, which is consistent with Neurogene's analysis of the NIH-sponsored, International Rett Syndrome Foundation (IRSF) Rett syndrome natural history study that shows patients ages 3 and above rarely learn new skills/reach developmental milestones or relearn skills once lost. The FDA's written agreement endorsed the Company's analysis. Dose: 1E15 vector genomes (vg). Primary Endpoint: Responder-based composite endpoint that will assess an improvement in the Clinical Global Impression-Improvement (CGI-I) scale with Rett syndrome anchors and the gain of a developmental milestone/skill, compared to a participant's own baseline. Responders are defined as participants who: Attain a CGI-I score of ≤ 3 ('minimally improved'); and Gain any one developmental milestone/skill from a list of 28, as captured through standardized video recordings and independently verified by blinded central raters. Developmental milestones/skills were informed by a Rett syndrome caregiver survey, provided to the FDA, demonstrating that the acquisition of any single skill within the selected set is considered clinically meaningful. The primary endpoint will be evaluated at 12 months following NGN-401 administration, with feedback pending from the FDA to consider the addition of a 6-month endpoint. Neurogene has begun registrational trial initiation activities. 'It has been incredibly rewarding to see how RSRT's early investments in foundational Rett syndrome science helped lay the groundwork for what's now a promising gene therapy program approaching a registrational trial,' said Monica Coenraads, Founder and Chief Executive Officer of RSRT. 'RSRT has been a long-time champion of addressing the underlying genetic cause of Rett syndrome and Neurogene's program has the potential to do just that. We appreciate the thoughtful design of the trial that importantly incorporates the caregiver perspective on what meaningful improvement may look like. We congratulate the Neurogene team on reaching alignment with the FDA and thank the Rett community at large for their support in advancing this program. The future is bright!' 'Our partnership with Neurogene reflects a shared commitment to accelerating meaningful treatments for Rett syndrome,' said Laura Hameed, Chief Executive Officer of the International Rett Syndrome Foundation (IRSF). 'The use of IRSF's Natural History Study data to support the NGN-401 gene therapy registrational trial design is a powerful example of how families accelerate and streamline therapeutic development. We are grateful to the families that contributed to the NHS, and to the families participating in this trial whose time and commitment are essential to evaluating gene therapy for Rett syndrome.' Phase 1/2 Trial Data Support Registrational Trial Design Previously disclosed clinical data from the Phase 1/2 study* support the registrational trial design. Data showed improvements in Rett syndrome assessments with an aggregate of 23 developmental milestones/skills acquired in the first four participants. Specifically, the four participants: Each achieved a clinically meaningful rating of 2, or 'much improved,' on the CGI-I; and Collectively achieved 23 developmental milestones/skills in the core clinical domains of Rett syndrome – hand function/fine motor, communication/language, and ambulation/gross motor, including: Participant 1 gained 10 skills across multiple domains by 15 months post-dose; Participant 2 gained 8 skills across multiple domains by 12 months post-dose; Participant 3 gained 3 skills across multiple domains by 9 months post-dose; and Participant 4 gained 2 skills by 3 months post-dose. *Efficacy data from the first four participants; as of data cut-off date of October 17, 2024 Phase 1/2 Trial Enrollment and Update Neurogene previously shared that five additional participants had been dosed in the Phase 1/2 portion of the NGN-401 clinical trial during the first half of 2025. A total of 10 participants have received the 1E15 vg dose. There has been no evidence of hemophagocytic lymphohistiocytosis (HLH) / hyperinflammatory syndrome in any participant at the 1E15 vg dose level. Neurogene remains on track to share updated clinical efficacy and safety data in the second half of 2025. Cash Runway Update As of March 31, 2025, Neurogene had cash, cash equivalents, and investments of $292.6 million. The Company's current budget reflects a reallocation of capital from pipeline development to support pivotal trial activities for NGN-401. Neurogene now expects its existing resources will be sufficient to fund operations into early 2028. About Neurogene The mission of Neurogene is to treat devastating neurological diseases to improve the lives of patients and families impacted by these rare diseases. Neurogene is developing novel approaches and treatments to address the limitations of conventional gene therapy in central nervous system disorders. This includes selecting a delivery approach to maximize distribution to target tissues and designing products to maximize potency and purity for an optimized efficacy and safety profile. The Company's novel and proprietary EXACT™ transgene regulation platform technology allows for the delivery of therapeutic levels while limiting transgene toxicity associated with conventional gene therapy. Neurogene has constructed a state-of-the-art gene therapy manufacturing facility in Houston, Texas. CGMP production of NGN-401 was conducted in this facility and will support pivotal clinical development activities. For more information, visit About NGN-401 NGN-401 is an investigational AAV9 gene therapy being developed as a one-time treatment for Rett syndrome. It is the first clinical candidate to deliver the full-length human MECP2 gene under the control of Neurogene's EXACT™ transgene regulation technology. EXACT technology is an important advancement in gene therapy for Rett syndrome, specifically because the disorder requires a treatment approach that enables targeted levels of MECP2 transgene expression without causing overexpression-related toxic effects associated with conventional gene therapy. NGN-401 was selected by the U.S. Food and Drug Administration (FDA) for its START Pilot Program and has also received Regenerative Medicine Advance Therapy (RMAT) designation, orphan drug designation, Fast Track designation and rare pediatric designation from the FDA. Neurogene was previously granted an INTERACT meeting with the FDA regarding the EXACT technology. NGN-401 also received Priority Medicines (PRIME) designation, orphan designation and advanced therapy medicinal product designation from the European Medicines Agency (EMA) and the Innovative Licensing and Application Pathway (ILAP) designation from the United Kingdom (UK) Medicines and Healthcare products Regulatory Agency (MHRA). Cautionary Note Regarding Forward-Looking Statements Statements in this press release which are not historical in nature are intended to be, and hereby are identified as, forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. These statements may discuss goals, intentions and expectations as to future plans, trends, events, results of operations or financial condition, or otherwise, based on current expectations and beliefs of the management of Neurogene, as well as assumptions made by, and information currently available to, management of Neurogene, including, but not limited to, statements regarding: trial designs, clinical development plans and timing for NGN-401, including elements of the registrational clinical study trial design subject to final approval of the FDA, such as the proposed number of participants in the Embolden trial and the addition of a six month endpoint, and timing of the conversion of the NGN-401 Phase 1/2 clinical trial to a registrational clinical trial; expected future interactions with or positions of the FDA; the safety, tolerability and efficacy of NGN-401; the potential for success of the Embolden registrational clinical trial for NGN-401 for the treatment of Rett syndrome; expected timing for additional interim data from the Company's NGN-401 Phase 1/2 trial for Rett Syndrome; the effectiveness of the monitoring and treatment protocol for HLH in Neurogene's Phase 1/2 clinical trial of NGN-401; and the time period over which existing cash resources may be sufficient to fund the Company's operations. Forward-looking statements generally include statements that are predictive in nature and depend upon or refer to future events or conditions, and include words such as 'may,' 'will,' 'should,' 'would,' 'expect,' 'anticipate,' 'plan,' 'likely,' 'believe,' 'estimate,' 'project,' 'intend,' 'on track,' and other similar expressions or the negative or plural of these words, or other similar expressions that are predictions or indicate future events or prospects, although not all forward-looking statements contain these words. Forward-looking statements are based on current beliefs and assumptions that are subject to risks, uncertainties and assumptions that are difficult to predict with regard to timing, extent, likelihood, and degree of occurrence, which could cause actual results to differ materially from anticipated results and many of which are outside of Neurogene's control. Such risks, uncertainties and assumptions include, among other things, uncertainties regarding interactions with and feedback received from the FDA staff responsible for approving the design of our registrational trial and the risks and uncertainties identified under the heading "Risk Factors" included in Neurogene's Annual Report on Form 10-K for the year ended December 31, 2024, filed with the Securities and Exchange Commission (SEC) on March 24, 2025, Neurogene's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, filed with the SEC on May 9, 2025, and other filings that the Company has made and may make with the SEC in the future. Nothing in this communication should be regarded as a representation by any person that the forward-looking statements set forth herein will be achieved or that the contemplated results of any such forward-looking statements will be achieved. Forward-looking statements in this communication speak only as of the day they are made and are qualified in their entirety by reference to the cautionary statements herein. Except as required by applicable law, Neurogene undertakes no obligation to revise or update any forward-looking statement, or to make any other forward-looking statements, whether as a result of new information, future events or otherwise.
India Today
2 days ago
- Science
- India Today
Astronaut Shubhanshu Shukla to make historic radio contact with India from space
Group Captain Shubhanshu Shukla, India's trailblazing astronaut on the Axiom-4 (Ax-4) mission, is set to make history once again by establishing a live ham radio contact with the UR Rao Satellite Centre (URSC) in Karnataka from the International Space event is being coordinated by ISRO and will also connect school students across India, inspiring the next generation of space who became the first Indian to reach the ISS and only the second Indian in space after Rakesh Sharma, is currently on a 14-day mission conducting science experiments and outreach activities as part of the international Ax-4 crew. This ham radio session will allow students and engineers on the ground to interact directly with the astronaut, ask questions about life and research in microgravity, and witness real-time international space IS HAM RADIO?Ham radio, officially known as amateur radio, is a non-commercial radio communication service operated by licensed designated radio frequencies, ham operators can communicate across cities, countries, and even with astronauts in space. Ham radio is renowned for its reliability during emergencies when conventional networks fail, and for fostering global friendships and scientific the ISS, astronauts regularly use ham radio to connect with schools and amateur radio clubs worldwide, making space exploration more accessible and upcoming with India!@Axiom_Space #Ax4 crew member Shubhanshu Shukla, VU2TNI, will talk to the UR Rao Satellite Centre (URSC) in Karnataka via ham radio from the Space Fri. July 4 at 10:17 UTC | 6:17 AM ET | 3:47 PM ISS via K6DUE telebridge. ARISS - Amateur Radio on the ISS (@ARISS_Intl) June 30, 2025advertisementShukla's upcoming contact will mark a significant milestone for India's space outreach, as young students will get the rare opportunity to speak directly to an Indian astronaut orbiting WILL RADIO CONTACT HAPPEN? The radio contact from the Space Station by Indian astronaut Shubhanshu Shukla is scheduled to happen on Friday, July 4, at 3:47 pm Shukla continues his historic journey, this ham radio contact will be a proud moment for Indian science, technology, and education, symbolising the nation's growing presence in global space exploration. - EndsTune InMust Watch
Business Wire
2 days ago
- Business
- Business Wire
The ViewSonic myViewBoard Digital Whiteboarding Software Awarded the ISTE Seal from the International Society for Technology in Education (ISTE)
SAN ANTONIO--(BUSINESS WIRE)-- ISTE LIVE 2025 – Booth 1734 – ViewSonic Corp., a leading global provider of visual and edtech solutions, announces that it has been awarded with the prestigious ISTE Seal by the International Society for Technology in Education (ISTE) for the myViewBoard whiteboarding software. ViewSonic will be at ISTELIVE '25, June 30-July 2, 2025 to showcase myViewBoard, along with a number of edtech solutions for the next-generation of schools, classrooms, teachers, and students. myViewBoard received ISTE Seal recognition in the 'Creativity Tools' category, celebrating solutions that empower students to collaborate, create, and communicate, fostering deeper learning. Share The ISTE Seal recognizes excellence in educational technology products and platforms. Products receive this honor only after undergoing a rigorous evaluation process that assesses quality in learning design, user experience, digital pedagogy, and alignment with ISTE Standards. The Seal is a trusted mark of excellence that is recognized by educators, schools, and partners around the world. myViewBoard received ISTE Seal recognition in the 'Creativity Tools' category, celebrating solutions that empower students to collaborate, create, and communicate, fostering deeper learning. This award highlights myViewBoard's ability to nurture real-world skills, innovative thinking, and student engagement, while also ensuring accessibility and equity. As a recognized software in the Creativity Tool category, myViewBoard helps students become active creators and collaborators—rather than passive consumers of information, enabling them to: Engage in deeper learning through creative problem-solving and critical thinking. Express their ideas visually, verbally, and interactively. Collaborate in real time with classmates using Participate Mode and the Throw feature. Utilize digital tools authentically to drive their learning journeys. 'ViewSonic is thrilled to have received this recognition from ISTE,' said Jeff Muto, Business Line Director at ViewSonic. 'The EdTech market is full of amazing products and services, so having an entity like ISTE and their Seal are significant to the industry. It allows companies like ViewSonic and products like myViewBoard to demonstrate our commitment to delivering essential tools to the education market. We are very proud to have been recognized for offering a product that emphasizes digital learning, as well as the needs of educators and students.' For schools, myViewBoard is not just a standard technology platform—it is a powerful tool designed to support students in developing essential real-world skills, such as communication, creativity, collaboration, and innovation. myViewBoard also accentuates accessibility and inclusivity, allowing all students to engage meaningfully in learning. About the ISTE Seal The ISTE Seal serves as a mark of high-quality product design for solutions that enable and guide high-quality learning. By choosing to demonstrate their commitment to supporting best practices for teaching and learning, these products show a purposeful and meaningful dedication to practical usability, digital pedagogical implementation, and the ISTE Standards. With a focus on user experience, product usability, and the most essential elements of instructional technology today, the ISTE Seal provides a set of criteria and simple indicators to guide educators, students, and technology directors toward the very best products on the market. ISTE awards a seal only after an extensive analysis conducted by trained ISTE reviewers that ensures a product meets all critical elements under specific review criteria. By earning an ISTE Seal, ISTE verifies that this product: Promotes critical technology skills. Supports the use of technology in appropriate ways. Incorporates digital pedagogy and the learning sciences. Addresses key elements of tech usability, user experience, and user interface. Aligns to ISTE Standards in specific ways. Utilizes digital tools authentically to drive their learning journeys. To find out more about ViewSonic, visit and follow on Facebook, YouTube, X and Instagram. About ISTE The International Society for Technology in Education (ISTE) is home to a community of global educators and solution providers who are passionate about using technology to revolutionize learning. Our vision is to create a bold community where education innovators are supported in reimagining and redesigning learning with a focus on using technology to create transformational and equitable experiences for learners. We're making this vision a reality by delivering practical guidance, evidence-based professional learning, virtual networks, thought-provoking events and the ISTE Standards. About ViewSonic Founded in 1987 in California, ViewSonic is a leading global visual solutions provider with a presence in over 100 countries. The company leverages over 35 years of expertise in visual technology to deliver a comprehensive portfolio of hardware, software, content, and services. ViewSonic offers a wide range of products, with screen sizes spanning from five-inches to a massive 760-inches. This includes interactive displays, large format displays, LED displays, pen displays, monitors, projectors, SaaS, AI services, interactive content, and more. This innovative ecosystem empowers education, workplaces, and individuals to foster creativity, collaboration, and seamless learning. ViewSonic focuses on designing products that deliver optimal performance and customer satisfaction while integrating sustainable production practices and upholding comprehensive environmental, social, and governance standards. The company's goal is to enable customers to 'See the Difference'. Learn more at This news release contains forward-looking statements that reflect the Company's expectations with regard to future events. Actual events could differ significantly from those anticipated in this document. Trademark footnote: ViewSonic and the ViewSonic trademarks are trademarks or registered trademarks of ViewSonic Corporation in the United States and/or other countries. All other corporate names and trademarks stated herein are the property of their respective companies. Program, pricing, specifications, and availability are subject to change without notice.
Extra.ie
2 days ago
- Health
- Extra.ie
Dublin mum still lives with devastating results of stroke after giving birth
A mother has relived the shock of a life-changing stroke just days after she brought her newborn son home from hospital. Lisa Kenny, 42, was separated from her family for seven months after the crippling health emergency derailed the joy of welcoming baby Alfie in October 2019. She now lives with aphasia, an acquired language disorder that often occurs following brain injury, such as stroke. Pic: Emma Kenny/PA Wire She spoke about her experience as part of Aphasia Awareness Month. Aphasia affects the understanding of spoken or written language, including reading and writing or the production of spoken language. Ms Kenny, from Balbriggan, north Co. Dublin, said: 'With my stroke and aphasia, it was hard to suddenly be separated from my children because I couldn't talk and I was on a lot of medication. When I was in hospital, it was so hard because I couldn't see my children: Emily, now 13, and Alfie.' Her first symptom of stroke, four days after returning home with Alfie, was a headache, and she later lost feeling in her right arm and leg before her face began to droop. Ms Kenny's fiancé, Paul, phoned for an ambulance, and a brain scan revealed she had experienced a haemorrhagic stroke, where there is a bleed in the brain as opposed to a blockage in a blood vessel. She underwent brain surgery and had another operation two months later to replace her skull bone. Due to complications including pneumonia and seizure, it would be seven months before Lisa could return home from the National Rehabilitation Hospital in Dún Laoghaire, where she worked with occupational, physical, speech and language therapists. 'Now, I'm okay with speaking and talking, it's 50/50. I have got back to normal texting, which is huge for my communication,' she said. Pic: Emma Kenny/PA Wire However, she could not return to work as a result of her aphasia, a disorder that affects how you communicate through speech, as well as the way you write. Lisa uses Irish Heart Foundation (IHF) supports to aid her recovery, including the Young Stroke Survivors Network, the Life After Stroke private Facebook group, the Aphasia-Friendly Café and the Rhythm of Recovery Choir. 'I continue to push and challenge myself and just try to stay positive. I keep going, keep strong and healthy, for Emily and Alfie. I choose to laugh, love and be happy because life keeps going on and I will always have them with me. My speech, language, and physiotherapy are the key, too,' she said. She is working with the national charity to improve her comprehension, reading and maths. Helen Gaynor, head of community support services with the charity, said the IHF 'offers a variety of support services for people living with the life-changing effects of a stroke, including the challenges of aphasia'. She added: 'Our Stroke Connect Service and peer support groups are available to anyone who has experienced a stroke, and those living with aphasia. Our Step By Step Through Stroke booklet, a helpful guide for stroke survivors, families and carers, helps people prepare for potential changes due to stroke, such as communication difficulties.' For more information, visit
Time Out
24-06-2025
- Entertainment
- Time Out
Meet the 10 street photographers headlining ‘Capture Bangkok'
What makes Bangkok the second-best city in the world? It's a question we asked earlier this year, and you answered. It's the energy, the food, the culture, the beautiful, beautiful chaos. But more than anything, it's the stories – the millions of tiny moments that unfold every second on its streets. Now, we want to see them through your lens. As part of our Capture Bangkok celebration, we're showcasing the work of ten of the city's most visionary street photographers at The Corner House in Charoen Krung from August 7-20. These are the artists who peel back the layers of the Big Mango, finding poetry in the traffic, romance in the tangled wires, and serenity amidst the rush. Their work will inspire, challenge and make you see your city in a whole new light. We're thrilled to bring this project to life with our partners, Canon and Coca-Cola. And the best part? One more photographer will join them on that gallery wall. That photographer could be you! Get ready: Time Out Capture Bangkok Street Photography Challenge submissions open on June 30 and run until July 15. This is your official call to action. Charge your batteries, hit the pavement, and prepare to show us your Bangkok when the Google Form link drops. But first, get inspired. Read on to meet the 10 photographers whose work defines the art of seeing this city. STYLEdeJATE For STYLEdeJATE, Bangkok is a city where the frenetic energy of bustling crowds, tangled overhead wires and relentless traffic offers an endless playground for the lens. He doesn't just capture the city; he remixes it, infusing his own perspective into the frame to create a visual dialogue with the urban environment. This experimental approach is at the heart of his work, turning the familiar tapestry of Bangkok into something uniquely personal. While he undertakes planned commercial and artistic projects, his true passion lies in the spontaneous exploration of the streets, a practice he champions through Fotoclub BKK, a community he co-founded. For over six years, STYLEdeJATE has led monthly photowalks, often collaborating with artists from around the globe to explore the historic Charoenkrung district. He finding that even after a hundred visits, the area's blend of past and future, tradition and progress, never fails to offer a new story. This deep, sustained engagement with his surroundings informs STYLEdeJATE's core philosophy: a commitment to sincere and thoughtful image-making. He believes the true elevation of a simple snapshot to a work of art lies in the artist's sincerity – a genuine drive to create, evolve and communicate a personal truth that resonates with the viewer. In an era of endless digital images, he advises aspiring photographers to shoot less and think more, embracing the limitations of film photography as a way to cultivate a more deliberate and meaningful practice. For STYLEdeJATE, the most powerful images of Bangkok are not just aesthetically pleasing but are born from a deep connection to the moment, capturing the city's multifaceted identity – a sometimes contradictory collage of experiences that is real, tangible, and anything but artificial. Darkle Darkle attempts to capture what is both visible and residual. Living in Chinatown for over two decades, he's less interested in the city's overt chaos and more in its layered, supernatural energy – the ghosts, patterns, and vibrational pull of a past that lingers in the present. His process is a self-described 'maniacal obsession,' a compulsive need to gather and archive fragments of the city before they vanish, treating surfaces and facades as portraits of a place and its history. He is a photographer scratching at the surface of the now, trying to uncover remnants of what's been lost and how those absences continue to shape what remains. This deep, forensic approach informs his entire philosophy. He sees the constant negotiation of shooting on the streets, guided by a deep-seated sense of kreng jai, as a space where real, human tension can be productively managed. It's a delicate balance between being an invisible observer and an engaged participant, a line that shifts constantly. This is exemplified by what has become a long-term project of sorts: repeatedly photographing the same gable at Lhong 1919, where the shifting shadows act like a clock, marking the subtle, inexorable passage of time. His advice to others is to be single-minded in their purpose: 'Ask yourself… what do I really want to say?' For Darkle, the most powerful images are not sight gags for a saturated online world, but personal, coherent statements that cut through the noise with resonance and insight. Christian Hogue Bangkok is not a story to be told, but a stage for moments waiting to be found, thinks street photographer Christian Hogue. He steps out without a preconceived narrative, preferring to let the city present its own scenes. His process is a reactive dance with the environment; he doesn't hunt for shots but trains himself to recognise when an image 'calls out' to him. Light is often his guide, drawing him to the reflected glow of late afternoon sun on buildings or the electric hum of neon signs against the twilight sky. He finds inspiration by deliberately avoiding the cliches, venturing beyond the usual tourist trails into local Thai neighbourhoods, hi-so districts, and the rich hunting grounds of neon-lit back alleys around areas like Siam Square and Phrom Phong. This philosophy of openness extends to his interaction with people. While sensitive to cultural context, Hogue embraces the friendly attitude of Thais towards being photographed, often preferring the engagement of street portraiture over distant, candid shots. He's fascinated by the unique, fleeting moment when a person realizes they are on camera, capturing that genuine, natural reaction. For him, the uniqueness of Bangkok is embedded in the bold colours and symbols of the everyday – the eclectic, bright soda bottles at a spirit house, a concrete policeman statue, or the folded fish charms dangling from a scooter. His essential advice for capturing the city's authentic spirit is simple and reflects his entire approach: 'Just be open to the moment.' Danny A walk through Bangkok with Danny is a search for the city's essential details. He moves like a wanderer, letting his intuition and the quality of the light guide him down character-filled alleyways in neighbourhoods like Charoenkrung and Samsen. His camera seeks out the elements that are quintessentially Bangkok: the specific design of a school uniform, the vibrant colours of local fruits, the unique script on a street sign and the warmth of its people. His process is candid and respectful; while he prefers to capture moments as they unfold naturally, he won't hesitate to ask for a quick portrait if a scene feels too perfect, always keeping the interaction brief to honour his subject's time. Embracing an open and inclusive view of art, Danny believes any photo taken with purpose can be a meaningful work. He usually shoots in full colour, but is oft-drawn to the symmetry and mystery of black-and-white, as seen in his favorite shot of a lottery ticket seller whose face is obscured but whose personality shines through in his posture. For Danny, the biggest challenge of shooting in Bangkok is simply staying present amidst the heat and crowds. His advice to others reflects this philosophy: go out with no agenda other than to observe. Take it slow, and whether you get the perfect shot or not, the time spent being mindful in the moment is a victory in itself. Don Amatayakul In a city defined by its relentless energy, photographer Don Amatayakul seeks out the opposite. For him, the true art of capturing Bangkok lies in discovering and framing its hidden pockets of peace. He approaches the city not as a whirlwind of activity to be documented, but as a complex space where tranquility can be found if one only knows where – and how – to look. His process is fluid; sometimes he wanders and lets the atmosphere guide his lens, while at other times he meticulously scouts a location, studying its light and angles a day before returning with his camera. This desire for serenity is the message he hopes to convey, offering viewers a chance to feel the city slow down, even just for a moment, through his images. As a photographer, Don operates as an invisible observer, believing that the most natural and honest expressions are captured when people are unaware of the camera. He navigates the streets with a profound (consideration for others), always mindful that he is a guest in the lives he photographs. This philosophy is perfectly encapsulated in his iconic image of the colossal Buddha statue at Wat Paknam, framed by the setting sun, serenely presiding over the chaotic rush of traffic below. For Don, this single frame captures his vision: a reminder that even in the heart of the capital's bustle, peace and beauty are always present. His advice for those wishing to see this other side of Bangkok? 'Wake up earlier.' In those quiet, early hours, and by spending more time simply absorbing a place, you might just discover a side of the city most people never see. Ganesh Sinkorkiat For Ganesh, Bangkok's story unfolds in the quiet moments often lost amidst the city's frantic pace. Six years ago, he saw only the rush and the traffic, but through his camera, he discovered a different city – one of stunning dawns, serene dusks and intricate details tucked away in forgotten alleys. His mission is to capture these fleeting moments of beauty, hoping his images make people pause and see their surroundings in a new light. He wants to provoke a sense of discovery, for locals to exclaim, 'I walk past here every day, but I never knew it was this beautiful!' Whether it's the warm morning light, the gorgeous evening glow, or the tranquility of night, Ganesh seeks to reveal a calmer, more profound side of Bangkok, offering a visual respite from the daily grind and perhaps inspiring a new weekend adventure. Ganesh often seeks a higher perspective, drawn to rooftops and vantage points that frame the city's unique architectural dialogue – where ancient temples stand in graceful harmony with modern skyscrapers. He is a hunter of the 'Golden Hour,' patiently waiting for the perfect light to wash over the city. His advice to aspiring photographers is simple yet profound: 'Walk a little slower, be mindful, and when you find the right angle, stay there longer.' It is in this deliberate stillness, he believes, that the true, authentic spirit of Bangkok reveals itself. Hiang Kanjinna For Hiang believes that, to truly captureing Bangkok one must means embraceing its boundless variety – what he calls the 'Diversity of the Metropolis.' Her lens finds stories in everything from the city's freneticchaotic energy and the hidden peace of a weekend at Khlong Lat Mayom to the fleeting moments of humour found on any given street. This philosophy demands flexibility; she is equally prepared to meticulously plan a shoot or to wander aimlessly, letting the city guide herim. The most critical rule is simply to have a camera ready at all times, because an opportunity can arise from anywhere. Whether observing from a distance or engaging directly with his subjects, she believes each approach yields a completely different, yet equally valid, emotional texture for an image. Growing up in Charoenkrung has given Hiang a deep appreciation for the district's layered soul, where historic buildings and temples blend seamlessly with modern high-rises. This personal connection informs heris wider view of the city: a place that defies easy categorization. Heris emblematic photograph, a shot of the majestic Wat Arun framed by a welcoming doorway and bathed in the warm evening sun, encapsulates his vision of Bangkok as both iconic and inviting. Heris ultimate advice for anyone wanting to capture the city's true spirit is to 'Set no expectations.' ShHe believes that by arriving with an open mind, you allow the city to reveal its unexpected wonders, leading to photographs that are deeply personal and uniquely your own. Golfwashere Golf observes that the city of Bangkok truly comes alive during 'special events.' While he always has a camera ready, his instincts as a landscape photographer kick in when the familiar skyline is transformed by the unexpected – a sudden fireworks display, a new skyscraper puncturing the clouds, or a local festival that remakes a street's atmosphere. These moments are more than just beautiful; they are anchors in time, creating powerful new memories of the city. Though he meticulously plans his shoots with a clear goal in mind, he finds that the most impressive shots are often the unplanned 'images in-between.' It's in these spontaneous moments that the true, unscripted character of Bangkok reveals itself. This fascination with duality defines Golf's vision. He sees a city of contrasts: a grand, sprawling metropolis that, on closer inspection, is woven from the intricate, individual lives of its people. His favourite compositions capture this dialogue, juxtaposing the warm orange tones of Old Town architecture against the cool, modern sheen of a new tower. He finds endless inspiration in neighbourhoods like Talat Noi, where older structures take on a colourful new life and light filters through narrow alleys in endlessly surprising ways. His ultimate advice for capturing the city's authentic spirit goes beyond the lens: talk to the locals. For Golf, no guidebook or map can replace the stories and insights shared by the people who call Bangkok home. Piti Amraranga Piti swears that the soul of Bangkok isn't found in its grand landmarks, but in the small, ingenious traces of human problem-solving left behind on the streets. He is drawn to the city's everyday creativity – the raw, simple ways people repair broken items or invent their own DIY solutions. To Piti, these acts reveal a deep-seated creative spirit and a distinctly local sense of humour. His process is one of patient observation; he wanders without a set plan, letting the streets guide him until something catches his eye. Once he finds a subject, be it a person, an object, or a place, he dedicates his time to it, working the scene until he captures the image he envisions or the moment passes. This quiet, observational approach defines his style, allowing him to document the city's candid spirit without intrusion. Piti's artistic vision revolves around discovering and framing the hidden relationships between objects. He seeks connections in all forms – light, colour, geometry, or human gestures – and his goal is to make viewers feel at ease, perhaps even smile. One of his most emblematic shots captures this philosophy perfectly: a classic Bangkok taxi juxtaposed with a pot of marigolds, two icons of Thai culture brought together by an accidental, yet perfect, colour harmony. He finds endless inspiration not in chaotic markets, but in the city's public parks, which he sees as perfect stages for street photography with their mix of people, activities, and open spaces. His advice to others is to spend time learning from the art and creativity you encounter; for Piti, it is this deeper understanding that truly shapes one's unique perspective and elevates a simple photo into a meaningful work of art. PK Vanasirikul With a background in fashion, PK approaches the city as his model, engaging in a creative dance to capture its unique details and moods. He looks past the obvious chaos that many photographers seek, searching instead for Bangkok's 'subtle romantic moments.' For him, this means letting the streets guide him toward quiet, timeless scenes where he can document the city's more spiritual side. This quest for tranquility often leads him to the walkable, story-rich sois of neighbourhoods like Song Wat and Charoenkrung, where micro-universes unfold away from the main thoroughfares. His goal is to create a visual 'safe haven,' producing images that are relaxing and relatable, finding beauty in the mundane and offering a sense of ease in a hectic world. This perspective is deeply tied to a desire to find beauty in the unconventional, born from a personal connection to Thai subcultures like the Dek Chang (vo-tech students). Seeing a raw, rockstar spirit that is often misunderstood, he aims to reveal the humanity and individuality within these groups, celebrating the non-conventional as a vital part of the city's fabric. This empathetic lens underpins his entire philosophy of 'ethical photography.' He believes the feeling between photographer and subject is paramount, and would rather let a moment disappear than capture a photo that makes someone uncomfortable. For PK, intentionality is what elevates a snapshot to art, and his intention is clear: to compose layers, reflections, and geometric abstractions that reveal a timeless, gentler and more nuanced Bangkok.
