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COVID-19 Hospitalisation Tied to Higher Kidney Failure Risk
COVID-19 Hospitalisation Tied to Higher Kidney Failure Risk

Medscape

time2 days ago

  • Health
  • Medscape

COVID-19 Hospitalisation Tied to Higher Kidney Failure Risk

TOPLINE: Patients with COVID-19 who required hospitalisation had a more than sevenfold higher risk for kidney failure than individuals without the condition, with this elevated risk persisting beyond 180 days. No elevated risk was observed among non-hospitalised patients. METHODOLOGY: Researchers conducted a population-based cohort study using linked primary and secondary care data from England through the OpenSAFELY platform to assess the long-term risk for kidney failure following COVID-19. They included 3,544,310 patients (median age, 44 years; 53.2% women) with COVID-19 and 10,031,535 matched individuals without COVID-19; 6.9% of patients with COVID-19 were hospitalised. Participants without preexisting kidney failure (initiation of dialysis or kidney transplant or estimated glomerular filtration rate [eGFR] < 15 mL/min/1.73 m 2 ) and with at least 3 months of prior follow-up were included. ) and with at least 3 months of prior follow-up were included. The median follow-up duration was 446 days for patients with COVID-19 and 410 days for matched individuals. Follow-up started from 28 days after the diagnosis of COVID-19. The primary outcome was the time to kidney failure; secondary outcomes were a 50% reduction in the eGFR and all-cause death. TAKEAWAY: Patients hospitalised with COVID-19 had a more than sevenfold higher risk for kidney failure than matched control individuals (adjusted hazard ratio [aHR], 7.74; 95% CI, 7.00-8.56), with the risk persisting beyond 180 days of follow-up; the risks for kidney failure were particularly pronounced among those admitted to the ICU or with acute kidney injury during hospitalisation. COVID-19 requiring hospitalisation was also significantly associated with increased risks for a 50% reduction in the eGFR (aHR, 3.49; 95% CI, 3.25-3.75) and death (aHR, 4.93; 95% CI, 4.83-5.04). No increased risk for kidney failure was found among non-hospitalised patients (aHR, 0.85; 95% CI, 0.79-0.90). Black ethnic groups faced significantly higher risks for kidney failure than White or South Asian ethnic groups. IN PRACTICE: "Our results suggest that interventions to minimise the risk of severe COVID-19 should continue to be optimised among vulnerable groups, and that kidney function should be proactively monitored after discharge," the authors wrote. SOURCE: This study was led by Viyaasan Mahalingasivam, London School of Hygiene & Tropical Medicine, London, England. It was published online on June 18, 2025, in The Lancet Regional Health - Europe. LIMITATIONS: The removal of higher-risk individuals from the non-hospitalised group may have led to an underestimation of the risk for kidney outcomes in this group compared with non-infected comparators. Detecting a 50% reduction in the eGFR relied on regular blood tests, which were more common in patients with chronic health conditions and may have inflated observed risks due to more frequent monitoring. Additionally, some important covariates, such as occupation and type of vaccination, were not included in the analysis. DISCLOSURES: This study was funded through a Career Development Award from the National Institute for Health and Care Research. Some authors reported receiving research grants or funding, travel grants, awards, reimbursements, fellowships, honoraria, and consulting fees and having other ties with several pharmaceutical companies. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Oral Antivirals Show No Benefit in Hospital COVID-19 Care
Oral Antivirals Show No Benefit in Hospital COVID-19 Care

Medscape

time2 days ago

  • Health
  • Medscape

Oral Antivirals Show No Benefit in Hospital COVID-19 Care

TOPLINE: In patients hospitalized with COVID-19, adding molnupiravir or nirmatrelvir-ritonavir to usual care was not associated with improved clinical outcomes, including 28-day mortality duration of hospital stay or progression to invasive ventilation or death. METHODOLOGY: Researchers conducted a randomized, controlled trial to evaluate the efficacy of oral antivirals molnupiravir and nirmatrelvir-ritonavir on clinical outcomes in patients with COVID-19 during the Omicron period. Overall, 445 patients hospitalized with confirmed SARS-CoV-2 infection received molnupiravir (mean age, 71.4 years; 83% received the COVID-19 vaccine ) and 68 received nirmatrelvir-ritonavir (mean age, 72.5 years; 85% received the COVID-19 vaccine ) in addition to usual care. Each group was matched with an approximately equal number of patients who received usual care alone. The primary outcome was 28-day all-cause mortality, and secondary outcomes included progression to invasive mechanical ventilation or death. TAKEAWAY: No significant differences were observed between the molnupiravir and usual care groups in 28-day mortality (hazard ratio [HR], 0.93; P = .66) or time to discharge alive within 28 days (HR, 0.96; P = .60). Similarly, outcomes for nirmatrelvir-ritonavir were comparable to usual care, with no significant differences in 28-day mortality (HR, 1.02) or time to discharge alive within 28 days (HR, 0.80). The duration of hospitalization or the proportion of participants progressing to invasive ventilation or death was not significantly different in either of the comparisons (risk ratio, 0.96; P = .75). IN PRACTICE: 'Interpreting the results of this study, it is unlikely that adding molnupiravir to usual care has significant clinical benefit in this group of patients. On the other hand, it is difficult to conclude whether nirmatrelvir-ritonavir improves clinical outcomes in hospitalized patients due to the restricted sample size,' the authors of a linked commentary wrote. SOURCE: This study was led by Peter W. Horby, Nuffield Department of Medicine, University of Oxford, Oxford, England. It was published online on May 15, 2025, in The Lancet Infectious Diseases. LIMITATIONS: Both comparisons were discontinued due to low recruitment. DISCLOSURES: This study was funded by UK Research and Innovation, the National Institute for Health and Care Research, and the Wellcome Trust. Two authors reported having financial relationships with pharmaceutical companies such as Pfizer and MSD. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.

Kelley Wolf Says She ‘Survived' Being Placed Under an ‘Involuntary 5150' Amid Scott Wolf Divorce
Kelley Wolf Says She ‘Survived' Being Placed Under an ‘Involuntary 5150' Amid Scott Wolf Divorce

Yahoo

time2 days ago

  • Entertainment
  • Yahoo

Kelley Wolf Says She ‘Survived' Being Placed Under an ‘Involuntary 5150' Amid Scott Wolf Divorce

Kelley Wolf insists her mental health is in check following her recent hospitalization. According to People, the Real World: New Orleans alum, 28, took to Instagram on Monday, June 23, and shared a post stating she has 'No mental illness. No addictions' and that she is 'Just a woman who SURVIVED an involuntary 5150.' 'I'm fine, y'all. I'm happy,' she assured her followers. However, per the outlet, Kelley did admit that she 'called suicide hotlines.(20 yrs ago)' and 'had my heart shattered and my body bruised… but still kickin!! Hello! 😂.' As Star previously reported, Kelley shared a video on Instagram of herself being detained as a man — believed to be a police officer — informed her that she had made 'concerning comments.' The public speaker was later admitted to a Utah hospital on June 13. The National Alliance on Mental Illness explains a 5150 hold is when 'certain designated professionals can place a person in an involuntary 72-hour psychiatric hold if they are experiencing a mental health crisis and evaluated to be a danger to others, themselves, or are gravely disabled.' Kelley's hospitalization came a few days after she confirmed that she and her husband, Scott Wolf — whom she wed in 2004 — were getting a divorce. The former couple share three children: Jackson, 16, Miller, 12, and Lucy, 11. In her June 23 Instagram post, Kelley shared that she was looking for love again, writing per People, 'went on a 1st DATE 2-night. So nervous! OMG!' She also explained that she was working on a TV show. 'I JUST CALLED ALL THREE KIDS to let them know that I pitched a show I've been dreaming about for OVER A DECADE,' she wrote. 'And guess what? The legendary Bunim/Murray Productions (yes, that Bunim/Murray—the ones who changed TV forever) AND I want @hulu 🤞.' Kelley explained the synopsis and said that she would star in it. 'Imagine if Curb Your Enthusiasm had a baby with Designing Women, and then sent that baby backpacking through Europe with Anthony Bourdain while journaling its weird, wild, funny life as a traveling writer, ex-reality TV weirdo, mom, and full-blown eccentric who somehow still manages to hold down a business and help clients not lose their minds,' she penned, per the outlet. 'That's ME! Hola! Bonjour! Hi. Yo.' 'Telling my kids we're going to Spain in a few weeks, and that when we come back, Mama might finally get to make the show she's been dreaming of since she was their age?' she added. 'Full. Circle. Moment.'

3-year-old hospitalized after being struck by vehicle, St. Paul police say
3-year-old hospitalized after being struck by vehicle, St. Paul police say

CBS News

time3 days ago

  • CBS News

3-year-old hospitalized after being struck by vehicle, St. Paul police say

A 3-year-old was hospitalized after being struck by a vehicle in St. Paul, police say. St. Paul police say it happened around 9:18 p.m. Tuesday on the 1200 block of Edgerton Street. Officers found the child conscious, breathing and bleeding from the head, authorities say. The 3-year-old was hospitalized with non-life threatening injuries. Police say the child ran out into the roadway before being struck. The driver remained on the scene and was released after being interviewed by investigators.

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