Latest news with #nitricoxide
Yahoo
4 days ago
- Health
- Yahoo
Nitric Boost Ultra Issues 2025 Update on Nitric Oxide Support, Clean-Label Ingredient Trends, and Non-Synthetic Circulation Supplements for Men
This 2025 formulation disclosure highlights how Nitric Boost Ultra aligns with rising search interest in nitric oxide support, non-stimulant circulation supplements, and transparency-driven men's health products. Austin, June 28, 2025 (GLOBE NEWSWIRE) -- With a growing demand for nitric oxide–supportive supplements and clean-label performance products, Nitric Boost Ultra has released a 2025 formulation and ingredient transparency update. The brand's approach reflects the surge in consumer searches related to non-stimulant circulation support, amino acid-based energy formulas, and plant-aligned men's wellness tools. This release provides insight into how Nitric Boost Ultra's profile matches evolving expectations around ingredient sourcing, educational positioning, and lifestyle supplementation for vitality and endurance—without reliance on synthetic additives or prescription frameworks. Introduction: Nitric Oxide Awareness and the Shift Toward Clean Supplementation The concept of nitric oxide (NO) as a biological messenger has entered the mainstream health discussion in recent years, particularly among those interested in stamina, circulation, and performance. In 2025, a growing number of individuals are exploring natural, over-the-counter strategies that align with broader wellness values rather than clinical interventions. This shift is evidenced in rising keyword searches for terms like 'best nitric oxide booster for men,' 'natural ways to support blood flow,' and 'plant-based supplements for stamina.' As a non-synthetic, soy-free, and stimulant-free formulation, Nitric Boost Ultra exists at the intersection of this modern movement. It offers a well-structured ingredient lineup with public-facing transparency, educational framing, and compatibility with plant-forward daily wellness goals. In an increasingly competitive market for male vitality products, this announcement reinforces the brand's commitment to clarity, not hype—providing the public with access to meaningful ingredient breakdowns and clear positioning within the non-clinical wellness sector. Consumer Search Trends in 2025: A Spotlight on Nitric Oxide and Natural Circulation Support Consumer behavior online continues to demonstrate heightened interest in nitric oxide-related supplements, especially those positioned as natural, stimulant-free, and part of a broader approach to energy and endurance. Google Trends and other search analytics tools show increased volume in queries such as: 'natural nitric oxide booster' 'non-stimulant pre-workout powder' 'amino acid powder for circulation' 'plant-based energy supplement for men' 'nitric oxide blood flow support stack' This trend aligns with broader shifts in male consumer health preferences, where individuals seek to avoid synthetic stimulants or pharmaceuticals in favor of options rooted in clean nutrition and proactive self-care. Platforms like Reddit's r/Supplements, TikTok fitness commentary, and wellness-focused YouTube channels frequently feature discussions around nitric oxide–supportive ingredients, emphasizing circulation, performance, and confidence through natural strategies. Nitric Boost Ultra was formulated to reflect—not lead—this shift. Rather than claim innovation, it offers clarity and transparency about ingredients already dominating the wellness conversation, such as L-Arginine, Beet Root, and L-Citrulline. As public search behavior continues to drive formulation decisions, brands that embrace user curiosity and platform feedback without promotional overreach are gaining increased traction. 2025 Formulation Overview: Nitric Boost Ultra's Plant-Aligned, Stimulant-Free Ingredient Structure Nitric Boost Ultra's 2025 formulation profile includes a blend of amino acids, botanicals, and nutritional compounds selected for their roles in supporting nitric oxide production, energy metabolism, and circulatory health. The formula is stimulant-free, non-GMO, soy-free, and dairy-free—meeting consumer preferences for clean-label, transparent products. Key Ingredients Beet Root Powder: Known for its naturally occurring nitrates, beet root has gained popularity in endurance communities and among health-conscious consumers for its supportive role in vascular tone and oxygen efficiency. Its presence in NO-boosting formulations is both well-documented and increasingly requested in product reviews. L-Arginine: As a direct precursor to nitric oxide in the body, L-Arginine is one of the most searched and studied amino acids in the performance support space. It plays a foundational role in the endothelial nitric oxide synthase (eNOS) pathway and is regularly featured in user-built supplement stacks. L-Citrulline DL-Malate: This combination merges the NO-boosting potential of L-Citrulline (which converts into L-Arginine) with malate, which is associated with energy metabolism. The blend is known for supporting sustained performance, and its inclusion reflects search-driven preferences in both fitness and longevity supplements. Horny Goat Weed (Icariin): Often mentioned in traditional wellness systems, Horny Goat Weed contains icariin, a bioactive compound that appears frequently in men's vitality formulations. Online interest in this botanical remains high, particularly in the context of circulation, confidence, and performance alignment. Ginkgo Biloba: With a long-standing reputation for supporting blood flow and cognitive alertness, ginkgo continues to rank among the top-searched plant-based compounds in wellness communities. It is often noted for its antioxidant properties and synergy with other circulatory support ingredients. The Nitric Boost Ultra formula is produced in a U.S.-based facility operating under Good Manufacturing Practices (GMP). The brand does not make medical claims or offer clinical guidance but emphasizes full ingredient transparency and responsible product labeling for lifestyle supplementation. Aligning With the Clean Wellness Movement: Lifestyle Support Without Clinical Claims 2025 has seen a broad consumer push toward non-medical, non-stimulant solutions for endurance, energy, and confidence. As part of the broader clean-label movement, Nitric Boost Ultra was formulated to fit seamlessly into daily routines focused on long-term well-being, not instant transformation. Unlike traditional performance supplements that lean heavily on caffeine or proprietary blends, Nitric Boost Ultra avoids masking its ingredient strategy. The formulation does not promise specific outcomes. Instead, it echoes the informational tone increasingly expected by supplement-savvy buyers: 'This is what's in it, here's how it aligns with your interests, and here's why it was chosen.' By positioning itself as part of a transparent wellness toolkit—rather than as a shortcut to clinical results—Nitric Boost Ultra supports the evolving self-directed supplementation culture. Ingredient Function Overview: How Each Component Supports Natural Nitric Oxide Pathways Nitric oxide plays a vital role in vasodilation, or the widening of blood vessels, which in turn supports healthy blood flow, oxygen delivery, and muscular endurance. Ingredients in Nitric Boost Ultra were selected based on their relevance to the body's natural nitric oxide pathways and energy metabolism. L-Arginine supports the direct synthesis of nitric oxide through the eNOS pathway. This pathway is central to maintaining vascular tone and is commonly referenced in fitness literature for its endurance implications. L-Citrulline is converted into L-Arginine in the kidneys, offering a secondary NO-boosting route that some experts consider more effective due to its slower, sustained release. Beet Root Powder provides dietary nitrates that the body converts to nitric oxide via the nitrate-nitrite-NO pathway. This route bypasses enzymatic dependence and has gained favor in athletic supplementation circles. Ginkgo Biloba and Horny Goat Weed contribute to circulatory and cognitive support. Though not direct NO precursors, these botanicals are frequently included in stacks aimed at comprehensive vascular health. Together, these ingredients offer a multi-pathway approach to NO support without relying on synthetic enhancers or rapid-onset stimulants. The formulation offers an educational view of how common, well-researched compounds intersect with natural vitality. Consumer Use Case Narratives: How Online Communities View Powder-Based Circulation Support Discussions across Reddit, StackExchange, and social wellness groups increasingly show interest in powder-based supplements. Many users report supplement fatigue from daily capsules and prefer powders that dissolve into morning beverages or pre-workout routines. Nitric Boost Ultra, available in this format, reflects that preference without compromising on clean-label commitments. Public forums show consistent curiosity in formulas that combine amino acids and botanicals for generalized energy support, especially when free from added sugars or chemical additives. While anecdotal experiences vary, recurring themes include: Appreciation for non-stimulant energy options Interest in stacking beet root, citrulline, and ginkgo Questions around daily use timing and synergy with exercise Nitric Boost Ultra is not presented as a solution to any clinical need. Instead, it's discussed as a convenience-friendly powder that fits into user-built lifestyle strategies focused on clarity, self-regulation, and ingredient legitimacy. Search-Informed Formulation: How Public Curiosity Shaped the 2025 Ingredient Update Search data has shaped many aspects of the Nitric Boost Ultra development process. Rather than predicting what users want, the brand analyzed thousands of trending terms to identify existing interest clusters. Some of the fastest-growing queries include: 'best nitric oxide supplement 2025' 'beet root pre workout blood flow' 'natural energy powder for circulation' 'non-gmo nitric oxide stack for men' Rather than attempting to define what works best, the brand reverse-engineered a formulation around these phrases—incorporating ingredients already researched, reviewed, and requested across forums. Nitric Boost Ultra is not a novelty; it is a response to real, repeated consumer behavior without positioning itself as an authority. This transparency-over-innovation approach appears to resonate in an increasingly educated supplement marketplace. Access and Transparency: How the Brand Avoids Promotional Triggers While Educating the Market Nitric Boost Ultra maintains an informational website where individuals can verify the full ingredient profile, sourcing philosophy, and manufacturing details. There are no endorsements, quotes, or incentivized sales tools present on the platform. Pricing is not used as a conversion tactic, and there are no limited-time offers or urgency-based promotions. Transparency efforts include: Full ingredient list with sourcing background Clear dietary disclosures (non-GMO, soy-free, dairy-free) No clinical claims or disease treatment language GMP certification details for manufacturing This content-forward, compliance-focused strategy prioritizes long-term brand trust over short-term conversions—positioning Nitric Boost Ultra as a reliable reference in the nitric oxide category. Industry Context: Responsible Formulation in a Crowded Nitric Oxide Market As regulation increases in the health supplement space, companies are under pressure to separate educational content from promotional messaging. Nitric Boost Ultra embraces this boundary by structuring its product as an option—not a solution. Its existence within the nitric oxide sector supports a responsible model for supplement disclosure: ingredient-based, user-informed, and publication-safe. Rather than adopting exaggerated claims, Nitric Boost Ultra fosters a climate of inquiry—where users explore, compare, and contextualize ingredients within their own routines. Public Commentary Summary: Search Sentiment Themes From Wellness Conversations Emerging positives: Appreciation for clean-label powder format Recognition of popular, stackable ingredients Favorable discussion of beet root and ginkgo synergy Cautionary trends: Desire for third-party user studies Emphasis on realistic expectations around lifestyle support Ongoing comparisons to conventional nitric oxide pills or pre-workout blends These themes are not endorsements but reflect the general sentiment from independent wellness audiences and communities seeking clarity in a complex supplement marketplace. About Nitric Boost Ultra Nitric Boost Ultra is a wellness formulation created by a U.S.-based team focused on plant-aligned innovation, transparency, and lifestyle-based performance support. The formula is designed for adults seeking stimulant-free circulation and energy alignment without medicalization or prescription dependency. The brand does not diagnose or treat health conditions. Instead, it supports informational empowerment through ingredient transparency and clean manufacturing standards. Contact Nitric Boost Ultra Email: info@ Website: CONTACT: Nitric Boost Ultra Email: info@ Website: beim Abrufen der Daten Melden Sie sich an, um Ihr Portfolio aufzurufen. Fehler beim Abrufen der Daten Fehler beim Abrufen der Daten Fehler beim Abrufen der Daten Fehler beim Abrufen der Daten
Yahoo
25-06-2025
- Health
- Yahoo
Performance Scientist Reveals Top Legal Performance Hack
At some point, every athlete hits that shift from newbie to intermediate. Your muscles aren't growing like they used to, but you're stronger than ever. You've found your rhythm, and a few miles in, your breathing's smooth and steady. Still, we live in a world obsessed with the next big fitness breakthrough. Whether it's a new protein powder for gains or pre-workout for that mental edge, there's always something promising better performance. But according to a top longevity expert, there's one supplement you're probably overlooking—beetroot juice—and it could seriously level up the way you is rich in dietary nitrates, naturally occurring compounds found in various foods that convert into nitric oxide in the body. Once in the body, it relaxes and widens blood vessels, which can improve blood flow, deliver more oxygen to your blood, and improve efficiency. "We've used a ton of different forms over the years," Andy Galpin, Ph.D., CSCS*D, NSCA-CPT*D, the executive director of the Human Performance Center at Parker University, said in an interview with Dr. Rhonda Patrick. "It's great because it's not a stimulant, so you can take it in the evenings and it doesn't compromise sleep. We will use it a lot for our individuals who are either exercising at night or training multiple times per day, and their stimulants come in the morning, but they still have high fatigue." Because beetroot juice boosts nitric oxide levels and improves blood flow and oxygen efficiency, it can give you more stamina, better endurance, and potentially faster recovery. There's some debate on how to take beetroot—powder or juice? According to Galpin, it doesn't really matter. What does matter is when you take it. And fair warning: It may not be as intense as caffeine, but you'll definitely feel it within minutes. 'Like caffeine, you're going to have a pretty acute effect,' he says. 'Some people are going to metabolize it faster, some people slower. So it's not a short-lasting thing—it'll be there for quite some time. If you're going to use it for performance benefits, whether it's in the podcast room, in the weight room, or dealing with the assembly at your kid's school…right before would be the time to go about it.' Performance Scientist Reveals Top Legal Performance Hack first appeared on Men's Journal on Jun 24, 2025
Yahoo
17-06-2025
- Health
- Yahoo
Beyond Air Submits FDA PMA Supplement for Next Generation LungFit® PH
LungFit PH II's smaller, lightweight, transport-ready design is expected to open the entirety of the NO market Final design based upon substantial feedback from respiratory therapists across the countryGARDEN CITY, N.Y., June 16, 2025 (GLOBE NEWSWIRE) -- Beyond Air, Inc. (NASDAQ: XAIR) ('Beyond Air' or the 'Company'), a commercial stage medical device and biopharmaceutical company focused on harnessing the power of nitric oxide (NO) to improve the lives of patients, today announced the submission of a premarket approval (PMA) supplement application to the U.S. Food and Drug Administration (FDA) for LungFit PH II, the next-generation therapeutic nitric oxide generator. Beyond Air has developed its LungFit PH II system to be smaller, lighter and fully transport-ready — while delivering all the breakthrough features of the currently FDA-approved version from the Company's therapeutic platform of nitric oxide generators targeting pulmonary disease. The new system uses the same Smart Filter and accessories as the first-generation device, ensuring continuity, streamlined logistics, and minimal disruption for existing customers. The LungFit PH platform uses the Company's patented Ionizer™ technology to generate unlimited on-demand nitric oxide from ambient air, which is then able to be delivered directly to a ventilator circuit, regardless of dose or flow. The LungFit PH system uses the equivalent power of a 60-watt lightbulb to ionize the nitrogen and oxygen molecules, forming nitric oxide with low levels of nitrogen dioxide (NO2) created as a byproduct. The gas then passes through a Smart Filter, which removes the toxic NO2 from the internal circuit. For the treatment of PPHN, the novel LungFit PH system is designed to deliver NO doses consistent with the current standard of care for delivery of 20 ppm NO, with a range of 0.5 ppm – 80 ppm (low concentration NO), for ventilated patients. Each Smart Filter provides 12 hours of therapy regardless of ventilator demands and can be replaced in seconds for uninterrupted treatment. 'We are pleased to announce that development of our transport-ready LungFit PH II has resulted in a NO system which we believe is far superior to legacy systems currently available in the market. While our first-generation system already delivers key advantages to hospitals, this next-generation device raises the bar with a reduced weight and footprint, simplified operation, longer service interval, and full compatibility with both air and ground transport. It also includes an automated backup system that retains most primary system capabilities,' said Steve Lisi, Chairman and Chief Executive Officer of Beyond Air. 'Once approved, we are confident that the introduction of LungFit PH II will play a pivotal role in accelerating our market expansion and advancing our position as a global leader in hospital-based NO delivery.' NO gas is a vasodilator approved in dozens of countries to improve oxygenation and reduce the need for extracorporeal membrane oxygenation (ECMO) in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilator support and other appropriate agents. Low concentration inhaled NO therapy has been the standard-of-care for PPHN for over 20 years in the United States. PPHN is a lethal condition and secondary to failure of normal circulatory transition at birth. It is a syndrome characterized by elevated pulmonary vascular resistance (PVR) that causes labile hypoxemia due to decreased pulmonary blood flow and right-to-left shunting of blood. Its incidence has been reported as 1.9 per 1,000 live births (0.4-6.8/1,000 live births) with a mortality rate ranging between 4-33%. This syndrome complicates the course of about 10% of infants with respiratory failure and remains a source of considerable morbidity and mortality. In the European Union and many other countries outside the United States, NO is also approved for the treatment of peri- and post-operative pulmonary hypertension in adults and newborn infants, infants and toddlers, children and adolescents, ages 0-17 years in conjunction to heart surgery, in order to selectively decrease pulmonary arterial pressure and improve right ventricular function. About LungFit *Beyond Air's LungFit is a cylinder-free, phasic flow generator and delivery system designated as a medical device by the U.S. Food and Drug Administration (FDA). The ventilator-compatible version of the device can generate NO from ambient air on demand for delivery to the lungs at concentrations ranging from 1 ppm to 80 ppm. The LungFit system could potentially replace large, high-pressure NO cylinders, providing significant advantages in the hospital setting, including greatly reducing inventory and storage requirements, improving overall safety by eliminating NO2 purging steps, and offering other operational benefits. LungFit can also deliver NO at concentrations at or above 80 ppm for potentially treating severe acute lung infections in the hospital setting (e.g., COVID-19, bronchiolitis) and chronic, refractory lung infections in the home setting (e.g., NTM). With the elimination of cylinders, Beyond Air intends to offer NO treatment in the home setting. *Beyond Air's LungFit PH is approved for commercial use in the United States, European Union, Australia, Thailand and New Zealand. Beyond Air's other LungFit systems are not approved for commercial use and are for investigational use only. Beyond Air is not suggesting NO use over 80 ppm or use at home. About PPHNPersistent pulmonary hypertension of the newborn (PPHN) is a lethal condition and secondary to failure of normal circulatory transition at birth. It is a syndrome characterized by elevated pulmonary vascular resistance (PVR) that causes labile hypoxemia due to decreased pulmonary blood flow and right-to-left shunting of blood. Its incidence has been reported as 1.9 per 1,000 live births (0.4–6.8/1000 live births) with mortality rate ranging between 4–33%. This syndrome complicates the course of about 10% of infants with respiratory failure and remains a source of considerable morbidity and mortality. NO gas is a vasodilator, is approved in dozens of countries to improve oxygenation and reduces the need for extracorporeal membrane oxygenation (ECMO) in term and near-term (>34 weeks gestation) neonates with hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension in conjunction with ventilator support and other appropriate agents. About Beyond Air®, Air is a commercial-stage medical device and biopharmaceutical company dedicated to harnessing the power of endogenous and exogenous nitric oxide (NO) to improve the lives of patients suffering from respiratory illnesses, neurological disorders, and solid tumors. The Company has received FDA approval and CE Mark for its first system, LungFit® PH, for the treatment of term and near-term neonates with hypoxic respiratory failure. Beyond Air is currently advancing its other revolutionary LungFit systems in clinical trials for the treatment of severe lung infections such as viral community-acquired pneumonia (including COVID-19) and nontuberculous mycobacteria (NTM). The Company has also partnered with The Hebrew University of Jerusalem to advance a pre-clinical program dedicated to the treatment of autism spectrum disorder (ASD) and other neurological disorders. Additionally, Beyond Cancer, Ltd., an affiliate of Beyond Air, is investigating ultra-high concentrations of NO with a proprietary delivery system to target certain solid tumors in the pre-clinical setting. For more information, visit Forward Looking StatementsThis press release contains 'forward-looking statements' concerning the potential safety and efficacy of inhaled nitric oxide and the ultra-high concentration nitric oxide product candidate, as well as its therapeutic potential in a number of indications; and the potential impact on patients and anticipated benefits associated with inhaled nitric oxide and the ultra-high concentration nitric oxide product candidate. Forward-looking statements include statements about expectations, beliefs, or intentions regarding product offerings, business, results of operations, strategies or prospects. You can identify such forward-looking statements by the words 'appears,' 'expects,' 'plans,' 'anticipates,' 'believes' 'expects,' 'intends,' 'looks,' 'projects,' 'goal,' 'assumes,' 'targets' and similar expressions and/or the use of future tense or conditional constructions (such as 'will,' 'may,' 'could,' 'should' and the like) and by the fact that these statements do not relate strictly to historical or current matters. Rather, forward-looking statements relate to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause actual results to differ materially from any future results expressed or implied by the forward-looking statements. These forward-looking statements are only predictions and reflect views as of the date they are made with respect to future events and financial performance. Many factors could cause actual activities or results to differ materially from the activities and results anticipated in forward-looking statements, including risks related to the ability to raise additional capital; the timing and results of future pre-clinical studies and clinical trials; the potential that regulatory authorities, including the FDA and comparable non-U.S. regulatory authorities, may not grant or may delay approval for our product candidates; the approach to discover and develop novel drugs, which is unproven and may never lead to efficacious or marketable products; the ability to fund and the results of further pre-clinical studies and clinical trials of our product candidates; obtaining, maintaining and protecting intellectual property utilized by products; obtaining regulatory approval for products; competition from others using similar technology and others developing products for similar uses; dependence on collaborators; and other risks, which may, in part, be identified and described in the 'Risk Factors' section of Beyond Air's most recent Annual Report on Form 10-K and other of its filings with the Securities and Exchange Commission, all of which are available on Beyond Air's website. Beyond Air and Beyond Cancer undertake no obligation to update, and have no policy of updating or revising, these forward-looking statements, except as required by applicable law. CONTACTS:Investor Relations contactsCorey Davis, Advisors, LLCCdavis@ 915-2577 A photo accompanying this announcement is available at
Entrepreneur
12-06-2025
- Business
- Entrepreneur
Former Dell Executive Launces Heart Health Supplement Company
Joel Kocher, CEO of humann, is betting on nitric oxide to change how people think about heart health. Opinions expressed by Entrepreneur contributors are their own. Joel Kocher thought he was done. After more than two decades in senior tech leadership—as a Fortune 500 company CEO and then seven years at Dell where he rose to become the #2 executive behind Michael Dell —he retired at 49. But something felt off. "I hated it," he says. "I did all the things you're 'supposed' to do—consulting, investing, coaching. None of it lit me up." One unexpected meeting changed his entire plan. A friend invited him to sit in on a presentation at the University of Texas Health Sciences Center. Researchers there had spent years studying nitric oxide, a little-known but critical gas molecule in cardiovascular health, and wanted to bring their findings to market. "I'd never heard of nitric oxide," Joel recalls. "But by the end of that meeting, I called my wife and said, 'We're doing this.' I didn't know what I was signing up for, but I knew I couldn't walk away." That chance encounter launched humann, a heart health supplement brand built around nitric oxide science and is on a mission to change the trajectory of cardiovascular health in the world. Fourteen years and 8 published clinical studies later, humann has become a mission-driven company with a large consumer following. He came on the One Day with Jon Bier podcast to talk about how he went from burnout to building again, and what he's learned from launching a science-backed company in one of the most unregulated spaces in health and wellness - the supplement category. Success doesn't guarantee repeat success At Dell, Kocher helped lead the company through a period of massive growth. He figured he could do it again. So when he stepped into his next role, he brought that same confidence with him. But it didn't play out the way he expected. "You learn a tough lesson," he says. "After the prolific success at Dell, I thought I had it dialed. I could do it anywhere, anytime I wanted, on command." Now he approaches every new endeavor with fresh eyes. "Every business has its own set of challenges. And you have to figure out how to conquer them." Related: Entrepreneurial Success Comes Down to Having the Right Mindset — Here's How to Make Sure You Do Shortcuts aren't an option Kocher knew that cutting corners might have made things easier in the short term. But from the start, he was committed to doing it the right way, telling himself, "If you're going to do this, do it the way it should be done." That meant investing in clinical trials, hiring real scientists, and holding the company to standards most supplement brands avoid. humann has completed 8 published clinical studies brought on a Science Advisory Board that includes leading experts in the field of cardiovascular wellness, and is trusted by over 6,000 medical practitioners and professionals. Ferid Murad, MD, PhD and Nobel Laureate (1936 - 2023) was among three pharmacologists who made the Nobel Prize-winning discovery of Nitric Oxide. Dr. Murad served on humann's Science Advisory Board from 2020 until his passing in 2023. It was slower, harder, and more expensive, but it was the only path that felt right. Related: From Lab to Launch: Scientists 'Cook Up' the Next Big Startup Make education part of the product Kocher learned early on that even the best science won't sell itself. When humann ran focus groups before launch, they discovered that most consumers—and even physicians—had never heard of nitric oxide. "We did three focus groups with consumers and two with physicians… Not a single person had ever heard of nitric oxide," he says. "A couple of them thought we were talking about laughing gas." That experience made one thing clear: before they could market a product, they had to teach people why it mattered. Don't let bad news derail you After the focus groups, Kocher stood under a streetlight and seriously questioned whether to move forward. With limited capital and a massive education gap, it didn't feel worth the hassle. But instead of walking away, he chose to slow down, re-strategize, and rebuild the path forward. "I'm bullheaded as hell," he recalls. "After I stood there for 30 minutes, I said, 'Screw it. This is too important a mission. We're doing this. We're gonna figure it out.'" Related: Every Entrepreneur Pivots Their Business Eventually — But in the Age of AI, the Stakes Have Never Been Higher
