Latest news with #nonHodgkinLymphoma
Daily Mail
14 hours ago
- Health
- Daily Mail
EXCLUSIVE 'I pray my mother burns in hell': These words seem unthinkable from a son. But read the unfathomable things 'abusive monster' Kate did to his beautiful cancer-struck sister before you judge his anguish
Just days before she lost her young life to cancer, 23-year-old Paloma Shemirani turned to social media to showcase the healthy foods and sweat therapies she believed were curing her. Having turned down the chemotherapy which offered a high chance of surviving her non-Hodgkin lymphoma, this beautiful, brilliant Cambridge graduate had embraced a 'natural' regime of juices, coffee enemas and saunas – all carefully administered at home by her mother, Britain's most notorious conspiracy theorist Kate Shemirani.
Daily Mail
2 days ago
- Health
- Daily Mail
BREAKING NEWS Notorious anti-vaxxer mother of Cambridge grad, 23, who died of cancer after refusing chemotherapy claims her daughter was being 'gaslit by doctors' and 'didn't have confirmed lymphoma diagnosis'
A conspiracy theorist who allegedly coerced her dying daughter into refusing cancer treatment has fired back furiously at her sons' claims that she is responsible for her death. Kate Shemirani, who rose to notoriety with rabid anti-vax rants in which she branded Covid vaccines as Satanic, has denied that daughter Paloma Shemirani was ever diagnosed with the blood cancer that killed her at the age of 23 in July last year. Paloma's brothers Gabriel and Sebastian explosively claimed earlier this week that their sister had been indoctrinated into refusing professional medical help for her non-Hodgkin lymphoma. The Cambridge graduate and beauty queen ultimately suffered a rapid deterioration in her health and suffered a heart attack a week before she died. Friends of Paloma had also claimed earlier this week that Kate had sought to cut her daughter off from her friends as her condition worsened - even as Paloma texted her boyfriend to claim that she was being 'abused' by her mother. But Ms Shemirani - who still calls herself a 'nurse' despite being banned from nursing for rabidly sharing misinformation online - has hit back at the claims online. In a post on X, she claims her daughter was 'gaslit' by doctors and has even suggested she was experimented on by medics, accusing doctors of breaching the Nuremberg Code drawn up in 1947 to control the safety of medical experiments. Do you know more about this story? Email: She wrote: 'Paloma was never "coerced." She was never "radicalised". She was a woman of conviction and clarity. 'Her voice has been preserved—signed, sealed, and submitted in her own hand—and will now be shared with the world. We will not allow our daughter's memory to be defamed, nor her death to be sanitised.' Paloma was diagnosed with cancer in 2023 and doctors had told her she had an 80 per cent chance of recovery if she underwent chemotherapy. Her then-boyfriend said he received a text from Kate in block capitals, warning: 'TELL PALOMA NOT TO SIGN IR (sic) VERBALLY CONSENT TO CHEMO OR ANY TREATMENT.' Paloma did not agree to chemotherapy - even as doctors expressed concern over her mother's overt influence - and instead reached out to a former partner of Kate's, who told her to consider Gerson therapy, which claims a plant-based diet and routine of coffee enemas could treat cancer. Established cancer charities and researchers say there is absolutely no proof that Gerson therapy can help with cancer treatment. However, Kate has today shared what appeared to be a sworn affidavit authored and signed by Paloma, seemingly dated April last year, in which the 23-year-old allegedly claimed to be a 'staunch advocate' for Gerson therapy. Bearing what appears to be Paloma's signature, it contains a denial that she was ever diagnosed with cancer and struck out the idea that she was being cut off from the world by her mother. 'I do NOT have a Non-Hodgkin's lymphoma b diagnosis. It is a differential diagnosis in which cancer could not be ruled out,' the statement reads. 'To suggest I am being isolated is ridiculous.' However, Gabriel and Sebastian have both indicated that they believe the document to have been written by their mother, and signed by Paloma under duress or in a state of reduced mental capacity. The pair - who have been estranged from their mother for years - both refer to her by her legal name of Kay. Sebastian told MailOnline today: 'When I read the statement, I read it in Kay's voice in my head - that's how obvious it is to me, as someone who escaped Kay's brainwashing, that it was written by Kay.' 'Kay wants you to believe that these are actually Paloma's words,' Gabriel said in a response on social media. The statement includes misinformation claiming that King Charles has opted for 'natural medicines and treatment for his own cancer diagnosis'. In reality, no details of the King's treatment for cancer have been shared publicly - though he has alluded to losing his sense of taste, a common side-effect of undergoing chemotherapy. Kate has further accused the NHS of being responsible for her daughter's death, without evidence. She has also accused doctors, coroners, lawyers and the media of suppressing 'medical negligence'. The brothers, along with some of Paloma's friends and a former boyfriend, went public earlier this week with their fears that the straight-A student had been coerced into refusing mainstream medical treatment by Kate. Speaking to the BBC's Panorama programme on Monday, Sebastian had said: 'My sister has passed away as a direct consequence of my mum's actions and beliefs and I don't want anyone else to go through the same pain or loss that I have.' Kate - who was banned from Twitter but returned when it was rebranded as X under Elon Musk - is said to have briefly worked for the NHS in the 1980s before working as a British Airways air hostess and model before administering Botox, fillers and peels while bringing up her children. Sebastian previously claimed his his childhood was 'hell' amid years of brainwashing, describing how he was left terrified aged 10 when Ms Shemirani told him 'the Rothschilds are planning to go live on a space station and how there's going to be this mass genocide'. This is a developing story - more to follow.
Daily Mail
5 days ago
- Health
- Daily Mail
Daughter of anti-vaxxer nurse who claimed Covid was a hoax died of cancer after 'falling for mother's conspiracy theories', her brothers claim
The beauty queen daughter of a conspiracy theorist nurse died of cancer after being indoctrinated by her mother into refusing conventional medical treatment, her siblings claim. Paloma Shemirani died in July last year aged 23 after being diagnosed with non-Hodgkin lymphoma, a form of blood cancer. Miss Brighton finalist Paloma was the daughter of Kate Shemirani, a notorious anti-vaxxer who was struck off the UK's nursing register in 2021 for her extreme anti-medicine views, including discouraging the use of masks and vaccines. Her brothers, Gabriel and Sebastian, claim that their sister ultimately ended up refusing conventional chemotherapy because of pressure from her mother, with whom she had been trying to build a better relationship. They also allege that their mother sought to isolate her daughter from friends, her boyfriend and other members of her family, even as the cancer's progression became distressingly clear. Paloma, a Cambridge graduate who was pictured beaming with her two A* and A results after finishing school, had aspired to embark on a career in publishing. But her life was cut tragically short due to, her brothers allege, undue influence from their mother, who rose to notoriety during the coronavirus pandemic. Kate, 60, continues to call herself a 'natural nurse' despite being banned from practising nursing in the UK. She has not commented on her sons' claims, instead claiming without evidence that the NHS is responsible for her daughter's death. Speaking to the BBC, Gabriel and Sebastian said Paloma had died just seven months after being diagnosed with cancer because of her mother's extreme views. Sebastian said: 'My sister has passed away as a direct consequence of my mum's actions and beliefs and I don't want anyone else to go through the same pain or loss that I have.' Kate - who was banned from Twitter but returned when it was rebranded as X under Elon Musk - is said to have briefly worked for the HS in the 1980s before working as a British Airways air hostess and mode before administering Botox, fillers and peels while bringing up her children. She now shares her extremist views on the NHS, immigration and vaccines with her 81,000 followers - and conspiracy theories were a common soundtrack on the school run, including those perpetuated by misinformation spreader Alex Jones. Jones has since been declared bankrupt after being told to pay $1.5billion to victims of the 2012 Sandy Hook school shooting in the US, which he claimed had been staged to tighten up American gun laws. At home, WiFi was switched off and the children were peddled other conspiracy theories by Kate and their father Faramarz Shemirani. In 2012, she was diagnosed with breast cancer - and had the tumour removed through surgery, undergoing a double mastectomy and reconstructive surgery. But online, she appears to suggest she was healed following 'Gerson therapy' - a baseless form of alternative medicine that advocates following a plant-based diet to treat cancer - and by taking vitamin and mistletoe injections. 'I'm still here and thriving. You can shove your poison mustard gas where the sun doesn't shine you pimps and assassins,' she wrote on X earlier this year, in reference to chemotherapy. Her recovery from cancer only fed into her anti-medicine views, according to Chantelle, a friend of Paloma's from school. She told the BBC she watched Paloma get sunburned after refusing to wear sunscreen for fear that it, not sun exposure, caused cancer. Gabriel and Sebastian are estranged from their mother but Paloma stayed in touch - trying, they felt, to build upon her relationship. Like her mother, she refused to accept a coronavirus vaccination. Texts seen by the broadcaster suggested that Kate was abusive, however, with one sent to Paloma's boyfriend reading: 'Im so so so sick of being abused all the... time. I'm just sat taking (redacted) from her and crying at the same time.' In 2023, when Paloma was diagnosed with cancer, doctors told her she had a 80 per cent chance of recovery if she underwent chemoterhapy. But Kate texted her daughter's boyfriend in all capitals, warning: 'TELL PALOMA NOT TO SIGN IR (sic) VERBALLY CONSENT TO CHEMO OR ANY TREATMENT.' Paloma did not agree to chemotherapy - even as doctors expressed concern over her mother's overt influence - and instead reached out to a former partner of Kate's, who told her to consider Gerson therapy - the baseless idea that a plant-based diet and routine of coffee enemas could treat cancer. Cancer Research says of Gerson therapy: 'There is no scientific evidence to use it as a treatment for cancer.' Many people turn to Gerson therapy, the charity says, because it gives them a sense of control over their cancer, particularly if they have been told that it cannot be treated. No clinical study has ever been conducted, and other studies have been found to have been biased or funded by pro-alternative medicine bodies. Kate's former partner has told the BBC that any 'assertions that I played a role in her death are legally inaccurate'. But as Paloma continued with the treatment, her friends noticed that her cancer was worsening and spreading, with new lumps appearing on her body. She spoke of cutting people off if they disagreed with the direction she was taking her treatment. Chantelle said of her friend: 'I don't think her ideology was strong enough to make those decisions is my personal belief. People have different opinions about these things, but I think her mum played a massive, massive role into it.' Gabriel had asked to see his sister, only to be told she could not go out because of the 'bad air'. He launched a legal case to have her properly medically assessed - but it never came to pass, as Paloma ultimately died in July 2024. She had suffered a heart attack caused by her tumour, and was taken off of life support after days in hospital. He only found out days after the event via his lawyer, and had to break the news to Sebastian. An inquest into her death is due to begin next month. She has previously claimed to have beaten cancer by following 'Gerson therapy' - baseless claims that a plant-based diet will beat cancer. In reality, she underwent a double mastectomy Kate Shemirani, who has not responded to the Mail's request for comment, has continued to post about her daughter's death on social media for the last year. She claims that the NHS killed her daughter 'in the name of medicine and cash for corpses', without evidence, and continues fundraising in her daughter's name for legal fees that she says will be used to challenge the NHS in court. Writing on X today, she said: 'When the time is ready we will put all of the documents in public but what I can say is that my daughter was given 12 times the dose of adrenaline and other drugs that did the same as the adrenaline. 'It destroyed her brain in front of us as it collapsed her circulation and the rest is just a cover-up.' Baselessly, she wrote online in a document co-authored with her ex-husband that Paloma's 'petite frame (was) subjected to excessive caused irreversible brain damage'. She also writes about Paloma on her website, where she sells branded vitamin supplements and offers one-to-one consultations for around £195, despite being banned from practising nursing in the UK. Kate was struck off by the Nursing and Midwifery Council - the regulatory body for nursing in the UK - in 2021 for her extreme anti-vaccine views. Calling yourself a nurse without good reason is not currently a criminal offence - but will change in the near future under government plans to make falsely identifying as a nurse a crime. In its announcement of the proposed legislation last month, the government directly alluded to Shemirani without naming her, referencing an incident in which she appeared to compare NHS bosses to the Nazis in 2021 , labelling her a 'bogus nurse'. Speaking at the anti-lockdown rally in question, she had referenced Nuremberg Trials, in which seven physicians affiliated with the Nazis were put to death for their roles in the Holocaust and crimes against humanity. She told an anti-lockdown gathering: 'At the Nuremberg trials, the doctors and nurses, they stood trial, and they hung. If you are a doctor or a nurse, now is the time to get off that bus.' Health secretary Wes Streeting said of the proposals: 'This new legislation will help crack down on bogus beauticians and conspiracy theorists masquerading as nurses, and those attempting to mislead patients.' Elsewhere, Shemirani has also appeared at anti-lockdown events alongside other noted conspiracy theorists such as David Icke and Mark Steele, who have shared baseless anti-vaccine and anti-5G conspiracy theories for years. But she was 'replatformed' after being allowed back onto X, as well as TikTok - which has since banned her account - and Facebook, where she remains active. Her sons said in an interview early in her rise to notoriety that she 'loves being the centre of attention',
Yahoo
5 days ago
- Business
- Yahoo
Enterome presents positive Phase 2 interim results in relapsed/refractory indolent non-Hodgkin lymphoma after EO2463 OncoMimics™ immunotherapy treatment at ICML
60% (12/20) complete response rate after treatment with EO2463 in combination with lenalidomide and rituximab (R2) EO2463 plus R2 was well tolerated in patients with follicular and marginal zone lymphoma EO2463 plus R2 combination treatment resulted in higher-than-expected rates of complete remission so far in this study compared to historical data for R2 alone Paris, France – 23 June, 2025 Enterome SA, a clinical-stage company developing first-in-class OncoMimics™ immunotherapies to treat cancer, presented positive interim results for its OncoMimics™ immunotherapy EO2463 from Cohorts 1 and 4 of the ongoing open label Phase 1/2 SIDNEY trial in patients with indolent non-Hodgkin lymphoma (iNHL), at the International Conference on Malignant Lymphoma (ICML) in Lugano. Interim data including 24 patients with follicular and marginal zone lymphoma (relapsed/refractory iNHL) showed that treatment with EO2463 in combination with lenalidomide and rituximab (R2) was well tolerated and demonstrated encouraging signs of efficacy that appear better than historical data in similar patients treated with R2. Importantly, EO2463 showed direct anti-lymphoma activity, including partial responses to the OncoMimics™ monotherapy, during the first six weeks of the study, a short time period during which just the first three doses of EO2463 were administered, before the protocol called for initiation of treatment with lenalidomide (followed subsequently by adding rituximab). Moreover, once lenalidomide and rituximab were added, the effect of EO2463 appeared to support a deepening of responses, resulting in a complete response rate of 60%, higher than would have been expected with R2 alone, based on historical data1. Pierre Belichard, CEO of Enterome said, 'The EO2463 interim results are very encouraging, demonstrating exceptional tolerability for an active immunotherapy, and showing a clear signal that the combination with R2 can provide more robust responses in this patient population over R2 alone. This is consistent with the strong response rate we observed with EO2463 monotherapy in patients with low tumor burden disease, the so-called 'watch-and-wait' population, included in Cohort 2 of SIDNEY. While we plan to focus our near-term efforts on initiating a registrational Phase 3 trial of EO2463 for the watch-and-wait population, this evidence of a complementary effect in combination with R2 in relapsed/refractory iNHL is very exciting and offers new hope for this patient group, most of whom still see insufficient efficacy with available therapeutics.' EO2463 is designed to expand pre-existing memory CD8+ T cells recognizing non-self-protein sequences from gut bacteria, which mimic several purposefully selected B cell antigens. The interim SIDNEY data from Cohorts 1 and 4 presented at ICML show fast, robust, and durable expansion of the specific CD8+ T cells that were active against EO2463 mimic peptides and the targeted B cell epitopes. Most important, the magnitude of the EO2463-driven expansion of specific CD8+ T cells correlated with the probability of complete remission upon treatment with EO2463 combined with R2 in the SIDNEY study. EO2463 in combination with lenalidomide and rituximab (R2 ) is well tolerated in patients with follicular and marginal zone lymphoma. Jan Fagerberg, Chief Medical Officer of Enterome, said, 'These early efficacy results suggest EO2463 offers additional benefit when used together with the R2 regimen in patients with relapsed/refractory iNHL. We previously reported data from Cohort 2 of SIDNEY, at ASH in December 2024, showing that EO2463 OncoMimics™ monotherapy generated a 46% objective response rate in patients who are usually proposed 'watchful waiting' and no active anti-lymphoma therapy – and also had an excellent tolerability profile. In short, taken together, these SIDNEY data indicate that this well tolerated novel active immunotherapy may well have broad potential across hematological malignancies.' EO2463 is an innovative, off-the-shelf OncoMimics™ active immunotherapy that combines four synthetic peptides. These non-self, microbial-derived peptides correspond to CD8 HLA-A2 epitopes that exhibit molecular mimicry with the B lymphocyte-specific lineage markers CD20, CD22, CD37, and CD268 (BAFF receptor). It also includes the helper peptide (CD4+ epitope) universal cancer peptide 2 (UCP2). The unique ability of EO2463 active immunotherapy to selectively target multiple B cell markers enables the destruction of malignant B lymphocytes. By ensuring broad target coverage across malignant B cells, this novel approach aims to simultaneously improve safety and maximize efficacy, reducing the tumor cells' capacity to develop immune-resistance mechanisms such as antigen escape. SIDNEY is an ongoing open label Phase 1/2 study that aims to assess safety, tolerability, immunogenicity, and preliminary efficacy of EO2463 monotherapy and combination therapy with lenalidomide/rituximab in up to 55 patients with follicular lymphoma and marginal zone lymphoma including four cohorts of three patient populations: Cohort 2: patients with newly diagnosed, previously untreated low tumor burden disease, not in need of standard of care therapy, i.e., the 'watch-and-wait' setting; treatment = EO2463 monotherapy Cohort 3: patients with newly diagnosed, previously untreated low tumor burden disease, in need of therapy; treatment = EO2463 in combination with rituximab Cohorts 1 and 4: patients with relapsed/refractory disease and at least one prior treatment; treatment = EO2463 in combination with lenalidomide and rituximab (R2) OncoMimics™ are synthetically produced peptides designed in silico using AI and machine learning to mine Enterome's extensive proprietary database of microbial bacteria. Unlike cancer antigens, OncoMimics™ bypass a gating process, known as thymic deletion, that prevents the immune system from mounting an attack against the 'self' proteins (e.g. antigen) on tumor and blood cancer cells. Furthermore, that they trigger a more targeted, rapid and robust immune response than would otherwise be possible, because very early in human development the immune system learns to protect the body from microbiome bacteria. This means that OncoMimics™ call up memory CD8+ T cells that selectively target the cancer cells that carry the mimicked antigen(s). This therapeutic strategy takes inspiration from and is de-risked by emulating the gut microbiome's causal role in certain autoimmune diseases. OncoMimics™ are easy to manufacture, store, distribute and administer as an 'off-the-shelf' subcutaneous injection. In clinical testing to date they have been shown to be extremely well tolerated, especially compared to other potent immunotherapies. Enterome SA ( is a privately held clinical-stage biopharmaceutical company developing breakthrough OncoMimics™ immunotherapeutics for cancer. The three most advanced product candidates have shown positive early data in Phase 2 clinical development, supporting novel OncoMimics™ modality. The company's pioneering approach to drug discovery is based on the unique and powerful bacterial Mimicry drug discovery platform, which allows it to discover OncoMimics™ with high similarity to tumor associated antigen (TAA) based on the big-data insights from millions of gut bacterial proteins, that live in humans. For more information, please contact: ENTEROMEPierre BelichardChief Executive Officer+33 (0)1 75 77 27 85communication@ INVESTOR & MEDIA RELATIONSCohesion BureauChris Maggos / Giovanni Ca' Zorzi+41 (0)79 367 6254 / +33 (0)7 84 67 07 27enterome@ 20250623 Enterome PR#6 - Lugano data_final_ENError in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
E&E News
12-06-2025
- Health
- E&E News
Cancer patient urges SCOTUS not to dismiss Roundup verdicts
A Missouri man who developed non-Hodgkin lymphoma after using a popular weedkiller for decades wants the Supreme Court to reject the manufacturer's request to grant it immunity from his lawsuit and thousands of others. John Durnell in a brief filed Monday says a jury found that Monsanto's Roundup caused his blood cancer and that the company is liable for damages. But, he added, the company is arguing 'as it has argued with little success for years' that it should be immune from lawsuits that it says are barred by federal law. His filing comes after Bayer in April asked the high court to determine whether the Federal Insecticide, Fungicide and Rodenticide Act (FIFRA) should invalidate thousands of lawsuits that claim the company has a duty to warn about health risks from the product. Advertisement Bayer acquired Monsanto in 2018, and the company has been inundated with what it says were 'unfounded' legal challenges across the country from customers alleging the weedkiller was responsible for their cancers.
