Latest news with #qualityOfLife


Independent Singapore
08-07-2025
- Lifestyle
- Independent Singapore
Is condo living in Singapore about lifestyle—or just looking rich?
SINGAPORE: Is living in a condo worth the steep premium compared to HDB flats? A candid, soul-searching query by a Reddit user to fellow Singaporeans. Presently residing in an HDB (Housing & Development Board) flat, the poster admitted to being at a crossroads. Just like many middle-class Singaporeans, he is thinking of a condo upgrade but wants to understand first whether it is truly an improvement in quality of life or just a costly status symbol. A mixed bag of reality and perspective Comments poured in, and they were as multifaceted and diverse as the Singapore skyline. 'It's peaceful… and my bike is safe.' One condo tenant shared how the best part isn't the glitzy amenities but gaining peace of mind. 'I leave my S$1,500 road bike outside my unit, unlocked,' the commenter said, adding that his neighbour does the same with a S$5,000 bike. Another cited how parcel theft, a common occurrence in many HDB estates, is practically non-existent in their condo. Soundproof sanctuaries For others, true value lies in the quiet being afforded. One longtime Singaporean who's resided in both HDBs and older condos emphasised how the soundproofing in old-school condos built 15+ years ago was a game-changer. 'When the windows are closed, it's completely quiet. No Zumba music, no funeral drums, no stomping above your head,' the commenter said. For those working from home or longing for tranquillity, this kind of audio insulation can't be taken too lightly. Gyms and pools — nice perks, not essential So, what about those swanky amenities — the gym, the pool, the BBQ pit that usually gets featured in property advertisements? Opinions were mixed. 'I work out five times a week — I use the gym and pool extensively,' said one user, undoubtedly taking advantage of the pluses. Still, others confessed that the facilities usually only look great on flyers rather than at the actual site. 'Condo gyms are small. Great for bicep curls, not so much for barbell squats. If you're serious about fitness, you'll still need a commercial gym,' one said. See also Keeping up with Kaftans In other words, they're 'nice to have' but not essential and definitely not life-changing. Dollars and sense: Can you really afford it? One realistic Redditor took the discussion back to hard numbers: 'Whether it's 'worth it' or not, only your salary can answer. If your total debt — mortgage, car, loans — is more than 33% of your base salary, it's probably not worth the stress.' That insight ploughed through the lifestyle chatter with an unemotional financial sense. Yes, condo dreams are fine, but not at the cost of financial worry. Status pressure? It's real Finally, the 800-pound gorilla: Are condos about showing off? Some admitted that the societal burden to advance is real and enticing. Others dismissed it as a matter of individual perception, comparing it to picking between an iPhone and an inexpensive Android. 'Both do the same thing. One just costs more,' said one user. So, is it worth it? It depends. See also Jung Ho Yeon to star in Hollywood film If you value tranquillity, discretion, and safety, and you can easily afford it, a condo would be a sincere lifestyle advancement, but if you're racing for status, underusing the conveniences, and extending your cash thin just to 'keep up,' the condo reverie might come with more trauma than pleasure and fulfilment. One wise commenter nailed it: 'It's really personal preference. If you think it's worth it, then it's worth it.' In a city as active and diverse as Singapore, maybe that's the only answer that matters.
Yahoo
06-07-2025
- Health
- Yahoo
People Are Sharing The Habits That Completely Destroyed Their Quality Of Life, And It's A Cautionary Tale
We all make mistakes, but sometimes we pick up a bad habit that is so significant that it digs us deeper into a life hole. On the popular subreddit r/AskReddit, Reddit user u/Unlikely_Bid8892 asked: What's something you did that reduced your quality of life so much that you wish you had never done it? The results were brutally honest and will make you rethink your life choices: 1."Taking on student loans." —u/Beautiful-Signal7249 2."Worked 12-hour days for a job that wasn't worth it." —u/sylphdreamer 3."Neglect my body for years. Almost no movement. Rather poor hygiene. Horrible food. And little to no sleep." —u/Sad_Fee_4104 4."Succumbed to my food After two years of extreme dieting and exercise, I lost a significant amount of weight and achieved the best shape of my life, feeling very good about myself. Once I got down to an ideal weight, I didn't know what to do with myself anymore. I didn't know how to maintain it. I started eating horribly again and am now, just over a year later, at the heaviest point in my entire life. I binge eat to the extreme, and I'm pretty powerless to stop it. It affects pretty much every aspect of my life to some degree, and it's a very depressing feeling." —u/NocturnaPhelps 5."Bulimia for 15 years since I was a teen. All because my mom signed me up for Weight Watchers as a kid, since I was a little chubby. Never felt thin enough. Ruined my teeth and digestive health. 10/10 do not recommend." —u/ghostbustrnutclustr 6."Trying to impress people who don't GAF about you." —u/Brave_Calendar_941 7."Decided to give working in a warehouse a shot. Quality of life went from 90% to below 50%." —u/F3Grunge 8."Isolated myself for years. I'm not sure it could really have been otherwise with the issues I had, but it annihilated my social circle." —u/NuclearSoil 9."Living with a boyfriend who rages." —u/Equivalent_Hair_149 10."Vaped. Been nine months without it, and still cough and get winded easily. Used to sing as well and I can't hit notes for shit these days." —u/Ok-East-8412 11."I was jumping on our kids' trampoline and I hurt my back, and I've suffered sciatica pain all these years since. My life would be so much better if I had not thought jumping on a trampoline would be good exercise." —u/AvailableBreeze_3750 12."Spent years to impress the girl I like, I should have given that attention to my own self instead, improving my life." —u/OkAccess6128 13."Holding out for a management position instead of moving on. He won't retire. The man is mid-70s." —u/Funkyp0tat0chip 14."Trying to please people." —u/OrchidCrushxoxo_ 15."Not wearing earplugs at concerts." —u/organicbooger 16."Moved to a new province (state) thinking I needed a fresh start, but in reality I was just running from my problems!" —u/Smooth_Raspberry_007 17."Running too much in bad shoes. Now I have arthritis in my foot and I can't run anymore." —u/justablueballoon 18."GET INTO DEBT!!!" —u/ImpactSmooth299 19."Overeating." —u/Different_Cat7932 20."Caring for others who do not give a damn about me in return. Wasted far too many sleepless nights on people who wouldn't give a flying monkey if I was in a situation like theirs." —u/Party_Phrase2445 21."The wrong partner will wreck your life. I've been there, done that." —u/Top-Car-808 22."I went rock climbing one day without a helmet on. The first time I didn't have it on was on the day it was needed. A Severe TBI is an injury I wish upon no man, woman, or child." —u/Impressive-Dog-408 23."Smoked." —u/Verlin_Wayne 24."Going to prison at 19 for selling weed. In the end, it worked out. I've since graduated from college and have a nice engineering job and a great life. It was a rough patch in my life for sure. Freezing, stuck in a prison cell in Joliet for 77 days, I went weeks without showers or seeing sunlight. Then, I was shipped off to boot camp for 4.5 months to be further denigrated. In the end, it caused me to grow up and prioritize what I want in life. Worked and paid my way through a 2-year community college, followed by a MIS degree at a 4-year University. Life hasn't been perfect, but I always have perspective on a 'bad day' in that I've had it much worse." —u/leprechanmonkie 25."Putting effort into people who didn't do the same for me. Then getting anxiety over it." —u/MeltyFrog 26."Stayed in my college major even after I knew it wasn't for me. I wasted a lot of time that I can never get back." —u/SororitySue 27."Skipped the mammograms cause I had an 'it'll never happen to me' attitude when I was younger. Now I'm lying on a bed at a breast center waiting to get five biopsies for suspicious spots." —u/Snowfall1201 28."Being understanding when someone treats/talks/screams at you like shit. Don't stand for it." —u/Hangytangy 29."Ever touching nicotine." —u/titsmuhgeee 30."Drinking wine every night." —u/OpheliaJuliette 31."I left Walmart after 15 years to be a store manager at Starbucks —worst mistake of my life. I remember nights when I was there, ten after a closer called off, to have an opener call out, and knowing I'd have to wake up in four hours and work another shift, hoping the same thing wouldn't happen again. It was just awful, and the stories I'd hear from interviewing people made me realize how bad fast food was. People from other companies wanted to work at Starbucks cause those places were even worse." —u/bendystrawboy 32."Social media. It has seriously messed with my attention span. And I can't even remember how to enjoy free time without checking it every five minutes." —u/NeonPinkBag 33."Married young, at 18, now 61 divorced, wish I had planned my life better for my future first before I got married, I just didn't want to be alone." —u/Ok-Dependent4293 finally, "Dwelling on the past." —u/Ball2daW-all The National Eating Disorders Association helpline is 1-800-931-2237; for 24/7 crisis support, text 'NEDA' to 741741. The National Alliance on Mental Illness helpline is 1-800-950-6264 (NAMI) and provides information and referral services; is an association of mental health professionals from more than 25 countries who support efforts to reduce harm in therapy. Is there a bad habit that you feel has derailed your entire life? Comment below on what you are doing to change it!


Medscape
01-07-2025
- Health
- Medscape
Fast Five Quiz: The Psychosocial Burden of Psoriasis
The relationship between psoriasis and psychosocial symptoms tends to be a cyclical one. Psychological stressors can exacerbate the disease through overactivation of the hypothalamic-pituitary-adrenal axis and increased release of pro-inflammatory cytokines. Conversely, the cutaneous inflammatory response can cause body disfigurement, stigmatization, and ultimately anxiety and depression. What do you know about the psychosocial burden of psoriasis? Test your knowledge with this quick quiz. As patients with psoriasis experience a relapsing course, over time they often face a lower quality of life owing to their symptoms, social stigmas, and impacted self-esteem. For example, a review that evaluated the psychological comorbidities associated with this condition reported that patients with psoriasis who have visible psoriatic lesions face a significant negative impact on their quality of life. Further, Dermatology Life Quality Index (DLQI) and Health-Related Quality of Life (HRQOL) scores can be influenced by both lesion location and severity; increased Psoriasis Area and Severity Index scores have been linked to higher DLQI scores as well, which indicates that "as disease severity worsens, so does the overall impact on quality of life." Patients can experience any form of psychological and social distress as a result, not just anxiety. Although depression in psoriasis is common, the psychosocial impact of the disease has not been mainly linked with fear of developing psoriatic arthritis. Learn more about the prognosis of psoriasis. In patients with psoriasis, female sex has been identified as a risk factor for depression in this population. A systematic review exploring the burden of depression in psoriasis reported a higher overall prevalence of depression in females over males. This is consistent with other recent data; however, male patients with psoriasis still seem to have an increased prevalence of depression compared with males without psoriasis. Ultimately, current data point to the fact that the prevalence of depression is higher among all patients with psoriasis, but female patients with skin disease appear to be at greater risk than their male counterparts. Younger age is more frequently associated with depression, though older individuals with psoriasis can still be affected. Learn more about the prognosis of psoriasis. Pruritus is one of the main symptoms of plaque psoriasis. Although it varies in intensity, this symptom should not be disregarded owing to its significant impact on mental health. Anxiety and depression are linked to plaque psoriasis; these psychological comorbidities can increase the frequency and severity of pruritus, which results in an increased tendency to scratch; conversely, the increased pruritus and scratching also worsens anxiety and depression. It is estimated that 40% of patients with plaque psoriasis experience nail involvement. Further, nail involvement has been linked to "significant psychological distress, including anxiety and depression." Though any severity of skin pain can be linked to psychosocial burden in patients with chronic dermatological disorders such as plaque psoriasis, data have shown that patient-reported skin pain is usually of "moderate intensity" when HRQOL is negatively affected. Learn more about the signs and symptoms of plaque psoriasis. Psychosocial interventions have been shown to improve DLQI scores in patients with psoriasis. Specifically, the addition of mindfulness therapy to treatment as usual for psoriasis has been found to improve DLQI the most compared with other studied interventions (treatment as usual alone, psoriasis and lifestyle education, and online-based management). Cognitive-behavioral therapy in conjunction with pharmacological therapy has also been shown to improve psychosocial and disease-related symptoms. This result is most likely owing to stress as an identified trigger for psoriasis flares and decreased DLQI scores, with mindfulness therapy aiming to reduce stress and therefore flares. This is consistent with another recent review finding improvement in both disease severity and DLQI scores with various forms of mindfulness intervention. However, cognitive-behavioral therapy and treatment as usual were most effective for the other outcome measures, including anxiety, depression, and treatment adherence; mindfulness therapy was the least effective intervention for adherence. Education regarding psoriasis and lifestyle management that can help with symptoms was shown to improve HRQOL. Learn more about the treatment of psoriasis. Biologic therapy has been shown to effectively treat depression symptoms in the setting of psoriasis. Other therapeutic approaches that are effective for depression symptoms in psoriasis were conventional systemic therapy and phototherapy. Taken together, evidence supports the theory that improved skin disease is associated with improved psychiatric disease. Patients with psoriasis have a higher prevalence of hypertension. Beta-blockers in this setting can worsen psoriasis, which can negatively affect depression symptoms. Overall, evidence of a link between depression symptoms and beta-blocker use is mixed. Some psychotropic medications can cause flares in skin disease, including lithium, fluoxetine, and bupropion; these agents should therefore be prescribed with caution in this population. Similarly, the link between depression symptoms and psychotropic medication use is inconsistent. Though certain phosphodiesterase 4 inhibitors can improve psoriasis symptoms and can improve quality of life, data indicate that they can worsen depression symptoms. Learn more about the treatment of psoriasis. Editor's Note: This article was created using several editorial tools, including generative AI models, as part of the process. Human review and editing of this content were performed prior to publication.


Telegraph
30-06-2025
- Health
- Telegraph
Four best exercises to strengthen your knees
Knee pain becomes increasingly common as we age, with osteoarthritis (OA) being one of the primary culprits. The statistics are striking: knee OA affects approximately 16 per cent of the global population aged 15 and over, increasing to nearly 23 per cent in those over 40. In the United States alone, an estimated 32.5 million adults are affected by knee osteoarthritis. The good news? Strengthening exercises can significantly improve knee health and manage arthritis symptoms. Research shows that exercise is the most effective non-drug treatment for reducing pain and improving movement in patients with osteoarthritis. Regular physical activity not only helps decrease joint pain but also enhances function and quality of life. Why is it important to do knee-strengthening exercises? Strengthening the muscles around your knee, using controlled movements that build strength without compromising joint health, is crucial for maintaining stability and reducing the load on your knees during daily activities. Strong muscles act as shock absorbers, protecting your joints from excessive stress and can potentially slow the progression of arthritis and other painful conditions. How often should I do these exercises? For optimal results, incorporate exercises that strengthen the knees by working the surrounding musculature at least twice a week. Each exercise should be performed in sets of 6-15 repetitions, with 2-3 sets per exercise. This frequency allows for adequate muscle strengthening while providing sufficient recovery time. Best knee strengthening exercises 1. Bulgarian split squat This exercise strengthens the quadriceps, hamstrings and glutes, providing stability and support to the knee joint How to do it Stand a few feet in front of a bench or step, with one foot resting on the bench behind you. Keep your torso upright and lower your body by bending your front knee to about 90 degrees. Push through your front heel to return to the starting position. Keep your knee aligned with your toes and avoid letting it collapse inward. 2. Barbell lateral lunge This exercise strengths the muscles around the knee joint, as well as the inner and outer thighs. How to do it With a wide stance and toes turned out, rest a barbell on your shoulders. Shift to one leg, bending the knee to around 90 degrees. Push through your heel to return to the starting position and repeat, then switch to the other knee. 3. Weighted single-leg deadlift This exercise strengthens the hamstrings, glutes and stabilising muscles around the knee, improving balance and reducing the risk of injury. How to do it Hold a dumbbell in one hand and stand on the opposite leg. Hinge at the hips, lowering the dumbbell toward the floor while extending your free leg behind you. Keep your back flat and core engaged then return to the starting position by driving through your standing leg. 4. Banded clamshells Clamshells help strengthen the hip abductor muscles, improving hip stability and, in turn, preventing knee pain. How to do it Lie on your side with a resistance band placed just above the knees and your head resting on your lower arm. Bend your legs at 90 degrees with your legs stacked on top of each other evenly. Lift the top knee up, pushing against the resistance band, then lower back down. Repeat on the other side. How to stretch after exercise Proper stretching is crucial for maintaining flexibility and preventing injury. Hold each stretch for up to 30 seconds and repeat 2-3 times: 1. Couch stretch The couch stretch targets the hip flexors and quadriceps, which are essential for knee stability and reducing strain on the joint. Stretching these muscles improves flexibility and helps alleviate tension that can pull on the knees. How to do it Kneel on the floor with one knee close to a wall or couch, placing the shin of the back leg against the wall or couch. Step the opposite foot forward into a lunge position. Keep your torso upright and gently push your hips forward to feel a stretch in the front of the back leg. 2. Pigeon stretch The pigeon stretch opens the hips and stretches the glutes and piriformis deep within the buttocks, which can help reduce tension in the knees caused by tightness in these areas. How to do it Start in a plank position and bring one knee forward, placing it behind your hands with the shin angled across your body. Extend the opposite leg straight back, keeping your hips square to the floor. Lower your torso toward the ground for a deeper stretch. 3. Adductor mobiliser This stretch targets the inner thigh muscles (adductors), which play a key role in stabilising the knees during movement. Stretching these muscles can improve flexibility and reduce strain on the knee joint. How to do it Position yourself on all fours and take one foot out to your side. Keeping the long leg straight, start to sit back into the stretch. When you feel a good stretch in your inner thigh, pause and hold. FAQs How should I look after my knee if I have an injury? If you have a knee injury, follow these guidelines: Apply the RICE principle (Rest, Ice, Compression, Elevation) Avoid high-impact activities Consult a healthcare professional before starting exercises Use NSAIDs (non-steroidal anti-inflammatory drugs) or paracetamol for pain management as recommended Modify activities to avoid aggravating the injury Consider physical therapy for proper guidance and rehabilitation Does strengthening knees help with knee pain? Yes, research consistently shows that strengthening exercises can significantly reduce knee pain and improve function. Strong muscles around the knee provide better joint support, reducing stress on the joint structures. Just remember to start slow and progress gradually with any exercise programme. The key to successful knee strengthening is consistency and proper form, rather than intensity or speed of progression.
Yahoo
27-06-2025
- Health
- Yahoo
Neurocrine Biosciences Presents New Data Showing Significant Patient-Reported Improvements in Health-Related Quality of Life with INGREZZA® (valbenazine) Capsules in Older Adults with Tardive Dyskinesia
Data Add to Growing Body of Evidence Demonstrating Functional and Quality of Life Improvements in Patients Treated with INGREZZA for Tardive Dyskinesia Findings Presented at the 2025 American Association of Nurse Practitioners (AANP) National Conference SAN DIEGO, June 20, 2025 /PRNewswire/ -- Neurocrine Biosciences, Inc. (Nasdaq: NBIX) today announced the presentation of new analyses from a Phase 4 randomized withdrawal study demonstrating significant patient-reported improvements in health-related quality of life and functional measures among adults aged 65 years and older with tardive dyskinesia who received continued treatment with INGREZZA® (valbenazine) capsules. Findings will be presented at the 2025 American Association of Nurse Practitioners National Conference in San Diego. These post-hoc analyses of older adults expand on recently announced Phase 4 study results, which demonstrated that continued treatment with INGREZZA improved functional status and quality of life measures across the general patient population. "Older adults are not only at increased risk for developing tardive dyskinesia, but are also more susceptible to the profound physical, functional and social consequences of their uncontrolled movements," said Sanjay Keswani, M.D., Chief Medical Officer, Neurocrine Biosciences. "These new post-hoc analyses demonstrate that INGREZZA can provide significant and persistent improvements in quality of life for older adults with tardive dyskinesia and are consistent with the unique and substantial body of evidence that INGREZZA treatment can provide robust improvement in outcomes beyond tardive dyskinesia severity." The analyses were conducted in a subset of 29 adult patients (≥65 years) who participated in a Phase 4, double-blind, placebo-controlled, randomized withdrawal study (NCT03891862). During an initial eight-week, open-label period, all patients received up to 80 mg of INGREZZA daily. At Week 8 (randomization baseline), patients were randomized to either continue INGREZZA (n=13) or switch to placebo (n=16) for an additional eight weeks. Analyses were conducted for patients who had available data during the double-blind period from Week 8 to Week 16. Patients who received continued treatment with INGREZZA reported significant improvements in health-related quality of life and functional status, compared with those randomized to placebo. Two clinically validated scales were used to assess patient-reported outcomes, providing a comprehensive and scientifically robust measure of health status: The EuroQol 5-Dimension 5-Level (EQ-5D-5L) assessment tool, which measures health-related quality of life across five dimensions of health status (mobility, self-care, usual activities, pain/discomfort and anxiety/depression). The Sheehan Disability Scale (SDS), which measures patient-reported functional impairment in work/school, social life and family/home life impairment. These analyses contribute to the growing body of evidence for INGREZZA use in older adults (>65 years). A recently published post-hoc analysis from two 48-week studies, the KINECT® 3 extension and KINECT® 4, demonstrated the long-term safety profile and robust efficacy of INGREZZA in adults aged 65 years and older with tardive dyskinesia (TD). In addition, the analyses further reinforce findings from the KINECT-PRO™ study of INGREZZA – a first-of-its-kind study that demonstrated clinically meaningful improvement in patient-reported impact of TD with a vesicular monoamine transporter 2 inhibitor and used multiple clinically validated, patient-reported scales. Additional presentations at the 2025 AANP National Conference include: Real-World Insights on Tardive Dyskinesia: A Claims-Based Analysis of Demographics and Healthcare Resource Utilization (Poster #24) Clinically Meaningful Long-Term Improvements with Valbenazine 40 mg in Adults with Tardive Dyskinesia (Poster #25) About Tardive Dyskinesia Tardive dyskinesia (TD) is a movement disorder that is characterized by uncontrolled, abnormal and repetitive movements of the face, torso and/or other body parts, which may be disruptive and negatively impact patients. The condition is associated with taking certain kinds of mental health medicines (antipsychotics) that help control dopamine receptors in the brain. Taking antipsychotics commonly prescribed to treat mental illnesses such as major depressive disorder, bipolar disorder, schizophrenia and schizoaffective disorder and other prescription medicines (metoclopramide and prochlorperazine) used to treat gastrointestinal disorders are associated with TD. In patients with TD, these treatments are thought to result in irregular dopamine signaling in a region of the brain that controls movement. The symptoms of TD can be mild to severe and are often persistent and irreversible. TD is estimated to affect at least 800,000 adults in the U.S. About the KINECT-PRO™ Phase 4 StudyThe KINECT-PRO™ Phase 4, open-label study was designed to evaluate patient-reported outcomes on the use of INGREZZA® (valbenazine) capsules in a tardive dyskinesia (TD) patient population reflective of real-world clinical practice. Participants had at least mild TD, were aware of and experiencing at least mild distress from their abnormal, involuntary movements and had a clinical diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder or major depression. The KINECT-PRO study included a four-week screening period, a 24-week treatment period during which participants received 40 mg of INGREZZA once-daily for the first four weeks, followed by flexible dosing of 40 mg, 60 mg or 80 mg once-daily based on individual treatment needs and a two-week safety follow-up period. Baseline socio-demographic and clinical characteristics of the participants were broadly similar to those of the KINECT® 3 and KINECT® 4 studies. KINECT-PRO is the first and only study to specifically evaluate and demonstrate patient-reported improvement with vesicular monoamine transporter 2 inhibitor treatment on TD using multiple clinically validated scales, including the Tardive Dyskinesia Impact Scale (TDIS™). The TDIS is the only patient-reported outcome instrument designed for and validated in tardive dyskinesia patients that measures the physical, social and emotional impact of the involuntary movements of the condition. About the Tardive Dyskinesia Impact ScaleThe Tardive Dyskinesia Impact Scale (TDIS) is a novel, psychometrically validated patient-reported outcome measure in TD. It was developed by Neurocrine Biosciences from qualitative studies and Phase 3 trials of INGREZZA for the treatment of TD (KINECT 3 and KINECT 4) as a comprehensive measure of impact and burden of TD from a patient's perspective. The TDIS consists of 11 questions evaluating physical and socio-emotional impact. Six domains are assessed: mouth/throat, dexterity, mobility, pain, social and emotional. The TDIS allows people with TD to rate how their symptoms affect daily activities and how their uncontrollable movements make them feel. The questionnaire captures relevant information about the impact of TD to provide a more holistic assessment of the condition. Validation of this scale was published in the Journal of Patient-Reported Outcomes. About INGREZZA® (valbenazine) Capsules and INGREZZA® SPRINKLE (valbenazine) Capsules INGREZZA is a selective vesicular monoamine transporter 2 (VMAT2) inhibitor approved by the U.S. Food and Drug Administration for the treatment of adults with tardive dyskinesia and the treatment of chorea associated with Huntington's disease (HD). Only INGREZZA offers a therapeutic dose from day one with no required titration. INGREZZA, developed by Neurocrine Biosciences, selectively inhibits VMAT2 with no appreciable binding affinity for VMAT1, dopaminergic (including D2), serotonergic, adrenergic, histaminergic or muscarinic receptors. While the specific way INGREZZA works to treat TD and HD chorea is not fully understood, INGREZZA is unique in that it selectively and specifically targets VMAT2 to inhibit the release of dopamine, a chemical in the brain that helps control movement. INGREZZA is believed to reduce extra dopamine signaling, which may lead to fewer uncontrollable movements. INGREZZA is studied across the widest range of patients. It is always one capsule, once daily and can be taken together with most stable mental health regimens such as antipsychotics or antidepressants. Only INGREZZA offers the benefit of a sprinkle formulation, INGREZZA SPRINKLE, for those who experience dysphagia, have difficulty swallowing or prefer not to swallow a pill. INGREZZA and INGREZZA SPRINKLE dosages approved for use are 40 mg, 60 mg and 80 mg capsules. Important Information Approved Uses INGREZZA® (valbenazine) capsules or INGREZZA® SPRINKLE (valbenazine) capsules are prescription medicines used to treat adults with: movements in the face, tongue, or other body parts that cannot be controlled (tardive dyskinesia). involuntary movements (chorea) of Huntington's disease. INGREZZA or INGREZZA SPRINKLE do not cure the cause of involuntary movements, and do not treat other symptoms of Huntington's disease, such as problems with thinking or emotions. It is not known if INGREZZA or INGREZZA SPRINKLE is safe and effective in children. IMPORTANT SAFETY INFORMATION INGREZZA or INGREZZA SPRINKLE can cause serious side effects in people with Huntington's disease, including: depression, suicidal thoughts, or suicidal actions. Tell your healthcare provider before you start taking INGREZZA or INGREZZA SPRINKLE if you have Huntington's disease and are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts. Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings. This is especially important when INGREZZA or INGREZZA SPRINKLE is started and when the dose is changed. Call your healthcare provider right away if you become depressed, have unusual changes in mood or behavior, or have thoughts of hurting yourself. Do not take INGREZZA or INGREZZA SPRINKLE if you: are allergic to valbenazine, or any of the ingredients in INGREZZA or INGREZZA SPRINKLE. INGREZZA or INGREZZA SPRINKLE can cause serious side effects, including: Allergic reactions. Allergic reactions, including an allergic reaction that causes sudden swelling called angioedema can happen after taking the first dose or after many doses of INGREZZA or INGREZZA SPRINKLE. Signs and symptoms of allergic reactions and angioedema, include: trouble breathing or shortness of breath, swelling of your face, lips, eyelids, tongue, or throat, or other areas of your skin, trouble with swallowing, or rash, including raised, itchy red areas on your skin (hives). Swelling in the throat can be life-threatening and can lead to death. Stop taking INGREZZA or INGREZZA SPRINKLE and go to the nearest emergency room right away if you develop these signs and symptoms of allergic reactions and angioedema. Sleepiness and tiredness that could cause slow reaction times (somnolence and sedation). Do not drive a car or operate dangerous machinery until you know how INGREZZA or INGREZZA SPRINKLE affects you. Drinking alcohol and taking other medicines may also cause sleepiness during treatment with INGREZZA or INGREZZA SPRINKLE. Heart rhythm problems (QT prolongation). INGREZZA or INGREZZA SPRINKLE may cause a heart rhythm problem known as QT prolongation. You have a higher chance of getting QT prolongation if you also take certain other medicines during treatment with INGREZZA or INGREZZA SPRINKLE. Tell your healthcare provider right away if you develop any signs or symptoms of QT prolongation, including: fast, slow, or irregular heartbeat (heart palpitations), shortness of breath, dizziness or lightheadedness, or fainting or feeling like you are going to faint. Neuroleptic Malignant Syndrome (NMS). NMS is a serious condition that can lead to death. Call a healthcare provider right away or go to the nearest emergency room if you develop these symptoms and they do not have another obvious cause: high fever, stiff muscles, problems thinking, irregular pulse or blood pressure, increased sweating, or very fast or uneven heartbeat. Parkinson-like symptoms. Symptoms include: body stiffness, drooling, trouble moving or walking, trouble keeping your balance, shaking (tremors), or falls. Before taking INGREZZA or INGREZZA SPRINKLE, tell your healthcare provider about all of your medical conditions including if you: have liver or heart problems, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Make sure you tell all of your healthcare providers that you are taking INGREZZA or INGREZZA SPRINKLE. Taking INGREZZA or INGREZZA SPRINKLE with certain other medicines may cause serious side effects. Especially tell your healthcare provider if you: take digoxin or take or have taken a monoamine oxidase inhibitor (MAOI) medicine. You should not take INGREZZA or INGREZZA SPRINKLE if you are taking, or have stopped taking, a MAOI within the last 14 days. The most common side effects of INGREZZA or INGREZZA SPRINKLE in people with tardive dyskinesia are sleepiness and tiredness. The most common side effects of INGREZZA or INGREZZA SPRINKLE in people with chorea associated with Huntington's disease include sleepiness and tiredness, raised itchy red areas on your skin (hives), rash, and trouble getting to sleep or staying asleep. These are not all of the possible side effects of INGREZZA or INGREZZA SPRINKLE. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at or call 1-800-FDA-1088. Dosage Forms and Strengths: INGREZZA and INGREZZA SPRINKLE are available in 40 mg, 60 mg, and 80 mg capsules. Please see full Prescribing Information, including Boxed Warning, and Medication Guide. About Neurocrine Biosciences, Inc. Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, classic congenital adrenal hyperplasia, endometriosis* and uterine fibroids,* as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas. For three decades, we have applied our unique insight into neuroscience and the interconnections between brain and body systems to treat complex conditions. We relentlessly pursue medicines to ease the burden of debilitating diseases and disorders because you deserve brave science. For more information, visit and follow the company on LinkedIn, X and Facebook. (*in collaboration with AbbVie) The NEUROCRINE BIOSCIENCES Logo, NEUROCRINE, YOU DESERVE BRAVE SCIENCE, INGREZZA and KINECT are registered trademarks of Neurocrine Biosciences, Inc. KINECT-PRO and TDIS are trademarks of Neurocrine Biosciences, Inc. Forward-Looking Statements In addition to historical facts, this press release contains forward-looking statements that involve a number of risks and uncertainties. These statements include, but are not limited to, statements regarding the potential benefits to be derived from INGREZZA and the value INGREZZA may bring to patients. Factors that could cause actual results to differ materially from those stated or implied in the forward-looking statements include, but are not limited to, the following: risks and uncertainties associated with Neurocrine Biosciences' business and finances in general, as well as risks and uncertainties associated with the commercialization of INGREZZA; whether INGREZZA receives adequate reimbursement from third-party payors; risks and uncertainties relating to competitive products and technological changes that may limit demand for INGREZZA; risks associated with the Company's dependence on third parties for development and manufacturing activities related to INGREZZA, and the ability of the Company to manage these third parties; risks that additional regulatory submissions for INGREZZA or other product candidates may not occur or be submitted in a timely manner; risks that the FDA or other regulatory authorities may make adverse decisions regarding INGREZZA; risks that post-approval INGREZZA commitments or requirements may be delayed; risks that INGREZZA may be precluded from commercialization by the proprietary or regulatory rights of third parties, or have unintended side effects, adverse reactions or incidents of misuse; and other risks described in the Company's periodic reports filed with the Securities and Exchange Commission, including without limitation the Company's quarterly report on Form 10-Q for the quarter ended March 31, 2025. Neurocrine Biosciences disclaims any obligation to update the statements contained in this press release after the date hereof other than required by law. © 2025 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-VBZ-US-0069 06/2025 View original content to download multimedia: SOURCE Neurocrine Biosciences, Inc. Error in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data