Latest news with #thyroidcancer
Medscape
2 days ago
- Health
- Medscape
Safe to Skip Postop Radioiodine in Low-Risk Thyroid Cancers?
TOPLINE: A recent phase 3 trial found that 5-year recurrence-free survival was similar among patients who did and did not receive postoperative radioiodine, indicating the treatment can be safely avoided in patients with low-risk differentiated thyroid cancer — specifically those with pT1, pT2, and N0 or Nx tumors who have no adverse features after total thyroidectomy. METHODOLOGY: Although now used less often, total thyroidectomy followed by radioiodine has traditionally been the standard of care for treating differentiated thyroid cancer. Observational studies and the ESTIMABL2 trial , published in 2022, suggested that patients with low-risk disease could safely skip radioiodine, but confirmatory evidence was still needed. The recent randomized, noninferiority, phase 3 IoN trial aimed to answer this question. The study involved patients at 33 cancer centers in the UK who underwent complete resection following total thyroidectomy and stage pT1, pT2, pT3, or pT3a disease. Researchers randomly assigned 504 patients (77% women) to receive (n = 253) or not receive (n = 251) postoperative radioiodine. Patients underwent neck ultrasound scans annually and serum thyroglobulin measurements every 6 months. The median follow-up was 6.7 years. The primary outcome was 5-year disease-free survival, defined as the absence of locoregional recurrent or residual structural disease, distant metastases, or death from thyroid cancer. Noninferiority was assessed with a margin of 5 percentage points. Overall, 47% of patients had pT1 tumors, 44% had pT2, and 9% had pT3 or pT3a; 91% of patients had N0 or Nx disease, and 9% had N1a disease. TAKEAWAY: Overall, 17 recurrences were reported — 8 in the no-radioiodine group and 9 in the radioiodine group. The 5-year recurrence-free rate was 97.9% in the no-radioiodine group vs 96.3% in the radioiodine group, with an absolute risk difference of 0.5 percentage points (P for noninferiority = .033), highlighting the noninferiority of omitting radioiodine. Higher recurrence rates were observed in patients with pT3 or pT3a tumors than in those with pT1 or pT2 tumors (9% vs 3%) and in patients with N1a tumors than in those with N0 or Nx tumors (13% vs 2%). Additionally, baseline postsurgical thyroglobulin levels ≥ 2 ng/mL were associated with a higher risk for recurrence (hazard ratio, 12.75; P < .0001). Adverse events were comparable between the no-radioiodine and radioiodine groups, with fatigue (25% vs 28%), lethargy (14% in both), and dry mouth (10% vs 9%) being the most common. No treatment-related deaths or deaths from thyroid cancer were reported. But a total of eight patients died — an equal number in both groups. In the no-radioiodine group, deaths were due to two new primary cancers, one myocardial infarction, and one liver failure. In the radioiodine group, one death was due to bowel cancer and three due to vascular or unknown causes. IN PRACTICE: IoN and ESTIMABL2 together 'offer strong and complementary evidence showing' that postoperative radioiodine can be avoided in patients with low-risk differentiated thyroid cancer — more specifically, pT1 or pT2 tumors with N0 nodal status and no other adverse features, the study authors concluded. Although the evidence for or against radioiodine in patients with pT3, pT3a, or N1a tumors was deemed 'insufficient,' the authors concluded that 'most patients worldwide with low-risk differentiated thyroid cancer' can now safely avoid radioiodine. SOURCE: This study, led by Ujjal Mallick, Freeman Hospital, Newcastle upon Tyne, England, was published online in The Lancet. LIMITATIONS: Patients had relatively few recurrences, and the findings may not be applicable to the youngest patients. Additionally, molecular data (eg, on BRAF and TERT mutations) were not routinely collected from patients. DISCLOSURES: This study was funded by Cancer Research UK. One author reported receiving honoraria from Esai and the British Medical Ultrasound Society for presenting treatment options for differentiated thyroid cancer. Another author reported receiving honoraria from Esai for presenting treatment options for differentiated thyroid cancer. All other authors declared having no competing interests. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Daily Mail
2 days ago
- Business
- Daily Mail
Beloved ABC star tragically dies after battle with cancer
Veteran reporter Peter Ryan has died aged 64 after a long battle with thyroid cancer. The Walkley Award-winning journalist, who worked as a reporter for 45 years with the ABC, was diagnosed with metastatic thyroid cancer in 2014. His family has confirmed he passed away in Sydney on Friday night. Peter began his career as a cadet at the Sydney Daily Mirror before landing a job at the ABC. He worked as the head of TV news and current affairs in Victoria, before becoming the ABC's Washington bureau chief and the founding editor of Lateline Business, which later became The Business. From A-list scandals and red carpet mishaps to exclusive pictures and viral moments, subscribe to the DailyMail's new showbiz newsletter to stay in the loop. In 2017, Peter won the Walkley Award for his coverage of the Commonwealth Bank scandal, which exposed deposit machines being used by drug syndicates to launder millions of dollars. His coverage contributed to the calling of the banking Royal Commission. In 2018, he was the National Press Club Finance Journalist of the Year. He was also awarded the Order of Australia Medal in 2022 for his service to journalism. Peter was a senior business correspondent from 2016 until he retired in June. Peter moved into palliative care and wanted to spend more time with his wife Mary Cotter and daughter Charlotte. Following his retirement, Treasurer Jim Chalmers said: 'Peter Ryan is an absolute legend. 'Every day as you wake up and you think about what's happening in the economy, if you only needed to listen to one voice to be sure that you got its essential elements, it would be Peter's.' The ABC has paid tribute to the veteran reporter in a statement following news of his passing. 'The ABC is deeply saddened by the death of our great friend and esteemed colleague Peter Ryan,' the statement read. 'After a distinguished 45-year career in journalism Peter retired from the ABC last month due to ill health. 'We extend our heartfelt condolences to Peter's family.' ABC News Director Justin Stevens also said Peter has left a 'significant legacy' and 'touched the lives of many'. 'Through his journalism, he had a profound impact on the lives of Australians and our society. It was a privilege to know him and work alongside him.'
ABC News
2 days ago
- General
- ABC News
Tributes flow for Walkley Award-winning journalist Peter Ryan
Former ABC journalist and Walkley winner Peter Ryan has died in Sydney at the age of 64. He was diagnosed with thyroid cancer in 2014 and retired from the ABC in June this year. Ryan began his career as a copyboy and retired as a senior business correspondent, having held a raft of key positions. ABC NewsRadio's Sarah Morice spoke with Peter Cave, former foreign Affairs Editor for the ABC and long-time colleague and friend of Peter Ryan.
Daily Mail
2 days ago
- Health
- Daily Mail
BREAKING NEWS Beloved ABC star tragically dies after battle with cancer
Veteran reporter Peter Ryan has died aged 64 after a battle with thyroid cancer. The Walkley Award-winning journalist, who worked as a reporter for 45 years with the ABC, was diagnosed with metastatic thyroid cancer in 2014. His family confirmed he passed away in Sydney on Friday night. Peter began his career as a cadet at the Sydney Daily Mirror before landing a job at the ABC. He worked as the head of TV news and current affairs in Victoria, before becoming the ABC's Washington bureau chief and the founding editor of Lateline Business, which later became The Business. From A-list scandals and red carpet mishaps to exclusive pictures and viral moments, subscribe to the DailyMail's new showbiz newsletter to stay in the loop. In 2017, Ryan won the Walkley Award for his coverage of the Commonwealth Bank scandal which exposed deposit machines being used by drug syndicates to launder millions of dollars. He was awarded the Order of Australia Medal in 2022 for his service to journalism.
News.com.au
2 days ago
- Business
- News.com.au
‘Absolute legend': Veteran ABC journalist Peter Ryan dies at 64 after battle with cancer
Veteran ABC and Walkley Award-winning journalist Peter Ryan has died after a battle with thyroid cancer. The journalist, who worked as a reporter for 45 years with the ABC, was diagnosed with metastatic thyroid cancer in 2014. He died in Sydney on Friday night, his family confirmed. He was 64. Over the course of has 45-year career in journalism, Ryan spanned multiple roles. He began as a cadet and copyboy at the Sydney Daily Mirror before moving to the ABC, where he worked as the head of TV news and current affairs in Victoria and was the ABC Washington bureau chief. He was also the founding editor of Lateline Business in 2006 that became The Business in 2012. Ryan won the Walkley Award in 2017 for his coverage of the Commonwealth Bank scandal that involved millions of dollars flowing through to drug syndicates from the bank's intelligent deposit machines. He was awarded the Order of Australia Medal in 2022 for his service to journalism. Working as senior business correspondent from 2016, Ryan retired from his role in June and moved into palliative care, opting to spend more time with his wife Marry Cotter and daughter Charlotte. Upon Ryan's retirement, Treasurer Jim Chalmers said the ABC journalist was an 'absolute legend'. 'Every day as you wake up and you think about what's happening in the economy, if you only needed to listen to one voice to be sure that you got its essential elements, it would be Peter's,' he said. Former ABC Breakfast host Michael Rowland paid tribute to Ryan on Sunday evening, describing him as an 'unrivalled' reporter who was 'courageous' in his journalism and a 'generous mentor'. 'He had a big impact on so many ABC careers,' Rowland penned online. 'We've all lost a good one.' ABC News senior director Justin Stevens said Ryan left behind a 'significant legacy'. 'Through his mentorship, friendship, and professionalism, he directly touched the lives of many at the ABC,' he said. 'Through his journalism, he had a profound impact on the lives of Australians and our society. 'It was a privilege to know him and work alongside him.' Before his retirement in 2025, the journalist offered a piece of advice to other budding reporters. 'Avoid cynicism – be passionate. A good team can often be a very small team – I've worked in some of the best,' he said. 'Be proactive – come to the table with a great story so no one else comes up with a dud that might waste your time. 'Work closely with top people – shut up and absorb like a sponge. 'Maintain a fastidious contact book – some low-profile contacts could soon move into higher powered roles or more importantly work in backrooms where the big decisions are often made. 'Show up to work early and prove that you're ready to take on the big story of the day. 'Try to have a Plan B in your back pocket just in case your original brilliant idea doesn't go anywhere and the EP comes walking your way. 'Finally, be kind and caring to people who need it.'
