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Time of India
3 days ago
- Health
- Time of India
Popular sugar alternative found safe and even effective at killing pancreatic cancer cells
Cancer prevention might just become a 'sweet' journey. That too, with the help of a natural sweetener! According to a recent study, published in the International Journal of Molecular Sciences , stevia might pave the way for effective prevention of pancreatic cancer. How? Read on to know more. The 'sweet' breakthrough: Stevia might soon be more than just a sweetener! Researchers have discovered that when stevia is fermented with a bacterium found in banana leaves, it can effectively target pancreatic cancer cells while leaving healthy kidney cells unharmed. While discussing the recent study result, study co-author Narandalai Danshiitsoodol from Hiroshima University, said, 'Globally, the incidence and mortality rates of pancreatic cancer continue to rise, with a five-year survival rate of less than 10%,' adding, 'Pancreatic cancer is highly invasive and prone to metastasis, showing significant resistance to existing treatments, such as surgery, radiotherapy, and chemotherapy. As such, there is an urgent need to identify new and effective anticancer compounds, particularly those derived from medicinal plants.' What did the study reveal? For the study, the research team used a specific bacterium, Lactobacillus plantarum SN13T, to ferment stevia leaves. They compared the fermented version (which they call FSLE) to regular stevia extract and found that FSLE performed better in every way they tested. As Masanori Sugiyama explained, 'To enhance the pharmacological efficacy of natural plant extracts, microbial biotransformation has emerged as an effective strategy.' by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like AirSense 11 – Smart tech for deep sleep ResMed Buy Now Undo They optimized the fermentation process and found that stevia was most effective when fermented for 72 hours, at 37°C, without oxygen. The results were impressive: fermented stevia effectively killed pancreatic cancer cells (PANC-1) while barely affecting healthy cells, even at higher doses. This selectivity is crucial for safe cancer treatments. Instead of an immediate kill, FSLE sometimes slowed down cancer cell growth, making them look weak and unhealthy. Fermented stevia also showed strong antioxidant properties, which is essential since oxidative stress is a big factor in cancer development. It neutralized free radicals more effectively than the non-fermented version, achieving a 94% scavenging power in one test. What's the takeaway? Researchers believe that fermentation transforms compounds into more active versions. For example, a compound called chlorogenic acid is converted into chlorogenic acid methyl ester (CAME) during fermentation. CAME was found to be more effective than regular chlorogenic acid in halting cancer cell growth and triggering cancer cell self-destruction. Its potency was significant: the dose needed to kill half the cancer cells was much lower for CAME compared to regular chlorogenic acid. CAME works by blocking the cell cycle and forcing cells into apoptosis, their self-destruct mode. On a genetic level, CAME influenced genes associated with cell death, activating pro-apoptotic genes while shutting down those that prevent cell death. This supports the observed effects, showing that CAME doesn't just kill cells randomly; it drives them into a specific self-destruction pathway. To sum up in simpler terms, this research suggests that fermented stevia could be a promising new avenue for effective cancer treatment, particularly for hard-to-treat pancreatic cancer. What is stevia? Stevia is a sweet sugar substitute that is about 50 to 300 times sweeter than sugar. It is extracted from the leaves of Stevia rebaudiana, a plant (shrub) native to tropical and subtropical America, and areas of Paraguay and Brazil. The active compounds in stevia are steviol glycosides, and the leaves may be used as a calorie-free substitute for sugar. Stevia is heat-stable, pH-stable, and not fermentable. More than just a sweetener: Stevia is not just a substitute for sugar anymore; it's stepping up its game! Thanks to fermentation, researchers have discovered that stevia extract can be transformed into a compound that fights cancer while leaving healthy cells unharmed. This exciting change is linked to specific enzymes from a bacterial strain called SN13T. As per Danshiitsoodol, 'This microbial transformation was likely due to specific enzymes in the bacteria strain used.' The findings show that this new compound, CAME, is more effective at harming cancer cells and promoting cell death in PANC-1 cells than chlorogenic acid alone. The way ahead: What's next for this research? The team has plans to take their work from the lab to the real world, with mouse studies coming up. This will test if fermented stevia can work within living systems, which have complex immune responses and metabolism. According to Danshiitsoodol, 'The present study has substantially enhanced our understanding of the mechanism of action of the Lactobacillus plantarum SN13T strain in the fermentation of herbal extracts, while also offering a valuable research perspective on the potential application of probiotics as natural anti-tumor agents.' Going by this research, with the right microbes, even a simple leaf like stevia could become a powerful weapon against cancer. It's not bad for a sugar substitute anymore; it's a natural and valuable component with more than its sweetening qualities. Cancer immunotherapy may also treat certain autoimmune diseases, claims study
Health Line
03-07-2025
- Health
- Health Line
Compounds in Coffee May Help Lower Type 2 Diabetes Risk, Study Finds
Researchers say black coffee can help lower the risk of type 2 diabetes. The findings of a new study suggest that people who regularly drink caffeinated and decaffeinated coffee benefit from some of the beverage's naturally occurring polyphenols. Experts say the amount of coffee a person can tolerate varies, and you should avoid adding sugar or cream or eating unhealthy breakfast foods with your coffee. A new research analysis suggests that black coffee, whether caffeinated or decaffeinated, may help lower the chances of developing type 2 diabetes. Researchers affiliated with universities in the Republic of Korea say people who drink 3 to 5 cups of black coffee per day benefit from natural compounds known as polyphenols. The findings were recently published in the International Journal of Molecular Sciences. For the study, the researchers compiled data from 149 publications to examine coffee's effects on the metabolic forces involved in the development of type 2 diabetes. They focused on five hydroxycinnamic acids found in coffee and analyzed the effects these polyphenols had on the small intestines, pancreas, liver, muscle, and tissue. The analysis shows that daily consumption of black coffee can help modulate blood sugar levels, suppress inflammation, enhance insulin sensitivity, provide antioxidant properties, and improve glucose metabolism. The results were similar for both caffeinated and decaffeinated coffee, so the benefits appeared to be derived from compounds other than caffeine. This included a 20–30% lower risk of type 2 diabetes incidence for regular coffee drinkers. The scientists say further research is necessary, but the benefits of daily coffee consumption appear to be clear. 'Coffee and its bioactive compounds, including chlorogenic acid and its hydroxycinnamic acid derivatives… have significant potential in the prevention and management of [type 2 diabetes],' the researchers wrote. Zhaoping Li, MD, a professor of medicine and the chief of the Division of Clinical Nutrition at the University of California, Los Angeles, agreed. Li wasn't involved in the study. 'Drinking coffee provides natural benefits,' she told Healthline. 'You can make coffee part of your healthy lifestyle.' Marilyn Tan, MD, a clinical associate professor of medicine at Stanford University in California, had some cautions about the findings. Tan was likewise not involved in the study. She said the findings are notable, but added that some of the research reviewed was conducted in lab settings. She said that observational studies don't always account for external factors such as coffee drinkers' overall health. '[The research] is a very bold statement, as a 20–30% risk reduction is very large and meaningful,' Tan told Healthline. 'Interestingly, whether the coffee was caffeinated or not did not seem to make a difference, which suggests it's not the caffeine driving the benefit, but rather the other components of the coffee.' How does coffee impact type 2 diabetes risk? Li explains that coffee is a natural product. If you drink it black, it's basically just coffee beans and hot water. Li said coffee beans contain about 200 compounds, many of which have potential health benefits. In some cases, the mixture of compounds is beneficial. Many of these compounds are also similar to the ones found in certain spices. 'Humans can take advantage of what this [coffee] plant provides,' Li said. 'The health benefits of black coffee seem to be obvious.' Previous research has indicated that there are other health benefits to regular coffee drinking. Another recent study reported that regular consumption of black coffee can reduce a person's overall mortality risk as well as their risk of death from cardiovascular disease. Other studies have associated coffee with improved brain health, lowering the risk of depression, and protecting against certain liver conditions. Most people should avoid excess caffeine, coffee Li cautioned people to be wary of their caffeine intake if they are drinking 3 to 5 cups of coffee per day. She said 3 cups daily is probably fine for most people, but some folks may not be able to handle the caffeine load from 4 or 5 servings per day. People with certain heart conditions should also carefully monitor their caffeine intake. 'Everybody is different,' Li said. Tan shared similar concerns. 'Three to five cups of coffee is a significant amount,' she said. 'If the coffee contains caffeine, excess caffeine may also have other unwanted symptoms, such as headaches, jitteriness, nausea, [and] insomnia. In addition, with certain health conditions (pregnancy, heart disease), this much caffeine may cause physical harm.' Li said those who can't tolerate a lot of caffeine can simply drink decaffeinated coffee. 'You remove the caffeine, but the rest of the compounds are still there,' she said. People can also drink tea or use spices in their cooking instead of sugar and salt to obtain some of these health benefits, Li added. How to maximize your coffee intake Li said the most important way to derive health benefits from coffee is to drink it black without adding sugar or cream. She advised against unhealthy breakfast foods with coffee, such as sugary donuts. Li noted that coffee can be particularly helpful if it's a substitute for other types of liquids, particularly those high in sugar. 'Black coffee is beneficial, especially if you are replacing sugary drinks with it,' she said. What to know about type 2 diabetes The Centers for Disease Control and Prevention (CDC) reports that nearly 39 million U.S. adults — roughly 15% of the adult population — have diabetes. The percentage rises with age, reaching nearly 30% in people ages 65 and older. The condition is also more prevalent in non-white populations and is slightly higher among males than females. Type 2 diabetes is a chronic condition that is characterized by high blood glucose levels, resulting from the body's ineffective response to insulin or insufficient insulin production. The symptoms of type 2 diabetes can include: unusual hunger fatigue or lack of energy excessive thirst frequent urination blurry vision There are a number of factors that can raise a person's risk of type 2 diabetes, such as: genetics excessive weight lack of physical activity a diet high in sugar, refined carbohydrates, and ultra-processed foods Li advised people to limit added sugars and monitor the starch and carbohydrates in their daily diets and reiterated the importance of daily exercise. Tan agreed that an overall healthy lifestyle can help reduce type 2 diabetes risk. Lifestyle factors that may influence risk include:
Economic Times
21-06-2025
- Health
- Economic Times
This one food habit could shield you from arthritis, obesity and diabetes. Science backs what Indian kitchens always knew
Fermented foods like idli, curd, and kanji aren't just staples of Indian kitchens—they're emerging as powerful allies in the fight against arthritis, diabetes, and inflammation. Packed with probiotics, these gut-friendly foods improve digestion, boost immunity, and regulate metabolism. Studies confirm that incorporating them into your diet can significantly reduce chronic health risks and promote long-term wellness. Tired of too many ads? Remove Ads The Good Bacteria You Need More Of Why India's Age-Old Recipes Deserve a Comeback Tired of too many ads? Remove Ads The Anti-Inflammatory, Diabetes-Defying Diet Shift Not Just a Food, But a Lifestyle Fix In a world where fast food dominates and lifestyle diseases rise unchecked, the cure to many modern ailments might already be simmering in Indian kitchens. From the spongy idli to the humble chaas, fermented foods are gaining scientific validation for their transformative effect on health. A recent report by the International Journal of Environmental Research and Public Health now confirms what ancient Indian culinary wisdom always hinted at: fermented foods aren't just delicious—they're disease-fighting foods are made or preserved using yeast, fungi, or beneficial bacteria—elements that might sound off-putting at first but are crucial for maintaining a healthy gut. According to the report, our digestive tracts host trillions of microorganisms, and feeding them right can influence everything from digestion to immunity. Fermented foods, rich in probiotics and prebiotics, help boost microbial diversity, reduce inflammation, and support the gut's ability to fight off believe this microbial harmony could be key to preventing chronic conditions like arthritis. The journal explains that fermented foods can lower oxidative stress and systemic inflammation—two markers often linked to the onset of autoimmune and degenerative kitchens have long relied on fermentation—not just as a preservation method but as a cornerstone of everyday meals. Dishes like dahi (curd), kanji (a tangy drink made from fermented carrots or mustard seeds), idli and dosa batters, pickles, fermented bamboo shoots from the Northeast, and even drinks like chaas and lassi are natural probiotic powerhouses. These are the very staples that modern research is now spotlighting for their health processed probiotics or supplements, these foods come integrated with taste, tradition, and tangible results. They naturally introduce helpful bacteria into the gut, helping regulate digestion, fight bad bacteria, and enhance nutrient absorption—all while staying true to your cultural plate.A separate study in the International Journal of Molecular Sciences further revealed that fermented foods could play a role in managing obesity. Their ability to improve metabolic function, control blood sugar, and even lower cholesterol and blood pressure suggests a compelling role in diabetes prevention and metabolic disorders like diabetes surge in India, this dietary insight couldn't come at a better time. Rather than eliminating food groups, the smarter strategy may be to reintroduce age-old ones that the modern diet has gradually promoting healthy weight loss to lowering the risk of autoimmune issues like arthritis, the evidence is stacking up: fermentation isn't just a culinary technique—it's preventative medicine. These foods also boost mental well-being, skin health, and immunity, thanks to their influence on the gut-brain axis and inflammation makes this resurgence in fermented food all the more compelling is its accessibility. No fancy ingredients, no complicated methods—just your grandmother's recipes, revived. And in that revival lies the potential to heal a India grapples with the double burden of malnutrition and non-communicable diseases, it may be time to rethink what's on our plates. Fermented foods offer a solution that's cost-effective, deeply cultural, and scientifically the next time you sip your lassi or scoop out a spoon of homemade curd, remember—you're not just feeding your body. You're fortifying your future.
Hindustan Times
07-06-2025
- Health
- Hindustan Times
Best fish oil capsules for skin and hair: 8 options for natural glow and growth
If your beauty cabinet is already packed but not showing results, it might be time to look inside. You might be low on essential nutrients like omega-3 fatty acids, which play a crucial role in maintaining skin hydration, elasticity, and hair strength. But most of us don't get enough of these nutrients through diet alone. This is where fish oil capsules come in. These tiny, power-packed supplements work from within to reduce inflammation, boost collagen production, nourish hair follicles, and give your skin that healthy, radiant glow. Unlike topical creams, fish oil delivers long-lasting results from the inside out. In this guide, we have highlighted 10 of the best fish oil capsules for skin and hair that can help you restore what your body might be missing. Omega-3s may help improve hair thickness and growth (International Journal of Molecular Sciences). Here are some of the best fish oil capsules that you may try in 2025 but only after consulting your healthcare provider: These triple-strength fish oil capsules deliver 550mg EPA and 350mg DHA per capsule. They are ideal for promoting joint health, glowing skin, and stronger hair. The advanced enteric coating prevents fishy burps and enhances nutrient absorption. Rich in anti-inflammatory omega-3s, this fish oil supplement is dairy-free, gluten-free, and keto-friendly. High potency Burpless Good EPA:DHA ratio Capsule size may be large for some WOW Life Science Omega-3 Fish Oil 1300 mg Triple Strength - 550mg EPA & 350mg DHA for Joints, Heart & Brain Health 60 Capsules Customers' reactions: Customers loved these best omega-3 supplements for joint relief and skin glow. However, feedback was mixed on taste and burp control. Formulated with 180mg EPA and 120mg DHA, these fish oil capsules support joint mobility, brain function, and youthful skin. They reduce inflammation and improve post-workout recovery. The vanilla coating improves taste and the swallowing experience. Flavoured Effective for joint and skin wellness Some users reported fishy burps HealthKart HK Vitals Fish Oil For Men And Women (60 Capsules) | 1000mg Omega 3 with 180mg EPA & 120mg DHA | For Brain, Heart, Eyes, and Joints Health Customers' reactions: This best fish oil capsules for skin and hair is good for energy, joint pain, and glowing skin. They liked the taste, but opinions were mixed on burp quality. Certified for purity and potency, these fish oil capsules are packed with 180mg EPA and 120mg DHA per capsule. It supports joint flexibility, reduces inflammation, and promotes better circulation and recovery. Moreover, these fish oil capsules for skin and hair are also beneficial for skin texture and elasticity. No aftertaste Trust-certified Some users reported a mild odor Some users reported a mild odor MuscleBlaze Omega 3 Fish Oil (90 Capsules) | Trustified Certified for Accuracy & Purity | 1000mg Omega 3 with 180mg EPA & 120mg DHA Customers' reactions: Customers have a positive impact on quality and skin health. However, a few complained about the odour. These triple-strength omega-3 capsules provide 892mg EPA and 594mg DHA, plus vitamins D3 and E for extra immune and skin nourishment. The lemon flavour also eliminates the fishy aftertaste. The two-soft gel serving supports skin elasticity, hair strength, heart and joint health, and overall anti-ageing benefits. Designed for optimal absorption and sourced from deep-sea fish, these best fish oil supplements are tested for heavy metals and contaminants. High strength Flavoured Added vitamins Two-capsule serving sizes may not suit everyone Neuherbs Deep Sea Omega 3 Fish Oil Supplement Triple Strength 2500 Mg, Essential Fatty Acid Combination of 1486 mg 892 mg EPA and 594 mg DHA per serving,120 Softgels Customers' reactions: Customers liked the joint comfort and smoother skin effectiveness. Some even appreciated the product's burpless formula. TrueBasics delivers 525mg EPA and 375mg DHA per serving for heart health, joint support, and glowing skin. Its enteric coating ensures no fishy burps and better nutrient absorption. With the triple-strength formula, these fish oil capsules promote radiant skin, improved brain function, and reduced inflammation. Moreover, it is ideal for busy lifestyles, free of heavy metals and offers clean, tested ingredients for daily use. Clean-label certified Easy to absorb Large capsule size TrueBasics Omega 3 Fish Oil (60 Capsules) | Triple Strength with 1150mg Omega, 525mg EPA & 375mg DHA | For Healthy Heart, Eyes & Joints, 60 grams Customers' reactions: Customers praised the joint and skin benefits of these fish oil capsules. However, reviews were mixed on size and smell. ALSO READ: Best iron supplements for anemia: 10 picks to restore vitality and fight deficiency These high-strength fish oil capsules offer 495mg EPA and 330mg DHA per softgel, promoting youthful skin, soft hair, joint flexibility, and cardiovascular well-being. They are molecularly distilled for purity and delivered in triglyceride form for faster absorption. The burpless formula ensures no fishy taste, and each softgel helps fight inflammation and dryness, supporting smoother, clearer skin and improved scalp health. Highly absorbable No fishy burps Slightly expensive for some users Carbamide Forte Triple Strength Omega 3 Fish Oil Capsule with 495 mg EPA & 330 mg DHA | 90 Softgel Capsules | Supports Heart, Joints and Skin (Pack of 2) Customers' reactions: Customers trusted the effectiveness of this best fish oil supplement. It helps reduce joint inflammation and brightens skin. This Australian-made fish oil provides 270mg EPA and 180mg DHA per capsule, supporting skin hydration, heart health, joint mobility, and eye care. It's sustainably sourced and odorless, which makes these fish oil capsules suitable for those sensitive to smell. With regular use, it helps maintain skin elasticity, reduces dryness, and supports shiny, stronger hair. Moreover, it is IFOS-certified and suitable for long-term, anti-ageing supplementation. High concentration No fishy odour Large capsule and seal concerns Swisse Fish Oil with 1500mg Omega 3 - 200 Capsules, One Capsule Per Serving,(Highest Fish Oil Concentrate In Single Capsule) Manufactured In Australia, Internationally Proven Formula Customers' reactions: This product is well-received for skin texture and joint support. Infused with vitamin E, these fish oil capsules deliver 180mg EPA and 120mg DHA to support skin radiance, hair health, brain performance, and heart function. They are sourced from salmon and tested for purity, which helps improve elasticity, reduce breakouts, and support scalp nourishment. Each capsule helps maintain skin balance, making it a good daily companion for holistic skin and hair care. Budget-friendly Supports multiple functions May cause skin reactions in rare cases TATA 1mg Salmon Omega 3 Fish Oil Capsules 1000mg with Vitamin E|Advanced Fish Oil with 180mg EPA & 120mg DHA|High absorption for Heart,Brain & Joints|Helps manage cholesterol|Pack of 90,174 grams Customers' reactions: Customers appreciated the capsule's effectiveness on energy and skin health. However, a few noted minor allergies. ALSO READ: Nutrition powders in India (2025): 10 picks for your health and fitness goals Best fish oil capsules Omega-3 content (EPA + DHA) Flavor / taste Special features / notes 1. Look for high levels of EPA and DHA. These are the most beneficial omega-3s for skin, hair, heart, and joint health. 2. Choose the right fish oil capsules that are third-party tested or have certifications (like IFOS) to ensure purity and safety from heavy metals. 3. Prefer fish oil capsules made from cold-water, wild-caught fish like salmon, mackerel, or sardines. 4. Opt for triglyceride or re-esterified triglyceride forms. They are more bioavailable than ethyl esters. 5. Look for enteric-coated or flavoured options to avoid unpleasant burps or taste. 6. To enjoy fish oil capsules' benefits, look for products with added vitamin E or D3. They offer bonus benefits for skin, immunity, and joint support. 1kg protein powder packs: Top 10 options to try in 2025 for muscle building Biotin supplement: How to pick the right one for your needs, plus top-rated brands to try Best fish oil supplement: Top 10 options to try in 2025 for heart, brain and joint support Fish oil capsules support heart, brain, skin, and joint health. They reduce inflammation, hydrate skin, boost hair strength, and improve cholesterol levels. Some people may experience fishy burps, an upset stomach, or a slight aftertaste. High doses can lead to thinning blood, so consult a doctor before long-term or heavy usage. You can take fish oil capsules any time with meals, but many prefer morning to avoid burps or discomfort. Taking them with food also improves omega-3 absorption. Yes, fish oil's anti-inflammatory properties can help reduce acne breakouts by lowering sebum production and calming skin inflammation, especially in cases of hormonal or cystic acne. Disclaimer: At Hindustan Times, we help you stay up-to-date with the latest trends and products. Hindustan Times has an affiliate partnership, so we may get a part of the revenue when you make a purchase. We shall not be liable for any claim under applicable laws, including but not limited to the Consumer Protection Act, 2019, concerning the products. The products listed in this article are in no particular order of priority.
Korea Herald
05-06-2025
- Health
- Korea Herald
FutureCeuticals, Inc. Announces Peer-Reviewed Publication Highlighting Cellular Health and Immune Support Benefits of vitAlign®
MOMENCE, Ill., June 5, 2025 /PRNewswire/ -- New research published in the International Journal of Molecular Sciences shows that vitAlign®, a proprietary and comprehensive healthy aging innovation from FutureCeuticals, delivers significant benefits for restoring cellular health and supporting a healthy immune response. The study highlights vitAlign's effectiveness in regulating cellular function and metabolic imbalances associated with immune stressors—from the seasonal cold and flu to more complex environmental and immune-related challenges. Researchers evaluated the impact of a low, 50 mg dose of vitAlign in medically stable adults aged 40–55 recovering from a moderate course of COVID-19, as defined by CDC guidelines. The study compared vitAlign to a 1000 mg dose of Vitamin C, focusing on key markers and processes that directly impact immune and cellular health. Results showed that vitAlign significantly reduced excessive reactive oxygen species (ROS) production in mitochondria and through the NOX2 and iNOS pathways—key mechanisms that influence immune and cellular function. Additionally, researchers observed increased levels of circulating, bioavailable nitric oxide, suggesting support for endothelial function and cardiovascular health. The authors noted that the increase in nitric oxide is likely attributable to vitAlign's ability to regulate multiple pathways of ROS production. Notably, vitAlign delivered measurable effects within 30 minutes, lasting up to three hours. In contrast, Vitamin C, which was used as a positive control, was administered at twenty times the dose and did not demonstrate comparable broad-spectrum activity. "These findings build on over a decade of published clinical research establishing vitAlign as a significant cellular health innovation, now extended directly to immune function," said J. Randal Wexler, FutureCeuticals' General Counsel and Vice President of R&D. "Previously, we've shown that vitAlign improves cellular energy efficiency and helps restore metabolic balance, both acutely and over time." Wexler added, "These new results, which compare favorably to a well-known antioxidant like Vitamin C, reinforce vitAlign's potential as a multi-faceted phytonutrient formula, providing broad support for healthy aging, cardiovascular health, and immune function. Our partners are excited about what this means for product innovation and their customers looking for daily cellular health support." About FutureCeuticals: FutureCeuticals, Inc. is the developer of vitAlign and a leader in the research, development, and manufacture of plant-based powders and extracts for the functional food, beverage, and dietary supplement markets.
