Pierre Fabre Laboratories Strengthen R&D Portfolio and Announce the Acquisition of the Worldwide Rights for PFL-721 and PFL-241
CASTRES, France, June 16, 2025 /CNW/ -- Pierre Fabre Laboratories are pleased to announce the acquisition from Antares Therapeutics, Inc. ("Antares"), a spin-out of Scorpion Therapeutics, Inc., of the worldwide rights for PFL-721 and PFL-241 (formerly known as STX-721 and STX-241, respectively). Under the terms of the agreement, Pierre Fabre Laboratories will expand its previous agreement with Scorpion Therapeutics to hold the global rights for both assets and will be leading the clinical development of both programs.
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PFL-721 is a mutant-specific EGFR exon 20 and HER2 exon 20 inhibitor, soon to transition to dose optimization within a first-in-human trial in NSCLC. PFL-241 is a mutant-specific, brain penetrant, 4th generation EGFR inhibitor, currently in dose escalation in a first-in-human trial, to address C797S resistance mutations in NSCLC patients.
NSCLC is the most common sub-type of lung cancer and various EGFR mutations are the most frequent drivers of NSCLC, occurring in approximately 14-38 percent of tumors, depending on geography. [1], [2], [3]
"With this agreement with Antares, Pierre Fabre Laboratories now own the global rights for all the assets within our R&D portfolio: exarafenib, PFL-002 (formerly VERT-002), PFL-721 and PFL-241. The R&D team is fully engaged and committed to progress the clinical development of these programs, aiming at providing novel and differentiated precision medicines to patient populations with significant unmet needs." said Francesco Hofmann, Head of Research and Development for Medical Care at Pierre Fabre Laboratories.
About Pierre Fabre Laboratories
Pierre Fabre Laboratories is the world's second-largest dermo-cosmetics company and one of Europe's leading pharmaceutical laboratories. Its Dermo-cosmetics & Personal Care portfolio includes international brands such as Eau Thermale Avène, Ducray, Klorane, A-Derma, René Furterer, Même Cosmetics, Darrow and Elgydium. Its Medical Care activity covers 5 main therapeutic fields: oncology, dermatology, rare diseases, primary care and family health care.
[1] The Prevalence of EGFR Mutation in Patients with Non-Small Cell Lung Cancer, Oncotarget, October 2016
[2] EGFR Mutation Incidence in Non-Small Cell Lung Cancer, J Cancer Res., August 2015
[3] Molecular Epidemiology of EGFR Mutations in Asian Patients, PLoS ONE, November 2015
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Fortnum – Labouchere RC Program During the quarter, the Labouchere RC program at Fortnum commenced with 21 holes for 3,167m drilled by the end of the period. The program is targeting potential structural repeats south of the historic Labouchere mine which produced 1.2Mt at 2.47g/t Au for 95.4Koz, as well as follow-up testing of targets defined by recent aircore drilling. Assay results for the program were pending at the end of the quarter. Peak Hill - Murphy Creek AC Program The Murphy Creek AC drill program was completed early in the quarter with 28 holes for 1,416m drilled during the current quarter and 56 holes for 3,315m drilled across the program. The program tested identified targets along strike to the northwest of the Company's Durack deposit which currently hosts an Indicated and Inferred Resource of 2.9Mt at 1.2g/t Au for 111Koz[1]. This potential strike extension has not previously been effectively tested due to the presence of very shallow Bryah Basin volcanic "cover". 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It is interpreted as a parallel, structural analogue to the Western Flanks and A Zone deposits, and is considered the third major mineralised shear zone system hosted in the Hunt Block. Table 3: Stage 1 Fletcher Zone Mineral Resource Estimate In September 2024, Westgold declared a global Fletcher Zone Exploration Target of 23-27Mt at 2.1-2.5g/t Au for 1.6-2.1Moz, including a Stage 1 Exploration Target of 12–16Mt at 2.1-2.5g/t Au for 0.8-1.2Moz Au. An aggressive drilling campaign has resulted in a Mineral Resource Estimates that has doubled the mid-point of the Stage 1 Exploration Target[2]. Westgold is continuing to capitalise on this success with drilling ongoing at Fletcher, producing results during the current quarter such as: 27.00m at 4.24g/t Au from 472.00m, 10.00m at 4.48g/t Au from 725.00m and 10.00m at 3.56g/t Au from 742.00m in FF475SP-61AEA; 21.00m at 2.03g/t Au from 210.00m, 32.40m at 1.79g/t Au from 292.00m, 2.05m at 34.41g/t Au from 335.00m and 31.00m at 1.69g/t Au from 709.00m in WF440DD-37AE; and 16.00m at 5.56g/t Au from 245.00m, 22.00m at 2.64g/t Au from 368m and 50.00m at 2.83g/t Au from 661.00m in WF490DD-47AE. 2 Refer to ASX release titled "Fletcher Exploration Target Defined at 1.6 - 2.1Moz Au" – 16 September 2024. Whilst the Fletcher MRE was the highlight of Resources Definition activities at Beta Hunt this quarter, the most spectacular Resource Definition drilling results received during the reporting period have been from the production mainstay Western Flanks area. Western Flanks is one of two main production zones and currently the major driver of mine output at Beta Hunt. Results such as those received this quarter will ensure that Western Flanks remains integral to the success of Beta Hunt well into the future. 8.03m at 101.72g/t Au from 8.00m in AWLINKDD-15AG; 55.50m at 4.51g/t Au from 179.00m in AWLINKDD-24AG; and 6.90m at 372.32g/t Au from 8.00m in WWSP4-31AG. Additionally, A Zone and Cowcill have continued to see significant drilling effort this quarter in keeping with Westgold's strategy to develop independent production zones which complement the current mine plan, and take advantage of existing capital infrastructure. Whilst A Zone is already a key constituent of the Beta Hunt mine plan, lifting the contribution from A Zone and integrating deposits such as Cowcill will significantly de-risk Westgold's plans to lift outputs at Beta Hunt. Higginsville At Higginsville, Westgold is continuing to have success at its small-scale Two Boys mine, with ongoing drilling defining a clear high-grade trend within the broader Two Boys system as demonstrated by recent results such as: 3.00m at 4.1g/t Au from 61.00m in 25TBDDG007; 1.00m at 10.8g/t Au from 79.00m in 25TBDDG008; and 1.60m at 11.1g/t Au from 133.00m in 25TBDDG021. This definition directs Westgold to focus mining efforts within the highest value part of the orebody, which in-turn has ensured Two Boys has consistently generated free cash flow month-on-month under Westgold management. The current Two Boys mine plan has development continuing to advance to the north, creating a drilling horizon from Two Boys to target opportunities at the Poseidon South zone of the 1.2Moz Trident Mine. Greenfields Exploration Activities Greenfields exploration activities in the Southern Goldfields included ongoing target assessment and drill program design, heritage survey planning and the completion of the Spargo's RC drilling program. Higginsville - Greater Spargo's RC Drill Program Results During the quarter an RC drill program was undertaken testing two targets in the Greater Spargo's area with a total of 19 holes for 2,454m completed. The program targeted a RAB anomaly and an area of elevated pathfinder elements in association with a sheared stratigraphic contact. Assay results from this program did not warrant further investigation, and no further work is currently planned for this anomaly. Beta Hunt – Mason Target As detailed in the Q3 Quarterly Report, the Mason target is considered to be the fault-offset extension of Fletcher to the south of the Alpha Island Fault (refer Figure 9 above). Preparation for the Mason Target UG drill program was completed in the quarter with work planned to commence early in Q1 FY26. This drill program has increased prospectivity given the results of the maiden Fletcher MRE outlined above. Compliance Statements Exploration Targets, Exploration Results, Mineral Resources and Ore Reserves The information in this report that relates to Mineral Resources is compiled by Westgold technical employees and contractors under the supervision of the General Manager of Technical Services, Mr. Jake Russell (Hons), who is a member of the Australian Institute of Geoscientists and who has verified, reviewed, and approved such information. Mr Russell is a full-time employee to the Company and has sufficient experience which is relevant to the styles of mineralisation and types of deposit under consideration and to the activities which he is undertaking to qualify as a Competent Person as defined in the 2012 Edition of the Australasian Code for Reporting of Exploration Results, Mineral Resources and Ore Reserves (the " JORC Code") and as a Qualified Person as defined in the CIM Guidelines and National Instrument 43-101 – Standards of Disclosure for Mineral Projects (" NI 43-101"). Mr. Russell is an employee of the Company and, accordingly, is not independent for purposes of NI 43-101. Mr Russell consents to and approves the inclusion in this report of the matters based on his information in the form and context in which it appears. Mr Russell is eligible to participate in short- and long-term incentive plans of the Company. The information in this report that relates to Ore Reserve Estimates is based on information compiled by Mr. Leigh Devlin, B. Eng MAusIMM, who has verified, reviewed and approved such information. Mr. Devlin has sufficient experience which is relevant to the styles of mineralisation and types of deposit under consideration and to the activities which they are undertaking to qualify as a Competent Person as defined in the JORC Code and as a Qualified Person as defined in the CIM Guidelines and NI 43-101. Mr. Devlin is an employee of the Company and, accordingly, is not independent for purposes of NI 43-101. Mr. Devlin consents to and approves the inclusion in this report of the matters based on his information in the form and context in which it appears. Mr. Devlin is a full time senior executive of the Company and is eligible to, and may participate in short-term and long-term incentive plans of the Company as disclosed in its annual reports and disclosure documents. The information in this report that relates to Exploration Targets and Results is compiled by the Westgold Exploration Team under the supervision of Chief Growth Officer, Mr. Simon Rigby (Hons), who is a member of the Australian Institute of Geoscientists and who has verified, reviewed, and approved such information. Mr Rigby is a full-time employee of the Company and has sufficient experience which is relevant to the styles of mineralisation and types of deposit under consideration and to the activities which he is undertaking to qualify as a Competent Person as defined in the JORC Code and as a Qualified Person as defined in the CIM Guidelines and NI 43-101. Mr. Rigby is an employee of the Company and, accordingly, is not independent for purposes of NI 43-101. Mr Rigby consents to and approves the inclusion in this report of the matters based on his information in the form and context in which it appears. Mr Rigby is eligible to participate in short-term and long-term incentive plans of the Company. Mineral Resources, Ore Reserve Estimates and Exploration Targets and Results are calculated in accordance with the JORC Code. Investors outside Australia should note that while Ore Reserve and Mineral Resource estimates of the Company in this report comply with the JORC Code (such JORC Code-compliant Ore Reserves and Mineral Resources being "Ore Reserves" and "Mineral Resources" respectively), they may not comply with the relevant guidelines in other countries. The JORC Code is an acceptable foreign code under NI 43-101. Information contained in this announcement describing mineral deposits may not be comparable to similar information made public by companies subject to the reporting and disclosure requirements of US securities laws, including Item 1300 of Regulation S-K. All technical and scientific information in this release has been prepared in accordance with the Canadian regulatory requirements set out in NI 43-101 and has been reviewed on behalf of the Company by Qualified Persons, as set forth above. This report contains references to estimates of Mineral Resources and Ore Reserves. The estimation of Mineral Resources is inherently uncertain and involves subjective judgments about many relevant factors. Mineral Resources that are not Ore Reserves do not have demonstrated economic viability. The accuracy of any such estimates is a function of the quantity and quality of available data, and of the assumptions made and judgments used in engineering and geological interpretation, which may prove to be unreliable and depend, to a certain extent, upon the analysis of drilling results and statistical inferences that may ultimately prove to be inaccurate. Mineral Resource estimates may require re-estimation based on, among other things: (i) fluctuations in the price of gold; (ii) results of drilling; (iii) results of metallurgical testing, process and other studies; (iv) changes to proposed mine plans; (v) the evaluation of mine plans subsequent to the date of any estimates; and (vi) the possible failure to receive required permits, approvals and licenses. Technical reports NI 43-101 compliant technical reports for each of Fortnum, Meekatharra, Cue, Beta Hunt and Higginsville operations are available under the Company's SEDAR+ profile at and the Company's website at Forward Looking Statements These materials prepared by Westgold Resources Limited (or the " Company") include forward looking statements. Often, but not always, forward looking statements can generally be identified by the use of forward looking words such as "may", "will", "expect", "intend", "believe", "forecast", "predict", "plan", "estimate", "anticipate", "continue", and "guidance", or other similar words and may include, without limitation, statements regarding plans, strategies and objectives of management, anticipated production or construction commencement dates and expected costs or production outputs. Forward looking statements inherently involve known and unknown risks, uncertainties and other factors that may cause the Company's actual results, performance, and achievements to differ materially from any future results, performance, or achievements. Relevant factors may include, but are not limited to, changes in commodity prices, foreign exchange fluctuations and general economic conditions, increased costs and demand for production inputs, the speculative nature of exploration and project development, including the risks of obtaining necessary licenses and permits and diminishing quantities or grades of reserves, political and social risks, changes to the regulatory framework within which the Company operates or may in the future operate, environmental conditions including extreme weather conditions, recruitment and retention of personnel, industrial relations issues and litigation. Forward looking statements are based on the Company and its management's good faith assumptions relating to the financial, market, regulatory and other relevant environments that will exist and affect the Company's business and operations in the future. The Company does not give any assurance that the assumptions on which forward looking statements are based will prove to be correct, or that the Company's business or operations will not be affected in any material manner by these or other factors not foreseen or foreseeable by the Company or management or beyond the Company's control. Although the Company attempts and has attempted to identify factors that would cause actual actions, events or results to differ materially from those disclosed in forward looking statements, there may be other factors that could cause actual results, performance, achievements or events not to be as anticipated, estimated or intended, and many events are beyond the reasonable control of the Company. In addition, the Company's actual results could differ materially from those anticipated in these forward looking statements as a result of the factors outlined in the "Risk Factors" section of the Company's continuous disclosure filings available on SEDAR+ or the ASX, including, in the company's current annual report, half year report or most recent management discussion and analysis. Accordingly, readers are cautioned not to place undue reliance on forward looking statements. Forward looking statements in these materials speak only at the date of issue. Subject to any continuing obligations under applicable law or any relevant stock exchange listing rules, in providing this information the Company does not undertake any obligation to publicly update or revise any of the forward-looking statements or to advise of any change in events, conditions or circumstances. This announcement is authorised for release to the ASX by the Board. SOUTHERN GOLDFIELDS All widths are downhole. 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- Cision Canada
Parkland Announces Date of 2025 Second Quarter Results
CALGARY, AB, July 22, 2025 /CNW/ - Parkland Corporation ("Parkland", "we", the "Company", or "our") (TSX: PKI) expects to announce its 2025 second quarter results after markets close on Tuesday, August 5, 2025. Financial Statements and Management's Discussion and Analysis will be posted to and after the results are released. Due to the pending arrangement with Sunoco LP that was previously announced on May 5, 2025, Parkland will not host a conference call or webcast to discuss its second quarter results. About Parkland Corporation Parkland is a leading international fuel distributor, marketer, and convenience retailer with safe and reliable operations in twenty-six countries across the Americas. Our retail network meets the fuel, and convenience needs of everyday consumers. Our commercial operations provide businesses with fuel to operate, complete projects and better serve their customers. In addition to meeting our customers' needs for essential fuels, Parkland provides a range of choices to help them lower their environmental impact, including manufacturing and blending renewable fuels, ultra-fast EV charging, a variety of solutions for carbon credits and renewables, and solar power. With approximately 4,000 retail and commercial locations across Canada, the United States, and the Caribbean region, we have developed supply, distribution, and trading capabilities to accelerate growth and business performance. Our strategy is focused on two interconnected pillars: our Customer Advantage and our Supply Advantage. Through our Customer Advantage, we aim to be the first choice of our customers through our proprietary brands, differentiated offers, extensive network, competitive pricing, reliable service, and compelling loyalty program. Our Supply Advantage is based on achieving the lowest cost to serve among independent fuel marketers and distributors in the hard-to-serve markets in which we operate, through our well-positioned assets, significant scale, and deep supply and logistics capabilities. Our business is underpinned by our people and our values of safety, integrity, community, and respect, which are embedded across our organization.
