logo
Novo and Lilly compete in India as obesity drugs demand hikes

Novo and Lilly compete in India as obesity drugs demand hikes

Yahoo19 hours ago
STORY: :: Eli Lilly
Demand for weight-loss drugs in India has shot up.
And rivals Novo Nordisk and Eli Lilly are battling for market share.
That's according to research firm Pharmarack.
It said sales of Lilly's Mounjaro, which launched in March, doubled from May to June.
Overall, it's almost hit close to 88,000 units sold - over $3 million.
:: Novo Nordisk
Meanwhile, Pharmarack said Novo sold almost 1,800 units of Wegovy since its late-June launch.
Medical journal the Lancet has said the incidence of obesity and diabetes is rising in India.
And the country ranks among the worst three globally for high obesity rates.
Pharmarack said the Indian obesity market has grown fivefold since 2021 and is valued at $73 million.
And affordability and willingness to try new drugs for obesity have propelled the growth of the market.
While Wegovy's only just launched, the active ingredient in it - semaglutide - has a two-thirds share in the Indian market, according to Pharmarack.
And Novo has sold oral versions of semaglutide for diabetes in India since 2022.
However, semaglutide will lose patent protection in India next year.
Enabling generic drugmakers to produce cheaper versions of Wegovy as India becomes a key battleground for drugmakers in the global obesity market.
Error al recuperar los datos
Inicia sesión para acceder a tu cartera de valores
Error al recuperar los datos
Error al recuperar los datos
Error al recuperar los datos
Error al recuperar los datos
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Mum has been left "skint" from weight loss jab - and reveals the secret hidden cost
Mum has been left "skint" from weight loss jab - and reveals the secret hidden cost

Yahoo

time2 hours ago

  • Yahoo

Mum has been left "skint" from weight loss jab - and reveals the secret hidden cost

A mum has been left "skint" after forking out nearly £2,500 on weight loss jabs - but says "being skinny is worth the price tag" after having to buy a new wardrobe and monthly vitamins. Lucy Davies, 32, has revealed the "hidden" associated costs with the weight loss drug, Mounjaro, after taking it for ten months since September 2024. Despite losing nearly six stone, purchasing of the injectable pens has set her back up £180 each month. On top of that, the mum-of-one has spent hundreds of pounds on new, smaller, clothes after dropping from a size 22 to a size 12-14. As well purchasing expensive monthly vitamins - to keep on top of her nutrition - Lucy said the costs associated with losing weight on the jabs have been like "another tax". Lucy has "no regrets" about taking the weight loss drug after slimming down from a 16st 11lbs to a 11stone, but is urging others to consider the "financial burden" before starting the jabs.

Verified Clinical Trials Launches in Japan in Partnership with Medical Revolutions Japan (MRJ) and JACIC to Prevent Duplicate and Professional Subjects in Clinical Trials
Verified Clinical Trials Launches in Japan in Partnership with Medical Revolutions Japan (MRJ) and JACIC to Prevent Duplicate and Professional Subjects in Clinical Trials

Yahoo

time2 hours ago

  • Yahoo

Verified Clinical Trials Launches in Japan in Partnership with Medical Revolutions Japan (MRJ) and JACIC to Prevent Duplicate and Professional Subjects in Clinical Trials

TOKYO & GARDEN CITY, N.Y., July 08, 2025--(BUSINESS WIRE)--Verified Clinical Trials (VCT), the global leader in clinical trial subject registry solutions, has officially launched operations in Japan through a collaboration with Medical Revolutions Japan (MRJ) and the Japan Association of Contract Institutes for Clinical Pharmacology (JACIC) to address the growing global challenge of duplicate and professional research subjects in clinical trials. For the past thirty years, Japan's only system for preventing duplicate subject registration was developed by JACIC and used across Phase 1 studies. However, a recent review concluded that the system requires substantial modernization to meet international standards and support the growing number of global clinical trials. In addition, duplicate subjects in clinical trials have become a growing concern in Phase II and Phase III trials as well. After extensive evaluation, the VCT platform—widely adopted as the global standard—was selected as the best solution and replacement. With the support of MRJ, which was commissioned by JACIC to assist with domestic implementation, Verified Clinical Trials has begun initiating sites in Japan, with additional sites expected to join in the coming weeks and months. These sites will benefit from the biometric capabilities of the VCT system, offering a higher level of subject authentication and protocol compliance. This rollout will include sites conducting Phase I through Phase IV clinical trials. "Given the sophisticated functionality and biometric identification capability of the VCT system, as well as its proven match for other Asian countries," a representative of MRJ commented, "I believe it is destined to become the new Japan standard for duplicate subject registration prevention." Verified Clinical Trials brings to Japan a cross-sponsor, cross-therapeutic area subject registry already in use in up to 40 countries. The platform not only detects but also prevents duplicate subjects and other protocol violations at the time of screening—and maintains protections throughout the entire duration of the trial. "We're honored to bring VCT to Japan as part of a shared mission to raise the standard of subject protection and trial integrity," said Mitchell Efros, MD, President and CEO of Verified Clinical Trials. "No clinical trial or geography is immune to the challenge of duplicate subjects—it's a global phenomenon. Our system provides an effective, scalable solution." "By introducing VCT in Japan, sponsors gain a real-time tool to proactively manage protocol risk and ensure only qualified participants are enrolled," added Kerri Weingard, ANP, Vice President and Chief Operating Officer of Verified Clinical Trials. "This launch represents our commitment to regulatory excellence and regional partnership across the APAC region," said Eve Hsu, Global Regulatory Director at Verified Clinical Trials. "With dedicated team members based throughout APAC, we're well-positioned to support sites and sponsors locally and help elevate clinical trial quality and compliance across the region." The VCT system was co-founded by Mitchell Efros, MD, and Kerri Weingard, ANP, both experienced clinical researchers who developed the registry to address long-standing challenges in subject eligibility, data quality, and compliance. About Verified Clinical Trials (VCT)Verified Clinical Trials is the world's largest research subject database registry designed to detect and prevent duplicate and professional subjects in clinical trials. VCT fills a critical gap in the clinical research industry by providing insight into a research subject's past trial participation. This enables better subject selection and helps ensure successful clinical trial execution. Active in up to 40 countries, VCT supports sponsors, CROs, and research sites across all trial phases and therapeutic areas, enhancing data quality, subject safety, and protocol compliance. About Medical Revolutions Japan (MRJ)Medical Revolutions Japan is a clinical trial consultancy managed and staffed by industry experts with long and rich experience in all facets of clinical development and research in the Japanese market. Founded in 2024 as an affiliate of Keikokai Medical Corporation, a longstanding clinical research unit operator in Tokyo, MRJ is currently expanding its global client base and working to connect both international and local players to help the domestic Japanese clinical development industry rise to the challenges brought about by technological disruptions as it continues to grow and internationalize. View source version on Contacts For media inquiries, please contact:connect@ Sign in to access your portfolio

Waist Measure Improved Mortality Prediction in Older Women
Waist Measure Improved Mortality Prediction in Older Women

Medscape

time3 hours ago

  • Medscape

Waist Measure Improved Mortality Prediction in Older Women

By using waist circumference along with BMI, modest gains were made in predicting which postmenopausal women were at a higher risk for premature death, a prospective cohort study has found. While obesity remains a pressing public health threat, prevention and treatment are made difficult by the limits of the BMI to accurately measure excess adiposity, according to the study's authors. 'Waist circumference is a simple, inexpensive method to assess visceral adiposity and correlates well with visceral fat as assessed by imaging,' Aaron K. Aragaki, MS, and his colleagues wrote. Aragaki is a researcher at the Fred Hutchinson Cancer Center in Seattle. The problem, wrote Aragaki and his colleagues, is that waist circumference is not often measured in the clinical setting. Further, 'Waist circumference would be especially valuable for staging of obesity risk if BMI-specific thresholds were available,' they wrote. The investigators said that the current recommended waist circumference thresholds do not complement BMI because most adults diagnosed with obesity are already beyond these thresholds. Currently accepted waist circumference thresholds for overweight are 88 cm or above for women and 102 cm or above for men. To stratify risk more accurately, new BMI-specific waist circumference threshold recommendations have been made recently by the International Atherosclerosis Society (IAS) and the International Chair on Cardiometabolic Risk (ICCR) Working Group on Visceral Obesity. They have proposed thresholds in women of 80 cm or greater, 90 cm or greater, 105 cm or greater, 115 cm or greater, and 115 cm or greater to correlate, respectively, with BMI categories: normal weight (18.5 to < 25), overweight (25 to < 30), obesity 1 (30 to < 35), obesity 2 (35 to < 40), and obesity 3 (≥ 40). In men, they propose the corresponding waist measurements of 90 cm or greater, 100 cm or greater, 110 cm or greater, 125 cm or greater, and 125 cm or greater to correlate with the respective BMI categories. A consensus statement issued in 2020 by the IAS and the ICCR suggested that prospective data were needed to further stratify BMI categories by waist circumference thresholds to improve mortality risk prediction compared with BMI categories. To that end, Aragaki and his colleagues examined all-cause mortality data from the Women's Health Initiative (WHI), a large, national, multicenter, population-based study of generally healthy postmenopausal women (aged between 50 and 79 years), with enrollment from 1993 to 1998 and follow-up through 2021. Data of 139,213 women from the WHI were distributed across three groups. There was a development cohort (N = 67,774) and two validation cohorts, one according to overweight and obesity prevalence, and another according to geography and diversity. Validation Cohort 1 (N = 48,335) had half the prevalence of prior cardiovascular disease and cancer as the development group, but a higher rate of overweight or obesity (72.6% vs 59.1%). Validation Cohort 2 (N = 23,104) had nearly twice the number of women who identified as Black compared with the development group (12.7% vs 6.4%) and nearly three times the number of women who identified as Hispanic (9.1% vs 3.1%). Aragaki and his colleagues analyzed annual all-cause mortality in the datasets and the National Death Index. They found that respective death rates at 10- and 20-year follow-up marks were 5808 and 22,124 in the development cohort; 3418 and 14,252 in Validation Cohort 1, and 2123 and 7668 in Validation Cohort 2. Validation Cohort 1 had a higher prevalence of large waist circumference (21.9%) than Validation Cohort 2 (18.2%), according to currently accepted BMI-specific thresholds. Nearly all women with obesity 2 or obesity 3 had a waist circumference of 88 cm or larger, whereas women with a normal weight did not much exceed this waist circumference threshold. Differences in the percentage of trunk fat between women with normal waist circumference and those with large waist circumference within the same BMI categories across centers were notable, ranging from 0.5 to 1.0 SDs. Baseline risk for mortality at 10 and 20 years was highest in those with a prior history of disease and was lowest in those with no prior disease or preexisting condition across 5-year age groups, Aragaki and his colleagues found. All estimated hazard ratios in the mortality model were associated with higher mortality risk compared with the baseline risk. When BMI categories > 30 were added to this model, they were positively associated with higher mortality risk in a dose-dependent manner compared with the BMI category of normal weight. After stratification of BMI categories by waist circumference thresholds, hazard ratios were consistently greater for BMI categories with large waist circumference than their counterparts with normal ones. The mortality risk in women with normal weight or overweight and large waist circumferences was similar to that in women with obesity 1 and a normal waist circumference. Mortality risk in those with obesity 1 and a large waist circumference was similar to that in women with obesity 3 and normal waist circumference. Stratifying BMI categories by waist circumference thresholds improved mortality discrimination over BMI alone at 10 years for Validation Cohort 1, with the c-statistic increasing from 60.7% (95% CI, 59.5%-61.9%) to 61.3% (95% CI, 60.2%-62.5%), an improvement of 0.7% (95% CI, 0.3%-1.0%). The c-statistic is the agreement between the number of observed outcomes and predicted risk at 10 and 20 years, according to Aragaki and his colleagues. Discrimination was not significantly improved for Validation Cohort 2, however, with a difference in c-statistics of 0.3% (95% CI, 0.2%-0.7%). 'Combining BMI and waist circumference assessments allows for more personalized decision making,' Aragaki and his colleagues wrote. 'Patients with a large waist circumference in any BMI category are at elevated cardiometabolic and mortality risk and may benefit from more aggressive interventions than those with similar BMIs but lower waist circumferences. Conversely, those with a normal waist circumference may require less aggressive care.' The results of the study reinforce other data in favor of supplementing BMI with a second metric to more completely assess cardiometabolic health, a clinical obesity specialist told Medscape Medical News . 'BMI is a flawed criteria for diagnosis of obesity as it reflects total body mass but does not distinguish between fat and lean mass or where fat is distributed,' said Reema Hamid Dbouk, MD. 'Waist circumference is a surrogate for visceral fat, which is more metabolically active and linked to cardiometabolic risk and mortality.' Dbouk is an assistant professor of obesity medicine at Emory School of Medicine and a Rollins Distinguished Clinician at the Emory Clinic, both in Atlanta. 'Waist circumference measurement is inexpensive, quick, and requires minimal training. The paper notes that embarrassment or discomfort among patients is low, particularly among older adults. Integration into EMRs and vital sign protocols could normalize its use. Patients may understand waist size more intuitively than BMI. Tracking waist circumference over time may be more encouraging, especially if muscle gain masks fat loss on the scale,' said Dbouk. Dbouk said she thought the study was thorough, even if more data are still needed. 'Waist circumference-based thresholds may not fully account for differences in fat distribution by race/ethnicity or body habitus. For example, Asians may have higher metabolic risk at lower waist circumference. The thresholds are a step toward personalized risk assessment, but they may still require refinement to account for racial/ethnic differences in fat distribution and risk. More research is needed to validate waist circumference thresholds in broader populations, including men and younger individuals.'

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store