
2025 NFL schedule: Game-by-game predictions for the Bills
We're in the heart of the 2025 NFL offseason and things are moving along slowly.
The start of the upcoming season is a long ways away, but the league has released the entire schedule so we know the journey the Buffalo Bills will take next season.
Let's have a prediction now.
Here is Bills Wire's early game-by-game predictions for the 2025 season:
Week 1: vs. Baltimore Ravens (SNF)
The Ravens are a good team and it feels like they could be due for a win against the Bills in a big AFC clash.
Prediction: Loss (0-1).
Week 2: at New York Jets
It's a new regime leading the Jets and this game will be early days for them.
Prediction: Win (1-1).
Week 3: vs. Miami Dolphins (TNF)
After a season-opening loss, the Bills will be motivated against the Dolphins--who are a team quarterback Josh Allen thrives against.
Prediction: Win (2-1).
Week 4: vs. New Orleans Saints
The Saints have so many question marks... these are games the Bills should win.
Prediction: Win (3-1).
Week 5: vs. New England Patriots (SNF)
While the Patriots are looking for a positive season, it still looks like the Bills are much better on paper and should take this one... and there will be motivation as Stefon Diggs returns to Buffalo.
Prediction: Win (4-1).
Week 6: at Atlanta Falcons (MNF)
Heading into the bye is motivation for the Bills and the Falcons are a young team.
Prediction: Win: (5-1).
Week 7: Bye
Record: (5-1).
Week 8: at Carolina Panthers
It's hard to bet against Buffalo head coach Sean McDermott after the bye. He's 8-0 in such games.
Prediction: Win (6-1).
Week 9: vs. Kansas City Chiefs
It should be another classic between these two...
Prediction: Win (7-1).
Week 10: at Miami Dolphins
While the Bills do dominate the AFC East, it's hard to sweep a division every season... and the Dolphins have to eventually be due against the Bills, right?
Prediction: Loss (7-2).
Week 11: vs. Tampa Bay Buccaneers
A loss in Week 10 will be bad news for the Bucs.
Prediction: Win (8-2).
Week 12: at Houston Texans (TNF)
While there is no more Diggs in Houston, the Bills will remember how poorly they played there in 2024.
Prediction: Win: (9-2).
Week 13: at Pittsburgh Steelers
The Steelers do play the Bills well on occasion (or get blown out), but there are too many question marks for them currently.
Prediction: (10-2).
Week 14: vs. Cincinnati Bengals
The Bengals are hoping for a massive bounce-back season and this would be a huge game for them... assuming they will improve.
Prediction: Loss (10-3).
Week 15: at New England Patriots
As the postseason approaches, the Bills will still be too much for the Pats.
Prediction: Win (11-3).
Week 16: at Cleveland Browns
The Browns are just all over the place.
Prediction: Win (12-3).
Week 17: vs. Philadelphia Eagles
Super Bowl preview? A fun one could unfold here.
Prediction: Win (13-3).
Week 18: vs. New York Jets
There could be something on the line here... or maybe not. Either way, there's no way the final game at the current Highmark Stadium should be a loss.
Prediction: Win (14-3).

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