
UK's first patient to trial Parkinson's implant says it is life-changing
The technology was switched on in January as part of a trial at Southmead Hospital.The implant has technology inside which can work out when Mr Morgan's symptoms are about to show and suppress them.He told BBC Radio Bristol it is "like not having Parkinson's" any more.
'I can enjoy my hobbies again'
"They switch it on and they have you walk up and down the corridor, and you can feel the difference. You feel balanced," he said.The device sends a small electrical signal to the tip of the wires into the brain, and that electricity changes the brainwaves.Mr Morgan said it is "constantly reading the brainwaves" and "it's like having a mini computer in my body".He said: "My right arm wouldn't swing before but it does now. It's been life-changing. "One of my hobbies is fly-fishing and standing in rivers, silly things like that. I can do that now."
Mihaela Boca, a consultant neurologist at Southmead Hospital, said the device is "a bit like having a pacemaker in the brain rather than the heart"."By having this electricity delivered into the brain, you're essentially getting your [condition] treated without having medication," she said."We are now in the future, as it were."More than 150,000 people are thought to be living with the disease which impacts mobility, speech, focus, sleep and independence.The number is expected to increase due to population growth and ageing.ADBS treatment is expected to be rolled out this year.
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Scottish Sun
2 days ago
- Scottish Sun
Disturbing link between Parkinson's disease and living beside a golf club revealed by new study
The possible exposure comes from an unexpected place OUT OF BOUNDS Disturbing link between Parkinson's disease and living beside a golf club revealed by new study Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) LIVING near a golf course might come with more than just scenic views - it could carry a hidden health risk. A new study has revealed a troubling connection between proximity to golf courses and the likelihood of developing Parkinson's disease. Sign up for Scottish Sun newsletter Sign up 2 Living near a golf course may raise your risk of Parkinson's disease, a new study has found (stock image) Credit: Getty 2 Living within one mile of a golf course was linked to a 126% increase in odds of developing Parkinson (stock image) Credit: Getty The research focused on residents in southern Minnesota and western Wisconsin, where pesticide use on golf courses may be a key factor. Led by the Barrow Neurological Institute in Arizona, along with Mayo Clinic, the study analyzed 419 Parkinson's patients with a control group. Data from the Rochester Epidemiology Project between 1991 and 2015 helped researchers compare Parkinson's patients with a control group. The greatest risk was seen in people living one to three miles from a golf course and the expansive lawns that come with it. READ MORE ON HEALTH LAB 'COVER UP' WHO still have no idea what caused Covid - but refuse to rule out lab leak Living within one mile of a fairway was linked to a 126% increase in odds of developing Parkinson's, the study found. Those in water service areas that included a golf course had nearly double the risk compared to areas without one. The risk jumped 82% for people living in under water service areas that also had vulnerable groundwater. 'Pesticides applied to golf courses may play a role in the incidence of PD [Parkinson's disease] for nearby residents,' researchers concluded in the study, published in JAMA Network Open. 'The strongest effects were in municipal water service areas with a golf course and in regions with vulnerable groundwater based on the bedrock and topography,' lead author Brittany Krzyzanowski, Ph.D told Fox News. She added, 'We speculate that pesticides might play a role. However, we didn't include data on pesticides in this study, so future research is needed to better understand what's going on.' Peter Andre shares emotional moment he's reunited with his mum Thea who's battling Parkinson's and Alzheimer's Medical director of the MS Center at Holy Name Medical Center in New Jersey, Dr. Mary Ann Picone, who was not involved in the research, weighed in on the findings. 'There has often been discussion regarding risks for development of Parkinson's disease and environmental agents such as pesticides,' she told Fox News. 'Further research is needed with larger groups of patients, but this study does increase the concern about the association between pesticide exposure and risk of Parkinson's,' Picone added. She also warned that airborne exposure to pesticides could contribute to the risk. What is Parkinson's disease? PARKINSON'S is a progressive neurological condition. This means that it causes problems in the brain and gets worse over time. People with Parkinson's don't have enough of the chemical dopamine in their brain because some of the nerve cells that make it have stopped working. Around 145,000 people live with Parkinson's in the UK. It's the fastest growing neurological condition in the world. Symptoms start to appear when the brain can't make enough dopamine to control movement properly. This usually happens around the age of 50, but some people might see the first signs in their 40s. There are over 40 symptoms, but the three main ones are: A tremor (shaking) Slowness of movement Rigidity (muscle stiffness) There are several different treatments, therapies and support available to help manage the condition. Source: Parkinson's UK The study did not measure individual levels of pesticide exposure, which researchers noted as a limitation. 'There are many other aspects as well that can interfere with developing a disease,' said senior author Dr. Rodolfo Savica of the Mayo Clinic. Researchers admitted the results may not apply to all areas, since the study focused on a region with hot, humid summers where pesticide use may be higher. Other risk factors, like head injuries or genetics were also not considered in the study. DEVELOPING PARKINSON'S Krzyzanowski pointed out that Parkinson's can take decades to develop, so the focus was on exposure from years ago. 'If pesticides were involved, they would be the ones sprayed a long time ago and that might be different from what's being sprayed today,' she said. Picone echoed that point, adding the research looked at exposure going back to 2013 or earlier. The Golf Course Superintendents Association of America pushed back on the study's implications. 'Public health experts and researchers who have reviewed the study have noted that the study's methodological limitations make it difficult to draw conclusions from the data,' the group said in a statement. They added that all pesticides used on golf courses are registered by the EPA and don't create 'unreasonable adverse effects' when applied properly. Mayo Clinic's Savica said older adults should still enjoy being active and social. 'I recommend people continue to play sports outdoors and enjoy the sociality of any activity, including playing golf,' he said. But he also advised people to be cautious around areas where pesticide exposure may be possible.


Scottish Sun
2 days ago
- Scottish Sun
Common cough medicine could help protect against a form of dementia, new study finds
Click to share on X/Twitter (Opens in new window) Click to share on Facebook (Opens in new window) A COMMON cough medicine could help protect people with Parkinson's against dementia. Around 145,000 people in the UK have Parkinson's, a progressive brain disease that affects movement - but they're also more likely to develop certain forms of dementia. Sign up for Scottish Sun newsletter Sign up 1 A cough medicine prescribed for decades in Europe - called ambroxol - could stabilise the progression of Parkinson's dementia Credit: Getty Some people start to have problems with thinking, memory and perception. In fact, about a third with Parkinson's eventually develop dementia, according Alzheimer's Society. Now, researchers at Lawson Research Institute are investigating whether Ambroxol - a cough medicine used safely for decades in Europe - can slow dementia in people with Parkinson's disease. Lead author Dr Stephen Pasternak, a cognitive neurologist, said: "Our goal was to change the course of Parkinson's dementia. "This early trial offers hope and provides a strong foundation for larger studies." Ambroxol is an over-the-counter medicine that breaks up phlegm, making it easier to cough "with an excellent safety record", according to researchers. But it isn't currently approved in the UK, researchers said. The study - published in JAMA Neurology - involved 55 people over the age of 50, who'd had Parkinson's disease for at least a year before developing mild to moderate dementia. They were either given a daily dose of Ambroxol - 525mg or 1,050mg a day - or a placebo. Researchers assessed their memory, psychiatric symptoms, and the blood marker GFAP linked to brain damage. I saw a subtle change in my husband's run but never expected brain diagnosis They found that the drug was safe and well-tolerated among participants. Dementia symptoms worsened in the placebo group, they remained stable in those taking Ambroxol, scientists said. 'Individuals receiving placebo showed a clinically meaningful worsening in neuropsychiatric symptoms, whereas those receiving ambroxol remained stable,' researchers wrote. Ambroxol boosts levels of an enzyme called GCase, which is known to help clear away waste products which have gathered in brain cells. In Parkinson's, a build up of a troublesome protein called alpha-synuclein is often seen in the brain tissue. It's thought that ambroxol may help improve the body's ability to clear away these clumps of alpha-synuclein and prevent damage to brain cells. Participants with high risk variants of a key gene linked to dementia - called GBA1 - showed improved cognitive performance on Ambroxol, researchers added. Markers of brain cell damage, GFAP, also increased in the placebo group but stayed stable in those taking Ambroxol. What are the symptom's of Parkinson's dementia? Most people with Parkinson's dementia have symptoms very similar to those of dementia with Lewy bodies. These include: Problems with staying focused Difficulties with making decisions Memory loss and forgetfulness Problems with the way the person sees things around them As well as problems with memory and thinking, Parkinson's dementia also often causes: Problems staying fully awake Very disturbed sleep Visual hallucinations - seeing things which are not really there Delusions – thinking things that aren't true Changes in appetite Mood symptoms, such as depression, anxiety, or apathy Source: Alzheimer's Society This suggested the cough medicine may have the potential to protect the brain from Parkinson's-related decline. 'Ambroxol was safe, well-tolerated, and demonstrated target engagement,' scientists wrote, however adding that the drug's clinical effect on cognition was 'not confirmed' in the study. Dr Pasternak said: "Current therapies for Parkinson's disease and dementia address symptoms but do not stop the underlying disease. "These findings suggest Ambroxol may protect brain function, especially in those genetically at risk. It offers a promising new treatment avenue where few currently exist." Scientists hope the study's findings could pave the way for larger clinical trials that test the effectiveness of Ambroxol in slowing dementia symptoms. Dr Pasternak is now is now looking into whether boosting GCase with Ambroxol could help protect the brain in Parkinson's-related diseases. "This research is vital because Parkinson's dementia profoundly affects patients and families," he said. "If a drug like Ambroxol can help, it could offer real hope and improve lives." Ambroxol was first explored as a possible Parkinson's treatment in 2009. A trial supported by Parkinson's UK that's currently taking place will observe 330 people with Parkinson's as they take ambroxol - a placebo drug - over two yeas, to see if it is beneficial in the long-term.


Daily Mirror
4 days ago
- Daily Mirror
Furious Covid-19 bereaved demand justice for care homes ‘disgrace'
The Covid-19 Inquiry will on Monday hear from relatives prevented from saying their final goodbyes to loved ones in care homes, while parties were being held in Downing Street Families are demanding that politicians are held to account after describing their heartbreaking final moments with loved ones. This week the UK Covid-19 Inquiry will look at the impact of the pandemic on care homes and how social distancing guidelines meant many relatives were prevented from saying their final goodbyes. Families have told of their anger that ex-PM Boris Johnson 's government had at the same time been holding parties in Downing Street and flouting social distancing rules. The first wave of the pandemic saw the virus sweep through care homes as untested residents were sent there from struggling hospitals. During the first peak between March and June 2020 66,000 people died in care homes, with a third of those deaths attributed to Covid-19. Sharon Cook's parents were care home residents in Hinckley, Leicestershire, and died a week apart in 2020. Sharon, 60, told the Mirror: 'There was no even waving through the window for us because they were on the second floor. 'When we found out the government were having parties it just felt like we were being disrespected. You have to put your grief on hold because you're dealing with your anger because your loss is being disrespected. Then we had all the denials and all these countless thousands of deaths were kind of being written off as some sort of typing error. That government was a disgrace.' Sharon's mum Joan, aged 85, fell ill and had to be taken to hospital and a few days later tested positive for Covid and passed away. Her dad Alf Cook, 87, was a Parkinson's sufferer and was given the news in his care home. Sharon explained: 'Dad had been very much looked after by mum in the care home and suddenly she wasn't there. I think sometimes he thought he was the problem, not the pandemic, and that everyone was wearing masks because of him. 'I'm an only child and I was all he had but at that point there were no more visits. I was really upset about that because I just felt he needed me. He didn't take long then he died. I did wonder if he just gave up because I wasn't allowed in. You just get swamped by grief.' The Mirror revealed in November 2021 that gatherings had taken place in Downing Street when London was under tier 3 restrictions during 2020. They included a number of leaving parties and a Christmas party on December 18. Louise Baker, from Aberdeen, told the Mirror her father Sandy Adam died at his care home two days before the infamous Christmas party. Louise, 49, said: 'Before lockdown dad would come round our house every Sunday for dinner. He had dementia but it wasn't that far progressed that he didn't know who we were. 'After lockdown none of it made sense to him. Initially we could just shout in through a small gap in his tilt window but he was very hard of hearing. We couldn't hug him. I was extremely angry because we found out one of those parties in Downing Street coincided with my dad's death. I'm absolutely furious.' Sandy, a retired dentist, had been allowed a meeting on the car park with Louise before his death at the age of 81 but they were not allowed within five metres of each other. She explained: 'It was so difficult because he felt the cold quite acutely and he was really grumpy. You weren't allowed to hug and like to do anything normal and he couldn't hear us. He just sat there with his arms folded.' Sharon and Louise's accounts will be played today in an impact film at the start of Module 6 in front of inquiry chair Baroness Heather Hallett. Louise added: 'In the next pandemic there has to be a balance struck between the protection of the both people who are vulnerable to infections and their right to dignity and the right to human contact and their right to family life. I'm not pretending I have any of these answers but we need to find a balance. "There needs to be a recognition of the damage being done by the deprivation that people were experiencing, that level of isolation and the removal of basic rites of passage, like being able to see your loved one's body in their coffin.' Among the key government decisions being discussed at the inquiry from this week will be that in March 2020 to rapidly discharge hospital patients into care homes without testing or a requirement for them to isolate. A 2022 High Court judgement that ruled the policy was unlawful as it failed to take into account the risk to elderly and vulnerable care home residents of asymptomatic transmission of the virus. Between early March and early June 2020, nearly 20,000 care home residents in England and Wales died with Covid-19. That's about a third of all care home deaths during that period. Many bereaved care home families, including Sharon Cook, say their loved ones had Do Not Resuscitate - so called DNRs - placed on them against their wishes. Sharon said politicians should be held to account for their handling of the pandemic and subject to criminal proceedings if found to be negligent. She said: 'There needs to be greater accountability. I often say that if it was a pilot that had acted so recklessly and cost people their lives unnecessarily, or if it was a surgeon, there wouldn't be any question about, they would be interrogated and summoned to court. So why are politicians any different? 'It's not right that people with this much power can treat it with such little respect, have such devastating outcomes and no consequences.' Covid-19 Bereaved Families for Justice UK has written an open letter to the inquiry chair Baroness Hallett objecting to the fact that ex-PM Boris Johnson will not appear before the latest module about the social care sector. Jean Adamson, a spokesperson for Covid-19 Bereaved Families for Justice UK, said: 'Bereaved families have waited years for this moment. The care module is one of the most important parts of the Inquiry. It will examine how and why thousands of people were left unprotected in care homes and in the community, and why so many died without support, without dignity, and without accountability. 'But we are seriously concerned about the way this module is being handled. It is unacceptable that Boris Johnson and other key decision-makers will not be called to give evidence.' A Lancet study later found that during the first wave of the pandemic care homes residents were 17 times more likely to die compared to private home residents of a similar age. This compared to a ten times higher risk before the pandemic, as people in residential care are generally more frail and unwell. Covid bereaved families are expected to gather outside the opening of Module 6 of the inquiry today. The £200 million inquiry was set up to examine the impact of the Covid-19 pandemic, the UK's response to it and to learn lessons for the next pandemic. Its latest module on the social care sector will take place at Dorland House in Paddington, west London. Ben Connah, Secretary at the UK Covid-19 Inquiry, said: 'Sharon and Louise's stories are so powerful. Sadly, their experiences are not unique. Tens of thousands of people living in care lost their lives to Covid during the pandemic. 'This is why it is so important that the UK Covid-19 Inquiry spends the next five weeks investigating how the virus affected the care sector. Questions will be asked in public of key politicians, scientists, healthcare professionals and other experts. Our Chair, Baroness Heather Hallett, will get answers. 'We will begin with powerful evidence from bereaved individuals. Their experiences are front and centre of our hearings this week. 'The inquiry is making speedy progress. The country must learn the lessons of the last pandemic as quickly as possible - because we all know there will be another one.' This week the inquiry will investigate the impact of the pandemic on the publicly and privately funded adult social care sector in England, Scotland, Wales and Northern Ireland. It will start with opening statements from core participants and impact evidence from bereaved individuals before an appearance from former Health Secretary Matt Hancock on Wednesday.