Colorectal cancer rates in the US have increased ‘steeply', research finds
The recommended screening age was lowered from 50 to 45 in 2021 to encourage earlier detection, as early onset cases have nearly doubled in young adults under 55 over the past decade.
Colorectal cancer is the third leading cause of cancer deaths in the U.S., with over 154,000 new cases projected for this year.
While theories such as poor nutritional health and gut toxins are being explored, researchers have not yet identified a definitive cause for the surge in cases.
Experts predict that by 2030, colorectal cancer could become the leading cause of cancer death for individuals under 50, highlighting the need for increased public awareness and screening.
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Reuters
2 hours ago
- Reuters
Sandoz to offer generic weight-loss drugs in Canada at up to 70% discount, FT reports
Aug 5 (Reuters) - Swiss generic drug manufacturer Sandoz (SDZ.S), opens new tab plans to launch unbranded weight-loss drugs in Canada at discounts of up to 70% compared to branded versions once patents begin to expire next year, CEO Richard Saynor told the Financial Times. Sandoz is yet to finalise the pricing for its generic weight-loss and diabetes drug semaglutide, but a price cut of "60 or 70 per cent of the list price" was achievable, Saynor told the newspaper. Prices could drop further as more generic versions become available, Saynor said, noting, "If you were selling this at $40 or $50 a month, the market could be two or three times bigger in terms of the number of patients." Branded weight-loss and diabetes medications, such as Novo Nordisk's Ozempic and Wegovy, and Eli Lilly's Mounjaro and Zepbound, are currently priced between $200 and $400 for a one-month supply, according to the FT report. Novo Nordisk's medications use semaglutide as the active ingredient, while Eli Lilly's medications use tirzepatide. Sandoz did not immediately respond to a Reuters request for comment. The move comes as demand for weight-loss and diabetes drugs has surged globally, driven by their effectiveness in managing obesity and diabetes. Last month, a top Biocon executive told Reuters that the biopharmaceutical company aims to launch generic copies of the blockbuster weight-loss drug Wegovy in Canada within the next two years.
The Independent
2 hours ago
- The Independent
Takeaways from AP's report on problems in the worldwide campaign to eradicate polio
For nearly four decades, the World Health Organization and partners have been trying to rid the world of polio, a paralytic disease that has existed since prehistoric times. While cases have dropped more than 99%, polio remains entrenched in parts of Afghanistanand Pakistan. In its quest to eliminate the virus, WHO and its partners in the Global Polio Eradication Initiative have been derailed by mismanagement and what insiders describe as blind allegiance to an outdated strategy and a problematic oral vaccine, according to workers, polio experts and internal materials obtained by the Associated Press. Officials tout the successes – 3 billion children vaccinated, an estimated 20 million people who would have been paralyzed spared – while acknowledging challenges in Pakistan and Afghanistan. WHO polio director Dr. Jamal Ahmed defended progress in those two countries, citing workers' tailored response in resistant pockets. Here are some takeaways from AP's report on what's happened in one of the most expensive efforts in all of public health. Documents show major problems on polio vaccination teams Internal WHO reports reviewing polio immunization in Afghanistan and Pakistan over the past decade — given to AP by current and former staffers — show that as early as 2017, local workers were alerting problems to senior managers. The documents flagged multiple cases of falsified vaccination records, health workers being replaced by untrained relatives and workers improperly administering vaccines. On numerous occasions, WHO officials noted, 'vaccinators did not know about vaccine management,' citing failure to keep doses properly cold. They also found sloppy or falsified reporting, with workers noting 'more used vaccine vials than were actually supplied.' According to an August 2017 report from Kandahar, Afghanistan, vaccination teams worked 'in a hurried manner,' reports said, with 'no plan for monitoring." A team in Nawzad, Afghanistan, covered just half of the intended area in 2017, with 250 households missed entirely. Village elders said no one visited for at least two years. Polio workers say problems have gone unaddressed Health officials in Afghanistan and Pakistan told AP their efforts to vaccinate children are often stymied by cultural barriers, misinformation about the vaccines, and poverty. Sughra Ayaz has traveled door to door in southeastern Pakistan for the past decade, pleading for children to be immunized. Some families demand basics such as food and water instead of vaccines. Others, without citing proof for their beliefs, repeat false rumors and say they think the oral vaccine doses are meant to sterilize their kids. Ayaz said that given the immense pressure for the campaign to succeed, some managers have instructed workers to falsely mark children as immunized 'In many places, our work is not done with honesty,' she said. Some scientists blame the oral vaccine Polio eradication demands perfection — zero polio cases and immunizing more than 95% of children. But some scientists and former WHO staffers say the campaign's efforts are far from perfect, blaming in particular the oral vaccine. It's safe and effective, but in very rare instances, the live virus in the oral vaccine can paralyze a child. In even rarer cases, the virus can mutate into a form capable of starting outbreaks among unimmunized people where vaccination rates are low. Except for Afghanistan and Pakistan, most polio cases worldwide are linked to the vaccine; several hundred cases have been reported annually since 2021, with at least 98 this year. Most public health experts agree the oral vaccine should be pulled as soon as possible. But they acknowledge there isn't enough injectable vaccine — which uses no live virus and doesn't come with the risks of the oral vaccine — to eliminate polio alone. The injectable vaccine is more expensive and requires more training to administer. More than two dozen current and former senior polio officials told AP the agencies involved haven't been willing to even consider revising their strategy to account for campaign problems. Last year, former WHO scientist Dr. T. Jacob John twice emailed WHO Director-General Tedros Adhanom Ghebreyesus calling for a 'major course correction.' John wrote that 'WHO is persisting with polio control and creating polio with one hand and attempting to control it by the other.' Ahmed told AP the oral vaccine is a 'core pillar' of eradication strategy and that 'almost every country that is polio-free today used (it) to achieve that milestone.' Critics say there's no accountability Dr. Tom Frieden, who sits on an independent board reviewing polio eradication, said he and colleagues have urged WHO and partners to adapt to obstacles in Afghanistan and Pakistan. Since 2011, the board has issued regular reports about program failures, but had little impact. 'There's no management,' he said. With an annual budget of about $1 billion, polio eradication is among the most expensive initiatives in public health. WHO officials have privately admitted that sustaining funding will be difficult without signs of progress. Roland Sutter, who previously headed polio research at WHO, said donors had spent more than $1 billion in Pakistan trying to get rid of polio in the last five years — and made little progress. 'If this was a private company, we would demand results," he said. Ahmed pointed to the program's many successes. "Let's not overdramatize the challenges, because that leads to children getting paralyzed,' he said. Mistrust of the vaccine persists Vaccine workers and health officials say it's hard for campaign leadership to grasp the difficulties in the field. Door-to-door efforts are stymied by cultural barriers, unfounded stories about vaccines, and the region's poverty and transience. The campaign is up against a wave of misinformation, including that the vaccine is made from pig urine or will make children reach puberty early. Some blame an anti-vaccine sentiment growing in the U.S. and other countries that have largely funded eradication efforts. In a mountainous region of southeastern Afghanistan where most people survive by growing wheat and raising cows and chickens, many are wary of the Western-led initiative. A mother of five said she'd prefer that her children be vaccinated against polio, but her husband and other male relatives have instructed their families to reject it, fearing it will compromise their children's fertility. 'If I allow it,' the woman said, declining to be named over fears of family retribution, 'I will be beaten and thrown out.' Cheng reported from London. The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.
Daily Mail
2 hours ago
- Daily Mail
The beauty powder that has TikTok obsessed - with users noticing results in DAYS: 'People actually asked what I've been using'
Daily Mail journalists select and curate the products that feature on our site. If you make a purchase via links on this page we will earn commission - learn more If you have ever found yourself scrolling endlessly on TikTok, it is more than likely that you have seen the viral wellness brand Bloom Nutrition. Influencers, celebrities, and social media users alike have been seen blending up the brand's famous Greens & Superfoods Powder time and time again, with the amount of rave reviews seemingly endless. The popular brand is wowing users yet again with their Colostrum & Collagen Peptides powder that has been coined a 3-in-1 beauty supplement. The unique combination of colostrum, collagen, and supporting ingredients such as vitamins comes together to create a one-of-a-kind wellness experience. And the best part is it is only $30 on Amazon! Now let's get into the nitty-gritty. The uniqueness of the Colostrum & Collagen Peptides powder comes down to what it's made with. The daily powder, which can be mixed into any liquid, uses grass-fed Collagen, a probiotic blend, and bioactive colostrum. Together, these three major components are creating a versatile wellness supplement that aims to support a plethora of beauty concerns, including tighter skin, thicker hair, scalp health, and more. Plus, it remains a gut-positive powder similar to Bloom Nutrition's other viral products! Non-GMO, third-party tested, and sustainably sourced — the list of green flags when it comes to the secrets behind the Colostrum & Collagen Peptides powder is vast. Users agree, with one saying: 'The health benefits I saw after only taking this for 3 days were insane! Easy to mix with any drink, even water! Doesn't have any weird smell to throw it off, it's so effective!! Felt like it made my gut health improve tremendously.' The increasingly popular 3-in-1 beauty supplement currently comes in a non-flavored version and two other delicious options, Strawberries & Cream and Orange & Cream. The dessert-themed flavors have been a hit this summer with shoppers calling them 'nostalgic.' Never before has there been such a sweet wellness cheat code! One user of the Orange & Cream powder said: 'I originally purchased this from the store because colostrum seems to be all the rage, and I love the nostalgic flavor of orange cream. I'm looking to improve my skin, hair, and nails since I'm aging. 'I really like this... I'm noticing improvement over the last couple of months, and quite a few people actually asked what I've been using, so I'm sold!' Whether you are looking to support hair growth, get brighter skin, or aide your gut — Bloom nutrition's Colostrum & Collagen Peptides powder has your back.
