Tigers at Pirates Prediction: Odds, expert picks, starting pitchers, betting trends and stats for July 22
Pittsburgh took Game 1 of the series, 3-0 to break a three-game losing streak. Detroit is 1-3 since the break, like Pittsburgh, but the Tigers have scored three runs in four games compared to the Buccos' who scored 10.
Let's dive into the matchup and find a sweat or two. We've got all the info and analysis you need to know ahead of the game, including the latest info on how to catch first pitch, odds, recent team performance, player stats, and of course, our predictions, picks & best bets for the game from our modeling tools and staff of experts.
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Game details & how to watch Tigers at Pirates
Date: Tuesday, July 22, 2025
Time: 6:40PM EST
Site: PNC Park
City: Pittsburgh, PA
Network/Streaming: FDSNDT, SNP
Never miss a second of the action and stay up-to-date with all the latest team stats and player news. Check out our day-by-day MLB schedule page, along with detailed matchup pages that update live in-game with every out.
Odds for the Tigers at the Pirates
The latest odds as of Tuesday:
Moneyline: Tigers (-147), Pirates (+123)
Spread: Tigers -1.5
Total: 8.0 runs
Probable starting pitchers for Tigers at Pirates
Pitching matchup for July 22, 2025: Casey Mize vs. Mitch Keller
Tigers: Casey Mize, (9-3, 3.15 ERA)Last outing: 3.0 Innings Pitched, 6 Earned Runs Allowed, 6 Hits Allowed, 1 Walk, and 4 Strikeouts
Pirates: Mitch Keller, (3-10, 3.48 ERA)Last outing: 6.0 Innings Pitched, 1 Earned Runs Allowed, 4 Hits Allowed, 0 Walks, and 3 Strikeouts
Rotoworld still has you covered with all the latest MLB player news for all 30 teams. Check out the feed page right here on NBC Sports for headlines, injuries and transactions where you can filter by league, team, positions and news type!
Expert picks & predictions for tonight's game between the Tigers and the Pirates
Rotoworld Best Bet
Vaughn Dalzell (@VmoneySports) likes Paul Skenes to win NL CY Young over Zack Wheeler:
"Entering the All-Star break, Skenes had a 1.19 ERA in career wins compared to a 2.39 ERA in losses or non-decisions, so either way, he hasn't been the Buccos' problem since he arrived. This year alone, Skenes has allowed 27 runs over 20 starts and the Pirates have lost 11 of those 20 games!
Pittsburgh's offense has scored the fewest runs in not just the NL, but all of baseball — even the Rockies and White Sox. For more context, the Phillies have scored 112 more runs than the Pirates in one less game.
Both Skenes and Wheeler will be dominant in the second-half, I have no doubts, but Skenes could post a sub 2.00 ERA this season (was doing so through 19 starts), sub .200 OBA, and still have a losing record, which on surface level makes no sense.
Despite how it looks or sounds, I think what Skenes is doing weighs more impressive, challenging, and deserving than what Wheeler is doing."
Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.
Our model calculates projections around each moneyline, spread and over/under bet for every game on the MLB calendar based on data points like past performance, player matchups, ballpark information and weather forecasts.
Once the model is finished running, we put its projection next to the latest betting lines for the game to arrive at a relative confidence level for each wager.
Here are the best bets our model is projecting for Tuesday's game between the Tigers and the Pirates:
Moneyline: NBC Sports Bet is recommending a play on the Detroit Tigers on the Moneyline.
Spread: NBC Sports Bet is leaning towards a play ATS on the Pittsburgh Pirates at +1.5.
Total: NBC Sports Bet is recommending a play on the over on the Game Total of 8.0.
Want even more MLB best bets and predictions from our expert staff & tools? Check out the Expert MLB Predictions page from NBC.
Top betting trends & insights to know ahead of Tigers at Pirates
Detroit is 11-5 when Mize pitches this season
Pittsburgh is 6-14 when Keller pitches this season
The Tigers have won 24 of 41 games following a defeat
In 8 of the Pirates' last 10 games with Mitch Keller starting the Under has cashed
With Mitch Keller starting the Pirates have covered the Run Line in 7 of their last 9 games
If you're looking for more key trends and stats around the spread, moneyline and total for every single game on the schedule today, check out our MLB Top Trends tool on NBC Sports!
Follow our experts on socials to keep up with all the latest content from the staff:
Jay Croucher (@croucherJD)
Drew Dinsick (@whale_capper)
Vaughn Dalzell (@VmoneySports)
Trysta Krick (@Trysta_Krick)
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