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Ultra-processed foods linked to higher lung cancer risk, study finds—Here's what you need to know

Ultra-processed foods linked to higher lung cancer risk, study finds—Here's what you need to know

Mint2 days ago
A new study finds that high consumption of ultra-processed foods (UPFs) is associated with a 41% increased risk of lung cancer, including both NSCLC and SCLC subtypes. The large-scale analysis of over 101,000 US adults over 12 years showed the link was independent of smoking and overall diet quality.
Eating a lot of ultra-processed foods—like packaged snacks, sodas, and ready meals—may raise your risk of lung cancer by up to 41%, even if you don't smoke or eat healthy otherwise, the study shows.
The new study published in Thorax reveals that high consumption of ultra-processed foods (UPF) is linked to a significantly increased risk of lung cancer — including both non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) subtypes. This association was found to be independent of other risk factors, such as smoking status and overall diet quality.
The study, based on more than 100,000 US adults followed over 12 years, found a 41% increased risk of lung cancer among those who consumed the most UPFs.
UPFs are industrial formulations made predominantly from substances extracted from foods or synthesized chemically, containing additives, preservatives, and flavor enhancers, with minimal or no intact whole foods. Their widespread consumption, particularly in Western diets—where over half of the daily caloric intake comprises UPFs—raises concerns about their long-term health impacts.
In a large-scale study, researchers have found a significant link between higher consumption of ultra-processed foods (UPFs) and an increased risk of developing lung cancer. This association was found to be independent of other risk factors, such as smoking status and overall diet quality.
The research, which analysed data from over 101,000 adults over a mean follow-up period of 12.2 years, revealed the following statistics:
There were a total of 1,706 new cases of lung cancer identified during the study period.
Individuals in the highest quarter for UPF consumption had a 41% higher risk of developing lung cancer compared to those in the lowest quarter. This finding was statistically significant and held true even after adjusting for a wide range of variables. For NSCLC, those with the highest UPF consumption had a 37% higher risk.
For SCLC, this risk was even higher, at 44%.
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"So Much Pressure": World Nearly Beat Polio But Missteps Aided Its Comeback
"So Much Pressure": World Nearly Beat Polio But Missteps Aided Its Comeback

NDTV

time9 hours ago

  • NDTV

"So Much Pressure": World Nearly Beat Polio But Missteps Aided Its Comeback

Karachi: For the past decade, Sughra Ayaz has traveled door to door in southeastern Pakistan, pleading with parents to allow children to be vaccinated against polio as part of a global campaign to wipe out the paralytic disease. She hears their demands and fears. Some are practical - families need basics like food and water more than vaccines. Others are simply unfounded - the oral doses are meant to sterilize their kids. Amid rampant misinformation and immense pressure for the campaign to succeed, Ayaz said, some managers have instructed workers to falsely mark children as immunized. And the vaccines, which must be kept cold, aren't always stored correctly, she added. "In many places, our work is not done with honesty," Ayaz said. The World Health Organization and partners embarked on their polio campaign in 1988 with the bold goal of eradication - a feat seen only once for human diseases, with smallpox in 1980. They came close several times, including in 2021, when just five cases of the natural virus were reported in Pakistanand Afghanistan. But since then, cases rebounded, hitting 99 last year, and officials have missed at least six self-imposed eradication deadlines. Afghanistan and Pakistan remain the only countries where transmission of polio - which is highly infectious, affects mainly children under 5, and can cause irreversible paralysis within hours -- has never been interrupted. The worldwide campaign has focused most of its attention and funding there for the past decade. But in its quest to eliminate the disease, the Global Polio Eradication Initiative has been derailed by mismanagement and what insiders describe as blind allegiance to an outdated strategy and a problematic oral vaccine, according to workers, polio experts and internal materials obtained by The Associated Press. Officials have falsified vaccination records, selected unqualified people to dole out drops, failed to send out teams during mass campaigns, and dismissed concerns about the oral vaccinesparking outbreaks, according to documents shared with AP by staffers from GPEI - one of the largest and most expensive public health campaigns in history, with over $20 billion spent and nearly every country in the world involved. In Afghanistan and Pakistan - which share a border, harbor widespread mistrust of vaccines, and have weakened healthcare systems and infrastructure - local staffers like Ayaz have for years flagged problems to senior managers. But those issues, along with concerns by staffers and outside health officials, have long gone unaddressed, insiders say. Officials tout the successes - 3 billion children vaccinated, an estimated 20 million people who would have been paralyzed spared - while acknowledging challenges in Pakistan and Afghanistan. Remote villages are hard to reach, some cultural and religious authorities instruct against vaccination, and hundreds of polio workers and security staff have been killed because of their alignment with a Western-led initiative. Dr. Jamal Ahmed, WHO's polio director, defended progress in those two countries, citing workers' tailored response in resistant pockets. "There's so many children being protected today because of the work that was done over the past 40 years," he said. "Let's not overdramatize the challenges, because that leads to children getting paralyzed." Ahmed said he believes authorities will end the spread of polio in the next 12 to 18 months. Its latest goal for eradication is 2029. The campaign says about 45 million children in Pakistan and 11 million in Afghanistan must be vaccinated this year. Children typically need four doses of two drops each to be considered fully immunized. Dr. Zulfiqar Bhutta, who has served on advisory groups for WHO, the Gates Foundation and others, said campaign officials should listen to the criticism of its tactics. "Continuing blindly with the same strategies that we have relied on since eradication began is unlikely to lead to a different result," he said. Internal WHO reports reviewing vaccination drives in Afghanistan and Pakistan over the past decade - given to AP by current and former staffers - show that as early as 2017, local workers were alerting significant problems to senior managers. The documents flagged multiple cases of falsified vaccination records, health workers being replaced by untrained relatives and workers improperly administering vaccines. On numerous occasions, WHO officials noted, "vaccinators did not know about vaccine management," citing failure to keep doses properly cold. They also found sloppy or falsified reporting, with workers noting "more used vaccine vials than were actually supplied." According to an August 2017 report from Kandahar, Afghanistan, local government authorities and others interfered in choosing vaccinators, "resulting in the selection of underage and illiterate volunteers." Vaccination teams worked "in a hurried manner," reports said, with "no plan for monitoring or supervision." A team in Nawzad, Afghanistan, covered just half of the intended area in 2017, with 250 households missed entirely. Village elders said no one visited for at least two years. Vaccine workers and health officials in Afghanistan and Pakistan confirmed the issues in the documents and told AP it's hard for campaign leadership to grasp the difficulties in the field. Door-to-door efforts are stymied by cultural barriers, unfounded stories about vaccines, and the region's poverty and transience. "Most of the time when we go to vaccinate and knock on the door, the head of the house or the man is not at home," said one worker, speaking on condition of anonymity because they weren't authorized to talk to the press. "Many people find it offensive that a stranger knocks on the door and talks to a woman." Some workers find families have moved. Occasionally, they say, the encounter abuse. "We have shared these problems with our senior officials," the worker told AP. "They know about it." In an email response to AP's questions about officials' knowledge of the issues, WHO polio director Ahmed noted "operational challenges" in Afghanistan and Pakistan and said the program has "robust monitoring and evaluation processes." Worker Ayaz described "fake finger marking" - placing the ink used to show a child is vaccinated on their pinky even when no vaccine has been given. "There is so much pressure," Ayaz said. Before the first polio vaccine was developed in 1955, the disease - spread mostly from person to person, through contaminated water and via fecal particles - was among the world's most feared, paralyzing hundreds of thousands of children annually. People avoided crowded places during epidemics, and hospital wards filled with children encased in iron lungs after the virus immobilized their breathing muscles. Polio is mainly spread when people are exposed to water infected with the virus. In countries with poor sanitation, children often become infected when they come into contact with contaminated waste. WHO says that as long as a single child remains infected, kids everywhere are at risk. Eradication demands near-perfection - zero polio cases and immunizing more than 95% of children. But public health leaders and former WHO staffers say campaign efforts are far from perfect, and many question the oral vaccine. The oral vaccine - proven to be safe and effective - has been given to more than 3 billion children. But there are some extremely rare side effects: Scientists estimate that for every 2.7 million first doses given, one child will be paralyzed by the live polio virus in the vaccine. In even rarer instances, the live virus can mutate into a form capable of starting new outbreaks among unimmunized people where vaccination rates are low. Worldwide, several hundred vaccine-derived cases have been reported annually since at least 2021, with at least 98 this year. Most public health experts agree the oral vaccine should be pulled as soon as possible. But they acknowledge there simply isn't enough injectable vaccine - which uses no live virus and doesn't come with the risks of the oral vaccine - to wipe out polio alone. The injectable vaccine also is more expensive and requires more training to administer. More than two dozen current and former senior polio officials told AP the agencies involved haven't been willing to even consider revising their strategy to account for some of the campaign's problems. Dr. Tom Frieden, a former director of the U.S. Centers for Disease Control and Prevention who sits on an independent board reviewing polio eradication, said it would be impossible to eliminate polio without the oral vaccine. But he's urged authorities to find ways to adapt, such as adopting new methods to identify polio cases more quickly. Since 2011, he and colleagues have issued regular reports about overall program failures. "There's no management," he said, citing a lack of accountability. Last year, former WHO scientist Dr. T. Jacob John twice emailed WHO Director-General Tedros Adhanom Ghebreyesus calling for a "major course correction." John shared the emails with AP and said he's received no response. "WHO is persisting with polio control and creating polio with one hand and attempting to control it by the other," John wrote. In his response to AP, WHO polio director Ahmed said the oral vaccine is a "core pillar" of eradication strategy and that "almost every country that is polio-free today used (it) to achieve that milestone." "We need to step back and really care for the people," he said. "The only way we can do that in large parts of the world is with oral polio vaccine." Ahmed also pointed to the success WHO and partners had eliminating polio from India, once considered a nearly impossible task. In the four years before polio was wiped out there, health workers delivered about 1 billion doses of the oral vaccine to more than 170 million children. Today, nearly all of the world's polio cases -- mostly in Africa and the Middle East -- are mutated viruses from the oral vaccine, except for Afghanistan and Pakistan. Scott Barrett, a Columbia University professor, called for an inquiry into how things went so wrong - particularly with a failed effort in 2016, when authorities removed a strain from the oral vaccine. They miscalculated, leading to outbreaks in more than 40 countries that paralyzed more than 3,000 children, according to an expert report commissioned by WHO. Last year, a mutated virus traced to that effort paralyzed a baby in Gaza. "Unless you have a public inquiry where all the evidence comes out and WHO makes serious changes, it will be very hard to trust them," he said. With an annual budget of about $1 billion, the polio initiative is among the most expensive in all of public health. This year, the U.S. withdrew from WHO, and President Donald Trump has cut foreign aid. WHO officials have privately admitted that sustaining funding would be difficult without success. Some say the money would be better spent on other health needs. "We have spent more than $1 billion (in external polio funding) in the last five years in Pakistan alone, and it didn't buy us any progress," said Roland Sutter, who formerly led polio research at WHO. "If this was a private company, we would demand results." Villagers, too, have protested the cost, staging hundreds of boycotts of immunization campaigns since 2023. Instead of polio vaccines, they ask for medicine, food and electricity. In Karachi, locals told AP they didn't understand the government's fixation on polio and complained of other issues - dirty water, heroin addiction. Workers are accompanied by armed guards; Pakistani authorities say more than 200 workers and police assigned to protect them have been killed since the 1990s, mostly by militants. The campaign also is up against a wave of misinformation, including that the vaccine is made from pig urine or will make children reach puberty early. Some blame an anti-vaccine sentiment growing in the U.S. and other countries that have largely funded eradication efforts and say it's reaching even remote areas of Afghanistan and Pakistan. In suburban southwest Pakistan, Saleem Khan, 58, said two grandchildren under 5 were vaccinated over his family's objections. "It results in disability," said Khan, without citing evidence for his belief. "They are vaccinated because officials reported our refusal to authorities and the police." Svea Closser, professor of international health at Johns Hopkins University, said Pakistan and Afghanistan were less resistant to immunization decades ago. Now, people are angry about the focus on polio and lack of help for diseases like measles or tuberculosis, she said, spurring conspiracy theories. "Polio eradication has created a monster," Closser said. It doesn't help, she added, that in this region, public trust in vaccine campaigns was undermined when the CIA organized a fake hepatitis drive in 2011 in an attempt to get DNA and confirm the presence of Osama bin Laden or his family. Workers see that continued mistrust every day. In a mountainous region of southeastern Afghanistan where most people survive by growing wheat and raising cows and chickens, a mother of five said she'd prefer that her children be vaccinated against polio, but her husband and other male relatives have instructed their families to reject it. They believe the false rumors that it will compromise their children's fertility. "If I allow it," the woman said, declining to be named over fears of family retribution, "I will be beaten and thrown out." (Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)

This One Diet Change Helped People Lose Double Weight - No Calorie Counting Needed!
This One Diet Change Helped People Lose Double Weight - No Calorie Counting Needed!

India.com

time11 hours ago

  • India.com

This One Diet Change Helped People Lose Double Weight - No Calorie Counting Needed!

New Delhi: Following a healthy diet to lose weight? Make sure it's minimally processed, suggests a study, which showed that reducing processing could help to sustain a healthy weight. In a first, researchers from the University College London (UCL) nutritionally matched minimally processed (MPF) and ultra-processed (UPF) diets. The results, published in the journal Nature Medicine, showed that participants lost twice as much weight eating minimally processed foods compared to ultra-processed foods. 'The primary outcome of the trial was to assess percentage changes in weight, and on both diets, we saw a significant reduction, but the effect was nearly double on the minimally processed diet,' said Dr Samuel Dicken, first author of the study from the UCL Centre for Obesity Research. The trial split 55 adults into two groups. One group started with an eight-week diet of MPF, such as overnight oats or homemade spaghetti Bolognese. After a four-week 'washout' period during which participants went back to their normal diet, they switched to a diet of UPF, such as breakfast oat bars or a lasagne ready meal. The other group completed the diets in the opposite order. In total, 50 participants completed at least one diet. After eight weeks on each diet, both groups lost weight, likely as a result of the improved nutritional profile of what they were eating compared to their normal diet. However, this effect was higher (2.06 per cent reduction) on the MPF diet compared to the UPF diet (1.05 per cent reduction). The greater weight loss experienced on the MPF diet came from reductions in fat mass and total body water, with no change in muscle or fat-free mass, indicating a healthier body composition overall, explained the researchers. Further, there were also significantly greater improvements in the number of cravings and ability to resist them (craving control). On the MPF diet compared to the UPF diet, participants reported a two-fold greater improvement in overall craving control, a four-fold greater improvement in craving control for savoury food, and an almost two-fold greater improvement in resisting whichever food they most craved. The study "underlines the need to shift the policy focus away from individual responsibility and on to the environmental drivers of obesity, such as the influence of multinational food companies in shaping unhealthy food environments", said Professor Chris van Tulleken, from UCL Division of Infection and Immunity.

The world nearly beat polio. But fake records, an imperfect vaccine and missteps aided its comeback
The world nearly beat polio. But fake records, an imperfect vaccine and missteps aided its comeback

Time of India

time13 hours ago

  • Time of India

The world nearly beat polio. But fake records, an imperfect vaccine and missteps aided its comeback

Karachi: For the past decade, Sughra Ayaz has traveled door to door in southeastern Pakistan, pleading with parents to allow children to be vaccinated against polio as part of a global campaign to wipe out the paralytic disease. She hears their demands and fears. Some are practical - families need basics like food and water more than vaccines. Others are simply unfounded - the oral doses are meant to sterilize their kids. Amid rampant misinformation and immense pressure for the campaign to succeed, Ayaz said, some managers have instructed workers to falsely mark children as immunized. And the vaccines, which must be kept cold, aren't always stored correctly, she added. "In many places, our work is not done with honesty," Ayaz said. The World Health Organization and partners embarked on their polio campaign in 1988 with the bold goal of eradication - a feat seen only once for human diseases, with smallpox in 1980. They came close several times, including in 2021, when just five cases of the natural virus were reported in Pakistan and Afghanistan. But since then, cases rebounded, hitting 99 last year, and officials have missed at least six self-imposed eradication deadlines. Afghanistan and Pakistan remain the only countries where transmission of polio - which is highly infectious, affects mainly children under 5, and can cause irreversible paralysis within hours -- has never been interrupted. The worldwide campaign has focused most of its attention and funding there for the past decade. But in its quest to eliminate the disease, the Global Polio Eradication Initiative has been derailed by mismanagement and what insiders describe as blind allegiance to an outdated strategy and a problematic oral vaccine , according to workers, polio experts and internal materials obtained by The Associated Press. Officials have falsified vaccination records, selected unqualified people to dole out drops, failed to send out teams during mass campaigns, and dismissed concerns about the oral vaccine sparking outbreaks, according to documents shared with AP by staffers from GPEI - one of the largest and most expensive public health campaigns in history, with over $20 billion spent and nearly every country in the world involved. In Afghanistan and Pakistan - which share a border, harbor widespread mistrust of vaccines, and have weakened healthcare systems and infrastructure - local staffers like Ayaz have for years flagged problems to senior managers. But those issues, along with concerns by staffers and outside health officials, have long gone unaddressed, insiders say. Officials tout the successes - 3 billion children vaccinated, an estimated 20 million people who would have been paralyzed spared - while acknowledging challenges in Pakistan and Afghanistan. Remote villages are hard to reach, some cultural and religious authorities instruct against vaccination, and hundreds of polio workers and security staff have been killed because of their alignment with a Western-led initiative. Dr. Jamal Ahmed, WHO's polio director, defended progress in those two countries, citing workers' tailored response in resistant pockets. "There's so many children being protected today because of the work that was done over the past 40 years," he said. "Let's not overdramatize the challenges, because that leads to children getting paralyzed." Ahmed said he believes authorities will end the spread of polio in the next 12 to 18 months. Its latest goal for eradication is 2029. The campaign says about 45 million children in Pakistan and 11 million in Afghanistan must be vaccinated this year. Children typically need four doses of two drops each to be considered fully immunized. Dr. Zulfiqar Bhutta, who has served on advisory groups for WHO, the Gates Foundation and others, said campaign officials should listen to the criticism of its tactics. "Continuing blindly with the same strategies that we have relied on since eradication began is unlikely to lead to a different result," he said. Documents show yearslong problems on polio vaccination teams Internal WHO reports reviewing vaccination drives in Afghanistan and Pakistan over the past decade - given to AP by current and former staffers - show that as early as 2017, local workers were alerting significant problems to senior managers. The documents flagged multiple cases of falsified vaccination records, health workers being replaced by untrained relatives and workers improperly administering vaccines. On numerous occasions, WHO officials noted, "vaccinators did not know about vaccine management," citing failure to keep doses properly cold. They also found sloppy or falsified reporting, with workers noting "more used vaccine vials than were actually supplied." According to an August 2017 report from Kandahar, Afghanistan, local government authorities and others interfered in choosing vaccinators, "resulting in the selection of underage and illiterate volunteers." Vaccination teams worked "in a hurried manner," reports said, with "no plan for monitoring or supervision." A team in Nawzad, Afghanistan, covered just half of the intended area in 2017, with 250 households missed entirely. Village elders said no one visited for at least two years. Vaccine workers and health officials in Afghanistan and Pakistan confirmed the issues in the documents and told AP it's hard for campaign leadership to grasp the difficulties in the field. Door-to-door efforts are stymied by cultural barriers, unfounded stories about vaccines, and the region's poverty and transience. "Most of the time when we go to vaccinate and knock on the door, the head of the house or the man is not at home," said one worker, speaking on condition of anonymity because they weren't authorized to talk to the press. "Many people find it offensive that a stranger knocks on the door and talks to a woman." Some workers find families have moved. Occasionally, they say, the encounter abuse. "We have shared these problems with our senior officials," the worker told AP. "They know about it." In an email response to AP's questions about officials' knowledge of the issues, WHO polio director Ahmed noted "operational challenges" in Afghanistan and Pakistan and said the program has "robust monitoring and evaluation processes." Worker Ayaz described "fake finger marking" - placing the ink used to show a child is vaccinated on their pinky even when no vaccine has been given. "There is so much pressure," Ayaz said. Critics point to continued use of the oral polio vaccine Before the first polio vaccine was developed in 1955, the disease - spread mostly from person to person, through contaminated water and via fecal particles - was among the world's most feared, paralyzing hundreds of thousands of children annually. People avoided crowded places during epidemics, and hospital wards filled with children encased in iron lungs after the virus immobilized their breathing muscles. Polio is mainly spread when people are exposed to water infected with the virus. In countries with poor sanitation, children often become infected when they come into contact with contaminated waste. WHO says that as long as a single child remains infected, kids everywhere are at risk. Eradication demands near-perfection - zero polio cases and immunizing more than 95% of children. But public health leaders and former WHO staffers say campaign efforts are far from perfect, and many question the oral vaccine. The oral vaccine - proven to be safe and effective - has been given to more than 3 billion children. But there are some extremely rare side effects: Scientists estimate that for every 2.7 million first doses given, one child will be paralyzed by the live polio virus in the vaccine. In even rarer instances, the live virus can mutate into a form capable of starting new outbreaks among unimmunized people where vaccination rates are low. Worldwide, several hundred vaccine-derived cases have been reported annually since at least 2021, with at least 98 this year. Most public health experts agree the oral vaccine should be pulled as soon as possible. But they acknowledge there simply isn't enough injectable vaccine - which uses no live virus and doesn't come with the risks of the oral vaccine - to wipe out polio alone. The injectable vaccine also is more expensive and requires more training to administer. More than two dozen current and former senior polio officials told AP the agencies involved haven't been willing to even consider revising their strategy to account for some of the campaign's problems. Dr. Tom Frieden, a former director of the U.S. Centers for Disease Control and Prevention who sits on an independent board reviewing polio eradication, said it would be impossible to eliminate polio without the oral vaccine. But he's urged authorities to find ways to adapt, such as adopting new methods to identify polio cases more quickly. Since 2011, he and colleagues have issued regular reports about overall program failures. "There's no management," he said, citing a lack of accountability. Last year, former WHO scientist Dr. T. Jacob John twice emailed WHO Director-General Tedros Adhanom Ghebreyesus calling for a "major course correction." John shared the emails with AP and said he's received no response. "WHO is persisting with polio control and creating polio with one hand and attempting to control it by the other," John wrote. In his response to AP, WHO polio director Ahmed said the oral vaccine is a "core pillar" of eradication strategy and that "almost every country that is polio-free today used (it) to achieve that milestone." "We need to step back and really care for the people," he said. "The only way we can do that in large parts of the world is with oral polio vaccine." Ahmed also pointed to the success WHO and partners had eliminating polio from India, once considered a nearly impossible task. In the four years before polio was wiped out there, health workers delivered about 1 billion doses of the oral vaccine to more than 170 million children. Today, nearly all of the world's polio cases -- mostly in Africa and the Middle East -- are mutated viruses from the oral vaccine, except for Afghanistan and Pakistan. Scott Barrett, a Columbia University professor, called for an inquiry into how things went so wrong - particularly with a failed effort in 2016, when authorities removed a strain from the oral vaccine. They miscalculated, leading to outbreaks in more than 40 countries that paralyzed more than 3,000 children, according to an expert report commissioned by WHO. Last year, a mutated virus traced to that effort paralyzed a baby in Gaza. "Unless you have a public inquiry where all the evidence comes out and WHO makes serious changes, it will be very hard to trust them," he said. Mistrust of the polio eradication effort persists With an annual budget of about $1 billion, the polio initiative is among the most expensive in all of public health. This year, the U.S. withdrew from WHO, and President Donald Trump has cut foreign aid. WHO officials have privately admitted that sustaining funding would be difficult without success. Some say the money would be better spent on other health needs. "We have spent more than $1 billion (in external polio funding) in the last five years in Pakistan alone, and it didn't buy us any progress," said Roland Sutter, who formerly led polio research at WHO. "If this was a private company, we would demand results." Villagers, too, have protested the cost, staging hundreds of boycotts of immunization campaigns since 2023. Instead of polio vaccines, they ask for medicine, food and electricity. In Karachi, locals told AP they didn't understand the government's fixation on polio and complained of other issues - dirty water, heroin addiction. Workers are accompanied by armed guards; Pakistani authorities say more than 200 workers and police assigned to protect them have been killed since the 1990s, mostly by militants. The campaign also is up against a wave of misinformation, including that the vaccine is made from pig urine or will make children reach puberty early. Some blame an anti-vaccine sentiment growing in the U.S. and other countries that have largely funded eradication efforts and say it's reaching even remote areas of Afghanistan and Pakistan. In suburban southwest Pakistan, Saleem Khan, 58, said two grandchildren under 5 were vaccinated over his family's objections. "It results in disability," said Khan, without citing evidence for his belief. "They are vaccinated because officials reported our refusal to authorities and the police." Svea Closser, professor of international health at Johns Hopkins University, said Pakistan and Afghanistan were less resistant to immunization decades ago. Now, people are angry about the focus on polio and lack of help for diseases like measles or tuberculosis, she said, spurring conspiracy theories. "Polio eradication has created a monster," Closser said. It doesn't help, she added, that in this region, public trust in vaccine campaigns was undermined when the CIA organized a fake hepatitis drive in 2011 in an attempt to get DNA and confirm the presence of Osama bin Laden or his family. Workers see that continued mistrust every day. In a mountainous region of southeastern Afghanistan where most people survive by growing wheat and raising cows and chickens, a mother of five said she'd prefer that her children be vaccinated against polio, but her husband and other male relatives have instructed their families to reject it. They believe the false rumors that it will compromise their children's fertility. "If I allow it," the woman said, declining to be named over fears of family retribution, "I will be beaten and thrown out." Cheng reported from London.

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