Seniors With Diabetes Benefit From Intermittent Scanning CGM
METHODOLOGY:
Although real-time CGM has shown effectiveness in improving glycaemic control and preventing hypoglycaemia in older adult patients, the efficacy of is-CGM remains understudied in this population.
Researchers in the Netherlands conducted a retrospective case-control study to compare reductions in A1c levels between patients aged 60 years or older with type 1 or insulin-dependent type 2 diabetes who used is-CGM and those who did not.
They selected 353 patients (median age, 67 years; 59.8% men) from an outpatient clinic in Groningen; those who used is-CGM (n = 142) were matched with control individuals (n = 211) who did not use is-CGM on the basis of age, sex, type of diabetes, and insulin treatment modality.
Data were collected at baseline and 3, 6, 9, 12, and 24 months following the initiation of is-CGM, focusing on A1c levels and sensor usage.
The primary endpoint was the difference in A1c levels over time between is-CGM users and control individuals relative to their baseline values.
TAKEAWAY:
Median baseline A1c levels were 7.9% and 7.8% among is-CGM users and control individuals, respectively. After 3 months of initiating is-CGM, a significant reduction in A1c levels was observed among users compared with control individuals (unadjusted estimates, −0.5% vs −0.01%; P = .013), with reductions persisting throughout the study.
= .013), with reductions persisting throughout the study. After accounting for potential confounders, initiating is-CGM led to persistent statistically significant reductions in A1c levels at 6 months (−0.46%; P = .006) and 24 months (−0.39%; P = .033).
= .006) and 24 months (−0.39%; = .033). Device acceptance was notably high, with only 2.8% of users discontinuing is-CGM due to device-related reasons. No cases of diabetes-related complications were seen in both the groups.
IN PRACTICE:
"Together with the minimal number of discontinuations due to device-related reasons, our findings argue for the use of this technology in the elderly (60+) population with DM [diabetes mellitus]," the authors wrote.
SOURCE:
This study was led by Riemer A. Been, MD, University Medical Center Groningen, Groningen, the Netherlands. It was published online on May 13, 2025, in Diabetes, Obesity and Metabolism .
LIMITATIONS:
The distribution of patients with type 1 diabetes was not evenly balanced between control and is-CGM groups. The study defined older adults as those aged 60 years or older, which may not have adequately reflected the diversity within this population, especially since those aged 80 years or older were underrepresented. The single-centre design at an academic hospital in the Netherlands may have limited the generalisability of the results to other regions.
DISCLOSURES:
This study was funded by the European Foundation for the Study of Diabetes. One author reported receiving an unrestricted educational grant from the European Foundation for the Study of Diabetes mentorship programme supported by AstraZeneca. The remaining authors reported having no conflicts of interest.
Hashtags
Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
Yahoo
an hour ago
- Yahoo
Researchers make concerning discovery embedded in tissue of staple fish — here's what you need to know
A new study has made a concerning discovery in one of Bangladesh's favorite fish. Researchers found that hilsa — a staple in kitchens across the country — is contaminated with not only toxic heavy metals but also dangerous levels of plastic embedded in its muscle tissue, liver, and intestines. As reported by The Daily Star, hilsa fish have been found to contain microplastics — tiny pieces of plastic smaller than 5 millimeters — along with cadmium, lead, mercury, and arsenic. These particles come from plastic bags, bottles, synthetic fabrics, and other items that wash into rivers and oceans. Plastic production in Bangladesh increased by 169% between 2005 and 2014, which is significantly higher than the global average of 25%. Researchers estimated that the Ganges and its tributaries may be dumping up to 30 billion microplastic particles into the Bay of Bengal every day. Hilsa and other animals ingest these particles, which then enter the food chain and our bodies. And it's not just hilsa. A 2022 study found that 17 fish species and three types of shellfish from another area were also contaminated. That means an adult eating just 300 grams of fish a week could end up ingesting over 74,000 microplastic particles a year. This raises serious public health concerns for the millions of people who eat this fish every week. Microplastics have been linked to health problems such as inflammation, hormonal disruption, and potentially cancer. Contaminating such a common food source could harm the long-term well-being of the public. Plus, many contaminated areas are also economically dependent on fishing. As fish become more polluted, communities may see their livelihoods affected, meaning more families could end up struggling financially. Microplastics also harm wildlife and disturb ecosystems, which has a ripple effect across the food chain. Even though Bangladesh has a ban on single-use plastics, it's not always enforced. Plastic bags are still used, and waste continues to end up in rivers from both industrial sources and households. There are calls for the Bangladesh government to strengthen enforcement, raise awareness about plastic pollution, and make affordable alternatives available to the public. This isn't the first time researchers have raised red flags about toxic fish. Similar discoveries have been made in the U.S. and Europe, and efforts to curb plastic production are gaining steam around the world. But with plastic production still rising, experts agree that we need to act now before more of our food becomes contaminated. Environmental groups also help with ocean cleanups to remove plastic waste before it breaks down. Everyday people can do their part by using less plastic — from ditching plastic bags and bottles to supporting refillable product systems. Do you think America has a plastic waste problem? Definitely Only in some areas Not really I'm not sure Click your choice to see results and speak your mind. Join our free newsletter for good news and useful tips, and don't miss this cool list of easy ways to help yourself while helping the planet.
Gizmodo
2 hours ago
- Gizmodo
Why the Weather Is Literally Giving You a Headache
If you are one of the 39 million Americans in the U.S. living with migraines, there's a good chance an intense headache will begin when the weather shifts. You aren't alone. Studies find 30% to 50% of people with migraines identify some type of weather change as a trigger, making it the most commonly reported migraine source. Yet, it's also one of the most puzzling. As a neurologist and headache specialist practicing in Colorado, a place with frequent weather shifts, patients often tell me that weather is one of their biggest migraine triggers. The results can disrupt work, school and social plans, and create a sense of helplessness. Doctors still don't fully understand why some brains are more sensitive to environmental changes. What we do know is that people with migraines have especially sensitive nervous systems and that certain environmental changes—like shifts in air pressure, temperature, humidity, and air quality—can activate pathways in the brain that lead to pain. Weather triggers can vary from person to person, but there are a few common migraine culprits: Barometric pressure changes, or changes in atmospheric pressure, are among the most commonly cited triggers. When a storm system moves in, the air pressure drops. Some scientists believe this change may affect the pressure inside your head or how blood vessels in your brain dilate and constrict. One theory is that changes in barometric pressure may cause a small imbalance in the pressure between the inside of your skull and the outside environment. That might directly stimulate pain-sensitive nerves in the head, triggering inflammation and the start of a migraine. Others point to inflammation, the way the brain processes sensory input, and changes in serotonin levels – which play a key role in activating migraine. Temperature extremes, with very hot or very cold days, or sudden changes in temperature, can throw off the body's internal balance. High humidity or rapid shifts in moisture levels can have a similar effect. Air pollutants like ozone and nitrogen dioxide can cause inflammation in the nerves that play a role in migraines. Bright sunlight can also be especially bothersome, likely due to heightened sensitivity to light and an overactive visual processing system in the brain. Lightning and strong winds may also be linked to migraine attacks in certain individuals. In short, weather changes can act as stressors on a brain that's already wired to be more sensitive. The exact triggers and responses vary from person to person, but the research suggests that the interaction between weather and our biology plays a significant role for a subset of patients with migraines. You can't change the weather, but you can be proactive. Here are a few tips to help weatherproof your migraine routine: It's important to remember that while weather can be a trigger, it's rarely the only one. Migraine is usually the result of a perfect storm of factors: genetic susceptibility, hormones, stress, sleep, food, and, yes, the weather. That's why identifying your personal triggers and building a plan, if necessary, with the support of a medical provider, can make a big difference in managing migraines. Weather-related migraine can be one of the most frustrating triggers because it feels completely out of your hands. However, with knowledge, tracking, and the right treatment strategies, you can take back a sense of control. Danielle Wilhour, Assistant Professor of Neurology, University of Colorado Anschutz Medical Campus. This article is republished from The Conversation under a Creative Commons license. Read the original article.
Yahoo
3 hours ago
- Yahoo
Elon Musk Is Compared to a Dictator in Luca Guadagnino's New Movie
New details about Luca Guadagnino's Artificial movie, including what role will play in the film, have been revealed. It was announced last month that Guadagnino will direct a movie about OpenAI for Amazon MGM Studios. The film will revolve around the period at the artificial intelligence company in 2023 that saw CEO Sam Altman fired and rehired in a handful of days. The cast of the movie includes Andrew Garfield, Monica Barbaro, and Yura Borisov. According to Puck, Elon Musk's role as an 'early OpenAI investor turned bitter rival' is explored in the film, though it is not yet clear who will play him. 'He's a minor character, especially after he tries to merge OpenAI into Tesla and then pulls his investment when he's rebuffed,' the article notes. 'But Elon, as famous for loving movies as he is for suing people, is probably not gonna like this portrayal — nor, likely, will his Grok chatbot (Unfortunately for Grok, there are no pro-Hitler references in the script). At one point, Murati says of Musk: 'Elon's not so bad, as far as dictators go.'' Puck also reports that Artificial, which was written by Simon Rich, centers more on Ilya Sutskever than it does on Altman. 'The film, which begins rehearsals next week in Italy, with a planned 2026 release, is actually the story of Ilya Sutskever, the idealistic and naive Israeli machine learning engineer (played by Anora breakout Yura Borisov) who co-founded the nonprofit. After several key breakthroughs, as depicted in the script, Sutskever is leveraged, marginalized, and ultimately betrayed by both his power-hungry friend Altman and the larger Silicon Valley community — with potentially disastrous consequences for all of humanity.' It is worth noting that Puck got this information after reading a 'recent draft' of the Artificial script; meaning there could still be edits that are made, given that the movie is not yet in production. The post Elon Musk Is Compared to a Dictator in Luca Guadagnino's New Movie appeared first on - Movie Trailers, TV & Streaming News, and More.
