Breakthrough In Male Birth Control As Hormone-Free Pill Passes Human Safety Test
The daily pill, called YCT-529, works by blocking a vitamin A metabolite from binding to its receptor in the testes. It prevents sperm production without affecting hormone levels, the study revealed.
The phase 1 clinical trial was conducted on 16 healthy men who had undergone vasectomies. The results showed that the drug was well-tolerated with no serious adverse events reported.
The optimal dosage is expected to be around 180 mg, based on the trial results. However, further studies will determine the exact dosage. The trial did not assess the pill's efficacy in reducing sperm and preventing pregnancy, with the medicine developer, YourChoice Therapeutics, running trials to collect that data.
However, Dr Stephanie Page, an endocrinologist at the University of Washington School of Medicine, who wasn't involved in the study, said that the safety finding is a crucial milestone. "We really need more reversible contraceptive methods for men," Page said as quoted by Scientific American.
Animal studies have shown that fertility returns within 4-6 weeks after stopping the drug in mice and 10-15 weeks in non-human primates.
The pill would provide a safe, reversible and non-hormonal alternative to current male birth control methods, such as condoms and vasectomies.
"A safe and effective male pill will provide more options to couples for birth control," Gunda Georg, who is a professor in the University of Minnesota College of Pharmacy, said in a statement. The drug molecule was developed there. "It will allow a more equitable sharing of responsibility for family planning and provide reproductive autonomy for men."
The pill is currently in phase 2 clinical trials. It may take several years to become available on the market, if it gets approval. Other options in development include NES/T, a hormonal gel, and ADAM, a hydrogel implant that acts as a reversible vasectomy.
"The positive results from this first clinical trial laid the groundwork for a second trial, where men receive YCT-529 for 28 days and 90 days, to study safety and changes in sperm parameters," the study authors wrote in their paper.
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Hindustan Times
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It also has pure gold leaves that give your skin a radiant glow while improving elasticity and skin tone. Suitable for all skin types, this serum hydrates and moisturizes your skin, making it look naturally bright and healthy. Reasons to buy Reduce dark spots and dullness Suitable for all skin types Skin brightening properties Reasons to avoid Mixed reviews on effectiveness Click Here to Buy Lotus Herbals WhiteGlow Vitamin C and Gold Radiance Face Serum Loading Suggestions... CITTA Vitamin C Brightening Face Serum is made with a powerful triple-blend of vitamin C—3-O-ethyl ascorbic acid, sodium ascorbyl phosphate, and kakadu plum, to give your skin a bright, healthy glow. It helps reduce dark spots, evens out skin tone, and fades pigmentation. It is enriched with moringa extract, hyaluronic acid, and vitamin E it also hydrates your skin deeply and boosts collagen, making your skin look youthful and fresh. The serum has a lightweight, non-greasy texture that absorbs quickly and suits all skin types, including sensitive, dry, oily, and combination skin. It's safe to use every day, as it's free from parabens, mineral oils, toxins, and harsh chemicals. Plus, it's cruelty-free and gentle on the skin. Reasons to buy Triple brightening formula Lightweight and suitable for all skin types Cruelty-free Reasons to avoid Can interact with other actives Click Here to Buy CITTA 12% Vitamin C Brightening Face Serum – For Oily, Combination & Acne-Prone Skin – With Hyaluronic Acid, Promotes Glowing Skin – Fights Dark Spots, Pigmentation & Uneven Tone – Non-Comedogenic, Dermatologically Tested – 30ml What are the benefits of using a vitamin C serum for glowing and even-toned skin? 1. Brightens dull skin: Serums with ingredients like vitamin C, niacinamide, and alpha arbutin help reduce dullness and give your skin a radiant, healthy glow. 2. Fades dark spots and pigmentation: Regular use of serums may target dark spots, acne marks, and uneven pigmentation, helping you achieve a more even skin tone over time. 3. Hydrates and plumps skin: Most serums are enriched with hydrating agents like hyaluronic acid, which deeply moisturize your skin, making it soft, plump, and fresh-looking. 4. Lightweight yet powerful: Unlike heavy creams, serums absorb deeper into the skin, delivering active ingredients directly where they're needed most without feeling greasy. 5. Improves skin texture: With regular use, serums help refine your skin's texture, making it smoother, softer, and more supple. How to choose the best vitamin C serum for glowing skin in India? 1. Choose the right type of vitamin C: Look for stable and effective forms like L-ascorbic acid, ethyl ascorbic acid. These are known to brighten the skin and reduce dark spots. 2. Pick the correct concentration: Beginners can start with 5–10% vitamin C, while experienced users can go for 15–20% for faster results. Higher percentages may irritate sensitive skin. 3. Check additional ingredients: Ingredients like hyaluronic acid (hydration), vitamin E and ferulic acid (antioxidant boost), niacinamide (brightening), and aloe vera or glycerin (soothing) improve the serum's effectiveness. 4. Avoid harsh chemicals: Go for formulas that are free from parabens, sulfates, alcohol, and synthetic fragrance, especially if you have sensitive skin. 5. Check brand reputation and reviews: Choose products from brands that are dermatologically tested, have clear ingredient lists, and are well-reviewed by users. 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You can look for ingredients like vitamin C (for brightening), niacinamide (for even tone), hyaluronic acid (for hydration), alpha arbutin (for dark spots), and vitamin E (for antioxidant protection). Is serum suitable for all skin types? Yes, most serums are lightweight and designed to suit all skin types. Just make sure to choose a formula that matches your specific needs: hydrating for dry skin, oil-free for oily skin, and soothing for sensitive skin. Disclaimer: At Hindustan Times, we help you stay up-to-date with the latest trends and products. Hindustan Times has an affiliate partnership, so we may get a part of the revenue when you make a purchase. We shall not be liable for any claim under applicable laws, including but not limited to the Consumer Protection Act, 2019, with respect to the products. The products listed in this article are in no particular order of priority.
Time of India
2 days ago
- Time of India
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Trichy: Indian intervention led to the postponement of the Axiom Mission 4 launch originally scheduled for July 11, ensuring the safety of astronaut Shubanshu Shukla and three others, chairman of the Indian Space Research Organisation ( Isro ) and secretary of the department of space, V Narayanan, has said. Speaking at the 21st convocation of the National Institute of Technology, Trichy (NIT-T) here on Saturday, Narayanan recalled the original launch of Axiom Mission 4 was scheduled for June 11, but on the morning of June 10, a liquid oxygen leak in the booster engine of the rocket was detected. "The rocket, which was supposed to take into space along with Shubanshu Shukhla and three other astronauts from different countries, had developed a problem. It was the Indian team that raised concerns and ensured the launch was called off on the evening of June 10 at 5.15pm, as the rocket was deemed unsafe to fly. The cracks were later fixed, and the rocket successfully lifted off on June 25, placing all the astronauts safely in orbit," he said. "Every Indian must be proud that, through our education system, knowledge, and the support of Isro, we were able to call off a mission in time to ensure the safety of the astronauts. Today, it is part of history that they were launched and brought back safely," he added. The Isro chairman also presented a model of the GSLV Mk-3 rocket to the institution. Praising India's space efforts, he said, "We have so far launched six rockets, with the heaviest being the GSLV Mark-3 vehicle, through which we placed Chandrayaan-2 and Chandrayaan-3 in orbit, completed commercial missions, and launched 72 foreign satellites. The same rocket is now set to lift a 6,500kg communication satellite of the USA into orbit. It will also carry Indian crew members to space in 2027." NIT-T director G Aghila presented a report about the academic, research accomplishments and reiterated its 9th ranking in NIRF and 31st among all higher education institutions. A total of 2,045 degrees were awarded which includes 175 Phd, 5 MS, 483 MTech, 18 M Arch, 95 MBA, 109 MCA, 90 17 M A, 995 B tech and 58 B Arch. Earlier, speaking to reporters at Trichy airport, Narayanan said, "On July 30, the NASA-Isro synthetic aperture radar satellite will be launched using GSLV mark 2 vehicle. The satellite is jointly realised by India, Isro and JPL (USA). This satellite is going to be useful for the global community in earth observation and disaster mitigation areas. It is an important satellite, and it will be the 102nd launch from Indian soil. "
