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Is It Possible to Overdose on Ibuprofen?

Is It Possible to Overdose on Ibuprofen?

Health Line24-06-2025
Taking too much ibuprofen can result in an overdose. This can cause dangerous side effects such as damage to your stomach or intestines. In rare cases, an overdose can be fatal.
Ibuprofen is an over-the-counter nonsteroidal anti-inflammatory drug (OTC NSAID) used to relieve inflammation, fever, and mild pain.
People take this medication to treat:
headaches
back pain
toothaches
arthritis
menstrual cramps
fevers
Brand names for ibuprofen include Motrin and Advil.
You should always take ibuprofen exactly as directed on the label or as recommended by a doctor.
If you think that you or someone you know has overdosed on ibuprofen, contact your local poison center or your local emergency services. In the United States, you can reach the poison center by calling 1-800-222-1222.
Recommended dosage
Your recommended dose of ibuprofen depends on your age.
For adults
The recommended dosage for adults is one to two 200-milligram (mg) tablets (400 mg per dose) every four to six hours. Adults should not exceed 3200mg in 24 hours.
Adults over 65 years old should take as little ibuprofen as possible to manage their symptoms. Older adults have a higher risk of kidney and gastrointestinal side effects.
For children
To determine the safe dosage for children, you need to know the child's weight and the formulation of ibuprofen you're using.
Ibuprofen for children is available in:
infant drops
liquids
chewable tablets
Liquid measurements are given in milliliters (mL). Make sure to read the label and measure carefully.
Never give your child more than four doses in one day. The following chart shows how much ibuprofen a child can consume depending on their weight.
Weight 50-mg/1.25-mL infant drops dosage 100-mg/5-mL liquid dosage 50-mg/1 chewable tablet dosage
12 to 17 pounds 1.25 mL (50 mg) Ask your doctor Ask your doctor
18 to 23 pounds 1.875 mL (75 mg) Ask your doctor Ask your doctor
24 to 35 pounds 2.5 mL (100 mg) 5 mL (100 mg) 2 tablets (100 mg)
36 to 47 pounds 3.75 mL (150 mg) 7.5 mL (150 mg) 3 tablets (150 mg)
48 to 59 pounds 5 mL (200 mg) 10 mL (200 mg) 4 tablets (200 mg)
60 to 71 pounds n/a 12.5 mL (250 mg) 5 tablets (250 mg)
72 to 95 pounds n/a 15 mL (300 mg) 6 tablets (300 mg)
over 95 pounds n/a 20 mL (400 mg) 8 tablets (400 mg)
For babies
Do not give ibuprofen to children under 6 months old.
For infants ages 6 months to 1 year, the safe dose of the infant formulation depends on their weight.
Weight 50-mg/1.25-mL infant drops dosage
under 12 pounds Ask your doctor before administering this medication.
12 to 17 pounds 1.25 mL (50 mg)
18 to 23 pounds 1.875 mL (75 mg)
Drug interactions
Certain medications can increase your risk of having an overdose of ibuprofen.
According to research, do not take any of the following medications with ibuprofen without first talking with your doctor:
Selective serotonin reuptake inhibitors (SSRIs), which can interfere with the metabolism of NSAIDs while also increasing pain and bleeding
antihypertensives, which are medications for high blood pressure that may increase the risk of kidney damage
aspirin, which may increase the risk of serious side effects
diuretics (water pills), which increase the risk of kidney failure when combined with ibuprofen
lithium, which increases the risk of toxicity
methotrexate, which increases the risk of toxicity
anticoagulants (blood thinners), such as warfarin, because they can increase your risk of serious gastrointestinal bleeding
Mixing ibuprofen with alcohol can also increase your risk of having serious side effects, like stomach or intestinal bleeding.
Symptoms of an ibuprofen overdose
Not everyone will experience symptoms of an ibuprofen overdose right away. Some people won't have any visible symptoms at all.
If you do experience symptoms of an ibuprofen overdose, they're usually mild. Mild symptoms may include:
tinnitus (ringing in the ears)
heartburn
nausea
vomiting
stomach pain
diarrhea
dizziness
blurred vision
rash
sweating
Severe symptoms can include:
difficult or slow breathing
convulsions
hypotension (low blood pressure)
seizures
little to no urine production
severe headache
bleeding in the stomach
coma
What should you do if you suspect an overdose?
If you or someone you know has taken more than the maximum recommended dose of ibuprofen, contact your local poison center. In the United States, you can reach the poison center by calling 1-800-222-1222. You can call this number 24 hours a day. Stay on the line for further instructions.
If possible, have the following information ready:
the person's age, height, weight, and gender
how much ibuprofen was ingested
when the last dose was taken
whether the person also took other drugs, supplements, or had any alcohol
You can also receive guidance by using the poison center's webPOISONCONTROL online tool.
TIP
Text 'POISON' to 202-677-7600 to save the contact information for poison control to your smartphone.
If you can't access a phone or computer, go to the nearest emergency room immediately. Do not wait until symptoms start. Some people who overdose on ibuprofen will not show symptoms right away.
Treating an overdose
At the hospital, doctors will monitor breathing, heart rate, and other vital signs. A doctor may insert a tube through the mouth to look for internal bleeding.
You may also receive the following treatments:
medications that make you throw up
decontamination of the stomach with activated charcoal
benzodiazepines to control seizures
breathing support, such as oxygen or a breathing machine (ventilator)
intravenous fluids
antihypertensive medications to reduce blood pressure
Children who consume more than 400 mg/kilogram (kg) of ibuprofen are at a higher risk of overdose and will likely require hospitalization. If they consume 100 mg/kg or less, they may be monitored at home.
Complications of an ibuprofen overdose
An overdose of ibuprofen can cause severe problems in the gastrointestinal tract. These include:
inflammation
bleeding
ulcers
stomach or intestinal perforation, which can be fatal
liver or kidney failure
Taking high doses of ibuprofen over long periods of time can also increase your risk of having a stroke or heart attack.
Takeaway
Taking too much ibuprofen can result in an overdose.
With prompt medical treatment, you're likely to recover from an ibuprofen overdose. However, some people develop liver, kidney, or stomach issues. People with a prior history of ulcers or gastrointestinal bleeding should not take NSAIDS like ibuprofen.
Always read product labels carefully and take the smallest amount of ibuprofen possible that will help relieve your symptoms.
An adult should not take more than 3,200 mg of ibuprofen per day. A safe dose for children is much less than that. If you or someone you know has taken more than the recommended dose, call your local poison center or your local emergency services.
If you experience symptoms of an ulcer after taking ibuprofen, stop taking ibuprofen and call a doctor.
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The information in this press release should be read in conjunction with a review of the company's filings with the SEC including the information in the company's most recent Annual Report on Form 10-K under the heading "MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS". - End of Text - - Tables to Follow - LABCORP HOLDINGS INC. AND SUBSIDIARIES CONSOLIDATED STATEMENTS OF OPERATIONS (In Millions, Except Per Share Data) Three Months Ended June 30,Six Months Ended June 30,2025202420252024 Revenues $ 3,527.3$ 3,220.9$ 6,872.4$ 6,397.5 Cost of revenues 2,481.12,294.54,878.24,573.8 Gross profit 1,046.2926.41,994.21,823.7 Selling, general, and administrative expenses 579.3557.81,125.31,066.2 Amortization of intangibles and other assets 68.362.2137.9122.3 Goodwill and other asset impairments ———2.5 Restructuring and other charges 4.111.610.516.6 Operating income 394.5294.8720.5616.1 Other (expense) income:Interest expense (57.1)(47.6)(113.1)(94.5) Investment income 1.71.38.24.2 Equity method loss, net (1.7)(0.3)(2.0)(0.2) Other, net (32.7)19.5(33.7)39.5 Earnings from operations before income taxes 304.7267.7579.9565.1 Provision for income taxes 66.462.1128.6131.2 Net earnings 238.3205.6451.3433.9 Less: Net earnings attributable to the noncontrolling interest (0.4)(0.3)(0.6)(0.6) Net earnings attributable to Labcorp Holdings Inc. $ 237.9$ 205.3$ 450.7$ 433.3 Earnings per common share:Basic earnings per common share $ 2.85$ 2.44$ 5.40$ 5.15 Diluted earnings per common share $ 2.84$ 2.43$ 5.36$ 5.13 Weighted-average basic common shares outstanding 83.484.183.584.1 Weighted-average diluted common shares outstanding 83.984.384.184.5 LABCORP HOLDINGS INC. AND SUBSIDIARIES CONSOLIDATED BALANCE SHEETS (In Millions) June 30, 2025December 31, 2024 ASSETSCurrent assets:Cash and cash equivalents $ 647.3$ 1,518.7 Accounts receivable, net 2,120.61,944.1 Unbilled services 156.1152.9 Supplies inventory 508.1493.2 Prepaid expenses and other 655.1697.6 Total current assets 4,087.24,806.5 Property, plant, and equipment, net 3,133.83,045.4 Goodwill, net 6,551.16,369.7 Intangible assets, net 3,494.43,488.9 Joint venture partnerships and equity method investments 160.416.3 Other assets, net 633.0652.2 Total assets $ 18,059.9$ 18,379.0 LIABILITIES AND SHAREHOLDERS' EQUITYCurrent liabilities:Accounts payable $ 793.0$ 875.8 Accrued expenses and other 835.8871.2 Unearned revenue 398.0392.2 Short-term operating lease liabilities 186.1184.6 Short-term finance lease liabilities 4.36.1 Short-term borrowings and current portion of long-term debt 499.61,000.3 Total current liabilities 2,716.83,330.2 Long-term debt 5,077.35,331.2 Operating lease liabilities 713.1676.3 Financing lease liabilities 65.674.3 Deferred income taxes and other tax liabilities 354.5383.1 Other liabilities 643.2517.4 Total liabilities 9,570.510,312.5 Commitments and contingent liabilitiesNoncontrolling interest 16.714.3 Shareholders' equity:Common stock, 82.9 and 83.4 shares outstanding at June 30, 2025, and December 31, 2024, respectively 7.57.6 Additional paid-in capital 1.82.8 Retained earnings 8,498.08,303.4 Accumulated other comprehensive loss (34.6)(261.6) Total shareholders' equity 8,472.78,052.2 Total liabilities and shareholders' equity $ 18,059.9$ 18,379.0 LABCORP HOLDINGS INC. AND SUBSIDIARIES CONSOLIDATED STATEMENTS OF CASH FLOWS (In Millions) Three Months Ended June 30,Six Months Ended June 30,2025202420252024 CASH FLOWS FROM OPERATING ACTIVITIES:Net earnings $ 238.3$ 205.6$ 451.3$ 433.9 Adjustments to reconcile net earnings to net cash provided by operating activities:Depreciation and amortization 170.3156.9337.1311.4 Stock compensation 34.130.866.962.4 Operating lease right-of-use asset expense 50.844.599.488.6 Goodwill and other asset impairments ———2.5 Deferred income taxes (6.1)(19.6)(12.2)(39.1) Other, net 38.039.646.136.6 Change in assets and liabilities (net of effects of acquisitions and divestitures):Decrease (increase) in accounts receivable 30.9(5.1)(139.9)(192.2) Decrease (increase) in unbilled services 0.9(37.1)4.826.8 (Increase) decrease in supplies inventory (11.9)28.3(3.5)27.7 Decrease in prepaid expenses and other 12.846.557.821.6 Increase (decrease) in accounts payable 67.069.4(80.6)(51.7) Increase (decrease) in unearned revenue 0.210.8(8.7)(30.8) Decrease in accrued expenses and other (4.7)(9.5)(179.4)(166.4) Net cash provided by operating activities 620.6561.1639.1531.3 CASH FLOWS FROM INVESTING ACTIVITIES:Capital expenditures (77.9)(128.2)(203.9)(262.0) Proceeds from sale of assets 1.90.12.40.2 Proceeds from sale or distribution of equity affiliates or other investments 6.9—6.9— Proceeds from sale of business ———13.5 Purchase of equity affiliates or other investments (15.0)(23.0)(172.0)(36.7) Acquisition of businesses, net of cash acquired (10.0)(33.9)(63.5)(293.1) Net cash used for investing activities (94.1)(185.0)(430.1)(578.1) CASH FLOWS FROM FINANCING ACTIVITIES:Payments on senior notes ——(1,000.0)— Proceeds from revolving credit facilities —698.764.8951.9 Payments on revolving credit facilities —(721.3)(64.8)(932.1) Proceeds from accounts receivable securitization ——225.0— Net share settlement tax payments from issuance of stock to employees (3.5)(23.1)(29.0)(37.8) Net proceeds from issuance of stock to employees ——25.726.7 Dividends paid (59.9)(60.4)(121.5)(122.5) Purchase of common stock (200.0)(100.0)(200.0)(100.0) Other, net (4.0)(3.9)(7.3)(7.9) Net cash used for financing activities (267.4)(210.0)(1,107.1)(221.7) Effect of exchange rate changes on Cash and cash equivalents 18.8(0.3)26.7(3.2) Net increase (decrease) in Cash and cash equivalents 277.9165.8(871.4)(271.7) Cash and cash equivalents at beginning of period 369.499.31,518.7536.8 Cash and cash equivalents at end of period $ 647.3$ 265.1$ 647.3$ 265.1 LABCORP HOLDINGS INC. AND SUBSIDIARIES Condensed Combined Non-GAAP Segment Information (Dollars in Millions) Three Months Ended June 30,Six Months Ended June 30,2025202420252024 Diagnostics LaboratoriesRevenues $ 2,748.8$ 2,524.9$ 5,378.4$ 5,004.6 Adjusted operating income $ 482.8$ 441.5$ 910.3$ 859.4 Adjusted operating margin 17.6 %17.5 %16.9 %17.2 % Biopharma Laboratory ServicesRevenues $ 784.8$ 707.0$ 1,506.1$ 1,417.9 Adjusted operating income $ 123.3$ 107.4$ 230.2$ 207.3 Adjusted operating margin 15.7 %15.2 %15.3 %14.6 % ConsolidatedRevenues $ 3,527.3$ 3,220.9$ 6,872.4$ 6,397.5 Adjusted segment operating income $ 606.1$ 548.9$ 1,140.5$ 1,066.7 Unallocated corporate expense (74.5)(69.0)$ (139.9)$ (134.0) Consolidated adjusted operating income $ 531.6$ 479.9$ 1,000.6$ 932.7 Adjusted operating margin 15.1 %14.9 %14.6 %14.6 % The consolidated revenue and adjusted segment operating income are presented net of intersegment transaction eliminations and other amounts not used in determining segment performance. Adjusted operating income and adjusted operating margin are non-GAAP measures. See the subsequent reconciliation of non-GAAP financial measures. LABCORP HOLDINGS INC. AND SUBSIDIARIES Reconciliation of Non-GAAP Measures (Dollars and Shares in Millions, Except Per Share Data) Three Months Ended June 30,Six Months Ended June 30, 2025202420252024Adjusted Operating Income Operating income$ 394.5$ 294.8$ 720.5$ 616.1 Amortization of intangibles and other assets (a)68.362.2137.9122.3 Restructuring and other charges (b)4.111.610.516.6 Acquisition and disposition-related costs (c)15.125.144.246.0 Launchpad costs (d)17.231.537.340.4 Asset impairments (e)———2.5 Other31.931.846.443.5 TSA reimbursement (f)0.522.93.845.3 Adjusted operating income$ 531.6$ 479.9$ 1,000.6$ 932.7Adjusted operating profit margin15.1 %14.9 %14.6 %14.6 %Adjusted Net Income Net income$ 237.9$ 205.3$ 450.7$ 433.3 Impact of adjustments to operating income137.1185.1280.1316.6 Loss on venture fund investments, net (g)32.71.536.15.7 Gain on sale of business (h)———(4.9) TSA reimbursement (f)(0.5)(22.9)(3.8)(45.3) Other 0.70.30.70.3 Income tax impact of adjustments (i)(43.4)(37.3)(75.3)(61.5) Adjusted net income$ 364.5$ 332.0$ 688.5$ 644.2Weighted-average diluted common shares outstanding83.984.384.184.5Adjusted net income per share$ 4.35$ 3.94$ 8.19$ 7.62 (a) Amortization of intangible assets acquired as part of business acquisitions. (b) Restructuring and other charges represent amounts incurred in connection with the elimination of redundant positions and facilities and contract termination costs within the organization in connection with our LaunchPad initiatives, and acquisitions or dispositions of businesses by the company. (c) Acquisition and disposition-related costs include due-diligence legal and advisory fees, retention bonuses, impact of delayed contract or license transfers, and other integration or disposition related activities. (d) LaunchPad costs include non-capitalized costs associated with the implementation of systems, consolidation of processes, and consulting costs incurred as part of various business process improvement initiatives. (e) The company impaired certain fixed assets which are no longer realizable by the business. (f) Represents transition services fees charged to Fortrea Holdings Inc. related to administrative and IT systems support. The costs to provide these services are included in operating income but the service fees are included in other income. (g) The company makes investments in companies or investment funds developing promising technology related to its operations. The company recorded net gains and losses related to several distributions from venture funds, increases in the market value of investments, and impairments of other investments due to the underlying performance of the investments. (h) The company recorded a gain on the disposition of the Beacon Laboratory Benefits Solutions business. (i) Income tax impact of adjustments calculated based on the tax rate applicable to each item. View original content to download multimedia: SOURCE Labcorp Holdings Inc

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