
Nearby Sculptor galaxy revealed in ultra-detail
The Sculptor galaxy is similar in many respects to our Milky Way. It is about the same size and mass, with a similar spiral structure. But while it is impossible to get a full view of the Milky Way from the vantage point of Earth because we are inside the galaxy, Sculptor is perfectly positioned for a good look.
Astronomers have done just that, releasing an ultra-detailed image of the Sculptor galaxy on Wednesday obtained with 50 hours of observations using one of the world's biggest telescopes, the European Southern Observatory's Chile-based Very Large Telescope.
The image shows Sculptor, also called NGC 253, in around 4000 different colours, each corresponding to a specific wavelength in the optical spectrum.
Because various galactic components emit light differently across the spectrum, the observations are providing information at unprecedented detail on the inner workings of an entire galaxy, from star formation to the motion of interstellar gas on large scales. Conventional images in astronomy offer only a handful of colours, providing less information.
The researchers used the telescope's Multi Unit Spectroscopic Explorer, or MUSE, instrument.
"NGC 253 is close enough that we can observe it in remarkable detail with MUSE, yet far enough that we can still see the entire galaxy in a single field of view," said astronomer Enrico Congiu, a fellow at the European Southern Observatory in Santiago, and lead author of research being published in the journal Astronomy & Astrophysics.
"In the Milky Way, we can achieve extremely high resolution, but we lack a global view since we're inside it. For more distant galaxies, we can get a global view, but not the fine detail.
"That's why NGC 253 is such a perfect target: it acts as a bridge between the ultra-detailed studies of the Milky Way and the large-scale studies of more distant galaxies. It gives us a rare opportunity to connect the small-scale physics with the big-picture view."
Sculptor is about 11 million light-years from Earth, making it one of the closest big galaxies to the Milky Way. A light-year is the distance light travels in a year, 9.5 trillion km.
Like the Milky Way, it is a barred spiral galaxy, meaning it has an elongated structure extending from its nucleus, with spiral arms extending from the ends of the bar. Its diameter of about 88,000 light-years is similar to the Milky Way's, as is its total mass. One major difference is Sculptor's rate of new star formation, estimated to be two to three times greater than that of the Milky Way.
Nearly 30 per cent of this star formation is happening near the galaxy's nucleus in what is called a starburst region, as revealed in colourful emissions shown in the new image.
The observations have given information on a wide range of properties such as the motion, age and chemical composition of stars and the movement of interstellar gas, an important component of any galaxy.
"Since the light from stars is typically bluer if the stars are young or redder if the stars are old, having thousands of colours lets us learn a lot about what stars and populations of stars exist in the galaxy," said astronomer Kathryn Kreckel of Heidelberg University in Germany, a study co-author.
"Similarly for the gas, it glows in specific bright emission lines at very specific colours, and tells us about the different elements that exist in the gas, and what is causing it to glow," Kreckel said.
The initial research being published from the observations involves planetary nebulae, which are luminous clouds of gas and dust expelled by certain dying stars. Despite their name, they have nothing to do with planets. These nebulae can help astronomers measure the precise distances of faraway galaxies.
The researchers marveled at the scientific and aesthetic value of the new view of Sculptor.
"I personally find these images amazing," Congiu said.
"What amazes me the most is that every time I look at them, I notice something new - another nebula, a splash of unexpected colour or some subtle structure that hints at the incredible physics behind it all."
Hashtags

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles

The Age
13 hours ago
- The Age
Ozempic in a pill? The next generation of weight-loss drugs emerges
'The development of GLP-1 and incretin-based drugs has revolutionised the space. It has carved out the biggest class of drugs ever. And it has the power to truly revolutionise our health-span,' said Associate Professor Garron Dodd, head of the Metabolic Neuroscience Research Laboratory at the University of Melbourne and founder of Gallant Bio, which is developing its own obesity drugs. 'It's a glorious dawn, but it's just the start.' Weight loss in a pill Much as our eyes and ears sense the world and send data to our brains, our digestive tracts need ways of sending back data on what they are eating, and how much. They do this, in part, by secreting various chemical signals – hormones. Glucagon-like peptide-1 is secreted by the intestines and triggers the pancreas to produce insulin. The first GLP-1 drugs took advantage of this to become powerful treatments for diabetes. But GLP-1 has much wider effects beyond blood-sugar control. Receptors for the hormone spread throughout the body, even in the brain, where they trigger a feeling of fullness and decrease appetite. A once-weekly dose of semaglutide, plus lifestyle changes, led volunteers in a phase 3 trial to lose 14.9 per cent of their body weight over 15 months. GLP-1 drugs like Wegovy essentially copy that human hormone. That makes them fragile. They need to be kept refrigerated, and injected subcutaneously rather than taken by mouth – as the stomach's acid would quickly break them down. An oral version of semaglutide has been developed, but only 1 per cent of the drug actually makes its way to the target receptors, and it appears less effective than the injectable version for weight loss. Loading Researchers at Japan's Chugai Pharmaceutical Co figured out a way around this problem. They designed a small molecule that can bind to the same receptor as GLP-1 and trigger it. It mimics the effect without mimicking the structure. 'It's a development I never would have thought feasible,' said Professor Michael Horowitz, a University of Adelaide researcher who authored a commentary on the drug in the Lancet. Chugai licensed the molecule to US-based Eli Lilly in 2018. Last week, the company reported participants on the highest dose in a clinical trial lost 7.9 per cent of their body weight over 40 weeks. The full details of the trial have not yet been reported, and whether the weight loss is maintained over the longer term is unclear. More than a quarter of patients reported diarrhoea, 16 per cent nausea and 14 per cent vomiting. The preliminary results are 'close enough to broadly call it similar' to semaglutide, said Professor Jonathan Shaw, who led the Australian arm of Lilly's trial at the Baker Heart and Diabetes Institute in Melbourne. 'I don't think we can confidently say it's better or worse. It's definitely in the same ballpark.' It's also not known if the drug will offer the range of other benefits that GLP-1 inhibitors provide in addition to weight loss, like reductions in cardiovascular disease and Alzheimer's risk (and maybe even addictive behaviours). Horowitz said the efficacy data was promising, but he wanted to see more information about adverse effects, which he said were understated generally across semaglutide trials because they relied on patients to report their own side effects. 'It hasn't served the interests of pharma to quantify how well this is tolerated.' Pfizer was developing a similar once-daily GLP-1 pill but cancelled the program in April after a patient in a clinical trial suffered liver damage. A pill should, theoretically, be cheaper and easier to make than an injector – Novo Nordisk, maker of Wegovy and its diabetes drug antecedent Ozempic, has struggled to keep up with demand for semaglutide – and dramatically easier to transport. At present, the drug must be kept refrigerated right from European factories to a patient's home. 'That all adds to the cost,' said Shaw. There could also be cost benefits from increased competition as more drugs are approved – possibly pushing the price down far enough for governments to consider subsidising it. Lilly expects to apply for regulatory approval for the drug later this year. While orforglipron has attracted the most excitement – Eli Lilly's shares have surged since they announced the trial results – it is just one of several new drugs in late-stage development. These drugs might be of particular value to 15 per cent or so of people whose bodies do not seem to respond to semaglutide. And people don't seem to stay on the injectable drugs – less than half are still using them a year later, per a study 2024 study – despite the fact weight rebound is likely if you stop using them. 'Is it the injection? Is it the cost? Or is it due to adverse effects? We don't know,' said Horowitz. The new drugs might also offer weight-loss benefits. Mounjaro, for example, mimics both GLP-1 and the gastric inhibitory polypeptide, which increases metabolism and appears to lead to better weight-loss results. The new drugs, like Lilly's retatrutide, target even more receptors, with the hope of even greater effects. It's all good news for Rochelle McDonald. She does not mind taking a weekly injection – 'the stabby-stab' – now she's found ways of coping with the side effects. But paying $240 a month for her current dose of the medicine is 'a commitment in itself'. 'I think a daily pill would be good,' she said. 'If it comes in at a good price point.'

Sydney Morning Herald
13 hours ago
- Sydney Morning Herald
Ozempic in a pill? The next generation of weight-loss drugs emerges
'The development of GLP-1 and incretin-based drugs has revolutionised the space. It has carved out the biggest class of drugs ever. And it has the power to truly revolutionise our health-span,' said Associate Professor Garron Dodd, head of the Metabolic Neuroscience Research Laboratory at the University of Melbourne and founder of Gallant Bio, which is developing its own obesity drugs. 'It's a glorious dawn, but it's just the start.' Weight loss in a pill Much as our eyes and ears sense the world and send data to our brains, our digestive tracts need ways of sending back data on what they are eating, and how much. They do this, in part, by secreting various chemical signals – hormones. Glucagon-like peptide-1 is secreted by the intestines and triggers the pancreas to produce insulin. The first GLP-1 drugs took advantage of this to become powerful treatments for diabetes. But GLP-1 has much wider effects beyond blood-sugar control. Receptors for the hormone spread throughout the body, even in the brain, where they trigger a feeling of fullness and decrease appetite. A once-weekly dose of semaglutide, plus lifestyle changes, led volunteers in a phase 3 trial to lose 14.9 per cent of their body weight over 15 months. GLP-1 drugs like Wegovy essentially copy that human hormone. That makes them fragile. They need to be kept refrigerated, and injected subcutaneously rather than taken by mouth – as the stomach's acid would quickly break them down. An oral version of semaglutide has been developed, but only 1 per cent of the drug actually makes its way to the target receptors, and it appears less effective than the injectable version for weight loss. Loading Researchers at Japan's Chugai Pharmaceutical Co figured out a way around this problem. They designed a small molecule that can bind to the same receptor as GLP-1 and trigger it. It mimics the effect without mimicking the structure. 'It's a development I never would have thought feasible,' said Professor Michael Horowitz, a University of Adelaide researcher who authored a commentary on the drug in the Lancet. Chugai licensed the molecule to US-based Eli Lilly in 2018. Last week, the company reported participants on the highest dose in a clinical trial lost 7.9 per cent of their body weight over 40 weeks. The full details of the trial have not yet been reported, and whether the weight loss is maintained over the longer term is unclear. More than a quarter of patients reported diarrhoea, 16 per cent nausea and 14 per cent vomiting. The preliminary results are 'close enough to broadly call it similar' to semaglutide, said Professor Jonathan Shaw, who led the Australian arm of Lilly's trial at the Baker Heart and Diabetes Institute in Melbourne. 'I don't think we can confidently say it's better or worse. It's definitely in the same ballpark.' It's also not known if the drug will offer the range of other benefits that GLP-1 inhibitors provide in addition to weight loss, like reductions in cardiovascular disease and Alzheimer's risk (and maybe even addictive behaviours). Horowitz said the efficacy data was promising, but he wanted to see more information about adverse effects, which he said were understated generally across semaglutide trials because they relied on patients to report their own side effects. 'It hasn't served the interests of pharma to quantify how well this is tolerated.' Pfizer was developing a similar once-daily GLP-1 pill but cancelled the program in April after a patient in a clinical trial suffered liver damage. A pill should, theoretically, be cheaper and easier to make than an injector – Novo Nordisk, maker of Wegovy and its diabetes drug antecedent Ozempic, has struggled to keep up with demand for semaglutide – and dramatically easier to transport. At present, the drug must be kept refrigerated right from European factories to a patient's home. 'That all adds to the cost,' said Shaw. There could also be cost benefits from increased competition as more drugs are approved – possibly pushing the price down far enough for governments to consider subsidising it. Lilly expects to apply for regulatory approval for the drug later this year. While orforglipron has attracted the most excitement – Eli Lilly's shares have surged since they announced the trial results – it is just one of several new drugs in late-stage development. These drugs might be of particular value to 15 per cent or so of people whose bodies do not seem to respond to semaglutide. And people don't seem to stay on the injectable drugs – less than half are still using them a year later, per a study 2024 study – despite the fact weight rebound is likely if you stop using them. 'Is it the injection? Is it the cost? Or is it due to adverse effects? We don't know,' said Horowitz. The new drugs might also offer weight-loss benefits. Mounjaro, for example, mimics both GLP-1 and the gastric inhibitory polypeptide, which increases metabolism and appears to lead to better weight-loss results. The new drugs, like Lilly's retatrutide, target even more receptors, with the hope of even greater effects. It's all good news for Rochelle McDonald. She does not mind taking a weekly injection – 'the stabby-stab' – now she's found ways of coping with the side effects. But paying $240 a month for her current dose of the medicine is 'a commitment in itself'. 'I think a daily pill would be good,' she said. 'If it comes in at a good price point.'


West Australian
2 days ago
- West Australian
New dawn for NeuroScientific with stem cell acquisition
Stem cell therapies have long promised to press the body's reset button - potentially reversing injuries and damage from disease, regenerating tissue and reshaping modern medicine. For ASX-listed NeuroScientific Biopharmaceuticals, that promise starts now thanks to its $5.1 million acquisition of unlisted Perth-based stem cell therapy company Isopogen. The deal will hand NeuroScientific the keys to Isopogen's patented 'StemSmart' technology, which innovatively prepares a specific type of stem cell, mesenchymal stem cells (MSC), for use as an intravenous infusion. MSC are universal donor cells, meaning that there is no need for matching between a donor and recipient. The are effectively an 'off-the shelf' cell therapy. Over the past 20 years, haematology medical scientist Dr Marian Sturm, NeuroScientific's incoming chief scientific officer, pioneered the development of MSCs in her former role as facility director of Royal Perth Hospital's Cell and Tissue Therapies centre. The cells have so far been used in many patients, including as a last-line treatment for critically ill patients suffering severe immune complications from bone marrow transplantation and in kidney and lung transplant rejection, through early phase clinical trials and studies and on compassionate grounds, with promising results. The MSC technology has also been employed to treat patients with severe Crohn's disease, an inflammatory autoimmune condition that affects the gut. The disease can develop into very difficult-to-manage and treat forms, including refractory Crohn's, in which patients experience persistent uncontrolled flare-ups, and fistulising Crohn's, in which patients develop an open wound from a gut flare-up out to the skin. In a phase two trial targeting refractory Crohn's disease, a condition that no longer responds to standard treatments, of 18 patients treated with StemSmart MSC, 78 per cent of patients experienced clinical improvement and 44 per cent achieved full remission. That level of efficacy is considered impressive in the MSC field, particularly for refractory Crohn's. With the global market for refractory Crohn's treatment alone estimated to be worth about US$7.5 billion, it's no wonder StemSmart's new owner quickly hailed the system as a potential game-changer. StemSmart technology offers a step up from traditional MSC manufacturing in that the cells are grown in a special media, becoming activated in the process. The platform technology was developed at Royal Perth Hospital (RPH) and manufactured using RPH's processes. Notably, the manufacturing methodology can yield more than 200 cryopreserved clinical doses from just 10 millilitres of precious donated bone marrow, giving it both clinical flexibility and manufacturing scale. Based on the early results in Crohn's disease and in other conditions, Sturm now sees hope in employing MSCs to treat other autoimmune and inflammatory diseases, possibly including lupus, multiple sclerosis and rheumatoid arthritis. As the cells can grow into skin, bone, fat and other tissue cells, they also offer potential applications for tissue repair, such as bone repair for skull or long bone injuries, for example. The clinical development of MSC stretches back to 2002, when a Swedish paediatric haematologist used MSCs for the first time to treat a child gravely ill with complications from the treatment of leukaemia. The cells were isolated and grown in the doctor's laboratory from bone marrow donated by the child's mother. The child's clinical response to the cells was striking. No doubt, the successful experimental treatment would have caught the attention of immunology and haematology researchers and clinicians worldwide, including Sturm, an expert in blood, cell and tissue transplant manufacturing for clinical applications, who was the then-director of RPH's cutting-edge Cell and Tissue Therapy facility. At the time, Sturm was particularly focused on delivering MSCs as safely as possible into healthcare areas of unmet need. She began experimenting with ways to process the cells into a safe infusion that could be used to treat diseases and transplant complications where there were few or no existing clinical options. In 2007, Dr Sturm was approached by her clinical colleagues, who wanted to use the MSC product on compassionate grounds to treat a critically ill man with complications of bone marrow transplant to treat blood cancer. At the time, about 60 per cent of bone marrow transplant patients, who received donor marrow, developed a serious complication, known as graft-versus-host disease (GVHD), where the new blood system created by the bone marrow transplant rejects the recipient's body. It usually presents with symptoms that affect the gut, skin and liver, and is treated with steroids. With recent advancements in transplant practices, the incidence of acute GVHD has fallen to now occurring in about 25-30 per cent of cases. However, these medicines fail in about 30 per cent of acute GVHD cases – and most of this group die. After receiving MSC treatment, the man quickly recovered, spurring Sturm to keep working to develop a scalable, commercial-grade MSC product and patenting the manufacturing process. After an agreement was reached between Isopogen and the State Government's East Metropolitan Health Service (EMHS) giving Isopogen control of the MSC technology, NeuroScientific struck a deal with Isopogen to progress StemSmart. The all-scrip acquisition sees Isopogen shareholders receive 85.7 million NeuroScientific shares and 57.1 million performance shares tied to future clinical and commercial milestones. The market welcomed the move, with NeuroScientific's share price surging 97 per cent on the day of the announcement. A $3.5 million capital raise led by Perth corporate advisor Westar Capital, after existing funds, creates a war chest of about $7.5 million. This will support further development, including for a special access program or bigger phase 2/3 trials for patients with refractory and fistulising Crohn's, and will enable regulatory engagement with Australia's Therapeutic Goods Administration with a long-term goal of partial or full registration for StemSmart MSC, first up as a Crohn's treatment. The company is also eyeing the United States, where inflammatory bowel disease is forecast to grow into a lucrative US$13.8 billion market by 2026. About 30 per cent of Crohn's patients fail to respond to current gold-standard treatments, such as biologics, making them prime candidates for a new approach, such as StemSmart. The takeover signals a bold pivot for NeuroScientific, which previously focused on peptide-based drugs for neurodegenerative diseases such as Alzheimer's. Those drugs showed promise, but the timelines to market were long. By contrast, StemSmart's progress and results over decades of development position the product closer to near-term commercialisation, helped along by NeuroScientific's healthy bank balance. Nor will NeuroScientific be walking away from its roots completely. Two current directors will remain on the company's revamped board, and management will explore crossover applications for StemSmart, particularly to tackle the neuroinflammation that is a hallmark of inflammatory diseases such as Alzheimer's. That convergence could open a dual-front therapeutic pipeline, leveraging both peptide and cellular approaches. While competition in the stem cell space is fierce, the upside is enormous. Importantly, the US Food and Drug Administration (FDA) recently approved the first mesenchymal stromal cell therapy by ASX-listed, regenerative medicine company Mesoblast. While MSC products have been approved in other jurisdictions, the FDA approval of an allogeneic, bone marrow-derived MSC product for paediatric, steroid-refractory, acute graft-versus-host disease is momentous. According to NeuroScientific, StemSmart is differentiated by its purity, potency and consistency. In preclinical and early human data, the platform has shown enhanced potency over conventional MSCs. The recent regulatory FDA approval of MSC also tilt the momentum in StemSmart's favour, suggesting regulators are warming to well-characterised stem cell platforms with rigorous clinical data. Is your ASX-listed company doing something interesting? Contact: