
Entrepreneur UK's London 100: Unai
Unai is a UK-crafted sparkling drink that harnesses the wellness-boosting benefits of functional mushrooms, offering a refreshing approach to mindful living.
The brand is centered around themes of grounding and being present, promoting a lifestyle rooted in balance and intention.
Owned by London-based Matthew Glover, Unai is part of a growing movement that blends natural ingredients with modern wellness, providing consumers with a functional beverage that supports both body and mind.
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Understanding Poor Sleep's Mechanism of Action St-Onge emphasized that new research has also increased understanding around the associations between poor sleep and worsening cardiometabolic outcomes. Her research has shown that sleep restriction increases oxidative stress in the lining of the arteries that could lead to endothelial dysfunction. Short sleep also impairs the body's ability to counteract this oxidative stress. 'We see immune suppression from poor sleep duration and poor sleep quality,' St-Onge said. In addition, we have found links between sleep regularity and eating patterns, St-Onge noted. Gulati believes that the AHA statement represents an opportunity to raise awareness among patients, cardiologists, and clinical researchers about the importance of better understanding these causal effects of poor multidimensional sleep health. 'I think it is also a call to action to improve the assessment of sleep, particularly in research so we can rigorously assess these components,' Gulati said. 'We need to know what interventions can improve components of sleep as well, and their effect on cardiovascular health. Those knowledge gaps need to be closed.' Talking About Sleep Health Those knowledge gaps are why the statement did not offer guidance for clinical approaches, but St-Onge emphasized the importance of educating and discussing this topic with patients now. She recommended asking an open-ended question: 'How's your sleep?' 'That opens up a conversation for people to express exactly what's bothering them with their sleep.' For example, she said, 'It may be they get plenty of hours of sleep, but they lie there awake for way too long, or they're having a hard time falling asleep, or they get a lot of sleep, but they still wake up not feeling refreshed during the day.' Starting the conversation — and documenting it in clinical notes — will be the first step to helping patients with poor sleep health, she said. Marcus agreed that cardiologists should make time to discuss sleep health with patients, even though it can be more complicated than addressing cholesterol or blood pressure because 'sleep is not a number.' Still, she said that understanding a patient's poor sleep health can also provide physicians with new modifiable risk factors for improving their cardiovascular health. 'Sleep is the next target,' Marcus said. 'We know it impacts health, and it's just a matter of how do we screen for it.' Gulati reported financial relationships with Boehringer Ingelheim Pharmaceuticals, Medtronic, Merck & Co., New Amsterdam, and Zoll.