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Happiness researcher shares his '90-second rule' to live a better, more fulfilled life—it helps when you're angry or upset

Happiness researcher shares his '90-second rule' to live a better, more fulfilled life—it helps when you're angry or upset

CNBC3 days ago
Mo Gawdat's son, Ali, was 21 years old when he died due to medical negligence during a routine appendix surgery in 2014.
Gawdat was devastated, confused and in a palpable state of shock. Then, 17 days later, he started writing a book on how to be happy, in his son's honor.
Gawdat has researched the science of happiness for over 20 years from a logical and philosophical prospective, using flow charts and formulas to get to the root of unhappiness. A while back, he learned a habit that can almost instantly help you find joy and fulfillment.
It's called the 90-second rule, Gawdat told the "High Performance" podcast on June 17. When something angering or nerve-wracking happens in your life, give yourself a minute and 30 seconds to feel upset. Then, choose to focus on other things.
The habit is based on insight Gawdat learned from Harvard-trained neuroscientist Jill Bolte Taylor, who found that it takes only 90 seconds for stress and anger hormones, like cortisol and adrenaline, to be flushed out of the body.
"But then what happens is, you run the thought in your head again, and you renew your 90 seconds," said Gawdat, who served as chief business officer at Google X, the company's innovation lab, from 2015 to 2018. "You run it again, unconsciously, and you renew your 90 seconds. While in reality, what you get after those 90 seconds is a buffer ... [which] allows you to say, 'Now, what am I going to do?'"
Getting cut off while driving, for example, can be really agitating. You might yell or curse from behind the wheel, or even roll your window down to give the other driver a piece of your mind. But ruminating on the situation, telling everyone what happened when you get to the office, won't change it. So, what if you took a deep breath, turned your favorite song on, and sang along instead?
To recover more quickly from life's upsets, Gawdat asks himself three questions, he said:
"Ninety percent of the things that make us unhappy are not even true. Like your [partner] says something hurtful ... your brain is telling you [they] don't love you anymore," said Gawdat "That isn't true."
If your answer to question No. 1 is "no," drop it. If it's "yes," move on to question No. 2 and do the same thing over again. If there's something you can do about it, do it, he said. If not, go into "committed acceptance" – meaning, acknowledge what's happened and accept it as your new normal.
Building new habits can be difficult, especially when you're feeling emotional. In a 2009 study, psychology researcher Phillippa Lally found that it can take anywhere between 18 to 254 days to form a habit, depending on the person and their circumstances.
But being cognizant of how you respond to tough moments in life is the first step to being happier and more fulfilled, says Gawdat.
"Life doesn't give a s--- about you," Gawdat told Simon Sinek's "A Bit of Optimism" podcast on June 24. It puts you in good and bad situations, and lets you figure out the rest. "It's your choice, how you react to every one of them ... It's your choice to set your expectations realistically."
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Proteins called T cell receptors detect cancer antigens (substances on the surface of cancer cells. ) But the T-cell is unable to attack the cancer because another T cell protein, PD-1, is bound to a protein on the cancer cell, called PD-L1, that's putting the brakes on the immune system. Immunotherapy cancer drugs, anti-PD-1 medicines, release the brakes on the immune system and allow T cells to attack the cancer. SOURCE: Gordon Freeman, and program Biorender. RYAN HUDDLE/GLOBE STAFF and Adobe Shutterstock In a way, PD-L1 tricked the body's defenses into ignoring tumors, allowing them to grow and spread unchecked. Just when the immune system should be speeding ahead to fight cancer, PD-L1 slammed on the brakes. Sharpe and Freeman also took another step, demonstrating how the body could recognize cancer as dangerous and then release the immune system's brakes. They knew it was an important insight. Translating it from the lab setting into a treatment for patients, however, wasn't going to be easy. From bench to bedside Despite the promise of immunotherapy in the early 2000s, many cancer specialists remained skeptical. Chemotherapy was long-studied and widely used, even though using it was like dropping a bomb that obliterated cancer cells and healthy ones alike. Could immunotherapy, which sought to marshal the body's own defenses, really work? 'We thought we were at the vanguard of a whole new approach to treating cancer,' recalled Dr. Israel Lowy, then director of clinical science at Medarex, a small biopharmaceutical company in New Jersey. 'But no one took us seriously.' Lowy had been watching Sharpe and Freeman's breakthroughs closely, as Medarex developed an investigational cancer drug. In 2006, his team filed an application with federal regulators for MDX-1106, inspired by research from several scientists, including Sharpe and Freeman's work blocking the PD-L1 protein. Two years later, at a May 2008 conference, the team proudly With results like that, 'We were like kids in a candy store,' recalled Lowy, now a senior vice president at Regeneron, a biotech company. Cancer specialists weren't skeptical any longer. With approval to expand, researchers eventually launched a bigger clinical trial at 13 medical centers around the country, including three in Boston. This time, 306 cancer patients would receive infusions of the experimental drug every two weeks for nearly two years. One of those patients would be Stephen Sehy. The trials of a cancer patient By the winter of 2009, Sehy was getting sicker. It had been eight months since his diagnosis, but the melanoma tumors on his face and liver had overtaken the cocktail of chemotherapy drugs he'd been receiving. Still, from the beginning, Sehy had been determined to enjoy whatever time he had left. 'He would say to me, 'OK Jeanie, if I have only six months to live, you are not going to be crying around,'' Jean recalled. Sehy's first infusion of MDX-1106 was scheduled for December 21, 2009. When the couple returned from the 300 mile drive to Vanderbilt University Medical Center in Tennessee, Sehy sat down at a computer to type out a Christmas email. 'Have a great holiday, and enjoy each day,' he wrote to friends and family. 'All the little things in life add up to a big deal!' After that first infusion, he and Jean would not have to wait long for a positive sign. At Sehy's next appointment, just two weeks later, a doctor at Vanderbilt confirmed what the couple feared they'd only been imagining: the tumor near his right ear had shrunk by more than a tenth of an inch. They should know that happens sometimes, the doctor gently explained, and then the tumor comes charging back. The couple let themselves quietly start dreaming anyway, about a trip to Hawaii, maybe one to Alaska. They didn't know if Sehy would live long enough. But they could hope. 'Steve didn't want me to write this, because it may get everyone's hopes up, but I thought, so what?' Jean wrote to their loved ones at one point. 'That's what it's about. HOPE, isn't it?' Over time, the tumors on Sehy's face kept shrinking. They waited for him to suffer side effects, but none came. 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Oct. 2000 Harvard Medical School/Dana-Farber Cancer Institute researcher Gordon Freeman and colleagues show how cancer cells disable immune defenses, and how this cell process, known as PD1/PD-L1, could be blocked. Sharpe and Freeman's research is critical in the design of anti-PD-1 immunotherapies for cancer that restore the immune system's ability to spot and destroy tumors. April 2009 Stephen Sehy is given six months to live after a surgeon discovers melanoma has spread to his liver and spine. Dec. 2009 Sehy enrolls in the Phase One clinical trial of MDX1106, an experimental PD-1 antibody for the treatment of cancer, based on the research from Sharpe and Freeman. The treatment would become the cancer drug Opdivo, approved by FDA in 2014. Jan. - Sept. 2010 The first nine months of 2010 were busy for the Sehys; they welcomed four more grandchildren from January through September. Jan. 2011 Stephen and Jean Sehy take a trip to Hawaii. Oct. 2011 Stephen completes the clinical trial of MDX1106. Nov. & Dec. 2011 The Sehys welcome two more grandchildren, a girl and a boy. Dec. 2011 Scans show the tumors on Stephen Sehy's liver and spine are gone. Here, Sehy is pictured in a Christmas card photo. Aug. 2012 Stephen and Jean vacation in Alaska, where they try the Zip line. Jan. 2013 The couple's ninth grandchild, a grandson, is born. June 2014 Their fifth grandson is born. Later that year FDA approves Keytruda, a drug similar to Opdivo, and soon after approves Opdivo. The drugs enter wide circulation. Feb. 2015 Their sixth grandson, the 11th grandchild, is born. June 2016 A 70th birthday party for Stephen with 100 invited friends and family. July 2019 Stephen and Jean celebrate their 50th wedding anniversary with a party, dinner and dancing. July 2024 The couple vacation in Branson, Missouri with all four of their children and 11 grandkids. That December, two years after he was accepted into the MDX-1106 trial, Sehy received an early holiday gift: Two separate scans showed the tumors on his liver and spine were gone. Not slowing in their growth. Not shrinking. Gone. And Sehy wasn't alone. Word was trickling in from other MDX-1106 trial sites that tumors were also disappearing in other patients. The immunotherapy treatment was working. The age of immunotherapy Dr. Douglas Johnson had helped enroll participants in the MDX-1106 trial at Vanderbilt while he was training in oncology. Even then, he knew all about 'the conversation,' the time doctors had to advise melanoma patients to get their affairs in order. But after the arrival of immunotherapy, he said, that conversation 'changed almost overnight.' In 2011,federal regulators approved Yervoy, Three years later, MDX-1106 — the drug based on Sharpe and Freeman's research at Harvard and now named Opdivo — was approved for cancer patients, as was a similar drug called Keytruda. Today, these immunotherapies are used to treat at least 20 types of cancer and have provided additional years of life for millions of patients. (Last year alone, they also generated more than $23 billion in US sales, according to 'I fell in love with taking care of patients with melanoma in large part because of these drugs coming on board,' said Johnson, now an oncology professor at Vanderbilt who leads a melanoma research program. 'It's such a paradigm shift to be able to offer this to patients who previously didn't have many options.' Before immunotherapy drugs, survival rates for people with metastatic skin cancer were often dismal, Johnson said, with maybe up to 5 percent experiencing remission. Today, advanced melanoma patients treated with a combination of immunotherapies can have a 50 percent or higher survival rate. The number can be around 30 percent for people with bladder or lung cancers treated by immunotherapy. Experts now believe immunotherapy may also train the immune system, through its memory T cells, to recognize cancer if it recurs and keep fighting back, even after treatments have ended. 'In some cases, patients can now live for years with a durable response even after they stop therapy, and we never had anything like that before,' said Dr. Arnold Baskies, former chair of the American Cancer Society's National Board of Directors. Sehy pushed grandson Victor, 10, on a swing in his backyard. Kate Munsch for The Boston Globe That's the way it has gone for Sehy. Sixteen years after he was given six months to live, he remains cancer free. Sehy is now 79, with a shock of white hair and a serious pickleball hobby. The only visible mark of his place in immunotherapy history is a patch of discolored skin in front of his right ear, where doctors removed the last of his tumors months after his final MDX-1106 treatment. He and Jean made it on their trip to Alaska and many other places around the world, too. The two young grandchildren he thought of when he first heard his diagnosis are now 17 years old and have been joined by nine others. A portrait of Stephen and Jean Sehy's family above their fireplace includes their four children and 11 grandchildren. Kate Munsch for The Boston Globe 'There was a time I thought I would never see another grandkid,' Sehy said. 'Now, I'm thinking I just want to see one of them graduate college. And then I'll want to see them get married.' In search of new breakthroughs Whenever she sees advertisements for immunotherapy drugs, Arlene Sharpe does a double-take, remembering her early discovery at Harvard. Even more powerful is meeting cancer survivors who, thanks to treatments that followed, have lived years past their doctors' initial expectations. 'People will come up to me at different meetings and thank me, and they'll tell me that they received either Keytruda or Opdivo a decade ago,' she said. 'And every time, it's just chilling.' But Sharpe, now 71, spends most of her time looking forward, not back. Some patients' tumors don't respond to immunotherapy, and others struggle with significant 'We see that there can be success, and now we want to build on the success,' she said. In recent months, she's had to do that work without federal support. The Trump administration has choked off nearly all government funding to Harvard, including for her research and that of 12 other faculty in her department. She's now searching for private funding sources to keep everything afloat. But that's no guarantee, either. 'Private foundations often want to fund things at a later stage, they don't want to fund the discovery work,' she said. 'It's really the fundamental discovery science that [the government] funds.' Dr. Arlene Sharpe at Harvard Medical School. Jonathan Wiggs/Globe Staff Harvard is challenging the federal cuts, though it has already had to lay off staff and institute hiring freezes. The university has also Sharpe knows the road to a scientific breakthrough is long and twisting, but slowing down is out of the question. About 'There's an urgency here,' Sharpe said. 'Patients and their families don't have the time to wait.' Kay Lazar can be reached at

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