
Hepatitis services must be scaled up, included in essential health packages: WHO official
Hepatitis testing and treatment
services must be scaled up and decentralised to primary care, and services related to the infection should be embedded within essential health packages, Dr Catharina Boehme, Officer-in-Charge of WHO South-East Asia, said on Monday.
Speaking on
World Hepatitis Day
, which is observed on July 28 every year, Boehme said hepatitis must prioritise responses with maternal and child health, among others, and work towards reducing the toll of liver cancer due to
hepatitis B
and
hepatitis C
.
"We have the tools to prevent these infections: safe and effective hepatitis B vaccines, affordable diagnostics, highly effective hepatitis B medicines, and the game-changing hepatitis C direct-acting antiviral (DAA) medicines that cure the infection," she said.
"However, problems persist with the complexity and fragmentation in service delivery, lack of services at primary healthcare clinics, poor uptake of services, out-of-pocket expenses, limited awareness, and stigma," Boehme added.
World Hepatitis Day raises awareness of viral hepatitis, an inflammation of the liver that causes severe liver disease and liver cancer. It is observed on the birthday of Nobel Prize-winning scientist Dr Baruch Blumberg, who discovered the hepatitis B virus (HBV) and developed a diagnostic test and vaccine for the virus.
This year, the theme 'Hepatitis: Let's Break It Down' calls for urgent action to dismantle the financial, social and systemic barriers, including the stigma attached to the infection, that stand in the way of hepatitis elimination and
liver cancer prevention
.
Boehme said, "In our WHO South-East Asia region, viral hepatitis continues to cause needless suffering, silently leading to liver disease, cancer, and hundreds of thousands of preventable deaths each year."
Across the region, an estimated 61 million people live with hepatitis B, and 9 million with hepatitis C.
"Our region bears one of the highest burdens of chronic viral hepatitis globally, yet most people living with the disease remain undiagnosed and untreated," she said.
She said every year, over 2,60,000 lives are lost, many due to preventable complications of hepatitis and one of the most devastating outcomes is liver cancer, because of untreated hepatitis B and C infections.
"With limited access to early diagnosis and treatment, most liver cancer cases in our region are detected late, when curative options are no longer viable," Boehme said.
She said hepatitis testing and treatment services must be "scaled up, decentralised to primary care", and guidelines simplified, to reduce the toll of liver cancer due to hepatitis B and C.
"We must embed
hepatitis services
within essential health packages, leverage primary health care platforms, and align responses with maternal and child health, HIV, STIs, TB, non-communicable diseases, blood safety, infection prevention and control, occupational health and universal health coverage efforts.
"We have to prioritise hepatitis B birth-dose and completion of the vaccination schedule, integrated safe motherhood services, harm reduction services, and community-based outreach to close the equity gap," she said.
Boehme said progress was possible and countries across our region are innovating, including adopting simplified testing and treatment service models, integrating hepatitis as part of essential services and under social health insurance coverage.
"These efforts need to be scaled and sustained with strong political will and investment. Together, let's break it down by removing the complexity, ending the silence, and delivering on our promise to eliminate hepatitis by 2030," she said.

Try Our AI Features
Explore what Daily8 AI can do for you:
Comments
No comments yet...
Related Articles
&w=3840&q=100)

Business Standard
10 hours ago
- Business Standard
India launches formal rules to fix, streamline drug and device clearances
India has released its first official set of guidelines on how expert panels should review and approve new drugs, medical devices, and biologics, Mint reported. This move is aimed at fixing problems of unclear and inconsistent approvals that have previously slowed down drug launches and weakened the pharmaceutical industry's trust in the system. These new rules, issued by the Central Drugs Standard Control Organisation (CDSCO), are designed to improve how India regulates new medical products. The goal is to make the approval process quicker, more transparent, and predictable, the news report said. The guidelines define how Subject Expert Committees (SECs) should be formed, how experts are chosen, and how they must review applications. These SECs play a key role in advising the Drugs Controller General of India (DCGI) on whether a product should be approved. The overhaul follows recommendations from the World Health Organisation (WHO), which last year conducted a regulatory review of CDSCO and the office of the DCGI, who heads the organisation. The WHO called for stronger transparency and data integrity to align India's system with global standards. Why this is important for India's pharma sector? India's pharmaceutical industry is the world's third-largest by volume and 14th by value. It supplies around 20 per cent of the global generic drug demand and manufactures over 60,000 products across 60 therapy areas. The sector includes generic medicines, vaccines, biologics, over-the-counter drugs, and more. In its review, the WHO had asked Indian authorities to better track low-quality or fake medical products, start a market monitoring programme, and ensure drug advertisements are not misleading. Many of these suggestions are now being followed by the DCGI and those involved in SEC meetings, the news report said. Stricter criteria and structured evaluations Each SEC has eight members — one pharmacologist and seven other experts from research or medical fields. At least four members must be present to make a decision. Earlier, the lack of formal rules often led to delays and confusion in the approval process. Now, SEC members must meet strict criteria, such as having at least 10 published research papers and a 2:1 citation ratio. They are appointed for three years and must follow rules on confidentiality, impartiality, and attendance. Those who miss meetings without good reason can be removed. The new document also says SECs must evaluate drug safety, effectiveness, and risks using strong scientific standards. Decisions like clinical trial waivers must be clearly justified, and discussions must only focus on scientific and regulatory issues — not pricing or business concerns, Mint reported. US hits Indian exports with blanket 25% tariffs The US government has decided to impose a 25 per cent tariff on all Indian exports starting August 7 — without any exemptions. This new order removes earlier tariff breaks given to products like pharmaceuticals, electronics, and energy goods. GTRI founder Ajay Srivastava said this is one of the toughest trade measures by the US against India, news agency PTI reported. India's top export items to the US — like smartphones ($10.9 billion), petroleum products ($4.1 billion), and pharmaceuticals ($9.8 billion) — will be hit hardest. Srivastava said these sectors have high import content and low local value addition, making them vulnerable to the tariff hike. USFDA actions slow down Indian drug approvals Meanwhile, Indian drugmakers are also facing regulatory challenges abroad. In the first quarter of FY25, the US Food and Drug Administration (USFDA) sharply reduced the number of abbreviated new drug application (ANDA) approvals for Indian firms, according to a report by The Times of India. Companies like Cipla, Sun Pharma, Dr Reddy's, Lupin, and Aurobindo Pharma are under increased inspection. Aurobindo's approvals dropped due to issues at its Unit III plant. In May, the company got seven observations from the USFDA at its Bhiwadi facility and earlier three more for its Andhra Pradesh site. Cipla also got six observations for its Goa plant in June. In a filing, the company said it was committed to addressing the concerns in time. A Business Standard report said that the USFDA's Centre for Drug Evaluation and Research recently found that 11 per cent of Indian drug manufacturing facilities had violations, including data integrity issues.


The Hindu
16 hours ago
- The Hindu
Scientists use AI-designed proteins to generate immune cells
A team of Harvard scientists has used artificial intelligence (AI), in the form of AI-designed proteins, to generate large numbers of immune cells and enhance immunity against diseases ranging from cancer to viral infections, a new research paper published in Cell said. The scientists engineered a synthetic activator of a key cellular pathway called Notch signalling, which plays a crucial role in cellular differentiation and is essential for transforming human immune progenitors into T cells. Notch signalling is a cell-to-cell communication system vital for various developmental processes and tissue homeostasis in multicellular organisms. Homeostasis is the body's way of keeping everything balanced and stable, despite what is happening around it. 'In response to viral infections or cancer, the body requires a higher production of T cells to mount an effective immune defence. However, this process depends on the activation of the Notch signalling pathway, for which no effective molecular activators have been available,' Rubul Mout from Assam, the principal scientist of the study, said. Associated with the Harvard Stem Cell Institute and the Stem Cell & Regenerative Biology Program at Boston Children's Hospital, he is one of 24 scientists involved in the collaborative effort. They include George Daley, the Dean of Harvard Medical School, and Nobel laureate David Baker. Improved method According to the study, an earlier method of activating Notch signalling in laboratory settings by immobilising Notch ligands on tissue culture dishes is not applicable for therapeutic use in humans. The quest for a viable, soluble activator of Notch signalling that could work in vivo (inside a living body) made the team develop a library of custom-designed soluble Notch agonists and systematically test their ability to activate the Notch pathway and support T cell development and function. AI-driven protein design technologies, an innovation that contributed to Dr Baker receiving the 2024 Nobel Prize in Chemistry along with Demis Hassabis and John Jumper, were used to address the challenge. Using the agonists, the researchers demonstrated the large-scale generation of T cells in a laboratory bioreactor, an important advancement given the growing demand for T cell production in hospitals worldwide for Chimeric Antigen Receptor (CAR) T cell-based cancer immunotherapies. Furthermore, when the agonists were injected into mice during vaccination, the animals displayed significantly improved T cell responses, indicating an enhanced immune response. The treatment resulted in increased production of memory T cells, which are crucial for the long-term impact of vaccines. 'Being able to activate Notch signalling opens up tremendous opportunities in immunotherapy, vaccine development, and immune cell regeneration,' Dr Mout said. 'What excites me the most is using this technology to engineer synthetic proteins that simultaneously bridge T cells and cancer cells, boost T cell-mediated killing, and neutralise the immunosuppressive tumour micro-environment. Our goal is to develop next-generation immunotherapies and cancer vaccines,' he added. The other collaborators of the study include Urban Lendahl of the Stockholm-based Karolinska Institutet and a former Chairman of the Physiology and Medicine Nobel Committee, Stephen C. Blacklow, the Chair of Harvard Medical School's Department of Biological Chemistry and Molecular Pharmacology, and R. Grant Rowe of Boston's Dana-Farber Cancer Institute.


Hans India
18 hours ago
- Hans India
Breastfeeding Week (1 to 7 August): Celebrating nature's first superfood
Breastfeeding is one of the most natural and powerful ways to nourish a newborn. Far beyond being just a means of sustenance, breast milk plays a crucial role in shaping an infant's health, development, and immunity. Packed with essential nutrients and living antibodies, it adapts to a baby's changing needs, offering unparalleled protection in the earliest stages of life. As science continues to uncover the remarkable benefits of breastfeeding, it becomes even clearer why this 'liquid gold' is considered the gold standard of infant nutrition Every year, from August 1st to 7th, the world observes Breastfeeding Week to raise awareness about the importance of breast milk for infants, mothers, and society at large. Organized by the World Alliance for Breastfeeding Action (WABA) and endorsed by the World Health Organization (WHO) and UNICEF, this week serves as a powerful reminder that breastfeeding is not just a personal act—it's a public health imperative. Why Breast Milk Matters Breast milk is more than just food; it's a living, dynamic source of nutrition uniquely tailored for each baby. It contains the perfect balance of proteins, fats, carbohydrates, vitamins, and antibodies that help an infant grow and build immunity. In fact, the first milk produced after childbirth, called colostrum, is often termed 'liquid gold' for its high concentration of protective antibodies and nutrients. 'Breast milk is nature's first vaccine—it not only provides optimal nutrition but also boosts the baby's immune system from day one,' says Dr. Swathi Gogineni, Consultant – Obstetrics & Gynecology, Infertility Specialist & Laparoscopic Surgeon, Apollo Cradle and Children's Hospital, Jubilee Hills, Hyderabad. According to the WHO, exclusive breastfeeding for the first six months of life reduces infant mortality and provides critical protection against diseases such as pneumonia, diarrhea, and even obesity later in life. After six months, continued breastfeeding along with appropriate complementary foods can protect and nourish the child well into the toddler years. Benefits for Babies • Stronger Immunity: Breast milk is packed with antibodies that help babies fight off viruses and bacteria. • Brain Development: Essential fatty acids in breast milk contribute to cognitive development and visual acuity. • Lower Risk of SIDS: Studies show a reduced risk of sudden infant death syndrome in breastfed babies. • Bonding: The act of breastfeeding promotes skin-to-skin contact and emotional bonding between mother and child. Benefits for Mothers • Faster Recovery: Breastfeeding helps the uterus return to its normal size and reduces postpartum bleeding. • Calorie Burn: It naturally helps in burning extra calories, aiding in postpartum weight loss. • Reduced Risk of Diseases: Women who breastfeed have a lower risk of breast and ovarian cancers, Type 2 diabetes, and postpartum depression. • Emotional Connection: It nurtures a deep, hormonal bonding experience that supports maternal mental health. Challenges and the Need for Support While the benefits of breastfeeding are well-documented, not every mother finds it easy. Pain, latching difficulties, lack of information, societal stigma, and returning to work can all be barriers. This is where awareness, education, and support systems are vital. Workplaces need to adopt mother-friendly policies—such as maternity leave, breastfeeding breaks, and hygienic nursing rooms. Hospitals and healthcare providers should promote the Baby-Friendly Hospital Initiative (BFHI) to encourage early initiation and exclusive breastfeeding. Families and communities play a central role, too. Encouraging words, helping hands, and emotional support can make a huge difference in a mother's confidence and commitment to breastfeeding. Spreading the Message This Breastfeeding Awareness Week, let us: • Educate new mothers about the science and benefits of breast milk. • Support lactating mothers at home, in workplaces, and in public spaces. • Normalize breastfeeding through positive messaging in media and community events. • Advocate for policy changes that create breastfeeding-friendly environments. Final Thoughts Breast milk is a natural, sustainable, and cost-effective way to nourish and protect infants. It's the first vaccine, the first food, and the first bond. By spreading awareness and supporting mothers in their breastfeeding journey, we contribute to a healthier generation and a more compassionate society.