logo
Sir David MacMillan: 'I'd bet my house' on treatment for Alzheimer's

Sir David MacMillan: 'I'd bet my house' on treatment for Alzheimer's

BBC News2 days ago
A Nobel Prize-winning Scottish chemist has told the BBC he thinks drugs to treat Alzheimer's disease will be available within five years.Princeton University's Prof David MacMillan, who is originally from North Lanarkshire, said "phenomenal things" are happening within medical research into neurological diseases."I would bet my house that within five years that we have marketed drugs for Alzheimer's," Prof MacMillan told the BBC's Scotcast podcast."My father died of vascular dementia and my aunt had dementia. I think that's such a horrible way to go."
The Scottish scientist was awarded the 2021 Nobel Prize in Chemistry alongside Prof Benjamin List after developing a new way of building molecules. Their work has led to developments in drugs for Alzheimer's, cancer and heart disease.Prof MacMillan, 57, said the award had made a massive impact on his life"On a Tuesday morning, I was a chemist that nobody, including half my pals, had been interested in talking to," he said."Then on the Wednesday, I was talking to like the New York Times and the Wall Street Journal."It was crazy - and I thought it would slow down but it just keeps on going."Prof MacMillan was awarded a half share of 10 million Norwegian krona (£842,611).He used it to set up The May and Billy MacMillan Foundation, named after his parents, where he funds Scottish students, providing educational opportunities to underprivileged young people.He said education and learning was always good and gaining more experience was incredibly important.
Passport to the world
It is something he knows about from his own life.He grew up in New Stevenston, near Bellshill, and gained his undergraduate degree in chemistry at the University of Glasgow before moving to the US for postgraduate studies."I realised that education is your passport to the world," he said.After studying in California in the early 1990s, he moved to Harvard and the University of California at Berkeley before becoming a professor at Princeton in 2006.He said working in the US had been great because its "research is the infrastructure that drives the health of the world".The possibilities of the people he was able to collaborate with had been "mind-boggling", he said. However, recent developments in US universities are causing concern, he said.President Donald Trump and his Vice-President JD Vance have long railed against higher education institutions and they have been putting pressure on them over funding.For the first time in 25 years, Prof Macmillan's research group at Princeton has received no funding for the first seven months of the year from the US government. He said: "Americans still care about the Nobel Prize."If that could happen to somebody like me, it could happen to anybody."The scientist said that academics were now the resistance as they try to deal with the politics of the current US administration "without selling their soul".Prof MacMillan said the cuts were "quite sinister" because it seemed like a way to control universities and the narrative by deciding who they can hire. Higher education has become a hub for progressive thinking, which in his opinion, he said the Republicans don't like. "What they care the most about is retaining power," he said.
Despite the pressure in the US, Prof MacMillan is not planning a return to Scotland just yet but he does regularly come back to see family - and some newfound friends. He told the podcast he had become good friends with a Scottish legend who phoned to congratulate him after he won the Nobel prize.Most people would ignore a call that said 'No Caller ID' but he answered to find Sir Alex Ferguson on the other end of the line.The professor, who was himself knighted in 2022, said he thought one of his friends had been joking with him by pretending to be Sir Alex.But he recognised that the voice sounded too similar to the former Manchester United football manager. The two spoke about their common ground of growing up in Glasgow and the pair are now good friends who will be watching Manchester United play Chelsea together later in the year.
Prof MacMillan not only sits next to Sir Alex at football games, the two will now feature together in the National Portrait Gallery of Scotland as the Scots chemist has had his portrait unveiled.The Scots scientist said he was "blown away by it".The painting by Christabel Blackburn depicts the chemist sitting in his office with a white lab coat in the corner. Prof MacMillan said it was actually a lab coat that he was "quite proud of" because it had been presented to him from his old school Bellshill Academy - which now sits in his office in Princeton University.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Please save our anorexic daughter, family pleads with NHS
Please save our anorexic daughter, family pleads with NHS

Telegraph

timea minute ago

  • Telegraph

Please save our anorexic daughter, family pleads with NHS

The family of one of Britain's sickest anorexia patients has issued a desperate appeal to the NHS to offer the 25-year-old a bed in an eating disorder unit. Patricia, as she is known under a court order, weighs 22kg (3st 6 lbs) – the average weight of a seven-year-old – and has a body mass index of 9, making her among the most unwell eating disorder patients in the country. On Thursday, her parents and aunt won a landmark legal battle overturning a court order that had blocked the NHS from treating her anorexia for 21 months. Mrs Justice Arbuthnot ruled that doctors must be permitted to provide life-saving treatment, including the option of force-feeding, which had been denied under an earlier court order. This is the first time the Court of Protection has reversed a ruling to withhold eating disorder care. 'In danger of deteriorating' On Saturday, her family issued a desperate appeal for the NHS to act on the judgment and help save her life. They told The Telegraph said: 'We are incredibly grateful to the judge. Her ruling has removed the legal barriers that prevented Patricia from being admitted to a specialist unit for almost two years. 'But unless a consultant steps forward now to offer her a bed, she will still die. Patricia is back home, still dangerously underweight and in danger of deteriorating. 'Every suitable unit in the country has been contacted, but for months none has replied to say they have a bed. 'We know how fragmented the system is, but Patricia doesn't have time for NHS bureaucracy to fail her. If a bed isn't found in the next few days, it may be too late. 'We're not asking for special treatment – just for our brilliant, bright and loving daughter and niece to receive the same care as any other critically ill patient. 'Please, if you run an NHS unit for complex eating disorder cases that is autism-friendly and works collaboratively with patients, check your referral inbox. 'We need every consultant psychiatrist with an available bed to ask their team, 'can we help save this young woman's life?' Patricia can only survive if someone says yes.' 'Don't let bureaucracy cost Patricia her life' Patricia's parents and aunt also issued a direct plea to the Health Secretary, who framed it as part of his war on red tape when he announced plans to scrap NHS England in March. 'Please, Mr Streeting, do not let bureaucracy cost Patricia her life,' they said. 'If a consultant with a bed does not see the referral in time, and she dies as a result, it would be a tragedy beyond words.' The original 2023 judgment in Patricia's case, issued by the now-retired Mr Justice Moor, followed a decision by clinicians at Cambridgeshire and Peterborough NHS Foundation Trust that her anorexia was 'untreatable'. The judge agreed, finding that although Patricia lacked the capacity to make treatment decisions, she had the 'autonomy' to refuse care. He claimed she was 'days or even hours' from death and ruled that force-feeding was not in her best interests. She could, he said, be discharged for palliative care at home. But Patricia, who has always insisted she wants to live, defied expectations. She survived the next 18 months, but without access to eating disorder treatment, her condition worsened. By March, she weighed just 19kg, with a BMI of 7.3 and was at 'immediate' risk of death. Over eight hearing days between March and May, Mrs Justice Arbuthnot heard evidence from Patricia's parents, a psychologist, gastroenterologist and several psychiatrists — including Dr Ali Ibrahim, a consultant who gave a pro bono opinion in favour of compulsory treatment to restore Patricia to a healthy weight. He acknowledged the trauma that force-feeding can cause, but cited outcomes showing patients often recover and later feel grateful for the care they had once resisted. The family was represented pro bono by barrister Oliver Lewis, who worked for more than 150 hours on the case. In court, he argued Patricia is so severely ill she 'cannot distinguish between broader wishes ['I want to live'] and the narrower ones regarding life-saving interventions ['I don't want NG feeding'].' The submission from her parents and aunt included increasingly desperate WhatsApp messages they had received from Patricia pleading for help. On 28 February, she wrote to her aunt: 'I don't want to die… I want to walk up mountains. I want to swim in the sea. I want cuddles and kisses. I want to play and have fun. 'I'm so so scared. I'm terrified. Please help me more. WE [sic] haven't got much time to play with. I'll never walk if we don't sort things now.' Norfolk and Norwich University Hospital NHS Trust, where she is being monitored, and Cambridgeshire and Peterborough NHS Foundation Trust, which provides her mental health care, opposed the family's application. Both argued that force-feeding would be futile, a position that appears to contradict NHS guidance that anorexia is not a terminal illness and should be treated. The trusts can be named after The Telegraph successfully challenged court reporting restrictions twice. NHS Norfolk and Waveney Integrated Care Board, which commissions Patricia's care, can also be identified. In her judgment, Mrs Justice Arbuthnot ruled in favour of the parents' application, stating: 'I agreed with Mr Lewis when he said, echoing Dr Ibrahim's observation, that by 'respecting [Patricia's] autonomy, the court [in 2023] had permitted her anorexia to call the shots'. The court found Patricia remained incapable of making treatment decisions, and that the previous ruling had failed to protect her welfare.

I lost three stone in just 10 weeks on Mounjaro, but suffered with an instant side effect that won't budge
I lost three stone in just 10 weeks on Mounjaro, but suffered with an instant side effect that won't budge

The Sun

timea minute ago

  • The Sun

I lost three stone in just 10 weeks on Mounjaro, but suffered with an instant side effect that won't budge

A WOMAN has revealed that she has lost three stone in just ten weeks thanks to weight loss jabs. Kayleigh Akister, from Lancaster, took to social media to share her weight loss transformation. 2 She wrote: "After 10 weeks I have lost 3 stone." Taking to social media, she shared images of herself before her weight loss wearing a beige floor-length dress. She revealed that she initially weighed 14.5st and had gone down to 11.5st. But now, Kayleigh looked much smaller and happier as she wore a silky, figure-hugging dress that showed off her new body. While Kayleigh was thrilled by the weight loss, she had experienced one setback. She revealed that since being on the weight loss jab, her hair had become thin and was falling out. Unfortunately, hair loss is listed as a common side effect of Mounjaro. This can be heightened with losing weight at a fast pace. Telogen effluvium is a form of alopecia that is temporary and caused by sudden changes in the body (like weight loss). I've lost nearly 6 stone in 9 months on fat jabs - trolls call me 'lazy' & say it's the 'easy way out' but I don't care It causes hair follicles to enter the resting phase and shedding phase of the hair growth cycle. Kayleigh's post was shared to the Facebook group, mounjaro ozempic wegovy weight loss support, and people were quick to share their tips on combatting hair loss on the drug. One person wrote: "Congrats on your success!! Hair loss is common with weight loss, especially a lot of weight loss in a short time. Make sure you're getting your protein, drinking water and taking a multivitamin." Another commented: "My hair is so bad. I don't know how I'm not bald already! I'm doing everything I can to stop the shed but nothing seems to be working!" "You look amazing. I believe losing weight too quickly will cause some hair loss," penned a third. Meanwhile, a fourth said: "I take collagen and biotin and it definitely helps me." "Try taking collagen supplements, they've really strengthened my hair and nails! My skin looks younger too. Been on them 2 months,' claimed a fifth Someone else added: "Bloody hell, well done. 16 weeks and a whopping 1 stone down." What to do if you lose too much weight too quickly whilst on Mounjaro IF you're losing too much weight too quickly while on Mounjaro, it's important to take action to avoid potential health risks like muscle loss, malnutrition, dehydration, and fatigue. Here's what you can do: Evaluate Your Caloric Intake Mounjaro reduces appetite, which can make it easy to eat too little. If you're losing weight too fast (more than two to three lbs per week after the initial adjustment period), try: Tracking your food intake to ensure you're eating enough calories (apps like MyFitnessPal can help). Increasing protein intake to preserve muscle mass (aim for 0.6–1g per pound of body weight). Adding healthy fats and complex carbs (e.g., avocados, nuts, whole grains) for balanced energy. Adjust Your Dosage (With Doctor's Approval) If your weight loss is too rapid or causing side effects, your doctor may: Pause dose increases or lower your dosage. Adjust your treatment plan to stabilise your weight loss. Strength Training & Exercise To prevent muscle loss: Incorporate resistance training at least two to three times per week. Stay active with low-impact exercises like walking or yoga. Hydrate & Manage Electrolytes Drink enough water (Mounjaro can reduce thirst). Electrolytes matter - Consider adding magnesium, sodium, and potassium if you feel weak or fatigued. Monitor for Malnutrition & Deficiencies Rapid weight loss can cause vitamin/mineral deficiencies (especially B12, iron, and electrolytes). If you experience: Fatigue, hair loss, or dizziness, ask your doctor about supplements. Consider Further Medical Guidance If your weight loss is excessive or causing health concerns, speak with your healthcare provider. They might adjust your dosage, diet, or exercise plan to help stabilise your weight loss.

Children ‘prescribed puberty blockers despite ban'
Children ‘prescribed puberty blockers despite ban'

Telegraph

time31 minutes ago

  • Telegraph

Children ‘prescribed puberty blockers despite ban'

The NHS will investigate if children were illegally given puberty blockers at a controversial GP surgery. The NHS has launched an investigation into the WellBN GP surgery in Brighton 'to identify patient harm' that may have occurred from the prescribing of powerful drugs to children who think they are transgender, despite being told to stop. As many as 130 children were being prescribed cross-sex hormones, puberty blockers or other drugs prescribed off label, such as to stop breast development, or a combination of them, as recently as May, new data seen by the Telegraph reveals. The investigation was launched because it had emerged that the clinic may have been operating outside of the national NHS guidance. In May it was ordered to stop initiating prescriptions for cross-sex drugs for under 18s. The clinic had attracted children from across Sussex and beyond because of its trans health hub and the doctors' willingness to prescribe puberty blockers and cross-sex hormones as the main approach to its 'informed consent' model of care. The investigation should begin as soon as possible because of the 'serious nature of the patient safety and safeguarding issues identified, and possible harm that has occurred to patients', the NHS Sussex and NHS England terms of reference state. It says the aim is then for a 'desktop review to be completed within four to five weeks', starting with assessments of under-18s prescribed the drugs by the clinic. It also says one of the purposes of the investigation is to establish if any individuals should be referred to the police. The document's annex specifically confirms that this applies if any individuals have supplied the now banned puberty blockers outside of the existing NHS protocols. 'If the investigation finds evidence of the 'sale or supply' through a private prescription, then this is a criminal matter,' it states. A ban on puberty blockers for children with gender dysphoria across the UK was made permanent by Wes Streeting, the Health Secretary, last year. The only exceptions are for children who partake in an NHS clinical trial that is yet to start, or for those who were already taking the drugs under the old guidance and have been allowed to continue. Dr Alice Hodkinson, the co-founder of Biology in Medicine, said: 'The number of young people prescribed cross-sex medications in one location is alarming.' 'The WellBN 'consent form' indicates that young patients are not being properly informed of the risks and complications of cross-sex hormones, which can cause infertility, loss of sexual function and other health damage,' she said. 'While much of the debate has rightly been focused on safeguarding under-18s we want to see a ban on cross-sex hormones for all young adults, as there is no evidence of psychological benefit and plenty of evidence of physical and psychological harm.' GPs have been specifically warned about entering 'shared-care agreements' with private providers, whereby they take on prescribing responsibility for such drugs. It is understood the investigation will look at whether this occurred at WellBN after concerns were raised by members of the public, including parents of children being treated at the clinic, and if any doctors will need to be referred to the police as a result. 'Ideology before safety' Rachel Cashman, the co-founder of PSHE Brighton, said the clinic had 'put ideology before safety, evidence and efficacy'. 'We also know of the brave parents and professionals who have been flagging concerns about this practice to authorities since 2021. We welcome this initial investigation but believe there are more questions to be answered as to how public sector leaders and regulators could possibly have commissioned, contracted and been assured in these circumstances.' The administration of cross-sex drugs, also known as gender-affirming hormones, involves giving hormones such as testosterone to help someone change their physical appearance. They are different to puberty blockers, which stop the onset of puberty by suppressing the release of hormones. The Cass review, led by the paediatrician Baroness Hilary Cass, said all under 18s questioning their gender should be seen by a team of experts for a range of conditions, including mental health issues and neurodevelopmental disorders such as autism, before any treatment is considered. The NHS is setting up seven regional hubs for gender-questioning children, of which three are in operation, to replace the Tavistock clinic that focused on prescribing drugs to children, in favour of an 'holistic' approach delivered by a range of medical staff. The independent review concluded that the use of drugs to treat gender issues had been 'built on shaky foundations' and called for puberty blockers to be banned, citing the 'weak evidence' to support their use in this group of patients. It urged 'extreme caution' in relation to cross-sex hormones in under 18s. A spokesman for WellBN said: 'Our practice is committed to providing the compassionate, supportive care for all of our patients. 'WellBN has always operated within the law and we are working to support the investigation in the best way possible to ensure all of our children and young people receive the care they need.' A spokesman for NHS Sussex said: 'Our clear priority, and the focus of this investigation, is to ensure that children and young people are receiving the most appropriate care and treatment. 'Following concerns raised about some prescribing for children and young people by WellBN in Brighton and Hove, that may fall outside of national clinical policy and guidance, we are working with NHS England and have launched this rapid investigation to determine the right clinical care and support for these young people going forward.'

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store