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アルコール業界が依存するヘビードリンカー

アルコール業界が依存するヘビードリンカー

ビールや蒸留酒の広告には大抵、「責任を持って飲みましょう」という注意書きが入っている。それでもアルコール業界は、公衆衛生当局が安全だとする量以上に飲む人たちに依存している。
株式調査会社バーンスタインが2023年に発表した分析によると、米国のアルコール販売量の推定90%は成人の5分の1が消費している。
Most ads for liquor or beer include a reminder to 'drink responsibly.' Still, the alcohol industry depends on people who drink more than public-health officials say is safe.
A fifth of adults account for an estimated 90% of alcohol sales volumes in the U.S., according to an analysis published in 2023 by equity research firm Bernstein.
'Heavier drinkers are obviously where the money is,' said Philip Cook, a professor emeritus at Duke University whose 2007 book, 'Paying the Tab,' was among the scientific studies analyzed by Bernstein.
That dependence has become a greater risk to companies as the U.S. government considers putting cancer warnings on alcohol packaging and lowering the recommended limit of drinks a day that people can safely consume.
The industry's sales are declining because of consumer health concerns, expanding legalization of cannabis, the use of GLP-1 drugs such as Ozempic and a generational shift toward less alcohol consumption. That leaves beer, wine and spirits companies more reliant on people like Kevin Turner.
'People know alcohol is bad for you, that it can be addictive. People understand that,' said Turner, 39 years old, of Orlando, Fla. 'It is poison. It is delicious poison, but it is absolutely poison.'
On weeknights, Turner enjoys a couple of glasses of liquor from his home bar, which includes a dozen Scotches, as well as other whiskeys, bourbons, rums, gins and liqueurs. On weekend evenings, he often meets up with friends at a local bar for three or four beers. Turner, a former smoker, said he is confident he could stop drinking if he wanted to, but a cancer warning label or a revision to the federal dietary guidelines wouldn't immediately change his habits.
For nearly three decades, the guidelines have said it is safe for men to have a maximum of two drinks a day and for women to have one. A standard drink measure in the U.S. is equivalent to 12 ounces of beer, five ounces of wine or 1.5 ounces of distilled spirits.
Alcohol-industry veterans say they are aware of the loyal customers but don't market to them.
'In any category, especially in alcohol, the industry is very concerned about overconsumption,' said Ann Mukherjee, the former North America chief at Pernod Ricard who introduced an Absolut Vodka marketing campaign addressing the role of alcohol in sexual assault.
The alcohol industry, she said, would prefer to 'be less reliant on just a small group driving a majority of consumption. They don't think this is healthy for their own business, sustainability of the category, and for their own consumers.'
Today, federal rules require alcohol labels with warnings about drunken driving and drinking during pregnancy, as well as a general warning that alcohol 'may cause health problems.' Beer, wine and spirits makers have corporate responsibility programs aimed at curbing underage drinking and impaired driving. And they try to avoid being seen as encouraging heavy drinking. Industry insiders say they spend more time worrying about how to attract new customers than retaining their old ones.
It is hard to pinpoint how much people drink because people often underreport their own consumption. According to survey data from the Centers for Disease Control and Prevention, 6% of American adults say they drink enough to meet the agency's definition of heavy drinking: at least 15 drinks a week for men and eight drinks for women. Bernstein's 2023 analysis put the figure much higher, finding that people who consume more than 14 drinks a week represent as much as 20% of adults in the U.S.
Federal guidelines on alcohol consumption could change this year in an update by the Agriculture and Health and Human Services departments. A report issued this month to inform the new guidelines found that for both men and women, one drink a day increases the risk of death from alcohol-related illnesses and injuries. The link between alcohol consumption and cancer risk has been established for at least seven types of cancer, including breast, colorectum, esophagus, liver, mouth, throat and voice box, according to the surgeon general. Alcohol consumption is the third leading preventable cause of cancer in the U.S., after tobacco and obesity.
The alcohol industry generally acknowledges that heavy drinking increases the risk for several types of cancer, and the industry acknowledges that some studies have linked moderate drinking with increased breast-cancer risk. But industry groups also say that alcohol consumed in moderation can be part of a healthy lifestyle for some people. Industry lobbyists are fighting to prevent any changes to the federal guidelines, arguing that the risks are already known and that the government should take into consideration a recent report showing that moderate drinking lowers mortality rates.
The discussion around the cancer risks of alcohol adds pressure to an already struggling industry.
Shares of Constellation Brands plummeted this month after the company reported lower-than-expected beer sales and a $2.25 billion write-down on its wine and spirits business. The company—which makes Modelo Especial beer, Meiomi wine and Casa Noble tequila—lowered its sales and profit forecasts.
Spirits maker Diageo has warned that it is facing weak consumer demand. And distillers in Kentucky are feeling pain as America's bourbon boom comes to an end, leaving them with a glut of barrels. Jack Daniel's maker Brown-Forman last week said it would cut about 12% of its workforce, or roughly 648 jobs.
These trends could make the alcohol industry's reliance on its most ardent fans more acute—and more fraught.
Tara Prinzivalli, 45, who lives in Staten Island, N.Y., drinks two or three glasses of wine nearly every evening at home or with her neighbors across the street. Prinzivalli, who prefers pinot grigio and Malbec, works as a radiation therapist treating cancer patients. She said a warning label about links between cancer and alcohol wouldn't prompt her to cut down.
'Cancer is not something I think about with wine,' Prinzivalli said. 'Maybe I love it too much or am just naive.'
Write to Laura Cooper at laura.cooper@wsj.com
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In 2023, a total of 24,731 new HIV diagnoses were reported across 30 EU/European Economic Area countries—an increase of 11.8% compared with 2022. 'These positive opinions from the CHMP are an important step toward a new HIV prevention option that could help meet the diverse needs of people across Europe and aim at helping end new HIV infections by the EU target of 2030,' said Jean-Michel Molina, MD, PhD, Université Paris Cité, Professor of Infectious Diseases and Head of the Infectious Diseases Department at the Saint-Louis and Lariboisière Hospitals. 'The opinions reflect the strength of the clinical evidence and the potential of long-acting innovations like lenacapavir to address real-world barriers to the use of PrEP. Expanding the range of PrEP options, in Europe and in countries around the world, is essential to making HIV prevention more accessible for people who need it most.' The positive opinions were supported by data from the Phase 3 PURPOSE 1 and PURPOSE 2 trials conducted by Gilead. In the PURPOSE 1 trial ( NCT04994509 ), data at the primary analysis showed that administration of twice-yearly subcutaneous lenacapavir led to zero HIV infections among 2,134 participants, 100% reduction in HIV infections and superiority of prevention of HIV infections when compared with once-daily oral Truvada ® (emtricitabine 200mg and tenofovir disoproxil fumarate 300mg; F/TDF) in cisgender women in sub-Saharan Africa. In the PURPOSE 2 trial ( NCT04925752 ), there were two HIV infections among 2,179 participants in the twice-yearly subcutaneous lenacapavir group, demonstrating 99.9% of participants did not acquire HIV infection and superiority of prevention of HIV infections when compared with once-daily oral Truvada among a broad and geographically diverse range of cisgender men and gender-diverse people. In both trials, lenacapavir demonstrated superiority of prevention of HIV infections when compared with background HIV incidence (bHIV) and was generally well-tolerated, with no significant or new safety concerns identified . Data from both trials were published in The New England Journal of Medicine and, based in part on the trial results, in December 2024 the journal Science named lenacapavir its 2024 'Breakthrough of the Year.' Continued Global Regulatory Filings for Lenacapavir for HIV Prevention, Milestone Partnerships and Global Guidance Gilead is executing a global access strategy informed by health advocates and organizations that prioritizes speed and enables the most efficient paths for regulatory review, approval of and access to twice-yearly lenacapavir for PrEP. More information about Gilead's recently announced strategic partnership agreement with The Global Fund to Fight AIDS, Tuberculosis and Malaria, as well as updates on Gilead's access strategies in countries and regions around the world: See Gilead press release More information about the WHO's recently announced guidelines for the use of lenacapavir for PrEP: See Gilead company statement Lenacapavir for PrEP is not approved by any regulatory authority outside of the United States. There is currently no cure for HIV or AIDS. About the PURPOSE Program Gilead's landmark PURPOSE program is the most comprehensive and diverse HIV prevention trial program ever conducted. The program comprises five HIV prevention trials around the world that are focused on innovation in science, trial design, community engagement and health equity. The PURPOSE trials are evaluating the safety and efficacy of an investigational, twice-yearly injectable medicine, lenacapavir, to reduce the chance of getting HIV. The Phase 2 and 3 program, consisting of PURPOSE 1-5, is assessing the potential of lenacapavir to help a diverse range of people around the world who could benefit from PrEP. More information about the PURPOSE program, including individual trial descriptions, populations and locations, can be found at About Lenacapavir Lenacapavir is approved in multiple countries for the treatment of multi-drug-resistant HIV in adults, in combination with other antiretrovirals. Lenacapavir is also approved in the United States to reduce the risk of sexually acquired HIV in adults and adolescents (≥35kg) who are at risk of HIV acquisition. The multi-stage mechanism of action of lenacapavir is distinguishable from other currently approved classes of antiviral agents. While most antivirals act on just one stage of viral replication, lenacapavir is designed to inhibit HIV at multiple stages of its lifecycle and has no known cross resistance exhibited in vitro to other existing drug classes. Lenacapavir is being evaluated as a long-acting option in multiple ongoing and planned early and late-stage clinical studies in Gilead's HIV prevention and treatment research program. Lenacapavir is being developed as a foundation for potential future HIV therapies with the goal of offering both long-acting oral and injectable options with several dosing frequencies, in combination or as a mono agent, that help address individual needs and preferences of people and communities affected by HIV. The journal Science named lenacapavir its 2024 'Breakthrough of the Year.' U.S. Indication for Yeztugo® Yeztugo (lenacapavir) injection, 463.5 mg/1.5 mL, is indicated for pre‑exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 in adults and adolescents (≥35kg) who are at risk for HIV-1 acquisition. Individuals must have a negative HIV-1 test prior to initiating Yeztugo. U.S. Important Safety Information for Yeztugo BOXED WARNING: RISK OF DRUG RESISTANCE WITH USE OF YEZTUGO IN UNDIAGNOSED HIV-1 INFECTION Contraindications Warnings and precautions Adverse reactions Drug interactions Dosage and administration About Gilead HIV For more than 35 years, Gilead has been a leading innovator in the field of HIV, driving advances in treatment, prevention and cure research. Gilead researchers have developed 13 HIV medications, including the first single-tablet regimen to treat HIV, the first antiretroviral for pre-exposure prophylaxis (PrEP) to help reduce new HIV infections, and the first long-acting injectable HIV treatment medication administered twice-yearly. Our advances in medical research have helped to transform HIV into a treatable, preventable, chronic condition for millions of people. Gilead is committed to continued scientific innovation to provide solutions for the evolving needs of people affected by HIV around the world. Through partnerships, collaborations and charitable giving, the company also aims to improve education, expand access and address barriers to care, with the goal of ending the HIV epidemic for everyone, everywhere. Gilead was recognized as one of the leading philanthropic funders of HIV-related programs in a report released by Funders Concerned About AIDS. About Gilead Sciences Gilead Sciences, Inc. is a biopharmaceutical company that has pursued and achieved breakthroughs in medicine for more than three decades, with the goal of creating a healthier world for all people. The company is committed to advancing innovative medicines to prevent and treat life-threatening diseases, including HIV, viral hepatitis, COVID-19, cancer and inflammation. Gilead operates in more than 35 countries worldwide, with headquarters in Foster City, California. Forward-Looking Statements This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks, uncertainties and other factors, including Gilead's ability to initiate, progress and complete clinical trials in the anticipated timelines or at all, and the possibility of unfavorable results from ongoing and additional clinical trials, including those involving Yeztugo (lenacapavir) (such as PURPOSE 1 and PURPOSE 2); uncertainties relating to regulatory applications and related filing and approval timelines, including regulatory applications for lenacapavir for PrEP, and the risk that any regulatory approvals, if granted, may be subject to significant limitations on use or subject to withdrawal or other adverse actions by the applicable regulatory authority; the possibility that Gilead may make a strategic decision to discontinue development of lenacapavir for indications currently under evaluation and, as a result, lenacapavir may never be successfully commercialized for such indications; Gilead's ability to effectively manage the access strategy relating to lenacapavir, subject to necessary regulatory approvals; and any assumptions underlying any of the foregoing. These and other risks, uncertainties and factors are described in detail in Gilead's Quarterly Report on Form 10-Q for the quarter ended March 31, 2025, as filed with the U.S. Securities and Exchange Commission. These risks, uncertainties and other factors could cause actual results to differ materially from those referred to in the forward-looking statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. The reader is cautioned that any such forward-looking statements are not guarantees of future performance and involve risks and uncertainties and is cautioned not to place undue reliance on these forward-looking statements. All forward-looking statements are based on information currently available to Gilead, and Gilead assumes no obligation and disclaims any intent to update any such forward-looking statements. U.S. full Prescribing Information for Truvada and Yeztugo, including Boxed Warning, are available Truvada, Truvada for PrEP, Yeztugo, Yeytuo, Gilead and the Gilead logo are registered trademarks of Gilead Sciences, Inc., or its related companies. For more information about Gilead, please visit the company's website follow Gilead on X/Twitter (@Gilead Sciences) and LinkedIn (@Gilead-Sciences). View source version on CONTACT: Ashleigh Koss, Media [email protected] Ross, Investors [email protected] KEYWORD: EUROPE UNITED STATES NORTH AMERICA CALIFORNIA INDUSTRY KEYWORD: AIDS HEALTH INFECTIOUS DISEASES HOSPITALS PHARMACEUTICAL BIOTECHNOLOGY SOURCE: Gilead Sciences, Inc. Copyright Business Wire 2025. PUB: 07/25/2025 03:00 AM/DISC: 07/25/2025 03:01 AM

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