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Corrections: June 5, 2025

Corrections: June 5, 2025

New York Times05-06-2025
An article on Wednesday about the large-scale deadly shooting near a food distribution center in southern Gaza on Tuesday referred imprecisely to the locations of the Gaza Humanitarian Foundation's aid distribution sites in Gaza. They are mostly in the south of the enclave, and one is in central Gaza.
An article on Wednesday about the spread of 3D-printed firearms in the Aland Islands, an autonomous stretch of rocky coves in the middle of the Baltic Sea, misspelled the surname of an Aland Islands gunsmith and misstated the year he died. His name is Janne Stenroos, not Stenros, and he died in 2022, not 2023.
An obituary on Sunday about the actress Loretta Swit referred incorrectly to the film 'Race With a Devil,' in which Ms. Swit appeared in 1975. It had a theatrical release; it was not a television movie. The obituary also misstated the rank of the father of Ms. Swit's character, Major Houlihan, in the television series 'M*A*S*H.' He was a colonel, not a general.
An obituary on Sunday about George E. Smith, who shared a Nobel Prize in Physics for his discovery of a revolutionary imaging device, referred incorrectly to an interview he gave in 2001. It was for an oral history project conducted by the IEEE History Center in Piscataway, N.J., not with the Engineering and Technology History Wiki website. The obituary also misstated the number of pages in his noted doctoral dissertation at the University of Chicago in 1959. It was eight pages, not three. (At the time, it was the shortest Ph.D. dissertation in the university's history.)
Errors are corrected during the press run whenever possible, so some errors noted here may not have appeared in all editions.
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Start your week smart: NASA's future, Starvation in Gaza, Stabbing incident, Extreme heat risk, Swimming showdown
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CNN

time15 hours ago

  • CNN

Start your week smart: NASA's future, Starvation in Gaza, Stabbing incident, Extreme heat risk, Swimming showdown

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Israeli Startups Using AI To Accelerate Drug Discovery
Israeli Startups Using AI To Accelerate Drug Discovery

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Israeli Startups Using AI To Accelerate Drug Discovery

AI Aiding in drug discovery Israel-based AION Labs wants to drive AI to revolutionize pharmaceutical drug discovery and development. AION is an innovative venture that brings together pharmaceutical heavyweights—Pfizer, AstraZeneca, Teva, and Merck—with entrepreneurial scientists, technology leaders, and successful investors. 'We are a venture studio that builds startups using computational technologies and artificial intelligence to unleash new capabilities to discover and develop new drugs with a venture model that we invented,' says Mati Gill, CEO of AION. This unique collaboration addresses a costly endeavor that is crucial to the quality of our lives. It takes $5 billion and ten years to bring a new drug to market. The world's top 20 pharmaceutical companies collectively spent $145 billion on R&D in 2022-23, according to a recent Deloitte report, which also noted 'AI is yet to become a 'game-changer' in pharma R&D.' A more comprehensive survey of 4,191 pharmaceutical companies worldwide, published in Nature Reviews Drug Discovery, found that they spent $276 billion on R&D in 2021. These R&D expenses have increased tenfold since the 1980s (after adjusting for inflation), and pharmaceutical companies now allocate approximately 25% of their revenue to R&D, nearly double the share seen in the early 2000s, according to CB Insights. 'AI could potentially cut years off the discovery process and compress clinical trial times by up to 30%. This would accelerate the delivery of new treatments to patients, unlock novel treatment approaches, and enable more personalized medicine,' noted CBI. Another CBI report, on the AI readiness of pharmaceutical companies, highlighted the importance of external collaboration, 'as breakthrough innovations increasingly emerge from partnerships rather than internal development alone.' Gill predicts that by 2030, the first truly AI-designed drugs will reach regulatory approval. He believes that Israel is uniquely positioned to be a leading ecosystem in transforming the global biotech and pharmaceutical landscape, given its strengths in multidisciplinary scientific discovery, entrepreneurial innovation, computational biology and big data analysis, as well as a robust and integrated healthcare system, and strong government support. 'For the first time, Israel's strengths are coinciding with what the future of the industry is going to be,' says Gill. There are three core principles behind every startup that AION selects and supports, explains Gill: they address a validated, well-defined, industry-wide problem statement; there's a multidisciplinary team that has expertise in both AI and biology and a technology that can solve that problem statement; and that at least one of AION' pharmaceutical partners is willing to commit to working with the startup to initially develop their technology and conduct with them a proof-of-concept at an early stage. The R&D teams of AION Labs' partners help select the specific industry-wide challenges to focus on and the technologies and scientist-led startups that will develop the solutions. To accomplish that, AION has established two tracks, one starting with the problem statement and the other starting with the technology. DenovAI is an example of starting with the problem statement. Is it possible to design proteins 'de novo' or completely from scratch? 'We ran a challenge and had 15 great candidates,' recounts Gill. 'We selected a senior scientist who had developed a technology called AlphaDesign that is basically doing the inverse of the famous AlphaFold.' The startup recently demonstrated its ability to generate new proteins with measurable, targeted function. Its AI-based platform for rapid de novo antibody discovery could reduce the discovery process from months to days, and broaden the scope of therapy to a wide range of diseases. Cassidy Bio is an example of starting with the technology. It is using large language models or LLMs to design new guide RNAs, unlocking the capability of gene therapy in a scalable and precise manner. Guide RNAs or gRNAs serve as the 'GPS' for CRISPR systems, directing the editing machinery to precise genetic targets. The design of gRNAs plays a critical role in determining both the efficacy and safety of gene-editing therapeutics. Professor Ayal Hendel of Israel's Bar-Ilan University, a leading expert in genome editing and gene therapy, teamed up with two experienced entrepreneurs to establish the startup. With AION Labs' help, they raised $8 million in seed funding and are working with AstraZeneca to validate their technology. Based on proprietary, clinically relevant genomic data generation, state-of-the-art predictive algorithms, and rigorous wet lab validation, Cassidy Bio is developing the first comprehensive predictive platform based on LLMs for gRNA design. Unlike the data driving AI consumer applications, which is mostly based on internet-scraped data, pharmaceutical data is proprietary data. AION Labs' unique collaborative model provides access to pharmaceutical firms' R&D teams and their data, along with a secure sharing environment facilitated by AION's tech partner, Amazon's cloud service. 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When To See ‘Shooting Stars' Tonight As Four Meteor Showers Collide
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Summer's 'shooting stars' season gets underway this week with the peaks of three meteor showers. The most famous meteor shower of all, the Perseids, will peak on Aug. 12-13, but a badly timed full moon makes this week the best time to see its shooting stars. A Perseid meteor streaks across the sky above Inspiration Point early on August 12, 2016 in Bryce ... More Canyon National Park, Utah. (Photo by) Getty Images The Piscis Austrinid meteor shower will peak in the early hours of July 28, with about five meteors per hour possible, according to The following morning, July 29, will see the peaks of two more meteor showers, the Southern delta Aquariids and the alpha Capricornids. The Southern delta Aquariid meteor shower produces up to 25 shooting stars per hour, with most being rather faint. Although the alpha Capricornids number just five shooting stars per hour at their peak, they tend to include bright and colorful fireballs, according to the American Meteor Society. For all three meteor showers, the best view will likely be had about 3:00 a.m. local time in North America (all timezones), when the radiant points — the constellations of Pisces, Aquarius and Capricorn — are highest in the sky. Those constellations are all visible low on the southern horizon, so the best views will be had the farther south in North America. July 28 and 29 will be excellent nights for stargazing and looking for shooting stars if the skies are clear because the light from the crescent moon will not bleach the night sky. The Perseid meteor shower is already active, having begun on July 17 and is expected to continue until Aug. 23. On the peak night, around 50-75 meteors per hour are visible, but in 2025, that number will be significantly reduced, with only the very brightest of its shooting stars visible. That's because Aug. 9 will see the rise of a full sturgeon moon, which will remain bright and dominant in the night sky on Aug. 12-13, rising just as the peak of the Perseids gets underway. It will remain in the sky for the rest of the night. When To See The Perseid Meteor Shower In 2025 There are two periods to watch the skies in 2025 if you want to see shooting stars from the Perseid meteor shower. The first is right now before the moon reaches its first quarter phase on Aug. 1. The second is Aug. 15, when the moon will rise around midnight and a little later on subsequent nights. According to NASA, the best way to watch a meteor shower is to get out of the city to the darkest location you can, such as a Dark Sky Place. However, it's wise to check the weather forecast in advance because a clear sky is imperative. Observe somewhere with a clear view of as much of the night sky as possible, with extra layers to keep warm, as well as bug spray, snacks and drinks. Be patient, take a break every 30 minutes and avoid looking at a smartphone whose white light will kill your night vision. The Next Major Meteor Shower After the Perseids come to an end on Aug. 23, the next major meteor shower will be the Orionids. Active from Oct. 2 to Nov. 12, it will peak overnight on Oct. 22-23, one day after October's new moon. That will be perfectly dark skies, making many of the Orionids' predicted 10-20 shooting stars per hour during the peak visible to observers away from light pollution. The Orionid meteor shower is one of two annual meteor showers caused by Halley's Comet, the most famous and one of the largest comets known. The other is the Eta Aquariids meteor shower, which next peaks on May 5-6, 2026. Further Reading Forbes NASA Urges Public To Leave The City As Milky Way Appears — 15 Places To Go By Jamie Carter Forbes Get Ready For The Shortest Day Since Records Began As Earth Spins Faster By Jamie Carter Forbes NASA Spacecraft 'Touches Sun' For Final Time In Defining Moment For Humankind By Jamie Carter

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