Career Pivot: A Physician's Guide to What's Next
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Medscape
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Dementia Diagnosis Takes an Average of 3 Years: New Data
TOPLINE: The average time to diagnosis (TTD) of dementia was 3.5 years in a new meta-analysis, with younger age at onset and having frontotemporal dementia consistently associated with even longer diagnostic intervals. METHODOLOGY: This systematic review and meta-analysis used data from 13 cohort studies published up to December 2024. More than 30,000 patients with a diagnosis of dementia were included, with the age at onset ranging between 54 and 93 years. TTD was defined as the interval between the onset of symptoms, rated by family carers or patients using interviews or medical records, and the final diagnosis. TAKEAWAY: A meta-analysis of 10 studies showed the average TTD across all types of dementia was 3.5 years (95% CI, 2.7-4.3), with moderate-quality evidence. An analysis of six studies showed that the average TTD of young-onset dementia was 4.1 years (95% CI, 3.4-4.9), also with moderate-quality evidence. An analysis by dementia type showed consistently longer TTDs for young-onset Alzheimer's disease (TTD, 4.0 years; 95% CI, 2.7-5.2) and frontotemporal dementia (TTD, 4.7 years; 95% CI, 3.0-6.4). In contrast, TTD in late-onset dementia was 2.9 years (95% CI, 2.6-3.2) in analysis of two studies. IN PRACTICE: 'Timely diagnosis of dementia remains a major global challenge, shaped by a complex set of factors, and specific healthcare strategies are urgently needed to improve it,' lead investigator Vasiliki Orgeta, PhD, Division of Psychiatry, University College London, London, England, said in a press release. 'Clinician training is critical to improve early recognition and referral, along with access to early intervention and individualized support, so that people with dementia and their families can get the help they need,' Orgeta added. SOURCE: The study was published online on July 27 in International Journal of Geriatric Psychiatry. LIMITATIONS: Definitions of TTD varied across studies, with different methods used to assess the first symptoms of dementia. The current meta-analysis did not assess factors affecting TTD. Additionally, individuals with severe dementia may not have accurately remembered when they first experienced symptoms, potentially introducing a recall bias. The findings were also not applicable to low- and medium-income countries. DISCLOSURES: The investigators reported having no relevant conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Business Wire
8 hours ago
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Compass Pathways to Participate in Canaccord Genuity 45th Annual Growth Conference on August 12, 2025 in Boston, MA
LONDON & NEW YORK--(BUSINESS WIRE)--Compass Pathways plc (Nasdaq: CMPS), a biotechnology company dedicated to accelerating patient access to evidence-based innovation in mental health, announced today that Management will participate in the Canaccord Genuity 45th Annual Growth Conference on August 12, 2025 in Boston, MA, with a company presentation scheduled at 4:00pm ET. Management will participate in the Canaccord Genuity 45th Annual Growth Conference on August 12, 2025. A broadcast of Compass's presentation will be accessible from the 'Events' page of the Investors section of the Compass website. A replay of this webcast will be accessible for 30 days following the event. For more information, please visit our investor website. About Compass Pathways Compass Pathways plc (Nasdaq: CMPS) is a biotechnology company dedicated to accelerating patient access to evidence-based innovation in mental health. Our focus is on improving the lives of those who are living with mental health challenges and who are not helped by existing standards of care. We are pioneering the development of a new model of psilocybin treatment, in which our proprietary formulation of synthesized psilocybin, COMP360, is administered in conjunction with psychological support. COMP360 has Breakthrough Therapy designation from the US Food and Drug Administration (FDA) and has received Innovative Licensing and Access Pathway (ILAP) designation in the UK for treatment-resistant depression (TRD). Compass is headquartered in London, UK, with offices in New York in the U.S. We envision a world where mental health means not just the absence of illness but the ability to thrive.
Medscape
10 hours ago
- Medscape
Breaking Barriers: How Inclusive Is Your Practice?
Primary care is often the first point of contact with the healthcare system and should be a space of welcome, respect, and active listening. However, many individuals from the LGBTI+ community continue to face significant barriers when visiting their family physicians. These challenges may stem from the use of noninclusive language or a lack of specific training in sexual and gender diversity. Barriers to Care Fear of Discrimination LGBTI+ patients report fear of disclosing their sexual orientation or gender identity during medical consultations because of the fear of being judged or treated differently by healthcare professionals. This fear is not without basis, as surveys have shown that some healthcare providers still hold unconscious discriminatory attitudes, contributing to distrust and patient withdrawal. Invisibility and Heteronormative Assumptions Heteronormative assumptions are common in clinical settings. Asking questions like 'Do you have a girlfriend?' or 'Do you have a partner?' followed by 'What's her name?' invalidate a patient's identity unintentionally. Such assumptions may contribute to feelings of exclusion or the pressure to conceal one's identity. Training Gaps LGBTI+ health content is rarely included in undergraduate, residential, or continuing education programs. As a result, key clinical needs are often unmet, including. Prevention of sexually transmitted infections (STIs) in same-sex relationships. Prescription and monitoring of preexposure prophylaxis (PrEP) Medical care for trans people, including hormone therapy Screenings adapted to sexual practices and gender identities, such as cervical cancer screening in trans men with a cervix Impact on Mental Health Invisibility, microaggressions, and stigma in healthcare settings can affect the mental health of LGBTI+ individuals. Combined with social or familial discrimination, these experiences increase the risk for anxiety, depression, and substance abuse among LGBTQ+ individuals. Primary care plays a critical role in the early detection and provision of support. Noninclusive Environment Minute details, such as forms that do not recognize nonbinary identities, can signal to patients that their experiences are not acknowledged. In contrast, inclusive symbols and visible LGBTQ+ resources can foster a more welcoming and trusting environment. Improving LGBTQ+ Care Family medicine, with its comprehensive, longitudinal, and person-centered approach, is uniquely positioned to lead efforts toward more inclusive and equitable healthcare for the LGBTQ+ community. Recently, the Spanish Society of General and Family Physicians (SEMG) signed a collaborative agreement with the Spanish LGBT+ Federation to address key gaps in care. The following areas were identified for improvement. Targeted Training in LGBTQ+ Health Although sexual and gender diversity topics are increasingly included in medical training, current coverage remains limited. Healthcare professionals should pursue ongoing education in the following ways: Sexual orientation, gender identity, and expression. Inclusive sexual and reproductive health that avoids norm-centric assumptions. Hormonal therapy and long-term care of transgender patients. Prevention and early detection of STIs across diverse sexual practices. Addressing stigma and associated psychosocial challenges. Inclusive Clinical Communication Communication significantly influences trust. An open, nonassumptive approach during history taking is essential. Ask 'Do you have a partner?' rather than assuming the gender or orientation. Confirm the patient's chosen name and pronouns, particularly in transgender individuals. Avoid terms such as 'normal life' or 'natural relationship,' which may imply judgment. Personalized Screening and Prevention Standard preventive protocols often overlook the nontraditional healthcare needs. Customization is essential. Transgender men with a cervix should be included in cervical cancer screening. STI screening should be offered on the basis of sexual practices rather than identity alone. Assess HIV risk without bias and discuss pre PrEP or postexposure prophylaxis as appropriate. Creating an Inclusive Clinical Environment Both physical and symbolic elements help foster a safe space in which patients feel comfortable sharing personal information. Display signage or guides indicating that the clinic is a safe and inclusive space. Provide informational materials that represent diverse identity. Ensure that condoms, lubricants, and brochures on STIs, PrEP, LGBTQ+ mental health, and related topics are readily available. Emotional and Psychosocial Support Mental health concerns among LGBTQ+ patients often arise from discrimination, exclusion, and violence. Healthcare should offer empathetic support rather than pathologizing these experiences. Screening for anxiety, depression, or social isolation linked to stigma or rejection. Provide emotional support and, when appropriate, refer patients to mental health professionals or community organizations for additional assistance. Community Collaboration Effective care extends beyond the clinic. Partnering with local LGBTQ+ organizations to support comprehensive care. These organizations often provide psychosocial services, legal support, sexual health workshops, and peer mentoring. Establishing collaboration between primary care teams and local community groups. Engage in public health initiatives that promote LGBTQ+ health and visibility. Conclusion Improving LGBTQ+ care in family medicine does not require significant resources; only awareness, consistent training, and commitment to inclusive clinical practice are needed. Creating an inclusive clinical environment can meaningfully improve the health and trust of LGBTQ+ communities, which have often been left out of the healthcare system. Disclosure This article is an editorial collaboration between the SEMG and Univadis Spain . Ríos is the lead of the Public Health Working Group at the SEMG.
