Latest news with #Harmoni


Business Wire
2 days ago
- Business
- Business Wire
SMMT Investors Have Opportunity to Join Summit Therapeutics Inc. Fraud Investigation with the Schall Law Firm
LOS ANGELES--(BUSINESS WIRE)-- The Schall Law Firm, a national shareholder rights litigation firm, announces that it is investigating claims on behalf of investors of Summit Therapeutics Inc. ('Summit' or 'the Company') (NASDAQ: SMMT) for violations of the securities laws. The investigation focuses on whether the Company issued false and/or misleading statements and/or failed to disclose information pertinent to investors. Summit announced the topline results from its Phrase III 'Harmoni' clinical trial on May 30, 2025. The Company's ivonescimab drug did not demonstrate a significantly significant difference in overall survivability during the trial. Based on this news, shares of Summit fell by 30.5% on the same day. If you are a shareholder who suffered a loss, click here to participate. We also encourage you to contact Brian Schall of the Schall Law Firm, 2049 Century Park East, Suite 2460, Los Angeles, CA 90067, at 310-301-3335, to discuss your rights free of charge. You can also reach us through the firm's website at or by email at bschall@ The Schall Law Firm represents investors around the world and specializes in securities class action lawsuits and shareholder rights litigation. This press release may be considered Attorney Advertising in some jurisdictions under the applicable law and rules of ethics.

Barnama
24-06-2025
- Lifestyle
- Barnama
Siti Khadijah Unveils New ‘Maharani' Face Design
KUALA LUMPUR, June 24 (Bernama) -- After a decade since its last face design, prayerwear and lifestyle brand pioneer Siti Khadijah today unveiled its latest collection, Maharani. Its founder, Padzilah Enda Sulaiman, said the sixth face design symbolises the brand's evolution and a tribute to women who embody grace, resilience and heritage - values that have defined Siti Khadijah since its inception in 2009. 'Maharani is more than just a new face design. It reflects our long journey in understanding the true needs of women. The process took time, but every step was approached with care and meaning,' she said at the launch ceremony. Padzilah Enda said Maharani builds on two of the brand's iconic face designs, namely Original, introduced in 2009 featuring a firm awning, and Harmoni (2016), which mimics an inner scarf at the forehead for a softer and lighter fit suitable for all-day wear. She said the name Maharani was inspired by the symbolic use of the awning, which resembles a tiara. 'The design makes Maharani both functional and elegant, a testament to Siti Khadijah's continuous innovation in offering comfort through every creation,' she added. In conjunction with the launch, the brand also introduced three new telekung collections featuring the Maharani face design. They are: Broderie Zahara, featuring intricate classic embroidery; Flair Sabira, offering a flowy, modern cut with lightweight textures; and Modish Maira Midi, with a mid-length cut ideal for use in the Holy Land. 'All three collections prioritise comfort, refined craftsmanship and contemporary style in line with the values and aesthetic of the Siti Khadijah brand,' she said.
Yahoo
02-06-2025
- Business
- Yahoo
Is Beaten-Down Summit Therapeutics Stock a Bad-News Buy?
Summit Therapeutics stock fell hard recently in response to disappointing clinical trial results. Ivonescimab failed to produced a statistically significant overall survival benefit in the phase 3 Harmoni trial. Ivonescimab has been approved by Chinese regulators, but Summit Therapeutics has a license to sell it outside of China. 10 stocks we like better than Summit Therapeutics › Shares of Summit Therapeutics (NASDAQ: SMMT) tanked more than 30% on Friday, May 30. Such dramatic price swings aren't unusual in the biotechnology industry; in this case, disappointing data from an important clinical trial drove the stock down. Stock markets have a tendency to sell first and ask questions later. After watching this stock plummet, some bargain-shoppers are wondering if it fell too far. Recent trial results missed the mark the company was hoping for, but the results weren't entirely discouraging. Let's weigh the bad news against the good to see if this stock could be a beaten-down bargain. Summit Therapeutics and its investors have been eagerly anticipating results from the phase 3 Harmoni trial of ivonescimab. It's a bispecific antibody that works like a compination of Keytruda (a PD-1 inhibitor) plus Avastin (a VEGF inhibitor). Summit's stock price rocketed higher in 2024 thanks to Harmoni-2 trial results that showed it outperformed Keytruda at limiting tumor growth in lung cancer patients. Although ivonescimab is already approved in China, it's not for sale in the U.S. and EU, where Summit Therapeutics has a license to sell it. The Harmoni trial enrolled second-line lung cancer patients and treated them with ivonescimab or a placebo plus standard chemo. The treatment reduced the risk of disease progression in terms of tumor growth by 48%, but failed to show a convincing overall survival benefit. Adding ivonescimab to standard chemo reduced patients' risk of death by 21%, but the results fell just outside a 95% confidence interval with a p-value of 0.057. It's highly unlikely the Food and Drug Administration will approve ivonescimab for sale in the U.S. based on the Harmoni trial results. According to Summit, the FDA has been clear about the need for a statistically significant overall survival benefit to support an application. The China-based company that owns ivonescimab, Akeso, recently earned a second approval to market the therapy to lung cancer patients in China. Keytruda sales rose to $29.5 billion last year, and a treatment that can outperform the leader could do even better. Ivonescimab is unlikely to earn approval in the U.S. for patients similar to those enrolled in the Harmoni trial. Given its ability to shrink tumors, though, it's probably just a matter of time before it produces statistically significant overall survival results for an underserved patient population. Tumor responses get attention, but oncologists are far more interested in giving patients a chance for long-term survival. Keytruda's a top seller now because it produced dramatic overall survival results, compared to the standard treatments of its time. The lack of convincing overall survival data so far for ivonescimab severely reduces the odds that it will go on to produce blockbuster sales in the places where Summit Therapeutics has a license to sell it. Despite the obvious challenges ahead, expectations are still sky-high. Drugmaker stocks tend to trade at mid-single-digit multiples of trailing annual sales. Summit has no sales, as ivonescimab is the only candidate in its pipeline. Despite the lack of options and an uncertain path forward, the stock finished May with a market cap above $13.5 billion. If ivonescimab goes on to produce sales anywhere near Keytruda's, investors who bought Summit Therapeutics at recent prices could reap enormous gains. Unfortunately, the Harmoni trial's failure to produce a convincing overall survival benefit suggests that future sales will be muted, even if the company can get it past the FDA. It's probably best to watch this story play out from a safe distance. Before you buy stock in Summit Therapeutics, consider this: The Motley Fool Stock Advisor analyst team just identified what they believe are the for investors to buy now… and Summit Therapeutics wasn't one of them. The 10 stocks that made the cut could produce monster returns in the coming years. Consider when Netflix made this list on December 17, 2004... if you invested $1,000 at the time of our recommendation, you'd have $651,049!* Or when Nvidia made this list on April 15, 2005... if you invested $1,000 at the time of our recommendation, you'd have $828,224!* Now, it's worth noting Stock Advisor's total average return is 979% — a market-crushing outperformance compared to 171% for the S&P 500. Don't miss out on the latest top 10 list, available when you join . See the 10 stocks » *Stock Advisor returns as of May 19, 2025 Cory Renauer has no position in any of the stocks mentioned. The Motley Fool has positions in and recommends Summit Therapeutics. The Motley Fool has a disclosure policy. Is Beaten-Down Summit Therapeutics Stock a Bad-News Buy? was originally published by The Motley Fool Sign in to access your portfolio


NBC News
11-02-2025
- Science
- NBC News
America's kids are still behind in reading and math. These schools are defying the trend
COMPTON, Calif. — Math is the subject sixth grader Harmoni Knight finds hardest, but that's changing. In-class tutors and 'data chats' at her middle school in Compton, California, have made a dramatic difference, the 11-year-old said. She proudly pulled up a performance tracker at a tutoring session last week, displaying a column of perfect 100% scores on all her weekly quizzes from January. Since the pandemic first shuttered American classrooms, schools have poured federal and local relief money into interventions like the ones in Harmoni's classroom, hoping to help students catch up academically following COVID-19 disruptions. But a new analysis of state and national test scores shows the average student remains half a grade level behind pre-pandemic achievement in both reading and math. In reading, especially, students are even further behind than they were in 2022, the analysis shows. Compton is an outlier, making some of the biggest two-year gains in both subjects among high-poverty districts. And there are other bright spots, along with evidence that interventions like tutoring and summer programs are working. The Education Recovery Scorecard analysis by researchers at Harvard, Stanford and Dartmouth allows year-to-year comparisons across states and districts, providing the most comprehensive picture yet of how American students are performing since COVID-19 first disrupted learning. The most recent data is based on tests taken in spring 2024. By then, the worst of the pandemic was long past, but schools were dealing still with a mental health crisis and high absenteeism — not to mention students who'd had crucial learning interrupted. 'The losses are not just due to what happened during the 2020 to 2021 school year, but the aftershocks that have hit schools in the years since,' said Tom Kane, a Harvard economist who worked on the scorecard. In some cases, the analysis shows school districts are struggling, even though their students may have posted decent results on state tests. That's because each state adopts its own assessments, and those aren't comparable to each other. Those differences can make it impossible to tell whether students are performing better because of their progress, or whether those shifts are because the tests themselves are changing, or the state has lowered its standards for proficiency. For example, Wisconsin, Nebraska and Florida seem to have relaxed their proficiency cutoff in math and reading in the last two years, Kane said, citing the analysis. The Scorecard accounts for differing state tests and provides one national standard. Higher-income districts have made significantly more progress than lower-income districts, with the top 10% of high-income districts four times more likely to have recovered in both math and reading compared with the poorest 10%. And recovery within districts remains divided by race and class, especially in math scores. Test score gaps grew by both race and income. 'The pandemic has not only driven test scores down, but that decline masks a pernicious inequality that has grown during the pandemic,' said Sean Reardon, a Stanford sociologist who worked on the scorecard. 'Not only are districts serving more Black and Hispanic students falling further behind, but even within those districts, Black and Hispanic students are falling further behind their white districtmates.' Tutors in class, after school and on Saturdays Still, many of the districts that outperformed the country serve predominantly low-income students or students of color, and their interventions offer best practices for other districts. In Compton, the district responded to the pandemic by hiring over 250 tutors that specialize in math, reading and students learning English. Certain classes are staffed with multiple tutors to assist teachers. And schools offer tutoring before, during and after school, plus 'Saturday School' and summer programs for the district's 17,000 students, said Superintendent Darin Brawley. The district also now conducts dyslexia screenings in all elementary schools. The low-income school district near downtown Los Angeles, with a student body that is 84% Latino and 14% Black, now has a graduation rate of 93%, compared with 58% when Brawley took the job in 2012. Harmoni, the sixth grader, said tutoring has helped her grasp concepts and given her more confidence in math. She has 'data chats' with her math specialist that are part performance review, part pep talk. 'Looking at my data, it kind of disappoints me' when the numbers are low, said Harmoni. 'But it makes me realize I can do better in the future, and also now.' Brawley said he's proud of the district's latest test scores, but not content. 'Truth be told, I wasn't happy,' he said. 'Even though we gained, and we celebrate the gains, at the end of the day we all know that we can do better.' That could be more difficult in coming years. Federal pandemic relief money has ended; many schools used it for programs like tutoring. Going forward, schools must prioritize interventions that worked. Districts that spent federal money on increased instructional time, either through tutoring or summer school, saw a return on that investment, Kane and Reardon said. Brawley said Compton hopes to maintain its tutoring programs using other funding sources. 'The question is, at what scale?' Elsewhere in the country, reading levels have continued to decline, despite a movement in many states to emphasize phonics and the ' science of reading.' So Reardon and Kane called for an evaluation of the mixed results for insights into the best ways to teach kids to read. Schools also must engage parents and tell them when their kids are behind, the researchers said. And schools must continue to work with community groups to improve students' attendance, they said. The scorecard identified a relationship between high absenteeism and learning struggles. Tutors also help with attendance In the District of Columbia, an intensive tutoring program helped with both academics and attendance, D.C. Public Schools Chancellor Lewis Ferebee said. In the scorecard analysis, the District of Columbia ranked first among states for gains in both math and reading between 2022 and 2024, after its math recovery had fallen toward the bottom of the list. Pandemic-relief money funded the tutoring, along with a system of identifying and targeting support at students in greatest need. The district also hired program managers who helped maximize time for tutoring within the school day, Ferebee said. Students who received tutoring were more likely to be engaged with school, Ferebee said, both from increased confidence and because they had a relationship with another trusted adult. Students expressed that 'I'm more confident in math because I'm being validated by another adult,' Ferebee said. 'That validation goes a long way, not only with attendance, but a student feeling like they are ready to learn and are capable.' Even now that federal pandemic relief money has ended, Ferebee said many of the investments the district made will have lasting impact, including the money spent on teacher training and curriculum development in literacy. Christina Grant, the District of Columbia's superintendent of education until 2024, said she's hopeful to see the evidence emerging on what's made a difference in student achievement. 'We cannot afford to not have hope. These are our students. They did not cause the pandemic,' Grant said. 'The growing concern is ensuring that we can ... see ourselves to the other side.'
Yahoo
11-02-2025
- Science
- Yahoo
America's kids are still behind in reading and math. These schools are defying the trend
COMPTON, Calif. (AP) — Math is the subject sixth grader Harmoni Knight finds hardest, but that's changing. In-class tutors and 'data chats' at her middle school in Compton, California, have made a dramatic difference, the 11-year-old said. She proudly pulled up a performance tracker at a tutoring session last week, displaying a column of perfect 100% scores on all her weekly quizzes from January. Since the pandemic first shuttered American classrooms, schools have poured federal and local relief money into interventions like the ones in Harmoni's classroom, hoping to help students catch up academically following COVID-19 disruptions. But a new analysis of state and national test scores shows the average student remains half a grade level behind pre-pandemic achievement in both reading and math. In reading, especially, students are even further behind than they were in 2022, the analysis shows. Compton is an outlier, making some of the biggest two-year gains in both subjects among high-poverty districts. And there are other bright spots, along with evidence that interventions like tutoring and summer programs are working. The Education Recovery Scorecard analysis by researchers at Harvard, Stanford and Dartmouth allows year-to-year comparisons across states and districts, providing the most comprehensive picture yet of how American students are performing since COVID-19 first disrupted learning. The most recent data is based on tests taken by students in spring 2024. By then, the worst of the pandemic was long past, but schools were dealing still with a mental health crisis and high rates of absenteeism — not to mention students who'd had crucial learning disrupted. 'The losses are not just due to what happened during the 2020 to 2021 school year, but the aftershocks that have hit schools in the years since the pandemic,' said Tom Kane, a Harvard economist who worked on the scorecard. In some cases, the analysis shows school districts are struggling when their students may have posted decent results on their state tests. That's because each state adopts its own assessments, and those aren't comparable to each other. Those differences can make it impossible to tell whether students are performing better because of their progress, or whether those shifts are because the tests themselves are changing, or the state has lowered its standards for proficiency. For example, Wisconsin, Nebraska and Florida seem to have relaxed their proficiency cutoff in both math and reading in the last two years, Kane said, citing the analysis. The Scorecard accounts for differing state tests and provides one national standard. Higher-income districts have made significantly more progress than lower-income districts, with the top 10% of high-income districts four times more likely to have recovered in both math and reading compared with the poorest 10%. And recovery within districts remains divided by race and class, especially in math scores. Test score gaps grew by both race and income. 'The pandemic has not only driven test scores down, but that decline masks a pernicious inequality that has grown during the pandemic,' said Sean Reardon, a Stanford sociologist who worked on the scorecard. 'Not only are districts serving more Black and Hispanic students falling further behind, but even within those districts, Black and Hispanic students are falling further behind their white district mates.' Tutors in class, after school and on Saturdays Still, many of the districts that outperformed the country serve predominantly low-income students or students of color, and their interventions offer best practices for other districts. In Compton, the district has responded to the pandemic by hiring over 250 tutors that specialize in math, reading and students learning English. Certain classes are staffed with multiple tutors to assist teachers. And schools offer tutoring before, during and after school, plus 'Saturday School' and summer programs for the district's 17,000 students, said Superintendent Darin Brawley. To identify younger students needing targeted support, the district now conducts dyslexia screenings in all elementary schools. The low-income school district near downtown Los Angeles, with a student body that is 84% Latino and 14% Black, now has a graduation rate of 93%, compared with 58% when Brawley took the job in 2012. Harmoni, the sixth-grader, said that one-on-one tutoring has helped her grasp concepts and given her more confidence in math. She gets separate 'data chats' with her math specialist that are part performance review, part pep talk. 'Looking at my data, it kind of disappoints me' when the numbers are low, said Harmoni. 'But it makes me realize I can do better in the future, and also now.' Brawley said he's proud of the district's latest test scores, but not content. 'Truth be told, I wasn't happy,' he said. 'Even though we gained, and we celebrate the gains, at the end of the day we all know that we can do better.' As federal pandemic relief money for schools winds down, states and school districts will have limited resources and must prioritize interventions that worked. Districts that spent federal money on increased instructional time, either through tutoring or summer school, saw a return on that investment. Reading levels have continued to decline, despite a movement in many states to emphasize phonics and the ' science of reading.' So Reardon and Kane called for an evaluation of the mixed results for insights into the best ways to teach kids to read. The researchers emphasized the need to extend state and local money to support pandemic recovery programs that showed strong academic results. Schools also must engage parents and tell them when their kids are behind, the researchers said. And schools must continue to work with community groups to improve students' attendance. The scorecard identified a relationship between high absenteeism and learning struggles. Tutors also help with attendance In the District of Columbia, an intensive tutoring program helped with both academics and attendance, D.C. Public Schools Chancellor Lewis Ferebee said. In the scorecard analysis, the District of Columbia ranked first among states for gains in both math and reading between 2022 and 2024, after its math recovery had fallen toward the bottom of the list. Pandemic-relief money funded the tutoring, along with a system of identifying and targeting support at students in greatest need. The district also hired program managers who helped maximize time for tutoring within the school day, Ferebee said. Students who received tutoring were more likely to be engaged with school, Ferebee said, both from increased confidence over the subject matter and because they had a relationship with another trusted adult. Students expressed that 'I'm more confident in math because I'm being validated by another adult,' Ferebee said. "That validation goes a long way, not only with attendance, but a student feeling like they are ready to learn and are capable, and as a result, they show up differently.' Federal pandemic relief money has ended, but Ferebee said many of the investments the district made will have lasting impact, including the money spent on teacher training and curriculum development in literacy. Christina Grant, who served as the District of Columbia's state superintendent of education until 2024, said she's hopeful to see the evidence emerging on what's made a difference in student achievement. 'We cannot afford to not have hope. These are our students. They did not cause the pandemic,' Grant said. 'The growing concern is ensuring that we can ... see ourselves to the other side.' ___ The Associated Press' education coverage receives financial support from multiple private foundations. AP is solely responsible for all content. Find AP's standards for working with philanthropies, a list of supporters and funded coverage areas at Annie Ma And Jocelyn Gecker, The Associated Press