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Straits Times
a day ago
- Health
- Straits Times
NUS team taps digital medicine to make treatments more precise for patients
Sign up now: Get ST's newsletters delivered to your inbox The NUS Yong Loo Lin School of Medicine has come far in 120 years. The Straits Times takes a look at some of its achievements and where it is headed. Professor Dean Ho and his team are developing ways to take the guesswork out of medication, and to optimise drug doses and combinations for each person. SINGAPORE - Drugs not only work differently on different people, but they could also have different effects on the same person at different times of their lives. Professor Dean Ho heads biomedical engineering at the National University of Singapore and is director of the Institute for Digital Medicine at the Yong Loo Lin School of Medicine. He and his team are developing ways to take the guesswork out of medication, and to optimise drug doses and combinations for each person. For instance, said Prof Ho, it is common for doctors to give cancer patients a two-drug combination as the standard dose. Though adequate, the treatment would be even more effective if there was a way to 'modulate the dose a little bit to study the interplay of the two within the patient'. In a clinical trial that he is conducting on his algorithm, called a small piece of a tumour is used to find the best dose for a particular patient. It is tested against up to a dozen drugs, providing about 900 different combinations to find which works best. His team then recommends the dose to the doctor, who will decide what to give the patient. Sometimes, the optimum dose for a patient might be lower than the standard dose, and it could change as treatment progresses. In Singapore , a lower dose could result in significant savings for the patient, who also benefits from the lower toxicity. Prof Ho, who moved to Singapore from the United States in 2018, is known for his work in the use of artificial intelligence in precision and personalised medicine, among other things. In 2023, he was invited by the US Food and Drug Administration to speak on defining and optimising drug dosages using AI. His work at NUS and the University of California, Los Angeles, where he started on it, has led to a spin-off company called KYAN Technologies. In March 2025, KYAN and Mayo Clinic Laboratories (MCL), a subsidiary of Mayo Clinic and a global leader in diagnostics , especially those related to cancers, formed a collaboration to test MCL's president and chief executive, Dr William Morice, said: 'This collaboration with KYAN Technologies provides another avenue for physicians to have access to the most robust and reliable diagnostic options available, empowering them to make informed decisions for better health outcomes and deliver customised treatment plans for their patients.' Digital medicine is important not only for cancer. Said Prof Ho: 'Digital medicine is our ability to leverage tools that we have, whether it's through wearables or through making better sense of our biomarkers and how they change over time, so we are able to better manage care, to better dose medicines, exercise, and even train our brains.' He is a strong proponent of wearable technology, which tracks people's exercise, sleep, stress levels and other patterns. He said people are more likely to make changes if they are aware of what is happening in their own bodies. His trials have also included cognitive training carried out on about 300 to 400 people: 'We developed this multitasking game, and we've helped healthy people sharpen their brain performance even more.' Another area Prof Ho plans to pursue is diabetes prevention, to give people tools 'to pre-emptively and behaviourally change, to strengthen insulin sensitivity, not lose it over time'. The American is an ardent supporter of Singapore, and he said he is never leaving because 'if you want to move your treatments from bench to bedside, from idea to implementation, Singapore is the place to be in'. 'It's not the technology alone. You need leadership at a university that really supports what you do. You need accessible stakeholders, policymakers, regulators, reimbursement people, implementation scientists. Singapore, in my opinion, is the only place in the world where you can have that access at a timescale that lets you help people quickly and safely.'
NBC Sports
2 days ago
- Sport
- NBC Sports
2025 Green Bay Packers Fantasy Preview: Can Jordan Love return to form?
The more things change, the more they stay the same. In year six as Green Bay's head coach, Matt LaFleur helmed the team to an 11-6 record and the team's fifth playoff appearance under his leadership. Much like previous seasons, the playoffs ended in disappointment, this time with a Wild Card Round loss to the eventual Super Bowl champion Eagles. 2024 Green Bay Packers Stats (Rank) Points per game: 27.1 (8th) Total yards per game: 370.8 (5th) Plays per game: 60.4 (25th) Dropbacks per game: 33.2 (32nd) Dropback EPA per play: 0.18 (7th) Rush attempts per game: 30.9 (6th) Rush EPA per play: -0.03 (9th) Josh Jacobs paves the way If you're looking at the above stats, the first thing that stands out is Green Bay's absurd tilt toward their ground game. They were top 10 in both pass and run EPA but leaned on Josh Jacobs with 301 carries. Only the Eagles and Colts logged lower pass rates versus expectation. This was a stark turn from the balanced and sometimes pass-first approach LaFleur took in previous seasons. This chart from shows Green Bay's pass rate on first and second down over the years. The Packers were slightly in favor of running the ball compared to league-average for LaFleur's first five years as a head coach. They then fall off the face of the Earth in 2024. LaFleur could have changed his offensive philosophy, but a more obvious explanation is that he was protecting his wounded quarterback. Love injured his MCL in Week 1 on the patchy turf of Arena Corinthians in São Paulo, Brazil. He missed two games, both of which Malik Willis won. Love later injured his groin in Week 8 and his elbow in Week 18. Packers were never going to be pass happy last year, but Jordan Love's injuries caused the extreme run heaviness. GB was 6th in neutral pass rate after Week 1 and finished the season last (by a mile). Packers Pass Rates Over Expected by week.. With a shutdown defense and an elite ground attack, LaFleur deployed his passing game sparingly but with devastating efficiency. Love threw deep at the second-highest rate in the league and Green Bay had the fourth-highest explosive pass rate. LaFleur has proven to be one of the most adaptable and successful coaches in the league. It's an unfair standard to hold almost any coach to, but an NFC title is the goal for 2025. Passing Game QB: Jordan Love, Malik Willis WR: Matthew Golden, Dontayvion Wicks WR: Jayden Reed, Savion Williams WR: Romeo Doubs, Christian Watson TE: Tucker Kraft, Luke Musgrave Green Bay's dreadful pass rate was punishing for fantasy managers expecting a breakout from Love and Co., but it did allow him to post marvelous efficiency numbers. He finished the regular season ranked ninth in EPA per play, 10th in AY/A, and 14th in PFF passing grade. The volume, of course, was an issue. Love attempted more than 35 passes in just two games. For reference, 31 passers hit that mark in three or more games. Love looked like one of the league's next stars at the quarterback position coming off his red-hot 2023 breakout. The following season didn't go as planned, but his play wasn't the issue. The Packers have since given us a clear signal via the draft that they want to open things up in 2025 by selecting Matthew Golden with the No. 23 pick. Golden was an odd prospect from an analytics perspective. He only played in college for three years and landed in the first round on the back of strong film grades and a blazing 4.29 Forty. On the other hand, he accounted for a measly 17 percent of his team's receiving yards in two years at Houston and only bumped that number up to 22 percent in his lone year at Texas. He averaged a pedestrian 2.1 yards per route run in 2024. His peak of 1.8 yards per team pass attempt doesn't hold a candle to the career-bests set by the other top-40 picks of this draft class either. Matthew Golden was great at the end of 2024. What limited his production at Houston? Golden doesn't have the skill set of a target dominator, but he should be able to leverage his speed into a solid role as Green Bay's deep threat out of the gates. He could be a stereotypical 'better in Best Ball' pick early in his career. Golden's selection was a clear indictment of Jayden Reed's standing in the pecking order for opportunities, despite his sterling statistical profile. He posted 1.95 YPRR as a rookie and increased that to 2.2 last year despite seeing fewer targets per route. The pushback on a Reed breakout is how Green Bay deploys him. He got above a route rate of 80 percent in three games last year. His 17 percent target share ranked 56th among wideouts. As great as his peripherals are, Reed isn't treated like a No. 1 wideout by his own team. Currently going off early draft boards as the WR43, Reed is a great bet on talent given his meager price. Romeo Doubs will round out the team's starting wideouts. Doubs is the receiver LaFleur trusts the most, even if he's the least exciting option they have. Doubs earned a 19 percent target share and ran a route on 83 percent of Green Bay's dropbacks in 2024, leading the way in both categories. The bad news is that a lack of explosive plays meant Doubs never topped 20 points in a game. Doubs is a low-ceiling bet fantasy managers only need to make it they are light on points early in the season. Beyond the aforementioned starting trio, we should still expect several receivers to see the field for Green Bay. Dontayvion Wicks ran over half of the team's routes last year and was an elite separator on deep routes. ESPN's player tracking data ranked him fourth in the league in Open Score. For those who drafted Wicks as a fantasy sleeper, this was all but meaningless. The young wideout caught a case of the yips and led the NFL with an 18 percent drop rate. It was the highest drop rate for a receiver with at least 75 targets since 2020. Christian Watson was expected to play a larger role in the passing game but rarely pushed beyond a part-time gig. Knee and ankle issues limited him throughout the year, though he was efficient as a field-stretcher, averaging 2.3 YPRR and 21.4 YPC. Watson's season ended with a torn ACL in Week 18, meaning we aren't likely to see him until midway through the 2025 season at best. The Packers added gadget receiver Savion Williams in the third round of the draft, giving them another part-time player to frustrate fantasy managers. Williams caught 60 passes and ran the ball 51 times as a senior at TCU. He's a project for the Packers and not on the redraft radar. At tight end, Tucker Kraft enters the season as the unquestioned starter. Kraft isn't much of a target earner. He saw the ball on 15 percent of his routes and earned a pedestrian 15 percent target share. When he did get opportunities, Kraft was a force of nature with the ball in his hands. His 8.8 yards after the catch per reception is the highest mark for a tight end since 2018. Kraft is a spike week TE2 who will need to command more targets to push into the TE1 ranks. Running Game RB: Josh Jacobs, MarShawn Lloyd, Emanuel Wilson, Chris Brooks OL (L-R): Rasheed Walker, Aaron Banks, Elgton Jenkins, Jordan Morgan, Zach Tom The Packers have a shockingly simple approach on the ground: Give the rock to Jacobs early and often. The free agent addition was one of six backs to top 300 carries. He turned that into 1,329 yards and 15 scores. Jacobs also amassed a 36/322/1 receiving line while averaging a respectable 1.4 YPRR. Love's various injuries certainly pushed Green Bay toward a run-heavy approach, but Jacobs gave them plenty of reasons to do so on his own. He matched his elite counting stats with impressive marks in the spreadsheets: 90.5 PFF Rushing Grade (4th) 3.5 YAC per carry (7th) .73 RYOE per carry (10th) 48.8 percent success Green Bay drafted MarShawn Lloyd on Day Two of the draft to be a lightning option to Jacobs' thunder. He dealt with several injuries as a rookie and only took the field for one game. The coaches have generally been positive on his outlook heading into year two, making him a fun late-round dart in best ball leagues. Matt LaFleur said that MarShawn Lloyd "worked his butt off" from the day the season ended to the day the Packers returned to the facility before another injury popped up, but he's overcome it. "He's in a lot better of a spot right now." Third-stringer Emanuel Wilson won't be going down without a fight for the RB2 job. Wilson averaged 4.9 yards per carry on 103 attempts as the primary backup to Jacobs last year and was capable as a pass-catcher out of the backfield. Jacobs isn't going to leave enough meat on the bone for a second back to be relevant on a week-to-week basis, but the winner of this camp battle will be one of the more exciting backup running backs to draft in deep leagues. Win Total DraftKings Over/Under: 9.5 Pick: Over (-120) LaFleur has hit double-digit wins in 4-of-6 seasons as the Packers' boss and did so last year while coaxing two wins out of Malik Willis. His team is also running back the squad they had in 2024 while everyone else in the NFC North is experiencing some sort of extreme turnover. If you're sold on the idea that LaFleur will be taking the restrictor plate off a healthy Love this year, his passing props also look enticing. DraftKings has Love priced at -110 to top 3,600 passing yards, a mark he easily cleared in 2023, when he was healthy and LaFleur was letting him sling it. Chris Simms explains why Green Bay Packers signal-caller Jordan Love falls into the "Want To Touch The Hiney" tier of his 2025 QB Countdown.
The Advertiser
2 days ago
- Sport
- The Advertiser
Dolphins suffer another injury blow to star playmaker
The Dolphins now have eight of their top 30 squad absent with long-term injuries after scans on in-form playmaker Kodi Nikorima's hamstring. Nikorima is predicted to miss six weeks and is due to return in either round 23 or 24 after suffering the injury in the 38th minute of the 50-28 win over South Sydney. The club already has key forwards Max Plath (knee), Tom Gilbert (shoulder), Daniel Saifiti (shoulder) and Thomas Flegler (shoulder) out for the rest of the year. Veteran forward Felise Kaufusi is due back from a medial cruciate ligament (MCL) injury in round 22, as is recent prop signing Sebastian Su'a who joined the club from Newcastle with a lingering knee issue but is yet to play a game. Winger Jack Bostock is also out of action until next year with a season-ending anterior cruciate ligament (ACL) injury. With the Dolphins having byes this weekend and in round 21 Nikorima, who has been in lethal form, may only miss three or four matches. The Dolphins are in eighth position and will likely need to win four of their remaining eight games to reach the finals if 30 competition points is the cut-off for the top eight. They at least have the advantage of a for-and-against of plus-162 - the second best behind Melbourne. Dolphins coach Kristian Woolf does have options to replace Nikorima ahead of the round 19 away clash with Cronulla on Friday week. Utility Kurt Donoghoe, who played in the halves for Fiji in last year's Pacific Championships, is one possibility. They could also move Jake Averillo from centre to No.6 or bring in natural half Sean O'Sullivan. Donoghoe has been one of the side's best performers in multiple positions but Woolf has rated highly his work at lock and it is likely to come down to either Averillo or O'Sullivan. The loss of Nikorima is a blow. His liaison with Katoa has been instrumental in the Dolphins' surge into the top eight. The duo are recognised as one of the leading pairings in the NRL this year, their creativity and close understanding integral to the side's attacking strength. The Dolphins now have eight of their top 30 squad absent with long-term injuries after scans on in-form playmaker Kodi Nikorima's hamstring. Nikorima is predicted to miss six weeks and is due to return in either round 23 or 24 after suffering the injury in the 38th minute of the 50-28 win over South Sydney. The club already has key forwards Max Plath (knee), Tom Gilbert (shoulder), Daniel Saifiti (shoulder) and Thomas Flegler (shoulder) out for the rest of the year. Veteran forward Felise Kaufusi is due back from a medial cruciate ligament (MCL) injury in round 22, as is recent prop signing Sebastian Su'a who joined the club from Newcastle with a lingering knee issue but is yet to play a game. Winger Jack Bostock is also out of action until next year with a season-ending anterior cruciate ligament (ACL) injury. With the Dolphins having byes this weekend and in round 21 Nikorima, who has been in lethal form, may only miss three or four matches. The Dolphins are in eighth position and will likely need to win four of their remaining eight games to reach the finals if 30 competition points is the cut-off for the top eight. They at least have the advantage of a for-and-against of plus-162 - the second best behind Melbourne. Dolphins coach Kristian Woolf does have options to replace Nikorima ahead of the round 19 away clash with Cronulla on Friday week. Utility Kurt Donoghoe, who played in the halves for Fiji in last year's Pacific Championships, is one possibility. They could also move Jake Averillo from centre to No.6 or bring in natural half Sean O'Sullivan. Donoghoe has been one of the side's best performers in multiple positions but Woolf has rated highly his work at lock and it is likely to come down to either Averillo or O'Sullivan. The loss of Nikorima is a blow. His liaison with Katoa has been instrumental in the Dolphins' surge into the top eight. The duo are recognised as one of the leading pairings in the NRL this year, their creativity and close understanding integral to the side's attacking strength. The Dolphins now have eight of their top 30 squad absent with long-term injuries after scans on in-form playmaker Kodi Nikorima's hamstring. Nikorima is predicted to miss six weeks and is due to return in either round 23 or 24 after suffering the injury in the 38th minute of the 50-28 win over South Sydney. The club already has key forwards Max Plath (knee), Tom Gilbert (shoulder), Daniel Saifiti (shoulder) and Thomas Flegler (shoulder) out for the rest of the year. Veteran forward Felise Kaufusi is due back from a medial cruciate ligament (MCL) injury in round 22, as is recent prop signing Sebastian Su'a who joined the club from Newcastle with a lingering knee issue but is yet to play a game. Winger Jack Bostock is also out of action until next year with a season-ending anterior cruciate ligament (ACL) injury. With the Dolphins having byes this weekend and in round 21 Nikorima, who has been in lethal form, may only miss three or four matches. The Dolphins are in eighth position and will likely need to win four of their remaining eight games to reach the finals if 30 competition points is the cut-off for the top eight. They at least have the advantage of a for-and-against of plus-162 - the second best behind Melbourne. Dolphins coach Kristian Woolf does have options to replace Nikorima ahead of the round 19 away clash with Cronulla on Friday week. Utility Kurt Donoghoe, who played in the halves for Fiji in last year's Pacific Championships, is one possibility. They could also move Jake Averillo from centre to No.6 or bring in natural half Sean O'Sullivan. Donoghoe has been one of the side's best performers in multiple positions but Woolf has rated highly his work at lock and it is likely to come down to either Averillo or O'Sullivan. The loss of Nikorima is a blow. His liaison with Katoa has been instrumental in the Dolphins' surge into the top eight. The duo are recognised as one of the leading pairings in the NRL this year, their creativity and close understanding integral to the side's attacking strength.
New York Post
4 days ago
- Sport
- New York Post
LeBron James' Lakers plans revealed ahead of NBA free agency
With NBA free agency set to begin on Monday, one major move appears to be locked in. LeBron James is expected to exercise his $52.6 million player option with the Lakers for the 2025-26 NBA season, ESPN reported on Saturday. The move will limit the Lakers' options for upgrading their roster as they try to win one more championship with the 40-year-old James, whose playing future is a constant question given his age, despite continuing to perform at a high level. LeBron James (23) is expected to exercise his $52.6 million player option. Icon Sportswire via Getty Images The ESPN report added that James is not entering next season, his 23rd in the league, with the idea it will be his last. During a live taping of 'The Shop' last weekend at Fanatics Fest, James was coy about when he would retire, only stating the obvious: 'I can't play that much further.' He did joke that 7-foot-3 Spurs stat Victor Wembanyama, who was on stage with James, could force him out of the league. 'The more and more time that I play,' James said, 'as long as [Wembanyama] keeps smacking my f–king shots into the stands, it's going to make me retire.' James averaged 24.4 points, 8.2 assists and 7.8 rebounds during the 2024-25 regular season. The Lakers, after acquiring Luka Doncic from the Mavericks for Anthony Davis in a seismic midseason trade, earned the No. 3 seed in the Western Conference at 50-32 but lost to the Timberwolves 4-1 in the first round of the NBA playoffs. James suffered an MCL sprain during the final game of the series. Bronny James (l.) and dad LeBron (r.) NBAE via Getty Images He just returned to on-court activities after working out with his son, Bronny, whom the Lakers picked No. 55 overall in last year's draft. Bronny made 27 NBA appearances as a rookie, averaging 2.7 points, while spending time in the G League.
Hans India
4 days ago
- Business
- Hans India
MCL to start operation in two new coal mines in Talcher
Sambalpur: Mahanadi Coalfields Limited (MCL), a subsidiary of Coal India Ltd (CIL), is going to start operation in two of its new mines having total coal reserve of 35 million tonnes (MT) in Talcher coalfield area of Angul district. 'We are going to start operation of Subhadra coal mine having a reserve of 25 MT in Talcher area by the end of financial year 2025-26,' Chairman-cum- Managing Director (CMD) of MCL, Uday A Kaole, said during a media interaction here. Similarly, the Balabhadra coal mine, with a capacity of 10 MT, will be made operational by the end of financial year 2029-30, he said. At present, MCL is operating 18 coal mines in Angul, Sundargarh and Jharsuguda districts of which three are underground mines and the remaining 15 are open-cast mines. Among the coal mines, the public sector company has seven operational mines in Angul district which include Jagannath, Bhubaneswari, Bharatpur, Hingula, Lingaraj, Kaniha and Talcher (UG). Now, the company is going to start exploration from Subhadra and Balabhadra mines, he said. To maintain transparency in its mining activities, MCL has installed CCTVs in 98 per cent of its operational areas while the remaining 2 per cent will be done soon, the CMD said, adding, 'We are also using artificial intelligence (AI) for real-time tracking of coal transportation vehicles which are GPS enabled.' He further said MCL has a reserve of about 35 MT of coal to ensure that there will be no crisis of coal for power generation. The company has produced 225 MT of coal during 2024-25 with a growth of 9 per cent compared to its previous financial year. The total coal dispatch was 210 MT, which also registered a growth of 6 per cent, he said. The CMD said '98 per cent of our total coal production is being done through eco-friendly surface mines, which is highest in the country.' The coal-producing company has targeted to achieve net zero carbon emission by FY 29. It has planned to set up several renewable energy projects including solar, wind and pumped storage power plant projects in different parts of the State with an estimated investment of Rs 17,900 crore, another official of the company said. Further, the company has set a target to produce 239 million tonnes of coal in FY26, which is expected to reach 300 MT by the fiscal 2029-30, he said.
