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Miami Herald
16-07-2025
- Miami Herald
Disappearances surge in Mexico during first half of year
July 16 (UPI) -- Mexico recorded 7,399 missing persons cases in the first half of 2025, marking a nearly 18% increase from the same period last year, according to the National Registry of Missing and Unlocated Persons. Between January and June, monthly reports consistently exceeded 1,000 cases, peaking in March at 1,279 and May at 1,377. The sustained trend reflects a steady escalation of the crisis nationwide. Mexico City recorded the highest number of disappearances during that period, with 1,099 cases -- an 88% increase from the same period in 2024. It was followed by the State of Mexico, with 1,063 cases, and Sinaloa, with 519. Michoacán, Baja California, Sonora, Jalisco, Guanajuato and Nuevo León -- states marked by high levels of violence and the presence of organized crime -- each reported between 325 and 467 cases. Disappearances in Mexico are part of a complex crisis that has developed over the past two decades. The issue is driven by a combination of factors, from organized criminal activity to systemic impunity, according to government reports, academic studies and human rights organizations. According to the National Search Commission and international organizations, more than 98% of cases remain unresolved in court. The systemic impunity has created an environment in which perpetrators know their actions carry no legal consequences, and families are forced to take on investigative roles. Search collectives have become the backbone of the fight against disappearances in Mexico, locating remains and demanding justice. One of the most prominent search collectives is Madres Buscadoras de Sonora (Searching Mothers of Sonora), which has become a national and international symbol. Just last weekend, the group discovered a suspected training camp believed to have been used by organized crime to train or hold new recruits hostage. Human remains and about 200 articles of clothing were found at the site, according to Univision. Since its founding in May 2019, Madres Buscadoras de Sonora has located more than 1,200 sets of human remains or bodies in clandestine graves and has pressed state and federal authorities to respond to reports of new burial sites. Young people ages 15 to 29 make up the majority of those who disappear in Mexico,- followed increasingly by girls, teenagers and migrants, according to the Inter-American Commission on Human Rights. In Jalisco, the state with the highest number of disappearances, authorities recorded a 63.6% increase in missing teenagers and a 72% rise in children ages 10 to 14 over the past two years, according to the University of Guadalajara. Routes used for drug trafficking, human trafficking and contraband often overlap with major hotspots for disappearances in states such as Tamaulipas, Jalisco, Guanajuato and Guerrero, where criminal groups fight for territorial control. In states like Zacatecas and Michoacán, authorities and search collectives have documented mass disappearances tied to violent clashes between criminal organizations. In 2022, the total number of cases in the registry surpassed 100,000. The number increased by 7.3% in 2023 and 6.3% in 2024, and is projected to rise by 12% in 2025, according to a report by Red Lupa. Roughly 90% of all recorded disappearances in Mexico have occurred between 2000 and May 16. Copyright 2025 UPI News Corporation. All Rights Reserved.
UPI
16-07-2025
- UPI
Disappearances surge in Mexico during first half of year
July 16 (UPI) -- Mexico recorded 7,399 missing persons cases in the first half of 2025, marking a nearly 18% increase from the same period last year, according to the National Registry of Missing and Unlocated Persons. Between January and June, monthly reports consistently exceeded 1,000 cases, peaking in March at 1,279 and May at 1,377. The sustained trend reflects a steady escalation of the crisis nationwide. Mexico City recorded the highest number of disappearances during that period, with 1,099 cases -- an 88% increase from the same period in 2024. It was followed by the State of Mexico, with 1,063 cases, and Sinaloa, with 519. Michoacán, Baja California, Sonora, Jalisco, Guanajuato and Nuevo León -- states marked by high levels of violence and the presence of organized crime -- each reported between 325 and 467 cases. Disappearances in Mexico are part of a complex crisis that has developed over the past two decades. The issue is driven by a combination of factors, from organized criminal activity to systemic impunity, according to government reports, academic studies and human rights organizations. According to the National Search Commission and international organizations, more than 98% of cases remain unresolved in court. The systemic impunity has created an environment in which perpetrators know their actions carry no legal consequences, and families are forced to take on investigative roles. Search collectives have become the backbone of the fight against disappearances in Mexico, locating remains and demanding justice. One of the most prominent search collectives is Madres Buscadoras de Sonora (Searching Mothers of Sonora), which has become a national and international symbol. Just last weekend, the group discovered a suspected training camp believed to have been used by organized crime to train or hold new recruits hostage. Human remains and about 200 articles of clothing were found at the site, according to Univision. Since its founding in May 2019, Madres Buscadoras de Sonora has located more than 1,200 sets of human remains or bodies in clandestine graves and has pressed state and federal authorities to respond to reports of new burial sites. Young people ages 15 to 29 make up the majority of those who disappear in Mexico,- followed increasingly by girls, teenagers and migrants, according to the Inter-American Commission on Human Rights. In Jalisco, the state with the highest number of disappearances, authorities recorded a 63.6% increase in missing teenagers and a 72% rise in children ages 10 to 14 over the past two years, according to the University of Guadalajara. Routes used for drug trafficking, human trafficking and contraband often overlap with major hotspots for disappearances in states such as Tamaulipas, Jalisco, Guanajuato and Guerrero, where criminal groups fight for territorial control. In states like Zacatecas and Michoacán, authorities and search collectives have documented mass disappearances tied to violent clashes between criminal organizations. In 2022, the total number of cases in the registry surpassed 100,000. The number increased by 7.3% in 2023 and 6.3% in 2024, and is projected to rise by 12% in 2025, according to a report by Red Lupa. Roughly 90% of all recorded disappearances in Mexico have occurred between 2000 and May 16.
Medscape
10-07-2025
- Health
- Medscape
Ichthyosis Score Reliable in Skin of Color
TOPLINE: In a cross-sectional study, the Ichthyosis Scoring System (ISS) demonstrated equal reliability in assessing scale and erythema severity across all skin types, with excellent interrater reliability for both light and dark skin tones. METHODOLOGY: To address the reliability of the ISS in individuals with skin of color, researchers conducted a cross-sectional study that involved 14 dermatologists rating 94 photographs from 61 individuals from the National Registry for Ichthyosis and Related Disorders between August and December 2023. Of the 94 photographs, 47 were of individuals with Fitzpatrick I-III skin types (57% Women; 89% White, 6% Hispanic, and 3% South Asian individuals) and 47 were of individuals with Fitzpatrick IV-VI skin types (46% Women; 62% Black, 15% Hispanic, and 15% South Asian individuals). Dermatologists used the ISS to score photographs from the upper back, legs, upper arm, and dorsal feet for scale and erythema severity. TAKEAWAY: The mean scale score was 2.49 for individuals with Fitzpatrick I-III skin types and 2.50 for those with Fitzpatrick IV-VI skin types (P < .86). The mean erythema scores were 1.94 and 1.88 in the two groups, respectively (P < .32). ISS scale scoring showed excellent interrater reliability (0.97-0.99) in both skin type groups. Erythema scoring demonstrated good to excellent reliability in III-IV skin types (0.90-0.94) and excellent reliability in I-III skin types (0.91-0.95). Overlapping CIs confirmed consistency between skin types. IN PRACTICE: 'This study supports the ISS as a reliable scoring instrument for ichthyosis severity across phototypes, providing a foundation for increasing diversity in clinical trials,' the study authors wrote. 'ISS's accessibility, ease of use, broad applicability, and robust reliability underscore its role as the standard ichthyosis severity scoring tool,' they added. 'The development and validation of tools like the Ichthyosis Scoring System, and ensuring that it is applicable to measure clinical outcomes in patients of all skin tones, is an essential step in providing equitable clinical care to all patients,' a JAMA Dermatology editorial fellow and associate editor wrote in an accompanying commentary. SOURCE: This study was led by Angela J. Luo, BA, Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, and was published online on July 9 in JAMA Dermatology. LIMITATIONS: Due to limited availability of comprehensive, high-quality photography among individuals with Fitzpatrick IV-VI skin types, researchers could only validate the ISS across four body sites: upper back, legs, upper arm, and dorsal feet. The authors noted that additional studies using full-body photographs would be beneficial to further validate the ISS's reliability for assessing global ichthyosis severity. Objective erythema measurements were not used. DISCLOSURES: Luo was funded by the Richard K. Gershon Endowed Medical Student Research Fellowship and the Yale School of Medicine Fellowship for Medical Student Research. Several authors reported receiving personal fees, advisory fees, grants, and other support from AbbVie, Eli Lilly, Incyte, Janssen, Sanofi, and various other drug companies. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Medscape
07-07-2025
- Health
- Medscape
Paclitaxel Matches Cisplatin HIPEC in Ovarian Cancer
TOPLINE: Patients with advanced ovarian cancer undergoing interval cytoreductive surgery who received paclitaxel-based hyperthermic intraperitoneal chemotherapy (HIPEC) during surgery appeared to have comparable overall survival and disease-free survival rates to those who received cisplatin-based HIPEC. METHODOLOGY: Although the use of HIPEC remains controversial, cisplatin-based HIPEC during cytoreductive surgery may benefit patients with advanced ovarian cancer; however, there is less evidence for paclitaxel-based HIPEC, typically used in patients who are frail or intolerant to platinum agents. To compare the two regimens, researchers analyzed data from the National Registry of Peritoneal Carcinomatosis, which included 846 patients (mean age, 59 years) who underwent interval cytoreductive surgery with either cisplatin-based HIPEC (n = 325) or paclitaxel-based HIPEC (n = 521). After propensity score matching, there were 199 patients per group (total = 398). HIPEC was administered post-surgery with cisplatin (75-100 mg/m2 for 90 minutes) or paclitaxel (120 mg/m2 for 60 minutes), both at 42-43 °C. TAKEAWAY: Using cisplatin as the reference group, the median overall survival was not significantly different between the two options (hazard ratio [HR], 0.74; P = .16); however, the median overall survival was 82 months in the paclitaxel group vs 58 months in the cisplatin group. Disease-free survival was also not significantly different between the two groups, with a median of 20 months in the cisplatin group and 21 months in the paclitaxel groups (HR, 0.95; 95% CI, 0.72-1.25; P = .70). Overall survival was comparable during the first 20 months of follow-up and disease-free survival was equivalent during the first 15 months of follow-up, based on a predefined equivalence margin of 0.1. Paclitaxel-based HIPEC was not associated with increased morbidity (odds ratio, 1.32; P = .06). IN PRACTICE: 'Our study suggests that cisplatin and paclitaxel are two safe and effective drugs to be used for HIPEC in [interval cytoreductive surgery] for advanced ovarian cancer. As cisplatin is the preferred drug according to strong evidence, paclitaxel could be a valuable alternative for patients with any contraindication to cisplatin, with similar oncological and perioperative outcomes,' the authors wrote. SOURCE: This study, led by Salud González Sánchez, MD, Reina Sofía University Hospital in Córdoba, Spain, was published online in JAMA Network Open. LIMITATIONS: The retrospective design of this study limited causal inference. The BRCA mutation status was not captured in the national registry. Additionally, the matching procedure resulted in a moderate sample size, which could have led to residual confounding. DISCLOSURES: The authors did not declare any funding information and reported no relevant conflicts of interest. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Yahoo
01-07-2025
- Automotive
- Yahoo
Medical examiners' records must be filed electronically: FMCSA
This story was originally published on Trucking Dive. To receive daily news and insights, subscribe to our free daily Trucking Dive newsletter. All medical certification records for commercial drivers must be filed electronically as of June 23, according to a Federal Motor Carrier Safety Administration press release. The U.S. Department of Transportation believes the new digitized system will reduce the opportunity for document fraud and make it easier for roadside inspectors and law enforcement to access drivers' medical certification statuses. Currently, 37 states are already compliant with the Medical Examiner's Certification Integration rule. The remaining states are expected to meet the requirements in the coming months. First published by the FMCSA in 2015, the Medical Examiner's Certification Integration rule does exactly what its name implies — it integrates medical certification records into state-managed systems, per the release. For CDL holders and carriers, that means paper records can no longer be used as proof of medical certification. It also means that carriers won't have to verify that those certificates were issued by a medical examiners on the National Registry, and drivers don't have to submit paper copies to state driver licensing agencies, per the NRII Fact Sheet. Instead, medical examiners must electronically submit examination results to FMCSA's National Registry by midnight of the next calendar day following the examination. FMCSA will electronically transmit drivers' examination results — which can be 'medically qualified,' 'medically unqualified' or 'voided' — from its National Registry to state driver licensing agencies. Then, states will make that information available on the Commercial Driver's License Information System driver motor vehicle record. 'By integrating electronic medical certification records directly into state-managed systems, NRII helps ensure only qualified drivers are on our roads while giving our state and enforcement partners the real-time information needed to do their jobs more effectively,' said FMCSA Chief Counsel Jesse Elison in the release. 'Implementation of this rule embodies FMCSA's commitment to commonsense, efficient, and effective solutions that enhance safety and accountability,' Elison said. Recommended Reading 'No longer necessary': FMCSA seeks to reduce redundant reporting of traffic violations
