Latest news with #PraveenGupta
Indian Express
07-07-2025
- Health
- Indian Express
Is your brain health at risk from foil food boxes and your wet raincoat? Here's all you need to know about forever chemicals
Written by Dr Praveen Gupta Is the food that you have from the cardboard/foil box delivered by a food app or the raincoat that's shielding you from the rain affecting your brain health? Many of us may not know this but our everyday items may be leaching compounds into our gut and skin that's insidiously triggering persistent health problems. This is because most consumer goods contain PFAs (per- and polyfluoroalkyl substances), a group of chemicals that have a powerful ability to repel oil and water and resist heat. For long these have been widely used in various products like non-stick cookware, firefighting foam, water-resistant clothing and food packaging, making them pervasive in everyday life. 'These do not get destroyed in the environment or the human body and tend to persist, earning the moniker forever chemicals. However, because of their persistence, they can cause significant health concerns. Many people are exposed to forever chemicals through drinking water, food and even dust,' says Dr Praveen Gupta, Chairman- Neurosciences, Marengo Asia Hospitals, Gurugram. The worst part, he says, is that they might be stuck in your body for years. A new study by the researchers from the Del Monte Institute for Neuroscience at the University of Rochester recently found that early life exposure to forever chemicals may increase anxiety-related behaviors and memory deficits in male mice. How do forever chemicals impact your health? They can interfere with the endocrine system, which regulates hormones, potentially affecting reproductive health and development. Studies have shown associations between exposure to forever chemicals and liver damage and thyroid dysfunction. PFAS can weaken the immune system, potentially reducing the body's ability to fight infections and respond to vaccines. Certain PFAs have been linked to an increased risk of kidney and testicular cancers, according to the National Cancer Institute. But now they are being studied for their impact on brain health? How neurotoxic are forever chemicals? This is a relevant concern now because of their ability to penetrate the blood brain barrier. This acts as a protective filter, regulating the movement of substances between the bloodstream and the brain, allowing essential nutrients in while keeping harmful substances out. But now the latest mice study has shown that they are permeating this barrier. This is significant because the damaging effects continued long after the exposure. Once the barrier is breached, these chemicals disrupt key neurotransmitters (chemical messengers that transmit signals across the nervous system) particularly dopamine, which impacts movement, motivation, mood and reward, as well as glutamate, which stimulates nerve cells so that they can pass on signals to each other. It's essential for normal brain function, including learning and memory. Forever chemicals may also destroy nerve cells by interfering with genes. They can also stimulate neuroinflammation and damage brain cells. That's why we have impaired sleep. All of this leads to neurodegenerative processes and impacts cognition and increases the risk of Alzheimer's. They can also be related to behavioural disorders in children like ADHD or lower academic performance. (The author is chairman, Neurosciences, Marengo Asia Hospitals, Gurugram)
NDTV
23-06-2025
- Health
- NDTV
Salman Khan Reveals He Is Working "Even With Brain Aneurysm". How Does The Condition Affect Normal Life?
The image was shared on X. New Delhi: Salman Khan isn't one to break under pressure, but his 'bones'? That's apparently a different story. In his recent appearance on The Great Indian Kapil Show, the actor stunned fans by revealing the extent of his ongoing health battles, including a brain aneurysm, trigeminal neuralgia and arteriovenous malformation (AVM). Appearing as the first guest of the show's new season, Salman spoke about the physical toll his body has endured over the years. "I'm out here breaking my bones every day - ribs are fractured, I'm working despite having trigeminal neuralgia, there's an aneurysm in the brain, yet I'm still working. There's also an AV malformation, and still, I'm carrying on," the actor said, describing how he continues to work despite multiple serious conditions. This revelation has sparked widespread public concern for Salman Khan's health, and what it actually means to live and work with a brain aneurysm. What follows is a closer look at the condition, what causes it, who is at risk, and how it can impact daily life - physically, mentally and neurologically. According to Dr Praveen Gupta, Chairman of Marengo Asia International Institute of Neuro & Spine (MAIINS), a brain aneurysm is a balloon-like bulge in the wall of an artery due to a weakness in the vessel wall. "Aneurysm is a condition where there is a weakness in the wall of the artery, which leads to the outpouching of the wall of an artery, creating a small balloon-like structure called an aneurysm. This is basically because the arterial wall in the aneurysm is weak. This site is prone to rupture, causing brain haemorrhage," Dr Gupta explains. Aneurysms are often called silent killers because they may remain asymptomatic for years, or even for life, until they rupture. Common? Yes. Harmless? Not Always. While brain aneurysms are relatively common, often discovered incidentally during imaging for other conditions, not all of them rupture. However, when they do, the consequences are severe. Dr Rahul Gupta, Senior Director & HOD Neuro and Spine Surgery, Fortis Hospital Noida, elaborates, "A brain aneurysm is a bulge in a blood vessel in the brain, and its seriousness depends on whether it ruptures. An unruptured aneurysm may cause no symptoms and might be discovered incidentally. However, a ruptured brain aneurysm leads to a type of stroke called a subarachnoid haemorrhage, which is a life-threatening emergency with high risk of death or permanent neurological damage." "Worst Headache Of Your Life" And Other Symptoms One of the most alarming features of a ruptured aneurysm is the sudden, intense headache, often described as the worst headache of one's life. Other symptoms include nausea and vomiting, stiff neck, blurred or double vision, sensitivity to light, seizures, loss of consciousness and confusion. Dr Praveen Gupta adds, "The first sign of this disease is the worst-ever headache in life, which can be associated with neck stiffness, tingling, numbness, visual symptoms, and double vision." In some cases, a "leaking" aneurysm may cause similar symptoms days or weeks before a major rupture, a critical period when intervention could be life-saving. How It Affects the Brain (Even When Unruptured) Even if a brain aneurysm does not rupture, its location in the brain can affect cognitive function. Neuroscientist Kumaar Bagrodia, founder of NeuroLeap and HALE, explains, "The location of the aneurysm significantly influences the resulting cognitive and neurological outcomes, even when unruptured. The brain's networks are spatially and functionally organised, so pressure, ischemia, or haemorrhage in specific regions can impair distinct functions." He notes the following examples: Frontal lobe/ACom artery: Memory, planning, emotional regulation Middle cerebral artery (MCA): Speech and attention Posterior aneurysms: Vision and spatial memory Post-diagnosis, even without rupture, patients may face "memory loss (hippocampal impact), poor attention and slower processing (network disruption), executive dysfunction (frontal circuits). When we do a whole brain map, this often shows slowed brainwave patterns." So... What Puts You At Risk? Is Gymming One of Them? Risk factors for brain aneurysms include high blood pressure, smoking, family history, ageing, genetic predisposition and unhealthy lifestyle. Dr Praveen Gupta warns, "Excessive physical activities, such as heavy gymming or stunt work, can put increased pressure on the arteries and may cause rupture of an already existing aneurysm." Kumaar Bagrodia adds, "Genetic predisposition is well-established, especially in familial intracranial aneurysm syndromes." Key genetic markers include COL3A1 (connective tissue), SOX17 (endothelial health), 9p21/CDKN2A (vascular inflammation). Diseases like polycystic kidney disease (PKD1/PKD2) can raise the risk 5-10x times. With age, vascular degeneration, oxidative stress, and inflammation further elevate the risk. "Elastin degrades, arteries stiffen, and impaired neurovascular coupling make some brain regions more vulnerable," Bagrodia notes. Treat It Or Leave It? The Answer Is Not Always Surgery Not all aneurysms get the scalpel treatment. Treatment for aneurysms depends on multiple factors: size, location, symptoms and risk of rupture. According to Dr Rahul Gupta, treatment options include: Monitoring: For small, stable, unruptured aneurysms Surgical Clipping: A metal clip seals off the aneurysm Endovascular Coiling: Coils fill the aneurysm via a catheter Flow Diversion: A stent redirects blood away from the aneurysm "Not all aneurysms require surgery. Many aneurysms are safely managed without it," says Dr Gupta. Dr Praveen Gupta also elaborates on diagnostics and surgical methods, "The immediate diagnosis is by CT angiogram or digital subtraction angiography (DSA). We can deploy coils or flow diverter stents to close the aneurysm. If it's not amenable to endovascular treatment, surgical clipping may be used to close the aneurysm so that it does not remain prone to bursting and causing haemorrhage." Can You Dance With Danger? Apparently, Yes Given the demanding physicality of Salman Khan's career, many are wondering: Is it really possible to work while carrying such a serious condition? "Yes, many people with unruptured aneurysms can lead normal lives, including working, performing, or engaging in physical activity, with medical guidance. The ability to continue high-energy activities like acting or dancing depends on symptoms, aneurysm size and stability, and overall health", says Dr Rahul Gupta The key lies in monitoring, medical supervision and lifestyle management. The Future: Lasers, Nanotech And Maybe... Light Therapy? Research is pushing boundaries, and the next few years could radically change how aneurysms are treated. "Gene therapies like CRISPR, siRNA aim to reduce inflammation in aneurysm-prone vessels by targeting genes like MMP-9 or IL-1β," says Kumaar Bagrodia. "Drug-loaded nanoparticles are in preclinical testing. Flow diverters are improving - even safe for smaller or distal aneurysms now." He also points to photobiomodulation therapy - using near-infrared light to enhance blood vessel repair and reduce oxidative stress. Busting Common Myths There's a lot of misinformation around brain aneurysms, says Dr Rahul Gupta: Myth: All brain aneurysms will rupture Fact: Many never rupture and remain symptomless Myth: Aneurysms only affect older people Fact: They can occur at any age Myth: Surgery is always needed Fact: Many cases are managed non-surgically Myth: Rupture means certain death Fact: With prompt treatment, survival and recovery are possible The Final Word Salman Khan's revelation has brought crucial awareness to an often misunderstood condition. It also serves as a wake-up call to not ignore warning signs and to prioritise health, because sometimes, the body doesn't scream until it's almost too late. Featured Video Of The Day Russia, China, Pak, 'Axis Of Resistance': Who Will Help Iran?
Hindustan Times
10-06-2025
- Health
- Hindustan Times
Are you always hooked to the screen? Doctor explains its impact on your brain and shares 7 key prevention tips
Whether for work or leisure, screens have become an inseparable part of our daily lives. From starting the day logged into our laptops to winding down with a movie or endlessly scrolling through social media, excessive screen time can take a toll on both our eyes and brain. In an interview with HT Lifestyle, Dr. Praveen Gupta, neurologist said, 'Too much screen time can have a variety of negative effects on our health, ranging from eye strain and neck pain to social isolation and cognitive function.' Also read | New research shows reducing screen time drastically improves your child's mental wellbeing in just 2 weeks 'Excessive screen use among adults may damage learning, memory, and mental health while also increasing the risk of early neurodegeneration. It causes thinning of the cerebral cortex, the brain's outermost layer responsible for memory processing and cognitive skills like decision-making and problem-solving,' said Dr Praveen Gupta. He added, brain-related conditions such as dementia, stroke, and Parkinson's disease were found to occur more commonly in individuals who watched television for five or more hours a day. 'Adults with excessive screen usage or a diagnosed smartphone addiction had less gray matter volume. Gray matter, the brain tissue crucial for functions like movement, memory, and emotions, naturally declines with age,' said the neurologist. Also read | Too much screen time can make your kid struggle with language: Study states Dr Praveen Gupta further noted down tips to prevent excessive screen exposure and protect your brain heath: You don't have to avoid screens entirely to safeguard your brain. The key is balance. Here's how you can prevent digital fatigue and stay productive: • Use night mode or blue light filters on your device. • Use blue light-blocking eyewear if you spend long hours on screens. • Swap late-night scrolling for a good book or calming activities like deep breathing or light stretching to support better sleep. • Plan screen-free lunches with family and friends. • Refresh your thoughts by going on walks or exercising away from screens. • Optimise phone or in-person interactions above digital socialising. • Optimise brightness and contrast to reduce eye strain. • Keep screens an arm's length away. • If your eyes feel dry, blink more frequently and use artificial tears. • Set app restrictions to prevent excessive scrolling. • Turn off unnecessary notifications to minimise distractions. • Use grayscale mode to reduce addictiveness in social networking apps. • Reset your thoughts with meditation or deep breathing exercises. • Create a screen-free bedtime regimen for improved sleep. Also read | Doctor shares 7 health consequences of excessive screen time and why a digital detox is the need of the hour • Enjoy offline hobbies such as reading, journaling, or creative activities. Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.
Business Standard
06-05-2025
- Business
- Business Standard
Premas Life Sciences and Sphere Bio Unite to Advance Single-Cell Research in South Asia
India PR Distribution New Delhi [India], May 6: Premas Life Sciences Pvt. Ltd. (PLS), a pioneering enabler of life science innovations in India, has announced a strategic collaboration with Sphere Bio, a global leader in picodroplet-based microfluidic technologies for functional single-cell analysis. This partnership represents a significant leap in bringing transformative, next-generation platforms to scientists and researchers in India and Bangladesh. The collaboration is rooted in a shared vision: empowering biopharma, biotech, and academic communities with cutting-edge tools that accelerate discovery and drive impactful science. With this alliance, Premas will bring Sphere Bio's high-performance solutions - including their flagship Cyto-Mine® platform and a growing assay portfolio - closer to researchers in South Asia, supported by localized technical expertise and seamless implementation support. Sphere Bio, formerly known as Sphere Fluidics, is widely recognized for its innovations in single-cell and picodroplet microfluidics. Their technologies enable ultra-high-throughput analysis, sorting, and isolation of individual cells - critical for applications such as antibody discovery, cell line development, and advanced cell therapy research. These platforms are currently used by leading pharma companies and research institutions around the world to enhance the speed and accuracy of biologic development. For Premas Life Sciences, this partnership is a natural extension of its mission to democratize access to advanced life science tools. Over the last 18 years, PLS has built a strong legacy of introducing globally benchmarked technologies to India's scientific ecosystem - spanning genomics, proteomics, bioinformatics, and diagnostics. Their ability to not only introduce but also embed technologies through technical training, application support, and long-term scientific partnerships makes them uniquely positioned to amplify the impact of Sphere Bio's offerings. "India is entering a new era of biomedical innovation, with increased investments in biosimilars, vaccines, and cell and gene therapies. This collaboration with Sphere Bio allows us to deliver the kind of scientific capabilities that can transform how research is done in this region--faster, more precisely, and with greater reproducibility. With the government's strong push through initiatives like the Bio-E3 policy, PRIP scheme, and its vision for bio foundries, we believe technologies like Sphere Bio's Cyto-Mine® will play a crucial role in accelerating antibody discovery and cell line development, further strengthening the 'Made in India' biotech ecosystem. We're excited to co-create a future where access to such platforms is not a barrier but a baseline." said Praveen Gupta, Managing Director of Premas Life Sciences. Sphere Bio echoed this optimism. "We see South Asia as a region with enormous scientific potential. Our partnership with Premas is about more than market access - it's about long-term impact. Premas brings deep local understanding, technical know-how, and a genuine commitment to enabling discovery. Together, we aim to catalyse the next wave of breakthroughs in biologics and personalized medicine." said Dale Levitzke, CEO of Sphere Bio "Our partnership with Premas Life Sciences is a key milestone in our mission to make cutting-edge single-cell technologies more accessible across the APAC region. India and Bangladesh represent rapidly growing innovation hubs, and we see immense potential in empowering local researchers with tools that meet global standards. Premas brings deep market understanding, strong scientific engagement, and a track record of successful technology integration--making them an ideal partner to drive regional adoption and impact." said Jay Manikandan, VP Commercial (APAC), Sphere Bio This alliance comes at a pivotal time, as the biotech landscape in India and Bangladesh rapidly evolves with government backing, rising R & D investment, and a growing scientific workforce. As demand for next-gen therapeutics increases, so does the need for high-resolution, scalable tools--precisely what Sphere Bio delivers. Together, Premas and Sphere Bio are building a scientific bridge between global innovation and regional potential. Beyond product access, the partnership offers localized support, training, and tailored solutions aligned with international standards. It sets a new benchmark for how advanced technologies can be effectively introduced and scaled in emerging biotech markets.
Hindustan Times
25-04-2025
- Health
- Hindustan Times
World Malaria Day 2025: Do you know about cerebral malaria; the deadliest form that affects the brain?
World Malaria Day 2025: Every year, World Malaria Day is observed on April 25 to discuss and discover treatment and precautions that can help in preventing malaria from spreading. This day helps in creating awareness about the health complications of the disease and the lifestyle habits that can help in staying safe. Also read | World Malaria Day 2025: Know how malaria can affect your heart We cannot possibly discuss the harmful effects of malaria without bringing up its deadliest form, that affects the brain cells. Known as cerebral malaria, it occurs when infected red blood cells block small blood vessels in the brain, leading to inflammation, swelling, and damage to brain tissue. In an interview with HT Lifestyle, Dr. Praveen Gupta, principal director and chief of neurology, Fortis Memorial Research Institute, Gurugram explained the causes, symptoms and fatality of the disease. Cerebral malaria is caused by the bite of a female Anopheles mosquito carrying P. falciparum. Once in the bloodstream, the parasite multiplies inside red blood cells. In severe cases, these infected cells adhere to the walls of cerebral blood vessels, disrupting blood flow and triggering inflammation. Symptoms typically develop within 7–10 days of infection. Key signs of cerebral malaria include: Diagnosis of cerebral malaria involves blood tests to detect malaria parasites, often through microscopy or rapid diagnostic tests (RDTs). Brain imaging and lumbar puncture may be used to rule out other neurological conditions like meningitis. Cerebral malaria is a medical emergency. Immediate treatment with intravenous antimalarial drugs such as artesunate or quinine is crucial. Supportive care, such as managing seizures, fluids, and oxygen, can also improve survival. Patients typically require intensive care. Also read | World Malaria Day 2024: 10 warning signs of the vector-borne disease you must know Prevention strategies focus on avoiding mosquito bites and controlling the spread of malaria. This includes: Note to readers: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.
