Latest news with #heartfailure
Medscape
14 hours ago
- Health
- Medscape
Higher BMI, Bigger Gains: Tirzepatide's Effects on HFpEF
TOPLINE: In patients with obesity-related heart failure with preserved ejection fraction (HFpEF), tirzepatide reduced the risk for worsening heart failure or cardiovascular death regardless of their baseline BMI or fat distribution, with larger gains observed among those with higher BMI. Those who lost more weight with tirzepatide showed greater improvements in exercise capacity and symptom severity. METHODOLOGY: The SUMMIT trial previously showed significant benefits of tirzepatide, a long-acting glucose-dependent insulinotropic polypeptide and GLP-1 receptor agonist, in patients with obesity-related HFpEF. In this secondary analysis, researchers looked at whether the effects of tirzepatide varied with the severity and distribution of a patient's obesity or by the extent of weight loss achieved after treatment. The trial included 731 patients aged 40 years or older (mean age, 65.2 years; 53.8% women) with obesity-related HFpEF (defined by the New York Heart Association's functional classes II-IV) and a BMI of 30 or higher. Participants were randomly assigned to subcutaneously receive either 2.5 mg/wk of tirzepatide (n = 364) or a placebo (n = 367). Patients were categorized into tertiles of their baseline BMI and waist to height ratio. Primary endpoints were the time to first adjudicated cardiovascular death or an event of worsening HF and a change in the symptom status measured using the Kansas City Cardiomyopathy Questionnaire Clinical Summary Score (KCCQ-CSS) at 52 weeks. Secondary endpoints included changes in exercise capacity (measured using the 6-minute walk distance), body weight, and blood pressure. TAKEAWAY: Patients in the highest tertile of BMI were younger and most likely to be women and had more severe HF, a greater volume overload, and more severe inflammation. Those with a higher waist to height ratio showed similar patterns, as well as shorter 6-minute walk distances and more severe kidney disease. Use of tirzepatide vs placebo reduced the risk for cardiovascular death or worsening HF across all BMI ranges and waist to height ratios. Tirzepatide was associated with greater improvement in the 6-minute walk distance in patients in the highest range for BMI (37.5 m) than in those in the middle (26.3 m) and lower (9.9 m) ranges (P for trend = .025); improvements in weight loss and systolic blood pressure followed similar patterns. After 52 weeks on tirzepatide, those who lost more weight had bigger gains in their 6-minute walk distance and changes in the KCCQ-CSS (P < .0001 for both). The same benefits were seen in those with larger drops in waist circumference. IN PRACTICE: 'These data provide further evidence supporting the importance of excess body fat, particularly visceral fat, as driving HF severity in patients with the obesity phenotype of HFpEF,' the researchers reported. 'While these findings reinforce the role of incretin therapies in HFpEF management, these data, perhaps more importantly, highlight the urgent need for precision strategies to define obesity and direct therapy to those who will benefit most,' experts wrote in an editorial accompanying the journal article. SOURCE: This study was led by Barry A. Borlaug, MD, of Mayo Clinic in Rochester, Minnesota. It was published online on July 21, 2025, in the Journal of the American College of Cardiology. The researchers presented the findings at the American College of Cardiology (ACC) Scientific Session 2025. LIMITATIONS: Categorizing patients into tertiles of their BMI or waist to height ratio may have masked some trends. The trial included a higher proportion of women and participants from Latin America, limiting generalizability. Imaging-based methods could possibly offer more precise measurements of obesity. DISCLOSURES: The original trial was funded by Eli Lilly and Company. The lead author reported receiving grants from the National Heart, Lung, and Blood Institute and US Department of Defense, receiving research grants from and consulting for several pharmaceutical companies, and being a named inventor for tools and approach for procedure to treat HF. Several other authors reported being employees of or consultants for Eli Lilly and Company and several other companies. This article was created using several editorial tools, including AI, as part of the process. Human editors reviewed this content before publication.
Yahoo
4 days ago
- Health
- Yahoo
Dad Recalls Thinking His 1-Year-Old Daughter Had Covid Before She Received a Heartbreaking Diagnosis in Emotional Interview
NEED TO KNOW A father in England is recalling thinking his daughter, 15 months, had Covid before she received a heartbreaking diagnosis Terry Archbold revealed on the U.K. show This Morning that his daughter, Bea, experienced "heart failure" and was diagnosed with a heart condition at just 15 months old She's since had a heart transplant after having to wait in the hospital for 14 months for a donor after being fitted with an artificial organA father in England is speaking out about the moment he mistook his daughter's potentially fatal medical condition for Covid. During an appearance on the Friday, July 18 episode of the U.K. show This Morning, police officer Terry Archbold said that his daughter Bea was born "fit" and "healthy" in 2021, before "she suddenly fell ill" and "deteriorated very, very quickly with heart failure" at just 15 months old. Terry shared that the family had been on vacation to Florida, and his partner Cheryl and their other daughter had contracted Covid. So, when Bea fell ill, they assumed she might also have the virus. Terry recalled, "We saw similar symptoms with Bea. Breathless, lethargic," adding that they weren't "overly concerned" at that point, but it "went on for a couple of days." After the infant stopped drinking, her parents sought medical advice, and after an ambulance was sent to the home, they recommended she go to a local emergency room to get checked out. "I expected her to be home in a couple of hours with antibiotics or whatever, never expecting to be told that they picked up a heart murmur, that she was in heart failure," Terry told hosts Dermot O'Leary and Sian Welby. Bea was taken to the Freeman Hospital in the U.K. city of Newcastle upon Tyne, where she was diagnosed with dilated cardiomyopathy, Terry recalled. Per the Mayo Clinic, "Dilated cardiomyopathy is a type of heart muscle disease that causes the heart chambers (ventricles) to thin and stretch, growing larger. It typically starts in the heart's main pumping chamber (left ventricle)." "Dilated cardiomyopathy makes it harder for the heart to pump blood to the rest of the body," the site adds. Little Bea, now 5, ended up having a Hickman line — which is a type of catheter that's fitted to help a patient receive medication, per the Cleveland Clinic — and her parents had then received a phone call to say they could visit their daughter and she was "doing well," Terry shared. However, after they got to the hospital, "We heard alarms and we heard staff shouting for equipment," Terry remembered on the show, adding, "And Cheryl said to me, 'Will you look?' We knew it was Bea, we just knew." He said that medics saved Bea by administering CPR after she went into cardiac arrest, but had then told them, "They said if she had another cardiac arrest, she would not make the night." "The only hope she had would be to go on the urgent transplant list. And to get her there, she would need to have a Berlin heart," Terry said, referencing the artificial heart which Bea ended up having. The little one ended up waiting 14 months in the hospital while she waited for a transplant, and Terry said the family had witnessed some tragic moments while there. "Within the space of a week, both the children either side [of Bea's bed] passed," Terry shared. Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. He said that the moment Bea received a transplant was "incredible," but he acknowledged the heartbreaking decision one family had to make to ensure that Bea lived. "The reality is, we know what it meant to the other side so it's like living an endless torture," he recalled. "Every day wondering, 'Is this the day that we lose Bea? Is it her last day with us?' And enjoying every moment." "And at the same time, very conscious of what it means for her to come home, that if she does, her life from that moment, every breath, everything she goes on to do is because of somebody else," Terry — who had previously made the difficult decision, along with Cheryl, to donate their stillborn daughter's heart — added. Read the original article on People
Yahoo
4 days ago
- Health
- Yahoo
Dad Recalls Thinking His 1-Year-Old Daughter Had Covid Before She Received a Heartbreaking Diagnosis in Emotional Interview
NEED TO KNOW A father in England is recalling thinking his daughter, 15 months, had Covid before she received a heartbreaking diagnosis Terry Archbold revealed on the U.K. show This Morning that his daughter, Bea, experienced "heart failure" and was diagnosed with a heart condition at just 15 months old She's since had a heart transplant after having to wait in the hospital for 14 months for a donor after being fitted with an artificial organA father in England is speaking out about the moment he mistook his daughter's potentially fatal medical condition for Covid. During an appearance on the Friday, July 18 episode of the U.K. show This Morning, police officer Terry Archbold said that his daughter Bea was born "fit" and "healthy" in 2021, before "she suddenly fell ill" and "deteriorated very, very quickly with heart failure" at just 15 months old. Terry shared that the family had been on vacation to Florida, and his partner Cheryl and their other daughter had contracted Covid. So, when Bea fell ill, they assumed she might also have the virus. Terry recalled, "We saw similar symptoms with Bea. Breathless, lethargic," adding that they weren't "overly concerned" at that point, but it "went on for a couple of days." After the infant stopped drinking, her parents sought medical advice, and after an ambulance was sent to the home, they recommended she go to a local emergency room to get checked out. "I expected her to be home in a couple of hours with antibiotics or whatever, never expecting to be told that they picked up a heart murmur, that she was in heart failure," Terry told hosts Dermot O'Leary and Sian Welby. Bea was taken to the Freeman Hospital in the U.K. city of Newcastle upon Tyne, where she was diagnosed with dilated cardiomyopathy, Terry recalled. Per the Mayo Clinic, "Dilated cardiomyopathy is a type of heart muscle disease that causes the heart chambers (ventricles) to thin and stretch, growing larger. It typically starts in the heart's main pumping chamber (left ventricle)." "Dilated cardiomyopathy makes it harder for the heart to pump blood to the rest of the body," the site adds. Little Bea, now 5, ended up having a Hickman line — which is a type of catheter that's fitted to help a patient receive medication, per the Cleveland Clinic — and her parents had then received a phone call to say they could visit their daughter and she was "doing well," Terry shared. However, after they got to the hospital, "We heard alarms and we heard staff shouting for equipment," Terry remembered on the show, adding, "And Cheryl said to me, 'Will you look?' We knew it was Bea, we just knew." He said that medics saved Bea by administering CPR after she went into cardiac arrest, but had then told them, "They said if she had another cardiac arrest, she would not make the night." "The only hope she had would be to go on the urgent transplant list. And to get her there, she would need to have a Berlin heart," Terry said, referencing the artificial heart which Bea ended up having. The little one ended up waiting 14 months in the hospital while she waited for a transplant, and Terry said the family had witnessed some tragic moments while there. "Within the space of a week, both the children either side [of Bea's bed] passed," Terry shared. Never miss a story — sign up for to stay up-to-date on the best of what PEOPLE has to offer, from celebrity news to compelling human interest stories. He said that the moment Bea received a transplant was "incredible," but he acknowledged the heartbreaking decision one family had to make to ensure that Bea lived. "The reality is, we know what it meant to the other side so it's like living an endless torture," he recalled. "Every day wondering, 'Is this the day that we lose Bea? Is it her last day with us?' And enjoying every moment." "And at the same time, very conscious of what it means for her to come home, that if she does, her life from that moment, every breath, everything she goes on to do is because of somebody else," Terry — who had previously made the difficult decision, along with Cheryl, to donate their stillborn daughter's heart — added. Read the original article on People
Daily Mail
4 days ago
- Health
- Daily Mail
This Morning guest breaks down in tears as he reveals two-year-old daughter was left fighting for her life after he mistook fatal condition for Covid
A guest on This Morning broke down in tears as he revealed his two-year-old daughter was left fighting for her life after he mistook her fatal condition for Covid. Police officer Terry Archbold, from the village of Burnopfield, County Durham, appeared on the ITV chat show on Friday to tell of the family's heartbreaking ordeal. His daughter Beatrix Adamson-Archbold spent more than a year in hospital waiting for an urgent heart transplant when she was just two years old. He told presenters Dermot O'Leary, 52, and Sian Welby, 38, how they initially mistook what turned out to be little Bea's heart failure as Covid. Terry explained after being born fit and healthy in 2021, the young girl suddenly fell ill at 15 months old after a family holiday to Florida. Terry's partner Cheryl Adamson and their other daughter had caught coronavirus: 'We saw similar symptoms with Bea. Breathless, lethargic.' The parents were not too worried at first - but her sickness continued for several years, with the little girl eventually stopping drinking. They rang 111 and the call handler sent round an ambulance crew, who recommended the parents take Bea to A&E for a more thorough check-up, which Cheryl did. Terry explained: 'I expected her to be home in a couple of hours with antibiotics or whatever, never expecting to be told that they picked up a heart murmur, that she was in a failure.' She was taken to the specialist Freeman Hospital in Newcastle where she was diagnosed with dilated cardiomyopathy - where one side of the heart is enlarged. Doctors could not administer all the medication Bea needed so she had surgery to fit a Hickman line, a kind of tube to deliver more. Luckily, her father said: 'We received a phone call to say, "She's OK, you can come over and see her, she's doing well". But no sooner had they arrived: 'We heard alarms and we heard staff shouting for equipment. 'And Cheryl said to me, "Will you look?" We knew it was Bea, we just knew.' 'They said if she had another cardiac arrest, she would not make the night', Terry said Bea had gone into cardiac arrest and was thankfully saved with CPR - but the family's ordeal was not over yet. 'They said if she had another cardiac arrest, she would not make the night', Terry said. 'The only hope she had would be to go on the urgent transplant list. And to get her there, she would need to have a Berlin heart.' It meant their young daughter lived in the Freeman Hospital for 14 months, supported by this device that does the job of a heart, waiting for a transplant. This was a scary time, as Terry recalled a particularly horrifying moment: 'Within the space of a week, both the children either side [of Bea's bed] passed.' Thankfully, Bea eventually did get a transplant - and has since returned to full health: 'That moment was incredible.' He added: 'And the reality is, we know what it meant to the other side so it's like living an endless torture. 'Every day wondering, "Is this the day we lose Bea? Is it her last day with us?" And enjoying every moment. 'And at the same time, very conscious of what it means for her to come home, that if she does, her life from that moment, every breath, everything she goes on to do is because of somebody else.' In a heartwarming moment, energetic Bea then ran to join her father on the sofa, charming everyone in the studio with her smiley, happy personality. They were joined on the sofa by Rachel Rowson, who manages the London organ donation team, who said demand for organs massively outweighs supply. Around 8,000 people are on the waiting list for a transplant across the country. In fact, actually, around 12,000 need a transplant but the other about 4,000 people are not currently on the list as they are not well enough to receive one. When a loved one dies, it is common, Rachel said, for the family to understandably feel hesitant about consenting to their relative's organs being donated. Rachel said: 'There's a real issue with families saying yes to organ donation... 'That's what we really need to focus on raising awareness about.' In a heartwarming moment, energetic Bea (pictured) then ran to join her father on the sofa, charming everyone in the studio with her smiley, happy personality Terry mentioned his own experience with this - another of his daughters, Isabelle, was tragically born stillborn in 2018 and he was at first hesitant to donate her organs. 'Every instinct I had going on at that point, every emotion was protective, I didn't want anybody to touch her', he said. 'Cheryl's response was, "Yes". So, you've got two parents, very similar circumstances, same emotions going on, same grief, same loss, and we did consent. 'And the thing that swung me was Cheryl made me stop and think that the pain that I was experiencing and that we were going through, would we want other families to feel that? 'And if we could do anything to prevent that, then it's the right thing to do.' Terry added: 'That's why the education is absolutely key because every transplant, every organ donation that takes place hinges on the ability of those that are asked to process that moment and say yes.' Rachel urged viewers to sign up to the NHS organ donor register as it is the best way to convey their wishes to healthcare professionals should the moment come. The healthcare professional also suggested people talk to their family about their wishes regarding organ donation just in case. Terry mentioned his own experience with this - another of his daughters, Isabelle, was tragically born stillborn in 2018 and he was at first hesitant to donate her organs It helps relatives, in a very difficult moment of bereavement and loss, feel clear and confident about what decision to make regarding their relative's organs, she said. Rachel also reminded parents they can sign their children under 18 up to the organ donor register - even though of course no one ever expects to need to. It comes after another recent guest on This Morning had viewers feeling emotional recounting their experience of loss too. A man named Dane Knight appeared on the show on Wednesday after his partner tragically passed away following a Brazilian bum lift - leaving him to raise his five daughters. A non-surgical BBL involves injecting filler into the buttocks and has recently grown in popularity. Dane, whose partner Alice died in August 2024, said he did not know Alice was even having the procedure and thought she was enjoying a day out. 'I didn't know she was getting the procedure done, obviously when we got the phone call I didn't know what the issue was from the hospital, it was more get there and then find out the current situation,' Dane explained. 'Prior to that, going back off the information, we talked about the procedures, as far as we were concerned, the information that was available at that date and time it was deemed as safe,' he added. A man named Dane Knight appeared on the show on Wednesday (pictured) after his partner tragically passed away following a Brazilian bum lift - leaving him to raise his five daughters 'Now I've learnt that it's not.' Dane shared with co-hosts Cat Deeley, 48, and Ben Shephard, 50, he felt Alice did not actually understand the risks because it was 'deemed as safe'. The couple have five daughters together - and Cat asked if Alice had been aware of the possible risks, whether she would have gone ahead with the procedure. 'No way Cat she wouldn't have, no chance,' Dane said. Cat and Ben had discussed the risks of similar procedures with Health Secretary Wes Streeting on Tuesday's episode and notified him of Dane and Alice's situation. On the show, Wes said: 'In the coming days and weeks we're going to be setting out the regulations. 'Over in the next week or so you should hear from the government about what we're going to do to clamp down on cosmetic cowboys here at home, when it comes to overseas it's more complicated...' 'Just hearing Dane speaking there and the thought of five children being left behind because they've lost their mother in these circumstances, that motivates me to act and I hope for people watching as well, it's just the worst possible reminder,' he added. Dane commented that the Health Secretary's comments and plans were 'comforting' but that he hoped to see 'action'. 'Something needs to be put in place sooner, rather than later, before this happens to another family,' he said.
Japan Times
4 days ago
- Health
- Japan Times
Emperor emeritus leaves hospital after heart treatment
Emperor Emeritus Akihito was discharged from the University of Tokyo Hospital on Friday after receiving an additional oral treatment for his heart. The 91-year-old former emperor, accompanied by Empress Emerita Michiko, 90, left the hospital in Tokyo's Bunkyo Ward by car at around 11:30 a.m. and headed for their residence, the Sento Imperial Residence in Tokyo's Minato Ward. In 2022, the emperor emeritus was diagnosed with right heart failure caused by tricuspid valve insufficiency. He was admitted to the university hospital in May for a heart examination and diagnosed with asymptomatic myocardial ischemia. After being discharged from the hospital, he was treated with medication to improve blood circulation. As there was no improvement, however, the medical team determined that he needed the additional oral medication to ease the load on his heart. He had been hospitalized since Monday for the dosage adjustment.
