Latest news with #HD
Newsweek
13 hours ago
- Automotive
- Newsweek
GM Recalls 62,000 Chevrolet Silverados: These Models Are Impacted
Based on facts, either observed and verified firsthand by the reporter, or reported and verified from knowledgeable sources. Newsweek AI is in beta. Translations may contain inaccuracies—please refer to the original content. General Motors has recalled more than 62,000 vehicles because of a potential brake defect that could increase the risk of fire, the U.S. National Highway Traffic Safety Administration (NHTSA) said on Thursday. The recall impacts 2019-2024 Chevrolet Silverado Medium Duty vehicles. The NHTSA said in a statement: "The brake pressure sensor assembly may leak brake fluid into the brake pressure switch and cause a short circuit." Newsweek contacted General Motors for comment by email outside of regular working hours. General Motors has recalled more than 62,000 Chevrolet Silverados because of a potential brake defect. General Motors has recalled more than 62,000 Chevrolet Silverados because of a potential brake defect. Gene J. Puskar/AP Why It Matters The NHTSA said that an electrical short in the brake pressure switch could "overheat the circuit and increase the risk of a fire while driving or parked." The NHTSA memo notes that the defect can trigger under-hood fires even when vehicles are parked or not running. The NHTSA has advised owners to park recalled vehicles outdoors and away from buildings until repairs are made to prevent potential fires. What To Know The recall affects 62,468 vehicles, according to the NHTSA. The models impacted are Chevrolet Silverado Medium Duty 4500 HD, 5500 HD and 6500 HD trucks built between 2019 and 2024. General Motors notified dealers about the recall on June 12 and plans to begin mailing recall notifications to affected owners in July. This recall follows other recent large-scale recalls by General Motors, including a recall of almost 600,000 Cadillac, Chevrolet and GMC vehicles earlier this year. General Motors had found "the connecting rod and/or crankshaft engine components in these vehicles may have manufacturing defects that can lead to engine damage and engine failure," the NHTSA said. Models Impacted By The Latest Recall 2023 Chevrolet Silverado 5500 HD: 10,097 vehicles 2022 Chevrolet Silverado 5500 HD: 7,339 vehicles 2019 Chevrolet Silverado 5500 HD: 6,948 vehicles 2024 Chevrolet Silverado 5500 HD: 6,632 vehicles 2021 Chevrolet Silverado 5500 HD: 6,424 vehicles 2020 Chevrolet Silverado 5500 HD: 5,439 vehicles 2023 Chevrolet Silverado 6500 HD: 5,102 vehicles 2022 Chevrolet Silverado 6500 HD: 3,635 vehicles 2019 Chevrolet Silverado 6500 HD: 2,248 vehicles 2024 Chevrolet Silverado 6500 HD: 2,191 vehicles 2021 Chevrolet Silverado 6500 HD: 2,135 vehicles 2020 Chevrolet Silverado 6500 HD: 1,804 vehicles 2024 Chevrolet Silverado 4500 HD: 514 vehicles 2022 Chevrolet Silverado 4500 HD: 483 vehicles 2023 Chevrolet Silverado 4500 HD: 415 vehicles 2019 Chevrolet Silverado 4500 HD: 389 vehicles 2021 Chevrolet Silverado 4500 HD: 360 vehicles 2020 Chevrolet Silverado 4500 HD: 313 vehicles What People Are Saying The NHTSA said in a statement: "Owners are advised to park outside and away from structures until the recall repair is complete. Dealers will replace the brake pressure switch wire harness, free of charge." What Happens Next Vehicle owners should expect to receive official notifications from General Motors beginning July 28, and will be instructed on how to receive their complimentary repair. Owners can get more information by calling General Motors at 1-866-467-9700, referencing recall no. N242482680.
Time of India
19 hours ago
- Science
- Time of India
Scientists discover rare space alcohol that could explain how life began on the Earth
Astronomers have uncovered a cosmic clue that takes us closer to answering one of humanity's oldest questions, 'How did life begin on Earth?' It has been found out that a young star system, located roughly 330 light-years away, is awash in alcohol! The discovered alcohol types and their isotopes are among the building blocks of the starting points for creating even complex organic molecules like amino acids. Locating these bits in such a young planetary nursery suggests that the seeds of life might be spread throughout the galaxy, tied to how comets and icy materials form. An alcohol-soaked star system A discovery around the star HD 10045, which is about 330 light-years from Earth, has for the first time, allowed scientists to detect not only methanol, an alcohol compound, but also its rare isotopes in the protoplanetary disk encircling this young star. Published on June 5 in The Astrophysical Journal Letters, the research was based on data from the Atacama Large Millimeter/submillimeter Array (ALMA) in Chile What makes these bits the 'cosmic alcohol'? Methanol is a simple alcohol that plays a crucial role in the formation of organic molecules like amino acids, the essential building blocks of life. Although methanol itself has been spotted in other star-forming disks, detecting its isotopes, which are also much rarer variants of the same, is an important step in the discovery of life's building block on Earth. As lead author Alice Booth from the Harvard & Smithsonian Center for Astrophysics explained, 'Finding these isotopes of methanol gives essential insight into the history of ingredients necessary to build life here on Earth.' by Taboola by Taboola Sponsored Links Sponsored Links Promoted Links Promoted Links You May Like Rabien Ab: ten wysokiej klasy aparat słuchowy zdominuje rynek w 2025 roku DRUGIE UCHO Undo Why is HD 100453 different from the others? This star is about 1.6 times bigger than our Sun. Because it's larger, the disk of gas and dust around it is warmer. That warmth keeps methanol in gas form, even far from the star, making it much easier for telescopes like ALMA to detect. In contrast, stars smaller than our Sun have cooler disks, where methanol usually freezes into ice, making it much harder to spot. Another interesting factor about it is that the amount of methanol, as compared to other organic molecules in this star's disk, is very similar to what we see in comets from our own solar system. This gives scientists a clue that these icy materials might come together to form comets, which can then crash into young planets and deliver important ingredients for life. 'This research supports the idea that comets may have played a big role in delivering important organic material to the Earth billions of years ago,' said Milou Temmink, a PhD student who studies planet-forming disks at Leiden University A mix of space chemicals has life-building potential What scientists found goes beyond just simple methanol. The study suggests there may be even more complex molecules hiding in the gas around the star, including things that could be the early building blocks of amino acids and sugars, which are key ingredients for life. According to , these discoveries include rare types of methanol like ¹³CH₃OH and possibly deuterated methanol. Their presence means that icy materials floating in space might survive even during the wild, chaotic process of planet formation. What could it mean for life beyond Earth? By following these organic molecules, be it tiny ice grains, comets, or to planets, scientists are starting to connect the dots on how life might form in different parts of the universe. The chemical mix found around the star HD 100453 could be very similar to what helped spark life on Earth billions of years ago.
USA Today
a day ago
- Automotive
- USA Today
General Motors recalls over 62,000 vehicles. See impacted models.
General Motors has recalled over 62,000 vehicles due to a break pressure issue that could lead to fires. Impacted vehicles include the 2019 to 2024 Chevrolet Silverado models in 4500 HD, 5500 HD, and 6500 HD, General Motors told the National Highway Traffic Safety Administration (NHTSA) in a memo on June 25 The recall includes 62,468 vehicles altogether, the company said. Here's what we know about the issue and what General Motors is doing to fix it. What's the issue with the vehicles? According to General Motors, the brake pressure sensor assembly on the recalled vehicles may leak brake fluid into the brake pressure switch, causing a short circuit. An electrical short in the brake pressure switch can overheat the circuit, increasing the risk of a fire while consumers are driving or parked. More car recalls: Nearly 133,000 Ford SUVs recalled over possible detaching parts: See impacted models Which vehicles have been impacted? Most of the impacted vehicles are 2023 Chevrolet Silverado 5500 HD trucks made between January 20, 2023 and March 19, 2024. General Motors said about 10,097 of them run the risk of malfunctioning, per manufacturing records. 'Vehicles prior to 2019 model year use a different design and are not affected by this recall,' the company said. '2024 model year vehicles that were produced with a brake switch wire harness that includes a silicone sealant are not affected by this recall.' Altogether, the recall includes vehicles listed as: What should drivers do if they have the impacted vehicles? Dealers will replace the brake pressure switch wire harnesses for free, General Motors said. The company notified dealers on June 12. General Motors plans to mail letters to owners by July 28. Once the repair is available, the company will mail a second round of letters. Until the recall repair is complete, owners should park outside and away from buildings. Who can drivers call for help or information? Drivers can contact: The company said these vehicles were previously repaired under recall no. 23V266 and need to undergo the new repair. Saleen Martin is a reporter on USA TODAY's NOW team. She is from Norfolk, Virginia – the 757. Email her at sdmartin@
Business Insider
6 days ago
- Business
- Business Insider
Home Depot (HD) Gets a Buy from Telsey Advisory
Telsey Advisory analyst Joe Feldman maintained a Buy rating on Home Depot (HD – Research Report) yesterday and set a price target of $455.00. The company's shares closed yesterday at $349.62. Confident Investing Starts Here: Easily unpack a company's performance with TipRanks' new KPI Data for smart investment decisions Receive undervalued, market resilient stocks right to your inbox with TipRanks' Smart Value Newsletter According to TipRanks, Feldman is a 5-star analyst with an average return of 8.2% and a 52.56% success rate. Feldman covers the Consumer Cyclical sector, focusing on stocks such as Costco, Lowe's, and On Holding AG. The word on The Street in general, suggests a Strong Buy analyst consensus rating for Home Depot with a $428.77 average price target, representing a 22.64% upside. In a report released on June 17, Citi also maintained a Buy rating on the stock with a $433.00 price target. The company has a one-year high of $439.37 and a one-year low of $326.31. Currently, Home Depot has an average volume of 3.56M. Based on the recent corporate insider activity of 84 insiders, corporate insider sentiment is negative on the stock. This means that over the past quarter there has been an increase of insiders selling their shares of HD in relation to earlier this year. Earlier this month, John A. Deaton, the EVP – Supply Chain & Prod. Dev of HD sold 8,892.00 shares for a total of $3,289,951.08.
Los Angeles Times
17-06-2025
- Health
- Los Angeles Times
Huntington's Disease: Genetics, Symptoms, and Hope for the Future
Huntington's disease (HD) is one of those rare conditions that affects not just the patient but the entire family—medically, emotionally and genetically. This inherited brain disorder causes gradual breakdown of nerve cells especially in the parts of the brain involved in movement, thinking and mood regulation. Although rare, affecting 3 to 7 people per 100,000 globally, its impact is profound and relentless. With no cure in sight, HD is at the center of intense research to understand its molecular roots and develop targeted therapies [1]. Huntington's disease is inherited in an autosomal dominant pattern, meaning if a person inherits one copy of the defective gene they will develop the disease. The culprit is a genetic mutation in the hd gene (also known as the huntingtin gene), where a DNA segment—specifically a CAG trinucleotide repeat—is abnormally expanded. Normally this segment is repeated 10 to 35 times. In HD it's repeated 36 times or more, sometimes even in the 100s [3] [4] [5] [6]. Huntington's disease is caused by a genetic mutation in the huntingtin gene, specifically the HD mutation involving expanded CAG repeats. This expanded repeat leads to the creation of a toxic version of a protein called huntingtin which misfolds and accumulates in brain cells. Over time these protein clumps disrupt cellular function and lead to death of neurons—especially in the striatum and cortex, areas responsible for motor control and cognition [4] [5]. The loss of nerve cells in these regions is what causes the symptoms of Huntington's disease. Different genetic variants can influence the age of onset and progression of the disease. Researchers have identified two distinct disease phases: an early phase where the brain seems to compensate for the damage and a later phase where symptoms are more visible and rapid neurodegeneration [7]. Understanding the disease process at the molecular level is key to developing new treatments. Huntington's disease symptoms usually emerge between 30-50 years and progress over 15-20 years. The classic triad of symptoms includes: The range of disease symptoms includes symptoms of HD and symptoms of Huntington's disease, covering motor, cognitive and behavioral changes throughout the course of the illness. Research in 2025 has shown that changes in how the striatum connects with the hippocampus may explain some of the memory difficulties HD patients experience, especially those involving spatial awareness [10]. Also worth noting are lesser-known symptoms like loss of smell in advanced disease stages [11] and subtle sex-based differences in disease expression. For example, male patients may have lower levels of 17β-estradiol and reduced number of DARPP-32+ neurons, which may influence disease severity [12]. Other symptoms like sleep disturbances and weight loss may also appear as the disease advances. As the disease progresses symptoms worsen over time with increasing severity of movement disorders, cognitive decline and behavioral changes. Motor symptoms especially uncontrolled movements and balance problems can lead to physical injury from falls or accidents, further impacting quality of life. Juvenile Huntington's disease is a rare form that affects children and adolescents, often presenting with unique features like seizures and more rapid progression compared to adult-onset cases. Huntington's disease diagnosis is confirmed by a genetic test showing 36 or more CAG repeats in the HTT gene. However, the diagnostic process also involves: Presymptomatic genetic testing is available for individuals without known family history of HD. While this can provide clarity, it raises ethical challenges, especially around mental health support and family planning [9]. Beyond the faulty gene itself, scientists have found a cascade of biological disruptions that drive HD. Imaging studies show that HD affects brain structure and function, leading to progressive changes in key brain regions and chemical systems: Huntington's disease affects both physical and mental health, leading to movement disorders, cognitive decline and psychiatric symptoms that worsen over time. Each of these changes leads to neuronal death, providing multiple targets for therapeutic intervention. Individuals who inherit the genetic mutation will develop Huntington's disease. There's no cure for HD yet, but several treatments can help manage symptoms: More exciting, however, are the experimental approaches in development: For updates on these trials, you can follow progress via resources like the HD portal, or the European Huntington's Disease Network. People with Huntington's disease benefit from tailored care and support, and their involvement in research and clinical trials is crucial for developing better therapies. Living with Huntington's isn't just about managing symptoms—it's about navigating a complex emotional and social landscape. Many patients grapple with: Family members are often deeply involved in caregiving, emotional support, and making important decisions throughout the course of the disease. Because of this, a team-based approach to care is critical. Neurologists, psychiatrists, genetic counselors, social workers, therapists, and genetic counseling services all play a part in supporting HD patients and their loved ones. A genetic counselor is a healthcare professional who guides patients through the genetic testing process, explains inheritance patterns, and answers questions about the benefits and risks of testing. Huntington's disease is a devastating diagnosis, but the landscape is slowly shifting. Thanks to advances in genetic research, brain imaging, and experimental therapies, we're moving closer to more personalized and effective treatments. Until then, early diagnosis, supportive care, and active participation in research remain key to improving quality of life for those affected by HD. [1] Stoker, T. B., Mason, S. L., Greenland, J. C., Holden, S. T., Santini, H., & Barker, R. A. (2022). Huntington's disease: diagnosis and management. Practical neurology, 22(1), 32–41. [2] Walker F. O. (2007). Huntington's disease. Lancet (London, England), 369(9557), 218–228. [3] Kim, A., Lalonde, K., Truesdell, A., Gomes Welter, P., Brocardo, P. S., Rosenstock, T. R., & Gil-Mohapel, J. (2021). New Avenues for the Treatment of Huntington's Disease. International journal of molecular sciences, 22(16), 8363. [4] Ghosh, R., & Tabrizi, S. J. (2018). Huntington disease. Handbook of clinical neurology, 147, 255–278. [5] McColgan, P., & Tabrizi, S. J. (2018). Huntington's disease: a clinical review. European journal of neurology, 25(1), 24–34. [6] Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., Nance, M., Ross, C. A., Scahill, R. I., Wetzel, R., Wild, E. J., & Tabrizi, S. J. (2015). Huntington disease. Nature reviews. Disease primers, 1, 15005. [7] Hong, E. P., MacDonald, M. E., Wheeler, V. C., Jones, L., Holmans, P., Orth, M., Monckton, D. G., Long, J. D., Kwak, S., Gusella, J. F., & Lee, J. M. (2021). Huntington's Disease Pathogenesis: Two Sequential Components. Journal of Huntington's disease, 10(1), 35–51. [8] Wolf, B., Schwarzer, A., Côté, A. L., Hampton, T. H., Schwaab, T., Huarte, E., Tomlinson, C. R., Gui, J., Fisher, J. L., Fadul, C. E., Hamilton, J. W., & Ernstoff, M. S. (2012). Gene expression profile of peripheral blood lymphocytes from renal cell carcinoma patients treated with IL-2, interferon-α and dendritic cell vaccine. PloS one, 7(12), e50221. [9] Rodríguez-Arribas, M., Yakhine-Diop, S. M. S., Pedro, J. M. B., Gómez-Suaga, P., Gómez-Sánchez, R., Martínez-Chacón, G., Fuentes, J. M., González-Polo, R. A., & Niso-Santano, M. (2017). Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease. Molecular neurobiology, 54(8), 6287–6303. [10] Glikmann-Johnston, Y., Delagneau, G., Barta, T., Stout, J. C., & Razi, A. (2025). Neural Mechanisms of Object Location Memory in Huntington's Disease. Movement disorders : official journal of the Movement Disorder Society, 10.1002/mds.30232. Advance online publication. [11] Bylsma, F. W., Moberg, P. J., Doty, R. L., & Brandt, J. (1997). Odor identification in Huntington's disease patients and asymptomatic gene carriers. The Journal of neuropsychiatry and clinical neurosciences, 9(4), 598–600. [12] Bode, F. J., Stephan, M., Suhling, H., Pabst, R., Straub, R. H., Raber, K. A., Bonin, M., Nguyen, H. P., Riess, O., Bauer, A., Sjoberg, C., Petersén, A., & von Hörsten, S. (2008). Sex differences in a transgenic rat model of Huntington's disease: decreased 17beta-estradiol levels correlate with reduced numbers of DARPP32+ neurons in males. Human molecular genetics, 17(17), 2595–2609.
