Loss of Pulse Detection Feature on the Pixel Watch 3 Is Coming to the US
Google announced the Loss of Pulse Detection feature in 2024 for select EU countries. It's since been available in 14 countries. Now that Google has received the green light from the FDA, it can be released in the US. This opt-in feature is expected to start rolling at the end of March.
The watch uses an AI-based algorithm and signals from the existing multipath heart rate sensor -- the flashing green light on the back of the watch-- to monitor your pulse. If it suspects your pulse was lost, additional sensor signals will be activated to search for the pulse or identify movement.
When nothing is detected, the watch prompts you with an initial check-in. If you don't respond to the message on the watch and no motion is detected, a loud alarm will play, and a countdown will appear on the screen. Then, an emergency services call is placed on your LTE smartwatch or phone. An automated message about the loss of pulse and your location will be shared with emergency operators.
While the Loss of Pulse Detection feature wasn't made for a specific health condition, this is another feature added to the Pixel 3's impressive catalog of safety and health features, such as fall detection and irregular heart rhythm notifications. As a Google Pixel user, I'm happy to see another feature in the medical safety space, especially for one in which immediate intervention is necessary.
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Miami Herald
42 minutes ago
- Miami Herald
AI overviews for attorneys: Winning the new search game
AI overviews for attorneys: Winning the new search game Imagine you are someone injured and in the hospital after a car crash. You grab your phone and search for "what to do after a car accident." However, you don't see the 10 or so site links that would typically show up on your screen. Instead, you see an AI-generated answer at the top of the search results, laying out a response to your query, along with links to the sources behind that answer. This scenario is no longer hypothetical. It's Google's AI Overviews. And it's here. In this article, Consultwebs discuss this new digital marketing platform as well as strategies that attorneys can use to optimize their online presence for AI Overviews, including providing content and using other methods that align with E-E-A-T - Experience, Expertise, Authoritativeness, and Trustworthiness - the core framework Google uses to evaluate content quality. The Changing Legal Search Landscape By this point, you're likely familiar with AI-generated answers to searches. The importance of organic search or paid search cannot be downplayed. However, these AI-generated results are changing how people search for legal help online. On the one hand, the shift in how potential law firm clients seek information presents a threat. But it also presents an opportunity. The threat lies in the possibility of law firms seeing lower click-through rates and traffic from informational AI results. The opportunity lies in the potential for law firms to increase their online visibility. Proprietary Consultwebs data shows higher conversion rates from AI sources; the higher rate is likely due to the higher level of intent behind the user's query. So, while the quantity of site traffic may decrease, the quality of that traffic will likely increase and lead to a higher number of leads for law firms. What Are AI Overviews? AI Overviews are Google's AI-generated answers that appear above traditional organic results. They directly answer user questions by combining content from multiple sources from across the web. AI Overviews appear when people ask legal questions like "How long do I have to file a personal injury claim in Texas?" or "What happens at a first DUI court appearance?" Instead of requiring users to click on links and search for answers on those websites, the overview provides direct answers. Google marks the summaries with an "AI Overview" label. They occupy the coveted "position zero" spot, which is the first thing users see before they see any other search results. The overview typically includes the following elements: Direct answer to the queryKey contextual information relevant to the legal questionOccasionally, related questions that help visitors expand searchList of sources for the summary, which can include law firm websites So, if a potential client searches for a response to a legal question and sees your law firm as a source in AI Overviews, it will help to establish your law firm's credibility and authority. How AI-Enhanced Search Affects Client Research Behavior Potential law firm clients can now get answers to their legal questions without having to visit law firm websites. For instance, when someone searches "statute of limitations car accident Florida," they will see the answer is "four years" in AI Overviews. Note: This result is also a great example of how AI can get things wrong, as Florida changed the statute of limitations to two years from the injury date in March 2023. This shift in search results could move a potential client's initial research away from websites and into Google's environment. Why AI Overviews Matter for Your Law Practice To get a better understanding of how Google's AI Overviews could affect your law firm's marketing campaign, consider the following three areas. Competitive Advantage Online visibility leads to citations and strengthens your position in AI-generated results. Lawyers can gain an edge when they optimize for AI Overviews, unlike competitors who focus only on traditional SEO. Firms that adapt can establish themselves as authoritative sources before market saturation. Google's AI does not necessarily feature websites based on historical domain authority or ranking position. Instead, it prioritizes content that answers certain legal questions, regardless of the firm's size or history. So, in this environment, even well-established law firms with strong traditional search rankings could be vulnerable. Larger firms that delay adapting their content strategy risk being overshadowed by smaller, more agile competitors who know how to quickly restructure their online presence to match how AI systems evaluate information. Practice Area-Related Benefits In several different practice areas, the ability to optimize for AI Overviews will give a law firm a competitive edge. Consider the following. Personal injury: Capturing potential clients at the moment of need - you can reach prospective clients during a critical decision-making moment, or right after an accident occurs. At that moment, by addressing urgent questions such as, "Should I accept the insurance settlement offer?" you can establish credibility when people are most receptive to hiring legal defense: Providing value during crisis moments - again, with AI Overviews, you can reach potential clients in this practice area when they face high-stress, time-sensitive situations. You can demonstrate your knowledge and experience on topics like "What happens at arraignment?" or "What are the penalties for a first DUI offense?" By taking advantage of AI Overviews, you will position your criminal defense firm as a trusted guide and establish authority at a time when potential clients need planning: Demonstrating knowledge of complex topics - in AI Overviews, you can simplify legal concepts that potential clients may find overwhelming and showcase your ability to make complex matters accessible. You can provide clarity and show your approachability, which are key qualities in this practice area, by providing answers to questions such as "What are the differences between a will and a living trust?" or "How can you avoid probate?" Local Market Domination AI Overviews have transformed how Google handles location-based legal searches, including in the following areas. Geographic targeting - When people search with local intent (for example, "child custody laws in Phoenix" or "slip and fall statute of limitations California"), Google will prioritize region-specific content in its AI summaries. So, if a law firm thoroughly addresses jurisdiction-specific questions, it can result in a visibility advantage. Building local authority through content - Your firm's prominence in local AI Overviews depends on your geographic content. By creating resources that address your state's laws, local court procedures, and other regulations, you can position your firm as a local authority. Near-me search optimization - This approach is particularly powerful for capturing "near me" searches and location-based legal questions that potential clients use in urgent situations. Firms that develop content covering all of their service areas will consistently outperform competitors in local AI Overview citations. So, your local SEO takeaways should be: Create jurisdiction-specific content addressing local laws and for location-specific legal questions that are common in your practice local citations and references to regional legal content for all geographic areas your firm serves. By implementing these strategies, you should be able to effectively drive higher-quality leads from potential clients seeking legal help. E-E-A-T and AI Overviews: The Critical Connection E-E-A-T stands for Experience, Expertise, Authoritativeness, and Trustworthiness. Google uses this core framework to evaluate content quality. For legal websites, Google applies heightened scrutiny because legal advice falls under "Your Money or Your Life" (YMYL) topics - information that could affect a person's well-being or financial security. Google's quality raters assess whether legal content demonstrates genuine expertise, comes from authoritative sources, and presents trustworthy information that won't harm users if followed. E-E-A-T matters more than ever with AI-generated results. When generating summaries, Google's AI systems prioritize content from sources with strong E-E-A-T signals to minimize the risk of spreading inaccurate legal information. E-E-A-T Signals You Can Send With Your Website Unlike traditional search rankings, where hundreds of factors determine position, AI Overviews appear to give heavy weight to E-E-A-T signals when selecting which law firms' content to feature. That means demonstrating clear expertise and authority is no longer just about ranking. Instead, it is about whether your content gets featured in the prominent AI summaries at all. The following are E-E-A-T signals that your law firm can send with your site. Expertise Signals Accurate and precise legal terminologyJurisdiction-specific information and lawsClear explanations that simplify complex concepts without oversimplificationContent addressing potential exceptions and edge casesPractice area focus and depthContextual examples that demonstrate applied knowledge Authoritativeness Markers Firm history and established reputationAttorney credentials and bar admissions - displayed clearlySpeaking engagements and published worksRecognition from legal peers and organizationsAttorney bio pages with verifiable credentialsTransparent firm information and historyProper legal schema markup implementationConsistent NAP (Name, Address, Phone) information across the web Trust Indicators Clear presentation of attorney credentials near relevant contentRegular content updates reflecting current lawsAppropriate disclaimers addressing limitations of general informationSecure website protocols (HTTPS)Clear privacy policies and terms of serviceTransparent client communication channelsAbsence of misleading claims or guaranteesSpecific, detailed client reviews, not just generic praise Citation and Reference Quality Citations to relevant statutes and case lawReferences to official legal resourcesInternal links to deeper explanationsExternal links to court websites and government resourcesBar association and legal directory citationsProperly attributed quotes from authoritative sourcesConsistent citation formatting Practical E-E-A-T Enhancements for Law Firms In general, your law firm's E-E-A-T Priority Checklist should be: Associate appropriate attorneys with specific content credentials directly alongside legal update content to reflect current authoritative legal comprehensive internal linking between related topics. Specifically, your law firm can take the following steps to align with E-E-A-T: Strategic Credential Placement Display attorney credentials throughout your website, not just on bio credentials with content (for example, "Written by Sarah Johnson, Board-Certified Family Law Specialist").Link attorney names to detailed profiles containing full credentials and specializations adjacent to relevant practice area content. Authority-Building Case Results and Testimonials Create practice area-specific case result pages with coordinated challenges and testimonials to highlight key legal expertise rather than general verification elements, such as client initials or case types, when testimonials that mention particular attorney skills (for example, "Attorney Miller's deep knowledge of estate tax law saved our family thousands."). Comprehensive Content Development Organize information with clear hierarchical FAQ sections anticipating related topic clusters with main pages linking to detailed subtopic jurisdictional variations relevant to your practice areas. Practical Strategies: Optimizing Your Digital Presence for AI Overviews To get a better understanding of what it means to optimize your law firm's digital presence for Google's AI Overviews, let's examine three specific areas. Content Structure and Format The structure and format of your law firm's online content can affect your ability to take advantage of the marketing opportunities that AI Overviews provides. Your content should feature the following. Question-focused headings that mirror natural client queries - Google's AI Overviews prioritize content that directly addresses the questions potential clients ask. Consider using question-based formats that match real search inquiries instead of traditional practice area headings. Content with natural language questions that mimic what clients would type into a search will increase the likelihood of being selected as a source for AI Overviews. A couple of examples are: Instead of "Car Accident Representation," use "What Should I Do Immediately After a Car Accident in [State]?"Instead of "Child Custody Services," use "How Is Child Custody Determined in [State] Divorce Cases?" Clear, concise paragraphs with definitive answers - Position definitive answers at the beginning of your content, followed by supporting information. Google's AI looks for content that provides clear answers without unnecessary preamble. For instance, in the example below, notice how the content provides a direct answer in the first sentence, followed by context and nuance. Query - How long do I have to file a personal injury claim in Texas?Content - In Texas, you generally have two years from the date of injury to file a personal injury lawsuit. This time limit, known as the statute of limitations, is established by Texas Civil Practice and Remedies Code § 16.003. Missing this deadline typically means losing your right to seek compensation through the court system. Bulleted lists and organized information for easy AI parsing - Organize key information in formats that are easy for AI systems to identify and extract. Bulleted lists and clear organizational patterns help Google's AI understand your content's structure. In the example below, the content has a structured format, which makes it easier for Google's AI to identify and extract information when generating overviews. Topic - Types of Compensatory Damages Available in Personal Injury CasesContent - The following are types of compensatory damages available in personal injury cases: Medical expenses (past and future) Lost wages and diminished earning capacity Property damage and repair costs Pain and suffering Emotional distress Loss of enjoyment of life Loss of consortium FAQ sections that directly address common legal questions - Include dedicated FAQ sections that address related questions potential clients might have. By using FAQs, you provide Google's AI with clear, pre-formatted answers to common follow-up questions. The following are examples of FAQ sections in the area of personal injury law that create valuable, self-contained content units that Google's AI can easily identify when generating overviews for related searches: Should I talk to the other driver's insurance company? No, you should avoid giving statements to the other driver's insurance company without legal representation. Insurance adjusters may use your statements to minimize your claim's value. What if the accident was partially my fault? [State] follows a comparative negligence rule, which means you may still recover damages even if you were partially at fault, though your compensation may be reduced by your percentage of fault. How much is my car accident claim worth? The value depends on several factors, including the severity of injuries, medical expenses, lost income, property damage, and impact on quality of life. An experienced attorney can provide a more accurate assessment based on your circumstances." Technical Optimization From a technical standpoint, optimizing your law firm's digital presence for AI Overviews involves the following: Schema markup for attorneys and legal content - Schema markup provides explicit signals to search engines about your content's meaning and helps Google's AI to better understand and categorize your legal knowledge for inclusion in AI Overviews. You should focus on: Attorney Schema - Tells Google who you are, your credentials, education, certifications, and practice Service Schema - Identifies your firm's services, practice areas, and service Schema - Structures your frequently asked questions so Google can easily extract them for AI Schema - Useful for procedural content like "How to file for divorce" or "Steps after a car accident."Local Business Schema - Enhances your local visibility with accurate name, address, and phone information While the technical implementation might require developer assistance, understanding the schema types helps you prioritize information on your website. Page speed and mobile optimization importance - Google's AI prioritizes content from sites that deliver excellent user experiences, with page speed and mobile optimization being important factors. Sites that load quickly and function well on mobile devices are more likely to retain users and encourage them to stay on the site. Key optimization areas include the following: Image Optimization - Compress images, use modern formats like WebP, and specify Responsiveness - Ensure all content is easily readable on mobile devices without horizontal Speed - Minimize unnecessary scripts, optimize CSS delivery, and leverage browser Web Vitals - Focus on improving Largest Contentful Paint, First Input Delay, and Cumulative Layout Shift metrics. These technical factors create a foundation for authority that complements your content quality. Site structure and internal linking strategies - A logical site structure with strategic internal linking helps Google's AI understand the relationships between your content pieces, establishing topical authority that increases your chances of being featured in AI Overviews. The following are effective approaches that your law firm can take: Topic Cluster Structure - Organize content around central practice area pages with supporting subtopic Internal Linking - Link related content naturally within text to establish content Navigation - Help users and search engines understand your site's hierarchical URL Structure - Create logical URLs that reflect your content organization. Content Development Strategy To optimize your content for AI-generated search results, you should focus on these items. Identify high-opportunity legal queries in your practice area - Strategic content development starts with identifying the specific questions that potential clients ask and which trigger AI Overviews. Focus on queries with high search volume and look for existing content that may lack depth or authority. Research methods for identifying high-value queries include the following: Use Google's "People Also Ask" sections to identify related competitor content that currently appears in AI your consultation notes for frequently asked initial keyword research tools to find question-based searches with significant volume. Examples of high-opportunity query types, by practice area, include: Personal Injury "How much is my [specific injury] claim worth?" "Who pays medical bills after a car accident in [State]?" "What if the accident was partially my fault in [State]?" Family Law "How is child support calculated in [State]?" "How long does divorce take in [State]?" "Can I modify a custody agreement without going to court?" Create comprehensive content clusters around primary topics - Develop interconnected content ecosystems that establish authoritative coverage of key legal topics. The depth will signal to Google's AI that your firm has expertise worthy of citation in AI Overviews. Here is an example of an optimized car accident content cluster structure: Primary Topic Page: "Car Accidents in [State]" Overview of state laws governing auto accidentsStatistics on accident frequency and common causesGeneral process for pursuing compensation Supporting Subtopic Pages: "[State] Car Accident Statute of Limitations"Detailed explanation of time limitsExceptions that may extend or toll the statuteCase examples illustrating deadline applications"Determining Fault in [State] Car Accidents"Evidence types used to prove liabilityHow comparative negligence affects recoveryThird-party liability scenariosSpecialized Pages for Specific Scenarios:Uber/Lyft accident claimsUninsured motorist scenariosMulti-vehicle accidentsCommercial vehicle collisions Update frequency and freshness factors - Google's AI prioritizes current, accurate legal information. Establish a review process to ensure your content reflects the latest laws, precedents, and procedures. Examples of content update triggers are: Legislative changes affecting the practice areaNew case lawProcedural changes in local courtsUpdated statistics or dataNew industry best practices To be proactive in addressing these triggers, you should follow a content audit schedule that incorporates: Quarterly Reviews - Check all high-traffic pages for Deep Audits - Review practice area Overhauls - Make major updates to primary practice area pages with case studies, statistics, and procedural information. Measuring Success: Tracking Your AI Overview Performance To determine if your optimization efforts are working, focus on these performance indicators, or key metrics to monitor: Visibility - Track which queries feature your content in AI Overviews by monitoring position improvements and using specialized tools like or Patterns - Compare organic traffic before and after Rates - Focus on what matters most - consultation requests and client inquiries. Your measurement approach should cover the following: Use Google Search Console to analyze impression and CTR changes for key monthly content audits, identifying "winners" (content frequently appearing in AI Overviews) and "underperformers."Apply successful patterns from high-performing content to other areas of practice. This story was produced by Consultwebs and reviewed and distributed by Stacker. © Stacker Media, LLC.
Yahoo
an hour ago
- Yahoo
3 Reasons to Buy Microsoft Stock Despite 11.7x P/S Premium Valuation
Microsoft MSFT presents a compelling investment opportunity for 2025 despite its premium 11.76x P/S valuation, which exceeds the Zacks Computer-Software industry average of 9.8 times, driven by explosive AI monetization, dominant cloud market position, and unmatched enterprise ecosystem company's explosive AI monetization, dominant cloud market position, and enterprise ecosystem integration create sustained outperformance versus competitors like Alphabet GOOGL, Amazon AMZN, and Nvidia NVDA. While Google leads in AI/ML tools, Microsoft's enterprise distribution through existing Office 365 and Azure relationships drives higher business customer adoption rates. Microsoft's AI-first approach contrasts favorably with AWS' infrastructure-focused strategy. Against Nvidia, Microsoft offers full-stack AI integration from infrastructure to applications, providing recurring revenue models through cloud services rather than hardware has outperformed the Zacks Computer & Technology sector and its competitors in the past six months. While shares of Nvidia and Amazon have returned 0.2% and 13.5%, respectively, Google has lost 9.1% in the same time frame. Microsoft's solid 17.1% six-month performance demonstrates superior execution. Image Source: Zacks Investment Research Microsoft has established itself as the clear leader in enterprise AI monetization, with its AI business surpassing $13 billion in annual revenue run rate — a 175% year-over-year increase that demonstrates the company's ability to translate AI innovation into tangible financial results. This growth trajectory significantly outpaces competitors, with AI services contributing 16 percentage points to Azure's robust 33% growth in third-quarter company's strategic $80 billion infrastructure investment for fiscal 2025 positions Microsoft to capture the massive wave of enterprise AI adoption. With over half of this investment focused on U.S. facilities, Microsoft is building the foundation to support both its own AI services and OpenAI's operations, creating a competitive moat that will be difficult for competitors to enterprise momentum represents a transformative growth catalyst, with existing customers expanding their Copilot seats by more than 10x over 18 months. The platform now serves 230,000+ organizations and 90% of Fortune 500 companies, generating $30 per user per month in enterprise pricing. This represents just the beginning of monetization across Microsoft's 520 million Microsoft 365 commercial 2025 announcements reinforce Microsoft's AI platform leadership with groundbreaking multi-agent orchestration capabilities, SQL Server 2025 with built-in AI functionality, and GitHub Copilot's evolution into a comprehensive coding agent. These developments expand Microsoft's AI ecosystem beyond simple assistants to comprehensive platforms that create deeper customer relationships. Microsoft Azure's market share has expanded to 20-25% globally, with the company gaining ground on Amazon-owned AWS' 29% market leadership through superior enterprise focus and ecosystem $42.4 billion Microsoft Cloud revenues, up 20% year over year, demonstrate the platform's resilience and scalability. Management noted that the majority of outperformance against expectations was on the non-AI piece of the business, indicating healthy underlying demand beyond AI services. This diversified growth reduces dependency on any single technology cloud adoption trends strongly favor Microsoft's integrated approach. With 89% of enterprises using multi-cloud strategies and 81% utilizing Azure versus 79% for AWS, Microsoft's position in enterprise accounts provides sustainable competitive advantages. The company's commercial bookings rose 67% year over year, with close to $300 billion in committed customer contracts providing exceptional revenue visibility. Microsoft's exceptional financial performance justifies its premium valuation through consistent execution and robust fundamentals. Third-quarter fiscal 2025 revenues of $70.1 billion grew 13% year over year, while operating income increased 16%, demonstrating strong operational leverage and margin expansion despite significant AI infrastructure company's diversified revenue streams across cloud, productivity, gaming, and search provide stability and growth. The Intelligent Cloud segment generated $26.75 billion in revenues, up 21% year over year, while Productivity and Business Processes contributed $29.9 billion, with 10% growth driven by Microsoft 365 commercial cloud revenue balance sheet fundamentals support continued investment in growth initiatives. With minimal debt burden, consistent dividend payments, and robust cash generation, Microsoft maintains financial flexibility to pursue strategic opportunities while returning value to shareholders through $9.7 billion in dividends and share repurchases in the third quarter Zacks Consensus Estimate for Microsoft's fiscal 2025 revenues is pegged at $279.09 billion, suggesting 13.86% year-over-year growth. The consensus mark for earnings is pegged at $13.36 per share, indicating a 13.22% year-over-year increase. Microsoft Corporation price-consensus-chart | Microsoft Corporation Quote Find the latest EPS estimates and surprises on Zacks Earnings Calendar. Microsoft's premium 11.76x P/S valuation reflects exceptional execution in AI monetization, cloud market leadership, and enterprise ecosystem integration. With $13 billion in AI revenues growing 175% year over year, Azure's growing market leadership and $80 billion in strategic infrastructure investment, Microsoft has positioned itself to capture the massive AI and cloud transformation opportunity. Image Source: Zacks Investment Research The combination of strong financial fundamentals, dominant market positions, and accelerating AI adoption creates a compelling investment case that justifies premium valuations and supports continued outperformance through 2025. Microsoft currently carries a Zacks Rank #2 (Buy). You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Inc. (AMZN) : Free Stock Analysis Report Microsoft Corporation (MSFT) : Free Stock Analysis Report NVIDIA Corporation (NVDA) : Free Stock Analysis Report Alphabet Inc. (GOOGL) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research
Yahoo
an hour ago
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Solid Biosciences Announces FDA IND and Health Canada CTA Approval for First-in-Class Cardiac Gene Therapy to Treat Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- SGT-501 is a novel gene therapy for rare, life-threatening, genetic arrhythmogenic disease with no approved therapies - - SGT-501 has received Orphan Drug Designation and Rare Pediatric Disease Designation from the FDA - - Solid expects to initiate Phase 1b clinical trial of SGT-501 in the fourth quarter of 2025 - - Expands Solid's clinical pipeline to include first cardiac indication with urgent unmet medical need - CHARLESTOWN, Mass., July 08, 2025 (GLOBE NEWSWIRE) -- Solid Biosciences Inc. (Nasdaq: SLDB) (the 'Company' or 'Solid'), a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases, today announced approval of its Investigational New Drug (IND) application by the U.S. Food and Drug Administration (FDA) and clinical trial application (CTA) by Health Canada for SGT-501, a novel gene therapy approach for the treatment of catecholaminergic polymorphic ventricular tachycardia (CPVT), a highly malignant, arrhythmogenic channelopathy caused by genetic mutations that impact the ryanodine receptor (RYR2) in cardiac muscle. The Company expects to initiate a Phase 1b clinical trial to evaluate the safety, tolerability and efficacy of SGT-501 in the fourth quarter of 2025. Gabriel Brooks, M.D., Chief Medical Officer of Solid, said: 'Despite being identified nearly 50 years ago, CPVT still lacks FDA-approved therapies – this announcement reflects a critical development in the treatment of this underserved, often fatal, cardiac disease. SGT-501 offers a precision genetic approach targeting the underlying pathophysiology of the disease: abnormal calcium releases from the sarcoplasmic reticulum in an otherwise structurally sound heart. We believe SGT-501 has the unique potential to provide durable protection and may be capable of liberating patients from the ever-present threat of lethal arrhythmias and life-limiting prohibitions on exercise. Solid is proud to launch this program to help address this clear unmet need, further expanding our pipeline of differentiated and thoughtfully designed genetic medicines.' Silvia Priori, M.D., Ph.D., Professor of Cardiology at the University of Pavia and Director of the Molecular Cardiology Unit at the IRCCS Maugeri in Pavia, Italy, said: 'After decades during which we, the clinical community, have been limited in our ability to treat people living with CPVT, I have long hoped for the day when a genetic-modifying therapy becomes available. We are proud to partner with Solid who advanced fundamental work from our labs at Maugeri, which demonstrated the principle that calsequestrin overexpression can have a therapeutic impact on multiple forms of CPVT in both cellular and mouse models of disease. This work was further developed into a compelling IND safety and efficacy package through close collaboration with, and studies conducted by, the Solid team. I look forward to clinical updates for SGT-501 and seeing how this potential medicine may benefit people living with CPVT who are in critical need of disease-specific medicines.' About SGT-501SGT-501 is an AAV-based gene therapy candidate designed to deliver a functional, full length, codon-optimized copy of the human cardiac calsequestrin (CASQ2) gene to heart muscle cells. In the context of RYR2 variants, increasing CASQ2 protein levels enhances buffering of free calcium in the sarcoplasmic reticulum, stabilizing the RYR2, which results in reduced diastolic calcium leak into the cytosol. Stabilization of the RYR2 in its closed conformation supports the maintenance of normal cardiac rhythm with the potential to protect against ventricular tachycardia. SGT-501 received Orphan Drug Designation and Rare Pediatric Disease Designation from the U.S. FDA and has potential as a first-in-class therapy to correct the underlying RYR2 instability and calcium dysregulation causes of CPVT. The AAV-CASQ2 gene therapy approach utilized by SGT-501 was pioneered by Dr. Silvia Priori and the IRCCS ICS Maugeri lab in Pavia, Italy. As a globally recognized leader in inherited arrhythmias, Dr. Priori has long been at the forefront of translational cardiac research. Solid Biosciences in-licensed this innovative therapeutic in 2023 and subsequently advanced it into IND-enabling preclinical development, marking an important step toward bringing this potential treatment to individuals living with CPVT. About Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a heart condition marked by abnormal rhythms; specifically, an abnormally fast heartbeat (ventricular tachycardia), which can be triggered by adrenergic stimulation such as physical activity or emotional stress. These arrhythmias can cause unexplained fainting, seizures, cardiac arrest and sudden death. CPVT is estimated to affect roughly 1 in 10,000 individuals globally, although it is often misdiagnosed, and is typically identified in children and young adults. It is mainly caused by mutations in the RYR2 and CASQ2 genes, which disrupt calcium regulation in heart muscle cells, impairing proper heart contraction and relaxation. There are currently no treatments that address the underlying mechanisms of CPVT. To learn more about CPVT and SGT-501, watch a brief CPVT expert and patient video by clicking here. About Istituti Clinici Scientifici Maugeri Spa SB (ICS Maugeri)ICS Maugeri S.p.A. Società Benefit is Italy's leading healthcare provider specializing in rehabilitation and comprehensive care for vulnerable patients. It stands out for its strong focus on scientific research, operating 18 Clinical Institutes - including 9 recognized as IRCCS (Scientific Institutes for Research, Hospitalization and Healthcare) and 9 as Scientific Clinical Institutes -along with 6 outpatient centers, 1 Environmental Research Center, and a Poison Control Center and National Toxicology Information Center. ICS Maugeri is involved not only in scientific research but also in the application of advanced technologies across medical disciplines, offering personalized care pathways and centers of excellence for specific conditions and clinical specialties. The Group employs more than 4,000 professionals, where medical and professional excellence is intrinsically linked to core values of equity, inclusivity, equality, and transparency - principles that have always guided Maugeri's mission. Headquartered in Pavia, ICS Maugeri operates 23 healthcare facilities across 7 Italian regions, including 9 IRCCS, 10 Scientific Clinical Institutes, 5 outpatient clinics, a Poison Control Center –Toxicology Center, and an Environmental Research Center. About Solid BiosciencesSolid Biosciences is a precision genetic medicine company focused on advancing a portfolio of gene therapy candidates targeting rare neuromuscular and cardiac diseases, including Duchenne muscular dystrophy (Duchenne), Friedreich's ataxia (FA), catecholaminergic polymorphic ventricular tachycardia (CPVT), TNNT2-mediated dilated cardiomyopathy, BAG3-mediated dilated cardiomyopathy, and additional fatal, genetic cardiac diseases. The Company is also focused on developing innovative libraries of genetic regulators and other enabling technologies with promising potential to significantly impact gene therapy delivery cross-industry. Solid is advancing its diverse pipeline and delivery platform in the pursuit of uniting experts in science, technology, disease management, and care. Patient-focused and founded by those directly impacted by Duchenne, Solid's mission is to improve the daily lives of patients living with devastating rare diseases. For more information, please visit Forward-Looking StatementsThis press release contains 'forward-looking statements' within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding future expectations, plans and prospects for the Company; the ability to successfully achieve and execute on the company's goals, priorities and achieve key clinical milestones; the Company's pipeline of programs for neuromuscular and cardiac diseases, including its SGT-501, SGT-212 and SGT-003 programs and expectations for CTA filings, site activations, clinical development, initiation and enrollment in clinical trials, dosing, availability of clinical trial data and potential accelerated approval; the sufficiency of the Company's cash, cash equivalents, and available-for-sale securities to fund its operations; and other statements containing the words 'anticipate,' 'believe,' 'continue,' 'could,' 'estimate,' 'expect,' 'intend,' 'may,' 'plan,' 'potential,' 'predict,' 'project,' 'should,' 'target,' 'would,' 'working' and similar expressions. Any forward-looking statements are based on management's current expectations of future events and are subject to a number of risks and uncertainties that could cause actual results to differ materially and adversely from those set forth in, or implied by, such forward-looking statements. These risks and uncertainties include, but are not limited to, risks associated with the company's ability to advance SGT-501, SGT-212, SGT-003, SGT-601, SGT-401 and other preclinical programs and capsid libraries on the timelines expected or at all; obtain and maintain necessary approvals from the FDA and other regulatory authorities; replicate in clinical trials positive results found in preclinical studies and early-stage clinical trials of the company's product candidates; obtain, maintain or protect intellectual property rights related to its product candidates; compete successfully with other companies that are seeking to develop Duchenne, Friedreich's ataxia and other neuromuscular and cardiac treatments and gene therapies; manage expenses; and raise the substantial additional capital needed, on the timeline necessary, to continue development of SGT-501, SGT-212, SGT-003, SGT-601, SGT-401 and other candidates, achieve its other business objectives and continue as a going concern. For a discussion of other risks and uncertainties, and other important factors, any of which could cause the company's actual results to differ from those contained in the forward-looking statements, see the 'Risk Factors' section, as well as discussions of potential risks, uncertainties and other important factors, in the company's most recent filings with the Securities and Exchange Commission. In addition, the forward-looking statements included in this press release represent the company's views as of the date hereof and should not be relied upon as representing the company's views as of any date subsequent to the date hereof. The company anticipates that subsequent events and developments will cause the company's views to change. However, while the company may elect to update these forward-looking statements at some point in the future, the company specifically disclaims any obligation to do so. Solid Biosciences Investor Contact:Nicole AndersonDirector, Investor Relations and Corporate CommunicationsSolid Biosciences Media Contact:Yuliya Kutuzava FINN in retrieving data Sign in to access your portfolio Error in retrieving data Error in retrieving data Error in retrieving data Error in retrieving data
