The shocking speed at which cold sore virus hijacks human DNA
A new study is the first to prove that the Herpes Simplex Virus (HSV-1) deliberately reshapes the human genome and reorganises infected cells within an hour of infection.
The virus compacts and densifies human DNA to access host genes essential for its reproduction, a previously unknown mechanism of manipulation.
Researchers discovered that blocking a single host cell enzyme, topoisomerase I, completely prevented the virus from rearranging the human genome and stopped infection in cell culture.
This finding offers a potential new therapeutic target to control HSV-1, which affects nearly four billion people worldwide.
HSV-1, while often causing benign cold sores, can lead to severe complications in rare cases and has been linked to dementia in older adults.
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The Sun
33 minutes ago
- The Sun
From a cat losing its meow to a dog with hayfever – your pet queries answered
HE is on a mission to help our pets . . . and is here to answer YOUR questions. Sean, who is the head vet at tailored pet food firm has helped with owners' queries for ten years. 4 4 Q) MY cat Pickles has lost her meow. She is happy and eating, but she has gone hoarse. She's 16 years old and otherwise seems fit. Does she need a check-up? BOB CASTLE, Doncaster A) This isn't necessarily cause for alarm as it can happen for no obvious reason in many older cats. However, there are a few health issues that need to be ruled out. I wonder if Pickles has any other symptoms such as increased hunger or thirst, or any sudden or severe weight loss? Some hormonal disorders can lead to these symptoms, as well as affecting a cat's voice. Is she still eating well, or perhaps eating from one side of her mouth, avoiding hard foods in favour of wet food, gravies or jellies? You may guess I'm looking at dental disease or pain as potential causes, which would not surprise me at her age. In any case, I think the best course of action is to get her a vet check. If they find nothing wrong, great news. If they find something, you can discuss if it's best treated now, managed lightly or just monitored. Q) CAN dogs get hayfever? And if so, what might ease it? F1 stars' pets including driver with thirteen cats, Leclerc's yacht-loving pooch and Hamilton's dog Roscoe with own car Luna, our labrador, gets a runny nose and sneezes. She's three and otherwise in good health. She also gets hotspots on her coat in summer. Please advise. EM BLAKELY, Barnstaple, Devon A) They do get hayfever, but usually not with the same symptoms as us humans. In dogs, we use the term atopy or atopic dermatitis to describe 'hayfever', or allergies to pollen, as well as many other environmental allergens. This is because it usually manifests with itchy skin, leading to scratching, inflammation, hotspots, skin and ear infections. A small number of dogs will also get a runny nose or eye irritation and discharge but not many. So Luna is either quite unusual or it could be a coincidence. It's worth a vet visit to find out and to keep her more comfortable. Q) OUR rabbit Lopsy is all alone now his brother Teddy has died. I'm planning to get a companion, but how should they be introduced? JULIE COLEMAN, Brighton A) There's definitely some science to it but often it's more of a dark art. A good rescue charity or organisation will usually help you find a new bunny pal, giving great advice on the bonding process. It takes time and gradual introductions. But, generally, there is always a match out there for every bun. I'm sure Lopsy would love a girlfriend, which might be easier than trying to introduce him to a boy he has not grown up with. I definitely encourage you to explore these options as rabbits really do need the company of their own kind. But also make sure both are spayed/neutered, or you may end up with more rabbits than you expected. Q) I AM thinking of fostering an elderly dog to get me out walking more now I'm retired. I'd like it to be an older pet. Do I need to make considerations like raised food bowls and rugs for an OAP pooch as I have wood floors? KELLY BLACK, Orpington, Kent A) Yes Kelly, those are certainly things to consider for older dogs with reduced mobility, perhaps. Slippery floors can be very difficult to navigate and can exacerbate pain and discomfort. If the dog has neck issues, raised bowls can be of benefit. The rescue you foster from should be able to advise on good adjustments to help your companion settle and live out their days with you. Well done for considering an older dog, as many struggle to find homes. Star of the week 4 THE HUNGARIAN Mudi dog will become an official breed in the UK next week. The breed, which has existed for 300 years, will be the 225th to be recognised by The Kennel Club. Janos, a nine-year-old Mudi, came to the UK from Hungary in 2016 and takes part in obedience competitions. Owner Dorit Powell, 54, from Ipswich, said: 'He has been our loyal companion on many adventures since he joined us as a puppy. 'Janos is always happy and puts a smile on our faces.' Kennel Club spokesperson Charlotte McNamara said: 'We're pleased to officially recognise this versatile Hungarian herding dog as a pedigree breed in the UK.' WIN: Chew Mees toys worth £39.96 DO you want a chance to try the brand new Chew Mees toys by Original Squishmallows? The four loveable character duo sets crinkle and squeak. We have six bundles to give away, each worth £39.96. For a chance to win, send an email headed Squishmallows to sundaypets@ by July 13. T&Cs apply. Search Squishmallows Pets on Amazon UK. TOP TEN POOCH-FRIENDLY STAYCATIONS 4 NEARLY a third of stay- cationers want to bring a dog, reports a holiday rentals firm. 'Pet-friendly' is the most frequently searched term on It also named the Cornish village of Crantock as the UK's No1 pet-friendly destination. A spokesman for Sykes Cottages said: 'Known for its dog-friendly beach and eateries that welcome four-legged friends, Crantock had the highest proportion of bookings with dogs. 'The village also boasts several pubs and cafes which welcomes dogs and offer them free treats.' Wales scored highly, too. New Quay in Ceredigion, with its coastal paths and dog-friendly pubs and cafes, placed second. Next was Rhosneigr in Anglesey where treats include beaches, the Oyster Catcher restaurant and Beaumaris Castle. The study's Top 10 staycations for dogs: Crantock, Cornwall; New Quay, Ceredigion; Rhosneigr, Isle of Anglesey; Carnforth, Lancs; Newborough, Isle of Anglesey; Beadnell, Northumberland; Filey, North Yorks; Cardigan, Ceredigion; Nefyn, Gwynedd; Amble, Northumberland.
BBC News
36 minutes ago
- BBC News
Lung cancer screening for smokers and former smokers in Wales
Smokers and former smokers aged 55 to 74 in Wales will be offered lung cancer screening, the Welsh government has announced. The phased rollout will begin in 2027, with the oldest eligible people expected to be sent the first cases of lung cancer are caused by smoking and the symptoms of the disease often do not appear until it has spread to other parts of the Health Wales (PHW) said the screening programme had the potential to save lives, particularly in more deprived areas where lung cancer mortality rates are significantly higher. The announcement follows a successful pilot in the Cwm Taf Morgannwg health board area, during which 600 people were screened and 12 cases of lung cancer were diagnosed - two-thirds at an early stage. Heather Lewis from PHW said lung cancer was often diagnosed too late, but that screening could detect lung cancer earlier when it is "easier to treat". "Lung cancer is the leading cause of cancer death in Wales," she said, adding that finding it earlier meant treatment could start sooner and more people could "live longer, healthier lives". Wales' Health Secretary Jeremy Miles said the lung cancer screening programme would use mobile CT scanners and include support to help people quit of 2022, around 340,000 people in Wales - 14.1% of the overall population - smoked cigarettes, according to the ONS. Miles said the screening programme's implementation would take place in three stages to help the NHS scale up its said it would also include protocols for detecting conditions such as COPD, adding that the full screening programme would cost around £13m a year.A similar lung cancer screening programme, targeting former and current smokers aged 55-74, is expected to be fully rolled out in England by 2029. What is lung cancer? According to the NHS, lung cancer is a common and serious disease which is often diagnosed late because symptoms do not usually become apparent until a later than 43,000 people are diagnosed with the condition every year in the mainly affects older people, with smoking being the leading cause. Treatment options and outcomes vary depending on the cancer type and stage, but early diagnosis significantly improves survival chances. What are the symptoms of lung cancer? A persistent coughCoughing up bloodPersistent breathlessnessUnexplained tiredness and weight lossAn ache or pain when breathing or coughing
BBC News
2 hours ago
- BBC News
Nutrition: Apple really dey good for your health?
Dem dey tell us say one apple a day dey keep di doctor away, but dis fruit really get dat kain positive effect on our health? Di world love apple. Every year, na almost 100 million tonnes of apples dem dey produce globally. Dis fruits dey come in different colours and for long, don get reputation say e dey help us stay healthy. Di popular saying "an apple a day dey keep di doctor away" originate from one Welsh proverb wey dem write for 1866: "Eat an apple wen you dey go to bed and you go keep di doctor from earning im bread." But any truth dey dis longstanding saying? And shey apples dey especially healthy compared with oda fruits? First, make we tink about di nutrients wey apples contain. For one tin, dem be rich source of phytochemicals, including flavanols. Dis compounds don dey linked to plenti health benefits, like maintaining healthy weight and to lower your heart disease risk. Why apples dey so healthy Apples also contain various polyphenols, including anthocyanins, wey dey help give some apple peel im red colour and dey associated wit improved heart health. Anoda polyphenol wey you go find in apples na phloridzin. Dem find say e dey help control blood glucose. Lots of fibres also dey inside apples, mostly pectin, wey dey reduce di amount of low-density lipoproteins (LDLs) – di unhealthy form of cholesterol – in our blood. Pectin also dey lower di amount of sugar and fat wey dey absorb from food, help to stabilise our blood sugar levels. Dis nutrients wey dey inside apples be like dem dey offer health benefits. One 2017 review of five studies bin report say to dey eat apples dey associated wit 18% reduction in di risk of developing type 2 diabetes. Anoda review from 2022, wey analyse 18 studies, find say to dey eat more apples, or apple-derived foods like apple juice, fit reduce cholesterol, if you sustain di habit for more dan one week. To get healthy diet in general fit lower your risk of cancer by up to 40%, mostly thanks to bioactive compounds, phytochemicals, wey dey common in apples. Some studies don even link apple consumption to get lower risk of developing some certain cancers. To dey eat apples regularly dey associated wit plenti health benefits – and we know say dem dey full wit healthy compounds. But apples, dey specifically, any more effective dan oda plant-based foods for keeping di doctor away? "Apples no get much vitamin C, and dem no get no iron or calcium, but dem get so many oda ingredients wey dey promote health and do wonderful tins for di body," Janet Colson, professor of nutrition and food science for Middle Tennessee State University in di US tok. "Some researchers say apples get di 'second highest level of antioxidant power among all fruits" Apples contain compounds wey dey common to many fruits and vegetables, including those helpful polyphenols, Flavia Guzzo, associate professor of plant biology for University of Verona in Italy tok. Polyphenols be strong antioxidant molecules. Dem dey help to balance di ratio of antioxidants to free radicals in our bodies – free radicals dey highly reactive, potentially cell-damaging oxygen molecules. By keeping free radicals in check, we dey reduce our risk of developing diseases including cancer and heart disease through long-term inflammation. "Some researchers say apples get di 'second highest level of antioxidant power among all fruits" Apples contain compounds wey dey common to many fruits and vegetables, including those helpful polyphenols, Flavia Guzzo, associate professor of plant biology for di University of Verona in Italy tok. Some researchers say apples get di "second highest level of antioxidant power among all fruits". Apples also contain di polyphenol phloridzin, wey dey much less common within di oda fruits in your fruit bowl. Like pectin, phloridzin appears to lessen di amount of sugar wey dey absorb into our blood from food. Apples also be good source of phenolic compounds, wey be anoda form of phytochemical. E get one study wey find say pipo wey dey live in di US get around one fifth of dia total phenolic intake from apples. Research suggests say apple phenolic compounds dey associated wit lower risk of heart attack, cancer, asthma, diabetes and obesity. But no be just di powerful polyphenols and antioxidant punch wey dey make some scientists to recommend apples over oda fruit. In some papers, scientists dey recommend regular apple-eating sake of say di fruits dey simply so widely available. Wey mean say, to dey eat dem regularly na sometin wey dey relatively achievable for many pipo. E dey clear say apples get di potential to improve our health. But na quite a big claim to say to dey eat one every day go make us no go to see doctor. One 2015 study bin chook eye for dis exact question. Researchers bin analyse one survey of nearly 9,000 pipo, wey di participants tok wetin dem eat during one 24-hour period, wey dem tok say dey indicative of dia typical daily diet. Dey find say apple-eaters dey more likely dan apple-avoiders to keep di doctor away, however, dis result no dey statistically significant wen we wan take into account say apple-eaters dey more likely to be more educated and dey less likely to smoke. "Di main finding, no say much of di association between pipo wey dey regularly consume one apple a day and di likelihood to visit physician, na sake of say e dey complex," lead researcher Matthew Davis, adjunct associate professor of epidemiology for Dartmouth Geisel School of Medicine in New Hampshire, US tok. "Pipo wey dey consume apples, based on our analyses, dey healthier in general." But dem also find say daily apple-eaters dey less likely to dey reliant on prescription medication – and dis na still one significant finding wen pesin adjust di socioeconomic differences between participants wey dey eat one apple per day and those wey no dey eat am. Therefore, di paper conclude say, one more key saying fit be say: "One apple a day go keep di pharmacist away." But Davis get issues wit di apple-a-day tok, and say anoda reason fit dey why im and im colleagues no find connection between daily apple consumption and to dey go see doctor. "Di underlying assumption na say you dey only visit di doctor wen you dey sick, but pipo dey visit di doctor for annual check-ups and oda prevention-type tins," e tok. Dis na why Davis also analyse di data around di likelihood of using prescription medication, too. "E mean say apples dey reduce di likelihood to get chronic illness," e tok. But ultimately, e say, apples alone no dey enough to stop your visit di GP, and say di most impactful tin na to get healthy diet overall. "Wey, really, be wetin di saying dey reason," e tok. Colson agree say di apple-a-day agree to regularly eating plant-based foods. Apples na good example sake of say dem dey so readily available, affordable and get long shelf-life. "Before fridges, you fit put apples for cellar and dem go last long time, and dem no dey attract mould," she tok. Oda studies don find health benefits wey relate to daily apple-eating – but only wen pipo dey consume more dan one per day. "Anoda study find say to dey eat three apples daily dey stimulate statistically significant weight loss" Inside one study wey dey publish for 2020, researchers bin split 40 participants (wey all get small elevated cholesterol levels) into two groups. One of those groups bin eat two apples per day while di oda get one apple drink wit similar calories. Di experiment bin last eight weeks and, apart from di apple products, di participants no make any oda changes to dia diets. Di researchers bin find say di apple-eaters get clinically significant lower level of cholesterol, at di end of di study. However, one weakness of dis study na im small size; 40 participants na relatively low sample size from which to draw any big conclusions. Anoda study bin find say to dey eat three apples daily dey stimulate statistically significant weight loss and improved blood glucose levels (wey bin no dey statistically significant wen e dey followed up) in 40 overweight women. As for how best to eat apples to get di greatest benefit from dem, Guzzo advise against removing di skin first. "We suppose dey eat di peel of apples, as dis na wia you go find most of di apple polyphenols," she tok. And ancient varieties dey preferable to new varieties of apple, Guzzo tok. For 2021, she and colleagues bin publish one paper wey dey look at di nutritional value of di Pom Prussian apple, one ancient apple from northern Italy, wey she find say dey richer in polyphenols dan more modern apple varieties. "Wen breeders select new varieties, dem dey look oda traits, including size and taste and robustness of di trees," she tok. "And wen dem select dis traits, rather dan polyphenol content, di variety become poorer [from a health point of view]." She tok say some polyphenols fit produce a bitter taste, and say sweeter varieties probably contain a lower proportion of dis compounds. As for colour, Guzzo tok say e no matter so much. Both di polyphenols wey dey cause apple skin to dey red or green dey both good for us. Ultimately, while to dey eat one apple a day fit no mean say you go visit di doctor less often, e fit impact your overall health or your reliance on long-term medication. But, as e always be di case, di bigger picture dey complicated. To dey eat one apple a day dey great, Guzzo tok – but only if dat na part of a diet wey dey rich in various oda plant-based foods, since dat na di key driver of good health.
