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Pronto Acquires SafeAI, Expanding Leadership in Off-Road Autonomy

Pronto Acquires SafeAI, Expanding Leadership in Off-Road Autonomy

National Post7 hours ago
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Strategic transaction extends Pronto's leadership in providing autonomous technologies to off-road industries with an initial focus on the mining, quarrying, and construction markets
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SAN FRANCISCO — Pronto.ai, Inc. (Pronto), the industry leader in scalable, affordable, OEM-agnostic Autonomous Haulage Systems (AHS), today announced it has completed its acquisition of SafeAI Inc., another pioneer in safety-focused, multi-sensor autonomous solutions for heavy industry. The transaction further establishes Pronto as the world's most capable and technologically advanced autonomy provider for the off-road sector.
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'Pronto is automating everything with wheels, starting with mining trucks, focused on becoming the first profitable autonomous vehicle company,' said Anthony Levandowski, CEO of Pronto.
The combined entity will offer the industry's first and only tiered technology portfolio, capable of serving the full spectrum of customer needs, from small quarries to large mines. This includes Pronto's commercially proven, camera-only AHS for customers prioritizing affordability and rapid deployment, as well as a multi-sensor premium offering, both of which will benefit from SafeAI's safety framework that has been ASIL D-certified, the highest safety integrity level in the industry.
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'Pronto is automating everything with wheels, starting with mining trucks, focused on becoming the first profitable autonomous vehicle company,' said Anthony Levandowski, CEO of Pronto. 'This acquisition solidifies our leadership in the automation of the mining, quarrying, and construction industries, and will help us further accelerate the commercial deployment of our technologies to sites around the world.'
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This strategic transaction comes as Pronto is experiencing rapid growth and gearing up for its next phase of expansion, after recently announcing a global agreement to deploy more than 100 autonomous trucks with Heidelberg Materials and expanding its team in Brazil.
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The acquisition brings together two of the most experienced teams in autonomy, with decades of experience spanning the DARPA Grand Challenges, Google, Waymo, Uber, Apple, Caterpillar, Lucid, Ford, General Motors, Tesla, and Topcon.
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About Pronto
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Pronto is Autonomy Simplified. Founded by the Silicon Valley pioneers who have been at the forefront of the most important advances in autonomous vehicles and robotics for the last two decades, Pronto provides the world's leading Autonomous Haulage System (AHS). Pronto AHS is designed to be the simplest, fastest to deploy, easiest to use, and most cost-effective solution in the mining and quarrying markets, increasing productivity, enhancing safety, and solving labor challenges for its customers. Learn more at www.pronto.ai.
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AECOM announces cash tender offer for any and all 5.125% Senior Notes due 2027
AECOM announces cash tender offer for any and all 5.125% Senior Notes due 2027

Globe and Mail

time5 minutes ago

  • Globe and Mail

AECOM announces cash tender offer for any and all 5.125% Senior Notes due 2027

AECOM (NYSE: ACM) today announced that it has commenced a cash tender offer (the 'Tender Offer') for any and all of its $997,293,000 principal amount outstanding 5.125% Senior Notes due 2027 (the 'Notes'). A comprehensive description of the terms of the Tender Offer is included in AECOM's Offer to Purchase, dated July 15, 2025 (the 'Offer to Purchase'), and the related Notice of Guaranteed Delivery (the 'Notice of Guaranteed Delivery' and, together with the Offer to Purchase, the 'Offer Documents'). The following table summarizes the material pricing terms of the Tender Offer, which is being made upon, and is subject to, the terms and conditions set forth in the Offer Documents. CUSIP Nos Outstanding Principal Amount Title of Notes U.S. Treasury Reference Security Bloomberg Reference Page Fixed Spread 00774CAB3 00774CAA5 U0081CAA0 $997,293,000 5.125% Senior Notes due 2027 4.375% due December 15, 2026 PX4 50 bps The Tender Offer will expire at 5:00 p.m., New York City time, on July 21, 2025, unless extended or earlier terminated by AECOM (the 'Expiration Date'). No tenders submitted after the Expiration Date will be valid unless delivered pursuant to the guaranteed delivery procedures described in the Offer to Purchase at or prior to 5:00 p.m., New York City time, on July 23, 2025 (the 'Guaranteed Delivery Date'). Tenders of Notes may be withdrawn any time at or prior to 5:00 p.m., New York City time, on July 21, 2025, by following the procedures described in the Offer to Purchase. The consideration (the 'Total Consideration') offered for each $1,000 principal amount of the Notes validly tendered and not validly withdrawn and accepted for purchase pursuant to the Tender Offer will be determined in the manner described in the Offer to Purchase by reference to the fixed spread for the Notes specified in the table above plus the yield to December 15, 2026, based on the bid-side price of the Reference Security specified in the table above, as quoted on the Bloomberg Bond Trader PX4 page as of 11:00 a.m., New York City time, on July 21, 2025, unless extended or earlier terminated by AECOM. In addition to the Total Consideration, AECOM will also pay accrued and unpaid interest up to, but not including, the Initial Settlement Date (as defined below). The settlement date for Notes validly tendered and not validly withdrawn and accepted for purchase and delivered at or prior to the Expiration Date is expected to be July 22, 2025, the next business day after the Expiration Date (the 'Initial Settlement Date'). The settlement date for Notes delivered pursuant to the guaranteed delivery procedures described in the Offer to Purchase is expected to be July 24, 2025, the next business day after the Guaranteed Delivery Date (the 'Guaranteed Delivery Settlement Date'). For the avoidance of doubt, accrued interest will cease to accrue on the Initial Settlement Date for all Notes accepted in the Tender Offer, whether such Notes are purchased on the Initial Settlement Date or the Guaranteed Delivery Settlement Date. Holders must validly tender (and not validly withdraw) their Notes at or prior to the Expiration Date, or deliver a properly completed and duly executed Notice of Guaranteed Delivery for their Notes at or prior to the Expiration Date, and tender their Notes at or prior to the Guaranteed Delivery Date (as defined in the Offer to Purchase), in accordance with the instructions set forth in the Offer to Purchase, in order to be eligible to receive the Total Consideration. AECOM's obligation to accept for purchase and to pay for the Notes validly tendered and not validly withdrawn pursuant to the Tender Offer is subject to the satisfaction or waiver of certain conditions, which are more fully described in the Offer to Purchase, including, among others, AECOM having raised net proceeds from its concurrently commenced offering of $1,000,000,000 in aggregate principal amount of its senior unsecured notes due 2033 (the 'New Notes Offering'), which, together with cash on hand or other immediately available funds, are sufficient to fund the purchase of all Notes validly tendered and accepted for purchase in the Tender Offer (such condition, the 'Financing Condition'). In addition, concurrently with the pricing of the New Notes Offering, the Company intends to issue a conditional notice of redemption to the holders of the Notes to redeem any and all Notes that remain outstanding after completion of the Tender Offer at a make-whole redemption price based on a make-whole spread of 50 basis points over the yield of the Reference Security specified above, calculated pursuant to the applicable provisions of the indenture governing the Notes, plus accrued and unpaid interest to, but not including, the date of redemption. The date of redemption is expected to be August 14, 2025 (the 'Redemption Date'). The redemption of any and all Notes that remain outstanding after completion of the Tender Offer will be made in accordance with the provisions of the Indenture, and will be conditioned upon the satisfaction of the Financing Condition. The Tender Offer does not constitute an offer to sell or a solicitation of an offer to buy any securities or other financial instruments that may be issued or otherwise incurred in connection with the New Notes Offering. AECOM reserves the right, subject to applicable law, in its sole discretion, to: (i) waive any and all conditions to the Tender Offer at any time and from time to time; (ii) extend or terminate the Tender Offer; or (iii) otherwise amend the Tender Offer in any respect. AECOM is not soliciting consents from holders of securities in connection with the Tender Offer. AECOM has retained BofA Securities to act as exclusive Dealer Manager for the Tender Offer. D.F. King and Co., Inc. has been retained to serve as both the tender and information agent (the 'Tender and Information Agent') for the Tender Offer. For additional information regarding the terms of the Tender Offer, please contact: BofA Securities at debt_advisory@ (email), (888) 292-0070 (toll free) or (646) 743-2120 (collect). Requests for copies of the Offer to Purchase and other related materials should be directed to D.F. King and Co., Inc. at aecom@ (email), (888) 887-0082 (U.S. Toll Free), (212) 365-6884 (Banks and Brokers). Copies of the Offer to Purchase and Notice of Guaranteed Delivery are available at the following web address: This press release is for informational purposes only and is not an offer to purchase or a solicitation of an offer to sell with respect to any Notes nor is this announcement an offer to sell or a solicitation of an offer to purchase new debt securities, or a notice of redemption of the Notes. The Tender Offer is being made solely pursuant to the Offer Documents, which set forth the complete terms and conditions of the Tender Offer. The Tender Offer is not being made to, nor will AECOM accept tenders of Notes from, holders in any jurisdiction in which the making or acceptance thereof would not be in compliance with the securities, blue sky or other laws of such jurisdiction. None of AECOM, its affiliates, their respective board of directors, the Dealer Manager, the trustee of the Notes or the Tender and Information Agent makes any recommendation to any holder of Notes in connection with the Tender Offer. Holders must make their own decisions as to whether to tender their Notes and, if so, the principal amount of Notes to tender. About AECOM AECOM (NYSE: ACM) is the global infrastructure leader, committed to delivering a better world. As a trusted professional services firm powered by deep technical abilities, we solve our clients' complex challenges in water, environment, energy, transportation and buildings. Our teams partner with public- and private-sector clients to create innovative, sustainable and resilient solutions throughout the project lifecycle – from advisory, planning, design and engineering to program and construction management. AECOM is a Fortune 500 firm that had revenue of $16.1 billion in fiscal year 2024. Cautionary Note Regarding Forward-Looking Statements All statements in this press release other than statements of historical fact are 'forward-looking statements' for purposes of federal and state securities laws, including any statements of the plans, strategies and objectives for future operations, profitability, strategic value creation, capital allocation strategy including stock repurchases, risk profile and investment strategies, and any statements regarding future economic conditions or performance, and the expected financial and operational results of AECOM. Although AECOM believes that the expectations reflected in these forward-looking statements are reasonable, actual results could differ materially from those projected or assumed in any of these forward-looking statements. Important factors that could cause AECOM's actual results, performance and achievements, or industry results to differ materially from estimates or projections contained in these forward-looking statements include, but are not limited to, the following: AECOM's business is cyclical and vulnerable to economic downturns and client spending reductions; potential government shutdowns, changes in administration or other funding directives and circumstances that may cause governmental agencies to modify, curtail or terminate AECOM's contracts; government contracts are subject to audits and adjustments of contractual terms; long-term government contracts and subject to uncertainties related to government contract appropriations; losses under fixed-price contracts; limited control over operations that run through AECOM's joint venture entities; liability for misconduct by AECOM's employees or consultants; changes in government laws, regulations and policies, including failure to comply with laws or regulations applicable to AECOM's business; maintaining adequate surety and financial capacity; potential high leverage and inability to service AECOM's debt and guarantees; ability to continue payment of dividends; exposure to political and economic risks in different countries, including tariffs and trade policies, geopolitical events, and conflicts; inflation, currency exchange rates and interest rate fluctuations; changes in capital markets and stock market volatility; retaining and recruiting key technical and management personnel; legal claims and litigation; inadequate insurance coverage; environmental law compliance and inadequate nuclear indemnification; unexpected adjustments and cancellations related to AECOM's backlog; partners and third parties who may fail to satisfy their legal obligations; managing pension costs; AECOM Capital real estate development; cybersecurity issues, IT outages and data privacy; risks associated with the benefits and costs of the sale of AECOM's Management Services and self-perform at-risk civil infrastructure, power construction and oil and gas construction businesses, including the risk that any purchase adjustments from those transactions could be unfavorable and any future proceeds owed to us as part of the transactions could be lower than we expect; as well as other additional risks and factors that could cause actual results to differ materially from these forward-looking statements set forth in AECOM's reports filed with the Securities and Exchange Commission. Any forward-looking statements are made as of the date hereof. AECOM does not intend, and undertakes no obligation, to update any forward-looking statement.

UAE Construction Equipment Market Sale to Reach 30.19K Units by 2030, Backed by Green Tech, Mega Projects & 5.78% CAGR Growth from 2024
UAE Construction Equipment Market Sale to Reach 30.19K Units by 2030, Backed by Green Tech, Mega Projects & 5.78% CAGR Growth from 2024

Globe and Mail

time10 minutes ago

  • Globe and Mail

UAE Construction Equipment Market Sale to Reach 30.19K Units by 2030, Backed by Green Tech, Mega Projects & 5.78% CAGR Growth from 2024

"UAE Construction Equipment Market Research Report by Arizton" The Industry Analysis Report Provides Market Trends, Drivers, Opportunities, Competitive Outlook, Market Size, Sales, and Growth Forecast for 2025-2030 According to Arizton's latest research, the UAE construction equipment market is projected to grow at a CAGR of 5.78% from 2024 to 2030, reaching 30.19 thousand units by 2030. This growth is fueled by massive government-led infrastructure investments, a booming real estate sector, and a sharp pivot toward electrification and sustainable construction technologies. In Q1 2025 alone, Dubai's residential real estate market recorded over 42,000 transactions, a 23.1% YoY rise, highlighting continued demand for residential, transport, and utility infrastructure, all of which rely heavily on construction equipment. Report Scope: MARKET SIZE- VOLUME (2030): 30.19 Thousand Units MARKET SIZE- VOLUME (2024): 21.55 Thousand Units CAGR- VOLUME (2024-2030): 5.78% MARKET SIZE- REVENUE (2030): USD 2.13 Billion HISTORIC YEAR: 2021-2023 BASE YEAR: 2024 FORECAST YEAR: 2025-2030 EQUIPMENT TYPE: Earthmoving Equipment, Road Construction Equipment, Material Handling Equipment, and Other Equipment Middle East Construction Equipment Market Accelerates Toward Electrification and Sustainability The Middle East is steadily transitioning toward electric and hydrogen-powered construction equipment, driven by national sustainability goals and the urgent need to diversify from fossil fuels. The UAE is leading this transformation through an ongoing construction boom and progressive policy frameworks like We the UAE 2031 and updated National Building Regulations. Construction equipment manufacturers are responding with increased investments and product innovation. Volvo Construction Equipment recently introduced the L120 Electric, a fully battery-powered wheel loader, marking its Middle East debut. The model underwent extensive regional testing in partnership with Al-Futtaim Auto & Machinery Company (Famco) to ensure climate and operational adaptability. Adding to this momentum, Niftylift unveiled its HR15 H2E and HR17 H2E hydrogen-electric boom lifts in April 2025. These machines, powered by hydrogen fuel cells, enable zero-emission operations,ideal for urban and indoor construction projects with strict environmental compliance. To support its growing customer base, Niftylift is also establishing a new regional office in Dubai. Key Market Highlights: UAE Construction Equipment Outlook Earthmoving equipment led the UAE construction equipment market in 2024, driven by strong public infrastructure investments. Excavators held the largest share within this segment. Material handling equipment demand is rising, supported by port expansions and logistics infrastructure. In March 2025, KEZAD Group and Metal Park launched Phase 1 of a new Storage Hub, expected to boost forklift demand. Road construction equipment is also gaining traction, projected to reach USD 135 million by 2030, fueled by projects like Dubai's USD 4.3 billion Main Roads Development Plan (2024–2027). Residential construction surged in 2024, supported by government housing schemes such as the Sheikh Zayed Housing Program announced in February 2025. Tourism and hospitality sector growth continues to drive demand for construction equipment, with over 11,300 hotel rooms set to open in Dubai by 2027, including 4,620 in 2025 alone. UAE's Infrastructure Investment Boom Signals Strong Demand for Construction Equipment The UAE is entering a transformative phase in 2025, with major public infrastructure and multi-use facility projects aligned with national goals such as Strategic Vision 2031 and Net Zero 2050. As the nation accelerates its shift toward a diversified, oil-free economy, large-scale developments, particularly in Dubai and Abu Dhabi, are driving heightened demand for construction equipment. Mega projects like Dubai South and Yas Island are being fueled by rising population needs for residential, transportation, and utility services. At the same time, the federal government has allocated over AED 27 billion ($7.4 billion) to upgrade healthcare and education infrastructure, its most ambitious investment to date. To expedite delivery, the UAE is increasingly leveraging public-private partnerships (PPP), creating strong growth prospects for construction equipment suppliers and technology providers in the region. UAE Construction Equipment Market Heats Up as Global OEMs Deepen Regional Investment The UAE's construction equipment market is becoming increasingly competitive, driven by a national infrastructure surge aligned with Vision 2031 and Net Zero 2050 targets. Global OEMs such as Caterpillar, Komatsu, Volvo CE, Hitachi Construction Machinery, and SANY continue to hold substantial market share, offering a broad range of machinery suited to both urban development and mega projects. Manufacturers are strengthening their presence through strategic partnerships, innovation, and product rollouts tailored for local needs. Komatsu, for instance, is expanding its regional operations while pushing AI-integrated and sustainable equipment solutions, reflecting a wider market shift toward smart construction. Meanwhile, specialized equipment providers are actively supporting landmark projects, especially in Dubai and Abu Dhabi, where large-scale developments and logistics investments are fueling demand for cranes, loaders, and material handling machines. As infrastructure pipelines grow, the UAE is positioning itself as a key hub for next-generation construction technologies in the Middle East. Key Vendors Caterpillar Komatsu Volvo Construction Equipment Hitachi Construction Machinery Liebherr SANY Xuzhou Construction Machinery Group Co., Ltd. (XCMG) JCB Kobelco Zoomlion Heavy Industry Science & Technology Co., Ltd. Other Prominent Vendors Bobcat CNH Industrial HD Hyundai Construction Equipment Liugong Machinery Co., Ltd. DEVELON Tadano Ltd. Terex Corporation Manitou BOMAG GmbH KATO WORKS CO., LTD. AUSA Wacker Neuson SE JLG Industries Toyota Material Handling The Manitowoc Company, Inc. AMMANN Distributor Profiles Abdulla Saeedi General Trading LLC Kanoo Machinery Al-Futtaim Auto & Machinery Company (FAMCO) M.H. Al Mahroos Al Marwan Heavy Machinery Galadari Trucks & Heavy Equipments Market Segmentation & Forecast Segmentation by Type Earthmoving Equipment Excavator Backhoe Loaders Wheeled Loaders Other Earthmoving Equipment (Other loaders, Bulldozers, Trenchers, Motor Graders) Road Construction Equipment Road Rollers Asphalt Pavers Material Handling Equipment Crane Forklift & Telescopic Handlers Aerial Platforms (Articulated Boom Lifts, Telescopic Boom lifts, Scissor lifts) Other Construction Equipment Dumper Tipper Concrete Mixer Concrete Pump Truck Segmentation by End Users Construction Mining Manufacturing Others (Power Generation, Utilities, Municipal Corporations, Oil & Gas, Cargo Handling, Power Generation Plants, Waste Management) Other Related Reports that Might be of Your Business Requirement UAE Elevator and Escalator Market - Size & Growth Forecast 2025-2030 UAE Crawler Excavator Market - Strategic Assessment & Forecast 2024-202 9 What Key Findings Will Our Research Analysis Reveal? How big is the UAE construction equipment market? What is the growth rate of the UAE construction equipment market? Which are the major distributor companies in the UAE construction equipment market? Who are the key players in the UAE construction equipment market? What are the trends in the UAE construction equipment market? Why Arizton? 100% Customer Satisfaction 24x7 availability – we are always there when you need us 200+ Fortune 500 Companies trust Arizton's report 80% of our reports are exclusive and first in the industry 100% more data and analysis 1500+ reports published till date Post-Purchase Benefit 1hr of free analyst discussion 10% off on customization About Us: Arizton Advisory and Intelligence is an innovative and quality-driven firm that offers cutting-edge research solutions to clients worldwide. We excel in providing comprehensive market intelligence reports and advisory and consulting services. We offer comprehensive market research reports on consumer goods & retail technology, automotive and mobility, smart tech, healthcare, life sciences, industrial machinery, chemicals, materials, I.T. and media, logistics, and packaging. These reports contain detailed industry analysis, market size, share, growth drivers, and trend forecasts. Arizton comprises a team of exuberant and well-experienced analysts who have mastered generating incisive reports. Our specialist analysts possess exemplary skills in market research. We train our team in advanced research practices, techniques, and ethics to outperform in fabricating impregnable research reports.

Metastatic Urothelial Carcinoma Pipeline Appears Robust With 40+ Key Pharma Companies Actively Working in the Therapeutics Segment
Metastatic Urothelial Carcinoma Pipeline Appears Robust With 40+ Key Pharma Companies Actively Working in the Therapeutics Segment

Globe and Mail

time11 minutes ago

  • Globe and Mail

Metastatic Urothelial Carcinoma Pipeline Appears Robust With 40+ Key Pharma Companies Actively Working in the Therapeutics Segment

DelveInsight's, 'Metastatic Urothelial Carcinoma Pipeline Insight, 2025' report provides comprehensive insights about 40+ companies and 40+ pipeline drugs in Metastatic Urothelial Carcinoma pipeline landscape. It covers the Metastatic Urothelial Carcinoma pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Metastatic Urothelial Carcinoma pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space. Explore our latest breakthroughs in Metastatic Urothelial Carcinoma Research. Learn more about our innovative pipeline today! @ Metastatic Urothelial Carcinoma Pipeline Outlook Key Takeaways from the Metastatic Urothelial Carcinoma Pipeline Report In July 2025, Inovio Pharmaceuticals announced a Phase I/IIA, open-label, multi-center trial to evaluate the safety, immunogenicity and preliminary clinical efficacy of INO-5401 + INO-9012 delivered by intramuscular (IM) injection followed by electroporation (EP), in combination with atezolizumab in participants with locally advanced unresectable or metastatic/recurrent Urothelial Carcinoma (UCa). In July 2025, Merck Sharp & Dohme LLC conducted a substudy is part of an umbrella platform study which is designed to evaluate investigational agents with or without pembrolizumab in participants with urothelial carcinoma who are in need of new treatment options. Substudy 04A will enroll participants with locally advanced or mUC whose disease is resistant to treatment with programmed cell death-1/ligand 1 (PD-1/L1) inhibitors. The protocol infrastructure will enable the rolling assignment of investigational treatments. In July 2025, Seagen organized a study will enroll participants with urothelial cancer (UC). UC can include cancer of the bladder, kidney, or the tubes that carry pee through the body (ureter, urethra). This study will try to find out if the drugs disitamab vedotin with pembrolizumab works better than platinum-containing chemotherapy to treat patients with UC. This study will also test what side effects happen when participants take these drugs together. A side effect is anything a drug does to the body besides treating the disease. DelveInsight's Metastatic Urothelial Carcinoma pipeline report depicts a robust space with 40+ active players working to develop 40+ pipeline therapies for Metastatic Urothelial Carcinoma treatment. The leading Metastatic Urothelial Carcinoma Companies such as PharmaMar, Ectin Research AG, Exelixis, Eli Lilly and Company, Merck Sharp & Dohme LLC, Astellas Pharma Inc, Seagen Inc., Shanghai Miracogen Inc., Advaxis, Inc. and others. Promising Metastatic Urothelial Carcinoma Pipeline Therapies such as BT8009, Olaparib, Enfortumab vedotin, Nivolumab, Gemcitabine, Carboplatin, Sacituzumab Govitecan-hziy, Pembrolizumab, Cisplatin, Ipilimumab, Tremelimumab and others. Stay informed about the cutting-edge advancements in Metastatic Urothelial Carcinoma treatments. Download for updates and be a part of the revolution in oncology Care @ Metastatic Urothelial Carcinoma Clinical Trials Assessment Metastatic Urothelial Carcinoma Emerging Drugs Profile MFA 370: Ectin Research AG Urothelial bladder cancer is one of the world's most aggressive cancers, current treatments can be tough to tolerate. MFA-370 is planned to be a simple oral tablet developed to eliminate tumors safely, with few if any side effects. MFA-370 is a combination of a medication from that substance family, together with one other standard, well-established drug. Both are tried, tested and trusted treatments that have already undergone large-scale clinical trials. It already demonstrated efficacy in preclinical results and 'patient zero' case. In addition to MFA-370 showing positive preclinical results in metastatic urothelial bladder cancer, it has also eliminated prostate, breast and colorectal cancer cells in preclinical tests too. Currently, the drug is in Phase I/II stage of Clinical trial evaluation for the treatment of Metastatic Urothelial Carcinoma. XL 092: Exelixis XL092 is a next-generation oral TKI that builds on our extensive experience with cabozantinib. XL092 also targets VEGF receptors, MET, TAM kinases and other kinases implicated in cancer's growth and spread. In preclinical tumor models, XL092 showed excellent activity as a single agent and in combination with ICIs. XL092 also has an optimized pharmacokinetic profile aimed at facilitating adverse event management in the clinic. XL092 is the first new Exelixis-discovered compound to come out of the company's reinitiated drug discovery activities, which entered phase 1 clinical development in 2019. Currently, the drug is in Phase I stage of Clinical trial evaluation for the treatment of Metastatic Urothelial Carcinoma. Lurbinectedin: PharmaMar Lurbinectedin, also known as PM01183, or commercially where approved as Zepzelca® is an analogue of a similar natural compound ET-736 with characteristics that make it similar but different to its parent compounds. Lurbinectedin inhibits active transcription of protein-coding genes through binding to promoters and irreversibly stalling elongating RNA polymerase II on the DNA template, thereby leading to double-stranded DNA breaks and apoptosis. Currently, the drug is in Phase II stage of Clinical trial evaluation for the treatment of Metastatic Urothelial Carcinoma. The Metastatic Urothelial Carcinoma Pipeline Report provides insights into The report provides detailed insights about companies that are developing therapies for the treatment of Metastatic Urothelial Carcinoma with aggregate therapies developed by each company for the same. It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Metastatic Urothelial Carcinoma Treatment. Metastatic Urothelial Carcinoma Companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects. Metastatic Urothelial Carcinoma Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type. Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Metastatic Urothelial Carcinoma market. Learn more about Metastatic Urothelial Carcinoma Drugs opportunities in our groundbreaking Metastatic Urothelial Carcinoma research and development projects @ Metastatic Urothelial Carcinoma Unmet Needs Metastatic Urothelial Carcinoma Companies PharmaMar, Ectin Research AG, Exelixis, Eli Lilly and Company, Merck Sharp & Dohme LLC, Astellas Pharma Inc, Seagen Inc., Shanghai Miracogen Inc., Advaxis, Inc. and others. Metastatic Urothelial Carcinoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as Intra-articular Intraocular Intrathecal Intravenous Ophthalmic Oral Parenteral Subcutaneous Topical Transdermal Metastatic Urothelial Carcinoma Products have been categorized under various Molecule types such as Oligonucleotide Peptide Small molecule Discover the latest advancements in Metastatic Urothelial Carcinoma treatment by visiting our website. Stay informed about how we're transforming the future of Oncology @ Metastatic Urothelial Carcinoma Market Drivers and Barriers, and Future Perspectives Scope of the Metastatic Urothelial Carcinoma Pipeline Report Coverage- Global Metastatic Urothelial Carcinoma Companies- PharmaMar, Ectin Research AG, Exelixis, Eli Lilly and Company, Merck Sharp & Dohme LLC, Astellas Pharma Inc, Seagen Inc., Shanghai Miracogen Inc., Advaxis, Inc. and others. Metastatic Urothelial Carcinoma Pipeline Therapies- BT8009, Olaparib, Enfortumab vedotin, Nivolumab, Gemcitabine, Carboplatin, Sacituzumab Govitecan-hziy, Pembrolizumab, Cisplatin, Ipilimumab, Tremelimumab and others. Metastatic Urothelial Carcinoma Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination Metastatic Urothelial Carcinoma Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III For a detailed overview of our latest research findings and future plans, read the full details of Metastatic Urothelial Carcinoma Pipeline on our website @ Metastatic Urothelial Carcinoma Emerging Drugs and Companies Table of Contents Introduction Executive Summary Metastatic Urothelial Carcinoma: Overview Pipeline Therapeutics Therapeutic Assessment Metastatic Urothelial Carcinoma– DelveInsight's Analytical Perspective Late Stage Products (Phase III) Drug name : Company name Drug profiles in the detailed report….. Mid Stage Products (Phase II) Lurbinectedin: PharmaMar Drug profiles in the detailed report….. Early Stage Products (Phase I) XL 092: Exelixis Drug profiles in the detailed report….. Preclinical and Discovery Stage Products Drug name : Company name Inactive Products Metastatic Urothelial Carcinoma Key Companies Metastatic Urothelial Carcinoma Key Products Metastatic Urothelial Carcinoma- Unmet Needs Metastatic Urothelial Carcinoma- Market Drivers and Barriers Metastatic Urothelial Carcinoma- Future Perspectives and Conclusion Metastatic Urothelial Carcinoma Analyst Views Metastatic Urothelial Carcinoma Key Companies Appendix About Us DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.

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