logo
Eli Lilly strikes $1.3 billion deal to buy gene-editing startup Verve Therapeutics, companies say

Eli Lilly strikes $1.3 billion deal to buy gene-editing startup Verve Therapeutics, companies say

CNBC17-06-2025
Eli Lilly will acquire gene-editing startup Verve Therapeutics for up to $1.3 billion, the companies said on Tuesday, sending Verve's shares up 77.7% in premarket trading.
Lilly has struck multiple partnership deals with gene-editing companies in the last two years to expand its portfolio beyond its blockbuster weight-loss and diabetes drugs.
The drugmaker will buy Verve for $10.5 per share, which is a premium of 67.5% on the company's last close.
The deal includes an upfront payment of almost $1 billion and a further $300 million based on the genetic-medicines firm achieving certain clinical milestones.
The companies are already partnering to develop gene-editing therapies to reduce high cholesterol in people with heart disease, which are expected to be used in combination with other drugs.
Shares of Lilly were down 1% before the bell.
Verve's gene-editing medicines target the PCSK9, ANGPTL3 and LPA genes responsible for regulating blood cholesterol levels.
Orange background

Try Our AI Features

Explore what Daily8 AI can do for you:

Comments

No comments yet...

Related Articles

Here is What to Know Beyond Why Eli Lilly and Company (LLY) is a Trending Stock
Here is What to Know Beyond Why Eli Lilly and Company (LLY) is a Trending Stock

Yahoo

time5 hours ago

  • Yahoo

Here is What to Know Beyond Why Eli Lilly and Company (LLY) is a Trending Stock

Eli Lilly (LLY) has recently been on list of the most searched stocks. Therefore, you might want to consider some of the key factors that could influence the stock's performance in the near future. Shares of this drugmaker have returned +4.3% over the past month versus the Zacks S&P 500 composite's +5.2% change. The Zacks Large Cap Pharmaceuticals industry, to which Lilly belongs, has gained 1.7% over this period. Now the key question is: Where could the stock be headed in the near term? Although media reports or rumors about a significant change in a company's business prospects usually cause its stock to trend and lead to an immediate price change, there are always certain fundamental factors that ultimately drive the buy-and-hold decision. Rather than focusing on anything else, we at Zacks prioritize evaluating the change in a company's earnings projection. This is because we believe the fair value for its stock is determined by the present value of its future stream of earnings. We essentially look at how sell-side analysts covering the stock are revising their earnings estimates to reflect the impact of the latest business trends. And if earnings estimates go up for a company, the fair value for its stock goes up. A higher fair value than the current market price drives investors' interest in buying the stock, leading to its price moving higher. This is why empirical research shows a strong correlation between trends in earnings estimate revisions and near-term stock price movements. Lilly is expected to post earnings of $5.56 per share for the current quarter, representing a year-over-year change of +41.8%. Over the last 30 days, the Zacks Consensus Estimate has changed +0.4%. For the current fiscal year, the consensus earnings estimate of $21.95 points to a change of +69% from the prior year. Over the last 30 days, this estimate has changed -0.5%. For the next fiscal year, the consensus earnings estimate of $30.91 indicates a change of +40.8% from what Lilly is expected to report a year ago. Over the past month, the estimate has changed +0.4%. Having a strong externally audited track record, our proprietary stock rating tool, the Zacks Rank, offers a more conclusive picture of a stock's price direction in the near term, since it effectively harnesses the power of earnings estimate revisions. Due to the size of the recent change in the consensus estimate, along with three other factors related to earnings estimates, Lilly is rated Zacks Rank #3 (Hold). The chart below shows the evolution of the company's forward 12-month consensus EPS estimate: While earnings growth is arguably the most superior indicator of a company's financial health, nothing happens as such if a business isn't able to grow its revenues. After all, it's nearly impossible for a company to increase its earnings for an extended period without increasing its revenues. So, it's important to know a company's potential revenue growth. In the case of Lilly, the consensus sales estimate of $14.47 billion for the current quarter points to a year-over-year change of +28%. The $59.92 billion and $72.43 billion estimates for the current and next fiscal years indicate changes of +33% and +20.9%, respectively. Lilly reported revenues of $12.73 billion in the last reported quarter, representing a year-over-year change of +45.2%. EPS of $3.34 for the same period compares with $2.58 a year ago. Compared to the Zacks Consensus Estimate of $12.62 billion, the reported revenues represent a surprise of +0.86%. The EPS surprise was -5.11%. Over the last four quarters, Lilly surpassed consensus EPS estimates two times. The company topped consensus revenue estimates three times over this period. Without considering a stock's valuation, no investment decision can be efficient. In predicting a stock's future price performance, it's crucial to determine whether its current price correctly reflects the intrinsic value of the underlying business and the company's growth prospects. Comparing the current value of a company's valuation multiples, such as its price-to-earnings (P/E), price-to-sales (P/S), and price-to-cash flow (P/CF), to its own historical values helps ascertain whether its stock is fairly valued, overvalued, or undervalued, whereas comparing the company relative to its peers on these parameters gives a good sense of how reasonable its stock price is. The Zacks Value Style Score (part of the Zacks Style Scores system), which pays close attention to both traditional and unconventional valuation metrics to grade stocks from A to F (an A is better than a B; a B is better than a C; and so on), is pretty helpful in identifying whether a stock is overvalued, rightly valued, or temporarily undervalued. Lilly is graded C on this front, indicating that it is trading at par with its peers. Click here to see the values of some of the valuation metrics that have driven this grade. The facts discussed here and much other information on might help determine whether or not it's worthwhile paying attention to the market buzz about Lilly. However, its Zacks Rank #3 does suggest that it may perform in line with the broader market in the near term. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Eli Lilly and Company (LLY) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research

I Was Horrified By What A Teacher Asked My Daughter To Do. His Response To Me Was Just As Disturbing.
I Was Horrified By What A Teacher Asked My Daughter To Do. His Response To Me Was Just As Disturbing.

Yahoo

time9 hours ago

  • Yahoo

I Was Horrified By What A Teacher Asked My Daughter To Do. His Response To Me Was Just As Disturbing.

I genuinely try to curb my mama bear instincts in most situations. So when my 15-year-old daughter Lilly climbed into our car during the second week of her sophomore year of high school and said that her health teacher was making the class keep a food journal, I fought to quiet the alarm bells going off in my head. 'It's OK, though,' she told me. 'Please — PLEASE — don't send one of your emails.' I sighed. 'Fine.' She was new to this high school and didn't want to be The Girl With That Mom. A week later, Lilly called me into her room. Her eyes were filled with tears. 'Today the health teacher said, 'I don't care if you eat just 1,000 calories a day.' I'm sure he was joking, but I don't think I can stay in this class.' She sighed. 'Also, he's making us use a calorie tracker for our food journals, the same one I used last year.' A cold fist squeezed my stomach because I knew exactly what she was referring to. I would never forget the days of watching my daughter eat less and less, turn down food at dinner, and throw away almost entire meals when we ate out, as she slipped into the trap of disordered eating. The worst part was that I knew that trap all too well. When I was her exact same age I was admitted to a hospital for anorexia nervosa. My weight was dangerously low after a series of traumatic circumstances left me reeling, grappling for a sense of control in my life, and finding that control in what I ate. Or rather, didn't eat. I was in treatment for 26 days, during which I was often confined to bed for hours due to problems with my pulse and blood pressure. After being discharged, I wanted to stay out of the hospital, but food was still one area of my life where I could exert control. Every night for over a year, I wouldn't let myself fall asleep until I tallied the calories of everything I'd eaten to ensure it was the Goldilocks amount — not too much to gain weight, but not too little that I would lose any either. Packaged foods made it easy to know exactly how much I had consumed, and I tried to eat most meals at home so I could measure and track my intake. It wasn't until I turned 16 that I stopped counting calories. I traveled to Australia that summer and quickly realized my system wasn't sustainable. Instead, I began listening to and trusting my body. I went to cafes with friends where we sipped frothy cappuccinos, then enjoyed stews or pasties for dinner and Lamingtons for dessert. Someone introduced me to TimTams, the heavenly chocolate cookies that managed to both crumble and melt in my mouth. I suddenly realized how exhausted I was by calorie tracking, and it was so freeing to fall asleep at night without conducting my obsessive tally. After that, I made it a point not to count calories, fast, or diet. I had always been athletic, but now I listened to my body and didn't try to hurt it with my workouts. When I became a mother, I wanted to make sure my children never knew the hell of disordered eating. I stopped buying popular women's magazines when I realized how they all had cover lines like, 'Lose 10 pounds this month!' in bright, bold letters. My kids saw me work out, but I kept the emphasis on being strong and using fitness to help me deal with stress. I never said degrading things about my body, never weighed myself except at doctor visits, and never demonized food in front of them. In 'Sleeping Beauty,' Aurora's parents destroy all the spindles in the kingdom after the evil fairy Maleficent says the princess will prick her finger on one and die — yet she still manages to find one. Aurora is drawn to it, though it's locked away in a tower, as if her demise is inevitable. What I didn't know then, but research is now proving, is that eating disorders may also be genetic, so, despite all my efforts, I watched a perfect storm headed straight for my daughter. Over the course of a year, during the pandemic, we moved twice, and the second time we found ourselves living abroad. Lilly attended a prestigious international school where she was bullied by her classmates whenever she asked questions and ridiculed for not already knowing the answers. Worse still, the girls who sat with Lilly at lunch threw out their meals after just a bite or two and acted horrified if she ate everything on her plate. I thought my daughter was different from me — less sensitive and more resilient — and that she would be able to handle what was happening. She had an effervescent personality and made friends wherever she went. Her uncle once joked that if it was possible to distill the essence of Lilly and distribute it to the world, there would be no need for antidepressants any more. Not only that, she was impressively strong and seemed to excel at whatever sport she tried. Instead, she began to crack under the pressure. One day, she found a calorie tracker online, unbeknownst to me, and stopped eating almost entirely. Her weight plummeted. It was terrifying for me to witness. She acknowledged her need for help, and though her struggle seemed hopeless, Lilly eventually fought her way back to health. We moved again, and the social environment at her new school was relaxed and friendly. She seemed happy and at peace, and I felt myself breathing deep sighs of relief — until she told me about the food journal and calorie tracking assignment. 'Lilly,' I said gently, after she told me about her health class struggles, 'we have to say something.' She paused, thinking for a moment, then nodded her head in agreement. First I sent the health teacher an email explaining why I was concerned and asking if we could exempt Lilly from the assignment or alter it to remove the tracker. I addressed his comment about eating 1,000 calories, since that isn't enough to even maintain weight, and offered to speak to his classes about eating disorders. He responded by saying that he didn't teach that material in his class, and of course he didn't mean what he had said, but there was no way that he would change the assignment for Lilly or anyone. I sent another email, fully aware I was quickly becoming That Mom. However, it was now about more than me wanting to protect just my daughter. In the absence of a holistic approach that included education about eating disorders, I was looking out for all of the kids who might not recognize a calorie tracker as the loaded gun it was and could, before they knew it, find themselves in the same trap that Lilly and I had once been in. I filled my follow-up email with links to articles on the relationship between calorie tracking and eating disorders, and then I hit 'send.' I didn't receive a reply. In light of how recent Lilly's recovery was and how delicate it still seemed, I decided to withdraw her from the class. Her guidance counselor, also a parent, was supportive and equally concerned about this teacher's curriculum. Calorie trackers have no place in middle or high school health classes. They teach us to look at our food consumption like a scorecard and judge whether we did terrible, OK, or excellent. Teenagers' prefrontal cortices are still developing, already making them more susceptible to social pressures and mental health issues, and assignments like these compound that risk. Although teens might find calorie trackers on their own, as Lilly did, using them in school assignments pushes them into a vulnerable — and potentially dangerous — position. There are better ways to present nutritive eating to kids and to talk about what food does for us. Health educators need to address the many forms of eating disorders that affect millions of people every year. Emphasizing how social media distorts reality is also essential. Lilly still needs to take a health class to complete her graduation requirements, and I know her next teacher might take the same approach as her last one. What then? my inner mama bear wonders, with no small amount of trepidation. Even though I hate that we both went through the same darkness of an eating disorder, I'm so thankful for our close relationship and that Lilly knows she can come to me with her struggles. I'm having to learn yet again that there's so much I cannot control, which means I can't guarantee my kids won't face challenges, but I can still try to protect them — and their friends and peers — from unnecessary peril. Joy Nicholas' writing has appeared in Business Insider, Brevity Blog, Coffee + Crumbs, and other publications. She grew up moving all over the world and is currently working on her first book, a memoir. Connect with her on Instagram at @joynicholaswrites and through her Substack Joy in the World. Do you have a compelling personal story you'd like to see published on HuffPost? Find out what we're looking for here and send us a pitch at pitch@ I Went To My Son's Class To Explain How He Goes To The Bathroom. Here's Why. My 15-Year-Old Daughter Died. I Recently Found A Box Of Hers — And What Was Inside Left Me Shaken. I'm A Teacher. Here's The Shocking Truth About The 'Woke' Indoctrination Of Students That Terrifies Conservatives.

Amgen Looks to Take Share of Booming Obesity Space: Will It Succeed?
Amgen Looks to Take Share of Booming Obesity Space: Will It Succeed?

Yahoo

time10 hours ago

  • Yahoo

Amgen Looks to Take Share of Booming Obesity Space: Will It Succeed?

Amgen AMGN is one of the several drug makers racing to develop the next blockbuster weight loss drug and take a share of the booming weight loss drug market. The obesity market is expected to expand to $100 billion by 2030, according to data from Goldman Sachs. Amgen is developing MariTide, a GIPR/GLP-1 receptor, as a single dose in a convenient autoinjector device with a monthly and maybe less frequent dosing. This key feature differentiates it from Eli Lilly's LLY and Novo Nordisk's NVO popular GLP-1-based obesity drugs, Zepbound and Wegovy, respectively, which are weekly injections. MariTide is a closely watched drug in the obesity market. In phase II studies, MariTide resulted in up to approximately 20% average weight loss over 52 weeks without reaching a weight loss plateau in people who were obese or overweight but without type II diabetes. However, the weight loss reduction was at the lower end of investor expectations of 20-25%. In patients with type II diabetes who were obese or overweight, the weight loss reduction was approximately 17% at 52 weeks. In March, Amgen initiated two phase III studies on MariTide in obesity as part of its comprehensive MARITIME phase III program. Separate phase III studies on MariTide in obesity, with or without type II diabetes, are currently enrolling patients. The primary endpoint for each study is the change from baseline body weight at 72 weeks. Additional MARITIME phase III studies on MariTide in people living with atherosclerotic cardiovascular disease, heart failure and obstructive sleep apnea will be initiated in 2025. Separate phase II studies on obesity and type II diabetes are also ongoing, with data readouts expected in the second half. A phase I study is also ongoing on another obesity candidate, AMG 513. Amgen has not disclosed the obesity candidate's mechanism of action. Amgen also has other preclinical obesity candidates in its pipeline, including oral and injectable approaches that comprise both incretin and non-incretin mechanisms. It's too early to say how strongly Amgen will be placed in the booming obesity space, which Novo Nordisk and Eli Lilly have so far dominated. Viking Therapeutics' VKTX dual GIPR/GLP-1 receptor agonist, VK2735, is being developed both as oral and subcutaneous formulations for the treatment of obesity. Recently, Viking Therapeutics initiated a late-stage program (VANQUISH), comprising two phase III studies evaluating the subcutaneous version of VK2735 in obesity and type II diabetes. VKTX initiated a mid-stage study (VENTURE) on the oral formulation of the candidate earlier this year. Others like Roche, Merck and AbbVie are also looking to enter the obesity space by in-licensing obesity candidates from smaller biotechs, which could threaten Novo Nordisk and Eli Lilly's dominance in the market. To maintain its prowess in the lucrative obesity market, both Novo Nordisk and Lilly are investing heavily in obesity and have several new molecules currently in clinical development. Amgen's stock has risen 8.9% so far this year against a decrease of 0.7% for the industry. Image Source: Zacks Investment Research From a valuation standpoint, Amgen is reasonably priced. Going by the price/earnings ratio, the company's shares currently trade at 13.26 forward earnings, which is lower than 14.87 for the industry. The stock is also trading below its five-year mean of 13.77. Image Source: Zacks Investment Research The Zacks Consensus Estimate for earnings has risen from $20.57 to $20.82 per share for 2025 over the past 60 days. For 2026, the consensus mark for earnings has risen from $21.13 to $21.29 per share over the same timeframe. Image Source: Zacks Investment Research Amgen has a Zacks Rank #3 (Hold). You can see the complete list of today's Zacks #1 Rank (Strong Buy) stocks here. Want the latest recommendations from Zacks Investment Research? Today, you can download 7 Best Stocks for the Next 30 Days. Click to get this free report Novo Nordisk A/S (NVO) : Free Stock Analysis Report Eli Lilly and Company (LLY) : Free Stock Analysis Report Amgen Inc. (AMGN) : Free Stock Analysis Report Viking Therapeutics, Inc. (VKTX) : Free Stock Analysis Report This article originally published on Zacks Investment Research ( Zacks Investment Research

DOWNLOAD THE APP

Get Started Now: Download the App

Ready to dive into a world of global content with local flavor? Download Daily8 app today from your preferred app store and start exploring.
app-storeplay-store