Heart disease: What cardiologists do to protect themselves
Over time, one or more of these can contribute to the narrowing of the arteries as fatty materials (called atheroma) such as cholesterol accumulate inside them.
It is when arteries become narrowed by plaque to the extent that blood flow to the heart and brain is restricted that heart disease is diagnosed.
Yet most cases – the British Heart Foundation says about 70 per cent – are preventable and cardiologists are convinced that if more of us were aware of the simple steps we can take to reduce our risk, the death toll would fall.
'By managing their lifestyle risk factors and keeping tabs on health, people can dramatically reduce their risk of heart disease,' says Oliver Guttman, consultant cardiologist at the HCA Wellington Hospital in London. 'This is true even for those who currently feel well, as early metabolic changes often occur silently.'
Coronary heart disease (CHD) remains one of the biggest killers in the UK, responsible for more than 66,000 deaths a year, with one person dying every eight minutes. It is the single biggest killer disease for men – one in eight dying from CHD – but the mistaken perception that heart attacks are not a big risk for women costs lives.
According to the British Heart Foundation, heart disease kills more women each year than breast cancer, with signs from studies that cases are rising among women under 65. The BHF forecasts there could be one million more people living with heart disease in the UK by 2030.
So, what are the rules for heart disease prevention? Here, Guttman and Hannah Douglas, consultant cardiologist at Guy's and St Thomas' NHS Foundation Trust, spell out their evidence-based recommendations. 1. Check your blood pressure at least once a year
Blood pressure is one of the most important controllable risk factors for cardiovascular disease, yet hypertension is ignored or remains undiagnosed. A normal or ideal adult pressure is considered to be between 90/60mmHg and 120/80mmHg.
'Blood pressure is critically important and is truly a 'silent killer',' Douglas says. 'High blood pressure puts the entire vascular system under constant pressure and is a very significant risk factor for heart disease.'
Having your blood pressure checked by your local pharmacy free of charge is the first step to take. Also investing in a home DIY monitor is an option and the BHF has a list of approved devices (bhf.org.uk). Blood pressure does ebb and flow, so a one-off high reading is usually nothing to worry about, but if it remains high for two or three weeks, see your doctor or nurse.
'Weight management and regular exercise are two of the easiest lifestyle methods that we know help to manage blood pressure,' Douglas says. 'But sustained high blood pressure should always be treated to reduce risk.' 2. Consider wearing a tracker if over 65
Devices such as smartwatches with ECG features, such as the Apple Watch and Fitbit, can be useful for detecting atrial fibrillation (AFib), an irregular heart rhythm that increases the risk of stroke and can contribute to heart failure.
'For people over 65 or those with symptoms such as palpitations or dizziness, these tools may help flag episodes of AFib early,' Guttman says. 'Do be aware that they can also give false positives, so any alerts should be followed up with proper clinical assessment.'
Routine monitoring for most under-65s is not necessary, he says, but if you are concerned about AFib speak to your GP: 'These trackers are best thought of as screening tools, not diagnostic devices, and their usefulness increases with age.' 3. Get your cholesterol levels checked
Measuring cholesterol and blood triglycerides – or your lipid profile – should be done every four to six years if you are someone considered at low risk of CHD. 'You will need to have it checked more often if your lipid profile is abnormal, you are genetically at a high risk of raised cholesterol or if you are on medication,' Guttman says.
Finger-prick cholesterol checks can be carried out by your GP or local pharmacy, or as part of the National Health Service health check in England. According to the BHF, below 4mmol/L (below 2.6mmol/L if you have had a heart attack) is a healthy level of non-HDL, bad cholesterol, the type that builds up in your arteries. Above 1mmol/L is a healthy level of good HDL cholesterol for men and above 1.2mmol/L is a healthy level for women. Healthy total cholesterol levels are below 5mmol/L (4mmol/L if you've had a heart attack). 4. Eat a diet rich in anti-inflammatory whole foods
'Chronic inflammation is one of the key drivers of atherosclerosis, the plaque build-up in arteries,' Guttman says. 'A diet rich in anti-inflammatory whole foods is ideal for helping to prevent this and is not only heart-protective but supports gut health, brain function and long-term weight management.'
He recommends a Mediterranean-style diet with vegetables, fruits, whole grains, legumes, healthy fats, particularly extra virgin olive oil, and nuts, and a regular consumption of fish and seafood, high in heart-healthy omega-3 fats.
A review of clinical evidence in the journal Nutrients showed the approach is beneficial in reducing inflammation that is a risk factor for CHD. 'By also reducing or eliminating ultraprocessed, pre-packaged foods such as ready meals from the diet, we instead use more whole ingredients to cook at home, so it is an important step to take,' Douglas says. 'Whole food ingredients are going to be largely anti-inflammatory provided we balance the food groups and take care with not adding too much extra fat and salt.' 5. Don't neglect cardio at the gym
Given its benefits for muscles, bones and the waistline, there is a trend for favouring weight training over cardiovascular exercise among the over-50s. But Douglas stresses that one is not necessarily better than the other for the heart. 'I tend to advise a 50:50 mix of cardio and light weight training for optimum cardiovascular health.
'Weight training has many benefits for blood pressure, general vascular health and bone density, but keeping active with cardiovascular or aerobic exercise is amazing for heart rate and blood pressure optimisation, weight management and has the secondary benefits of reducing the risk of other conditions such as type 2 diabetes, which in itself is closely linked with poor heart health.'
Guttman says that, as a minimum, we should aim for the government targets of at least 150 minutes of moderate aerobic activity per week, and muscle-strengthening activities on two or more days per week. 'A mix of the two offers the best protection for cardiovascular and overall health,' he says. 6. Measure your waist circumference
Being overweight is a risk factor for CHD, but central adiposity – fat around the middle – is generally more telling than the scales. Getting a tape measure out every 4-6 weeks is the best approach. 'The body mass index [BMI] is still commonly used, but it doesn't reflect body composition or fat distribution,' Guttman says. 'For most people, keeping an eye on waist circumference is the easiest and most reliable way to monitor central fat, which is metabolically harmful and strongly linked to CHD risk.' High-risk waist measurements are over 102cm (40in) for men and over 88cm (35in) for women, although the numbers shouldn't be taken in isolation.
Douglas says: 'We know that waist circumference has been linked with cardiovascular risk, so is definitely a useful gauge, but for those at higher risk of CHD an approach agreed between you and your clinician is best.' 7. Do focus on healthy sleep patterns
Sleep is a key component in managing general health. 'There are very few conditions, medical, physical and psychological, that aren't worsened by poor sleep,' Douglas says. 'This definitely includes heart disease.'
Poor or insufficient sleep is associated with high blood pressure, obesity, type 2 diabetes and irregular heart rhythm, all risk factors for CHD.
'Sleep apnoea, which causes pauses in breathing during sleep, is another serious and underdiagnosed condition that significantly raises cardiovascular risk,' Guttman says. 'Most adults need 7 to 9 hours of good-quality sleep per night and prioritising a regular sleep schedule, reducing evening screen time, and managing stress can all help improve your sleep and consequently support heart health.' 8. Stop smoking and vaping
Smoking remains one of the most powerful preventable risk factors for heart disease. 'It damages the arteries, increases blood pressure, promotes blood clotting and accelerates plaque build-up,' Guttman says. 'Even light or occasional 'social' smoking and passive smoking increase CHD risk.'
There is no safe form of smoking. Research presented to the American Heart Association by cardiologists at the University of Wisconsin reported significant negative heart health impacts after vaping and smoking cigarettes.
Immediately after vaping or smoking, increases in blood pressure, heart rate and blood vessel constriction were identified, and users of e-cigarettes performed worse than non-nicotine users on treadmill tests used to predict CHD risk.
'I do worry about the long-term effects of vaping,' Douglas says. 'Although easier said than done, all smokers need to work their hardest to become ex-smokers, with any support available.' The heart benefits of quitting begin within days, and over time the risk of CHD can fall to near that of a non-smoker. 9. Do discuss your family history of CHD
Most CHD risk comes from a combination of genes and lifestyle. If you have a family history of heart disease, Guttman says you should always discuss with your GP or cardiologist whether additional testing is appropriate for you.
'Genetic testing can be helpful, especially in cases of strong family history of premature heart disease [heart attack or stroke before age 55 in men or 65 in women],' he says. 'Certain inherited conditions, such as familial hypercholesterolaemia, which is characterised by very high levels of non-HDL cholesterol in the blood, greatly increase heart disease risk and often go undiagnosed without testing.'
However, routine genetic screening is not recommended. 'In asymptomatic patients it often raises more questions than it answers, unfortunately,' Douglas says. And even if you do have a genetic predisposition, there is no escaping the truth that healthy behaviours – not smoking, regular exercise, a balanced diet – will significantly reduce your CHD risk. 'Always discuss concerns with your GP or cardiologist, who will help to determine whether testing is appropriate for you,' Douglas says. 10. Women – be extra aware of symptoms around the menopause
Menopause is a key window for reassessing heart health and 'it's an ideal time for women to get their blood pressure, cholesterol and glucose checked to ensure they're on track for the years ahead', Guttman says. Some of the symptoms associated with the perimenopause and menopause, including sweating, palpitations, breathlessness, intolerance of exercise and panic attacks, are also symptoms of heart disease and can get overlooked.
'Understanding signs that can be associated with fluctuating hormone levels is key to recognising the difference between perimenopause and, for example, a cardiac arrhythmia,' Douglas says. 'Women should always seek medical help for worrying symptoms early. And if not satisfied with the outcome, seek a second opinion.'
HRT isn't prescribed to prevent CHD, but it may play a helpful role in managing menopausal symptoms in some women. For some of those under 60 or within 10 years of their menopause who are otherwise healthy, it may improve quality of life as well as improving some metabolic risk factors.
'I am a proponent of HRT for many peri and post-menopausal women for whom benefit outweighs risk,' Douglas says. However, HRT is not suitable for everyone, particularly women with a history of stroke, blood clots or known CHD.
'Decisions about HRT should be personalised, weighing the risks and benefits with a healthcare professional,' Guttman says.
The Times Read related topics: HealthHeart
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News.com.au
an hour ago
- News.com.au
MoneyTalks: Summit Biotech Fund's three standout ASX healthcare stocks
MoneyTalks is Stockhead's drill down into what stocks investors are looking at right now. We tap our list of experts to hear what's hot, their top picks and what they're looking out for. Today we hear from Australia's Summit Biotech Fund manager Reece O'Connell. With experience trading through multiple economic and market cycles, Reece O'Connell has developed a long-term investment approach focused on preserving and growing capital. In a career that has taken him from Perth to London and back again, he has worked closely with high-net-worth and wholesale investors, tailoring strategies to meet their objectives while navigating changing market conditions. At Summit Biotech Fund (SBF) he aims to provide long-term capital growth by investing in a portfolio of life science companies where innovation plays a crucial role in improving global health and economic outcomes. This includes biotechnology, pharmaceuticals, medical devices and equipment, medical data, information technology (e-health), and robotics. And in some good news for the fund, a rotation back into the healthcare sector appears to be gaining momentum with the S&P ASX 200 Health Care index rising 9.05% in July. "The healthcare sector has been the worst performing sector for two years and there's great positioning in quality healthcare names before the sector turns," he said. "We see these sector rotations every three to five years and I believe the ASX healthcare sector represents good value and plenty of upside in quality names with strong management." Here's three companies Summit Biotech Fund has invested in and why. Arovella Therapeutics (ASX:ALA) SBF is a major shareholder in Arovella, which is developing a next-generation cell therapy platform based on invariant Natural Killer T (iNKT) cells engineered with Chimeric Antigen Receptors (CARs) to target specific cancer antigens. Unlike traditional CAR-T therapies, Arovella's approach uses healthy donor cells to create off-the-shelf treatments, which reduces cost, complexity and time to treatment — the major issues currently faced by CAR-T companies. Arovella's lead candidate, ALA-101, targets CD19-positive blood cancers, and its pipeline encompasses therapy development for solid tumours such as gastric and pancreatic cancers. O'Connell reckons Arovella is in a hot area of cancer research. Nasdaq-listed MiNK Therapeutics recently soared following publication of a case report in the peer-reviewed Oncogene journal, detailing a patient with advanced, treatment-refractory testicular cancer who achieved complete remission after receiving its lead product iNKT Agentâ€'797, in combination with the immune checkpoint inhibitor nivolumab. "Arovella presents an opportunity in a rapidly growing sector, with a differentiated platform and strong early-stage clinical momentum," O'Connell said. "The company is the only ASX-listed biotech delving into CAR-iNKT therapies and one of only a handful globally." He said Arovella was well funded, finishing Q4 FY25 with cash of $20.9 million, which should fund the company through to completion of patient enrolment for its phase I clinical trial for ALA-101 n non-Hodgkin's lymphoma and leukaemia patients exhibiting the CD-19 biomarker – the target its CAR-iNKT cells recognise. The funding will also support the advancement of the company's solid tumour programs (CLDN18.2-CAR-iNKT targeting gastric cancer) and its armouring program (IL-12-TM). "ALA presents a highly compelling investment opportunity over the next six to 12 months, given the competitive landscape and the deals being struck for allogeneic assets and platforms," O'Connell added. SBF is a significant shareholder in Tryptamine, a clinical-stage biopharmaceutical company developing next-generation psychedelic medicines for neuropsychiatric conditions. Its lead program, TRP-8803, is a proprietary, IV-delivered formulation of psilocybin designed to provide more precise dosing and improved patient tolerability compared to oral psychedelic treatments. Phase 1b trials have already shown the drug to be safe and well tolerated in obese and non-obese participants. The company recently kicked off a world-first psilocin trial with TRP-8803 targeting Binge Eating Disorder (BED). The study, run in collaboration with Swinburne, will assess TRP-8803 when administered with psychotherapy with the goal to evaluate safety, feasibility and efficacy in adults diagnosed with BED. For O'Connell when analysing a biotech it as much about who is running the company as it is about the science. "One of the most important investment themes I always look for is a material monetary investment by directors in a company," he said. "Too many small ASX-listed companies have boards that aren't truly aligned with shareholders. "The number one way to be aligned is to have directors putting in their hard-earned cash like us. In this case, TYP ticks all the boxes.' He said directors, management,and major shareholders were collectively invested for more than $9m, with CEO Jason Carroll personally contributing more than $1 million. Carroll's 30-year career in big pharma includes two decades at Johnson & Johnson, where he led the strategy that doubled US sales of Remicade — a blockbuster IBD drug that ultimately reached US$10bn in annual global sales. O'Connell said other board members brought similar firepower. Executive director Chris Ntoumenopoulos was involved in the growth of Race Oncology (ASX:RAC) from $10m to north of $200m, founded former ASX-listed ResApp Health, which was acquired by Pfizer for ~$200m, and has helped double Island Pharmaceuticals' (ASX:ILA) value since joining its board. As part of the last raise experienced biotech investor Dr Daniel Tillett joined the Tryptamine board as a non-executive director and became a cornerstone investor. Tillet also cornerstoned a raise in Race Oncology in its early days and now leads it as CEO and managing director. Recent clinical progress provides Tryptamine with valuable proprietary data as its seek to advance the use of TRP-8803 in patient-specific indications. "With a differentiated psychedelic platform, directors heavily invested alongside shareholders, and multiple catalysts on the horizon, Tryptamine is emerging as one of the more compelling plays in the sector," O'Connell said. SBF also holds a strong position in NeuroScientific, which O'Connell said was positioning itself as a serious player in the fast-growing field of stem cell therapies for immune-mediated diseases, underpinned by its recently acquired StemSmart platform. The patented mesenchymal stromal cell (MSC) therapy has shown strong early results including a 53% remission rate in a phase II trial for refractory Crohn's disease and outperforming Humira, the long-time anti-inflammatory drug used as a standard of care. It also showed high response rates in a phase I trial for steroid-refractory Graft-versus-Host Disease (GvHD). "With the global markets for Crohn's and GvHD forecast to reach US$25 billion combined by 2035, StemSmart is tapping into significant unmet needs," O'Connell said. He also sees validation from the sector's leader Mesoblast (ASX:MSB), which recently secured US Food and Drug Administration (FDA) approval for its MSC product and now commands a $3.1bn market cap. He said by comparison, Neuroscientific trades at just ~23 cents but carries a midpoint valuation of 60 cents, representing around 161% upside based on a probability-adjusted DCF model assuming modest success rates and future partnerships. This assumes modest 20% success rates, 25% market penetration in Crohn's and potential partnerships with big pharma to fund late-stage trials. With a Special Access Program about to generate real-world data, plans to initiate Phase II trials in 18–24 months, and expansion into additional inflammatory and lung diseases, StemSmart offers a scalable pipeline. "For investors looking at the MSC space NSB could be an early-stage, high-upside opportunity positioned to follow Mesoblast's trajectory as the market matures," he said. The views, information, or opinions expressed in the interview in this article are solely those of the interviewee and do not represent the views of Stockhead. Stockhead has not provided, endorsed or otherwise assumed responsibility for any financial product advice contained in this article. Disclosure: Summit Biotech Fund held shares in Arovella, Tryptamine Therapeutics and NeuroScientific Biopharmaceuticals at the time of writing this article.

The Australian
21 hours ago
- The Australian
Heart disease: What cardiologists do to protect themselves
We are all aware of basic matters of the heart, that its normal healthy functioning can be harmed by big risk factors such as smoking and drinking, being overweight and underactive, making poor dietary choices and having high blood pressure. Over time, one or more of these can contribute to the narrowing of the arteries as fatty materials (called atheroma) such as cholesterol accumulate inside them. It is when arteries become narrowed by plaque to the extent that blood flow to the heart and brain is restricted that heart disease is diagnosed. Yet most cases – the British Heart Foundation says about 70 per cent – are preventable and cardiologists are convinced that if more of us were aware of the simple steps we can take to reduce our risk, the death toll would fall. 'By managing their lifestyle risk factors and keeping tabs on health, people can dramatically reduce their risk of heart disease,' says Oliver Guttman, consultant cardiologist at the HCA Wellington Hospital in London. 'This is true even for those who currently feel well, as early metabolic changes often occur silently.' Coronary heart disease (CHD) remains one of the biggest killers in the UK, responsible for more than 66,000 deaths a year, with one person dying every eight minutes. It is the single biggest killer disease for men – one in eight dying from CHD – but the mistaken perception that heart attacks are not a big risk for women costs lives. According to the British Heart Foundation, heart disease kills more women each year than breast cancer, with signs from studies that cases are rising among women under 65. The BHF forecasts there could be one million more people living with heart disease in the UK by 2030. So, what are the rules for heart disease prevention? Here, Guttman and Hannah Douglas, consultant cardiologist at Guy's and St Thomas' NHS Foundation Trust, spell out their evidence-based recommendations. 1. Check your blood pressure at least once a year Blood pressure is one of the most important controllable risk factors for cardiovascular disease, yet hypertension is ignored or remains undiagnosed. A normal or ideal adult pressure is considered to be between 90/60mmHg and 120/80mmHg. 'Blood pressure is critically important and is truly a 'silent killer',' Douglas says. 'High blood pressure puts the entire vascular system under constant pressure and is a very significant risk factor for heart disease.' Having your blood pressure checked by your local pharmacy free of charge is the first step to take. Also investing in a home DIY monitor is an option and the BHF has a list of approved devices ( Blood pressure does ebb and flow, so a one-off high reading is usually nothing to worry about, but if it remains high for two or three weeks, see your doctor or nurse. 'Weight management and regular exercise are two of the easiest lifestyle methods that we know help to manage blood pressure,' Douglas says. 'But sustained high blood pressure should always be treated to reduce risk.' 2. Consider wearing a tracker if over 65 Devices such as smartwatches with ECG features, such as the Apple Watch and Fitbit, can be useful for detecting atrial fibrillation (AFib), an irregular heart rhythm that increases the risk of stroke and can contribute to heart failure. 'For people over 65 or those with symptoms such as palpitations or dizziness, these tools may help flag episodes of AFib early,' Guttman says. 'Do be aware that they can also give false positives, so any alerts should be followed up with proper clinical assessment.' Routine monitoring for most under-65s is not necessary, he says, but if you are concerned about AFib speak to your GP: 'These trackers are best thought of as screening tools, not diagnostic devices, and their usefulness increases with age.' 3. Get your cholesterol levels checked Measuring cholesterol and blood triglycerides – or your lipid profile – should be done every four to six years if you are someone considered at low risk of CHD. 'You will need to have it checked more often if your lipid profile is abnormal, you are genetically at a high risk of raised cholesterol or if you are on medication,' Guttman says. Finger-prick cholesterol checks can be carried out by your GP or local pharmacy, or as part of the National Health Service health check in England. According to the BHF, below 4mmol/L (below 2.6mmol/L if you have had a heart attack) is a healthy level of non-HDL, bad cholesterol, the type that builds up in your arteries. Above 1mmol/L is a healthy level of good HDL cholesterol for men and above 1.2mmol/L is a healthy level for women. Healthy total cholesterol levels are below 5mmol/L (4mmol/L if you've had a heart attack). 4. Eat a diet rich in anti-inflammatory whole foods 'Chronic inflammation is one of the key drivers of atherosclerosis, the plaque build-up in arteries,' Guttman says. 'A diet rich in anti-inflammatory whole foods is ideal for helping to prevent this and is not only heart-protective but supports gut health, brain function and long-term weight management.' He recommends a Mediterranean-style diet with vegetables, fruits, whole grains, legumes, healthy fats, particularly extra virgin olive oil, and nuts, and a regular consumption of fish and seafood, high in heart-healthy omega-3 fats. A review of clinical evidence in the journal Nutrients showed the approach is beneficial in reducing inflammation that is a risk factor for CHD. 'By also reducing or eliminating ultraprocessed, pre-packaged foods such as ready meals from the diet, we instead use more whole ingredients to cook at home, so it is an important step to take,' Douglas says. 'Whole food ingredients are going to be largely anti-inflammatory provided we balance the food groups and take care with not adding too much extra fat and salt.' 5. Don't neglect cardio at the gym Given its benefits for muscles, bones and the waistline, there is a trend for favouring weight training over cardiovascular exercise among the over-50s. But Douglas stresses that one is not necessarily better than the other for the heart. 'I tend to advise a 50:50 mix of cardio and light weight training for optimum cardiovascular health. 'Weight training has many benefits for blood pressure, general vascular health and bone density, but keeping active with cardiovascular or aerobic exercise is amazing for heart rate and blood pressure optimisation, weight management and has the secondary benefits of reducing the risk of other conditions such as type 2 diabetes, which in itself is closely linked with poor heart health.' Guttman says that, as a minimum, we should aim for the government targets of at least 150 minutes of moderate aerobic activity per week, and muscle-strengthening activities on two or more days per week. 'A mix of the two offers the best protection for cardiovascular and overall health,' he says. 6. Measure your waist circumference Being overweight is a risk factor for CHD, but central adiposity – fat around the middle – is generally more telling than the scales. Getting a tape measure out every 4-6 weeks is the best approach. 'The body mass index [BMI] is still commonly used, but it doesn't reflect body composition or fat distribution,' Guttman says. 'For most people, keeping an eye on waist circumference is the easiest and most reliable way to monitor central fat, which is metabolically harmful and strongly linked to CHD risk.' High-risk waist measurements are over 102cm (40in) for men and over 88cm (35in) for women, although the numbers shouldn't be taken in isolation. Douglas says: 'We know that waist circumference has been linked with cardiovascular risk, so is definitely a useful gauge, but for those at higher risk of CHD an approach agreed between you and your clinician is best.' 7. Do focus on healthy sleep patterns Sleep is a key component in managing general health. 'There are very few conditions, medical, physical and psychological, that aren't worsened by poor sleep,' Douglas says. 'This definitely includes heart disease.' Poor or insufficient sleep is associated with high blood pressure, obesity, type 2 diabetes and irregular heart rhythm, all risk factors for CHD. 'Sleep apnoea, which causes pauses in breathing during sleep, is another serious and underdiagnosed condition that significantly raises cardiovascular risk,' Guttman says. 'Most adults need 7 to 9 hours of good-quality sleep per night and prioritising a regular sleep schedule, reducing evening screen time, and managing stress can all help improve your sleep and consequently support heart health.' 8. Stop smoking and vaping Smoking remains one of the most powerful preventable risk factors for heart disease. 'It damages the arteries, increases blood pressure, promotes blood clotting and accelerates plaque build-up,' Guttman says. 'Even light or occasional 'social' smoking and passive smoking increase CHD risk.' There is no safe form of smoking. Research presented to the American Heart Association by cardiologists at the University of Wisconsin reported significant negative heart health impacts after vaping and smoking cigarettes. Immediately after vaping or smoking, increases in blood pressure, heart rate and blood vessel constriction were identified, and users of e-cigarettes performed worse than non-nicotine users on treadmill tests used to predict CHD risk. 'I do worry about the long-term effects of vaping,' Douglas says. 'Although easier said than done, all smokers need to work their hardest to become ex-smokers, with any support available.' The heart benefits of quitting begin within days, and over time the risk of CHD can fall to near that of a non-smoker. 9. Do discuss your family history of CHD Most CHD risk comes from a combination of genes and lifestyle. If you have a family history of heart disease, Guttman says you should always discuss with your GP or cardiologist whether additional testing is appropriate for you. 'Genetic testing can be helpful, especially in cases of strong family history of premature heart disease [heart attack or stroke before age 55 in men or 65 in women],' he says. 'Certain inherited conditions, such as familial hypercholesterolaemia, which is characterised by very high levels of non-HDL cholesterol in the blood, greatly increase heart disease risk and often go undiagnosed without testing.' However, routine genetic screening is not recommended. 'In asymptomatic patients it often raises more questions than it answers, unfortunately,' Douglas says. And even if you do have a genetic predisposition, there is no escaping the truth that healthy behaviours – not smoking, regular exercise, a balanced diet – will significantly reduce your CHD risk. 'Always discuss concerns with your GP or cardiologist, who will help to determine whether testing is appropriate for you,' Douglas says. 10. Women – be extra aware of symptoms around the menopause Menopause is a key window for reassessing heart health and 'it's an ideal time for women to get their blood pressure, cholesterol and glucose checked to ensure they're on track for the years ahead', Guttman says. Some of the symptoms associated with the perimenopause and menopause, including sweating, palpitations, breathlessness, intolerance of exercise and panic attacks, are also symptoms of heart disease and can get overlooked. 'Understanding signs that can be associated with fluctuating hormone levels is key to recognising the difference between perimenopause and, for example, a cardiac arrhythmia,' Douglas says. 'Women should always seek medical help for worrying symptoms early. And if not satisfied with the outcome, seek a second opinion.' HRT isn't prescribed to prevent CHD, but it may play a helpful role in managing menopausal symptoms in some women. For some of those under 60 or within 10 years of their menopause who are otherwise healthy, it may improve quality of life as well as improving some metabolic risk factors. 'I am a proponent of HRT for many peri and post-menopausal women for whom benefit outweighs risk,' Douglas says. However, HRT is not suitable for everyone, particularly women with a history of stroke, blood clots or known CHD. 'Decisions about HRT should be personalised, weighing the risks and benefits with a healthcare professional,' Guttman says. The Times Read related topics: HealthHeart

The Australian
a day ago
- The Australian
Research uncovers unexpected benefits of snacking before bedtime
Put your feet up, relax in front of the TV and, almost inevitably, your stomach turns to snacking. To open the fridge or not is a question that plagues many afflicted by an evening attack of the nibbles. On the one hand are studies warning that to consume anything after 7pm – even after 5pm, according to one Columbia University study last year – is a route to metabolic disaster that will come back to bite us in the form of fat on the waistline, derailed sleep, disturbed blood sugar and raised risk of conditions such as type 2 diabetes. But is evening snacking as bad for us as we are led to believe? Reassuringly not all experts think so and some stress that we need a clearer perspective on the 'no night nibbles' rule. What you snack on, how close to sleeping you do so and what you eat during the rest of the day have a much greater bearing on health than a few squares of dark chocolate at 8pm, they say. For snackers – 95 per cent of UK adults have a snacking habit, according to research conducted at Kings College London (KCL) - that is welcome news. 'Not all night snacking is inherently bad and a nutrient-dense snack may even support better sleep for some people,' says Alex Ruani, a nutrition researcher at University College London and chief science educator at the Health Sciences Academy. 'Also, going to bed hungry can actually make it harder to fall asleep, especially if you had an early or light dinner, so a snack might offset that grumbling tummy.' In the KCL study snackers were shown to be healthier than non-snackers. 'They tended to have better BMIs and waist circumferences than people who don't snack at all,' says Dr Frederica Amati, research fellow and nutrition lead at Imperial College London's School of Public Health. And while the research did show that timing matters, it was less damning of evening intake than might have been expected. Only snacking after 9pm was associated with poorer blood markers – people who snacked at this time tended to eat sugary, high fat and more processed foods. 'It's less about 'the clock' and more about choosing snacks carefully and leaving enough time before bed, ideally avoiding eating immediately before lying down, as that can cause digestive discomfort or reflux that may disrupt sleep,' Ruani says. What about the weight gain associated with eating at night? 'Night snacks will mainly lead to weight gain only if they consistently push you into a calorie surplus,' Ruani says. 'But for some the right type of snack last thing may help to regulate appetite and reduce overeating the next day, which would have a positive effect on weight.' Of course, the message is to take your hand out of the tortilla chips packet and not to spoon ice cream from the tub last thing. So what do the experts do instead? Ruani snacks on cashews or pistachios 45 minutes to an hour before bedtime. 'I am convinced they help me to fall asleep faster, which I suspect is down to the natural sleep-inducing melatonin content of both,' she says. Amati says the trick is to plan ahead so that you avoid too much sugary temptation. 'We have young kids so tend to eat early and sometimes by 8.30pm I am thinking, hmmm, I might need something else,' she says. 'I make a date, crunchy peanut and dark chocolate bar to keep in the freezer or have dark chocolate almonds if I want something sweet, but there are plenty of options for healthy evening snacks.' Here's a guide to guilt-free evening snacking. What is the cut-off time for evening snacking? Trying not to snack after 9pm is ideal for most people who routinely go to bed between 10pm and 11pm, Amati says, but it's not a rule set in stone. 'If you have had a really busy or active day and are starving later on, then you are best off having a healthy snack than going to bed hungry,' she says. 'Equally, if you are going out for an occasional meal, don't miss out thinking there's a watertight cut-off beyond which you shouldn't eat.' Your body clock, or chronobiology, has an impact on when the best time is to stop snacking at night. 'For most people, eating after 9pm does have a negative consequence on metabolism the next day,' she says. 'However, if you are someone who routinely goes to bed later at midnight or 1am, then that threshold shifts accordingly and you might get the nibbles at 10pm.' Is an evening avocado going to boost my gut health? Eating avocados regularly has been linked to reducing everything from your risk of heart disease to the distribution of harmful belly fat and now it seems that as an evening snack they might have added value. Scientists at the University of Illinois found that snacking on avocados at night can trigger what they termed the 'second-meal effect', meaning that the composition of one meal affects how your body processes the next. The participants, all of whom were adults with raised blood sugar levels, were asked to eat either a whole avocado, a low-fat low-fibre snack or a processed snack designed to match the avocado's fat and fibre content between 8pm and 9pm each evening. It was the avocados alone that led the next morning to healthier metabolism of triglycerides, fats in the body that are a risk factor for type 2 diabetes when raised. Britt Burton-Freeman, professor of food science and the lead author of the study, said it was avocado's whole package – 'its whole-food matrix' – that produced the benefits and that avocados at night might also support general heart health. 'While the good fats and fibre in avocados already make them a satisfying snack, this research is making us think about how snacks before bed – something 84 per cent of people consume regularly – can influence how the body handles food later,' Burton-Freeman said. Will eating Greek yoghurt before bed really help to build strong muscles? A 2020 review in the journal Physical Activity and Nutrition showed that consuming at least 40g of casein protein, the type found in milk-based foods, approximately half an hour before sleep can aid muscle recovery and growth. However, there is an important caveat for most of us – it will only work if you have been lifting heavy weights in the hours beforehand. 'Yes, you do need to do the exercise first,' says George Morris, an exercise physiologist based at St Mary's University, Twickenham. 'The same benefits don't come if you just eat protein and do nothing.' There's evidence that we absorb more amino acids from protein when we sleep, Morris says, and if you are over 60, eating yoghurt or another form of protein in the evening might be even more beneficial. 'We get a bit less efficient at absorbing protein and distributing it throughout the day in later life,' Amati says. 'Having something like a yoghurt or oatmeal with kefir at night might help to maintain the nitrogen balance that is important for protein metabolism over the 24-hour period in your sixties and seventies.' Are pistachios the ultimate night-time snack? Most nuts are good for us and, within reason, snacking on them boosts diet quality, helps to protect against heart disease and, according to a 2025 study published in Clinical Nutrition improves the health profile of adults at risk for metabolic disease. But what about eating nuts at night? Amati says she keeps Kilner jars of nuts on standby in her kitchen in case of an evening snack attack and Ruani favours pistachios, recently shown to be a winner in the war against type 2 diabetes. It is sometimes recommended that adults with prediabetes, defined as higher than normal blood sugar, eat a night-time snack of 15-30g carbohydrates, such as one or two slices of wholegrain bread, to regulate blood sugar levels overnight, the scientists said. For her study in the journal Current Developments in Nutrition, Kristina Petersen, associate professor of nutritional sciences at Penn State University, asked 51 participants with the condition to consume 50 grams of pistachios each night instead. After three months, there were significant improvements to their microbiome including a rise in 'good bacteria' such as Roseburia and Lachnospiraceae. These beneficial bugs are known to produce short-chain fatty acids such as butyrate, an energy source for gut cells, which helps to maintain a healthy gut barrier and to reduce inflammatory processes that exacerbate metabolic disease. 'Pistachios seem to be able to meaningfully shift the gut microbial landscape in adults with prediabetes, especially when consumed as a nighttime snack,' Petersen said. 'These microbiome changes may offer other long-term health benefits, potentially helping to slow the development of type 2 diabetes or to reduce systemic inflammation.' I've heard that eating cottage cheese at night will aid recovery from workouts Eating two tablespoons of cottage cheese before bed was shown to have a positive effect on repair and regeneration of muscles and on general health, with no negative effect on metabolism or hunger levels the following morning. In a study of active women in their twenties at Florida State University, physiologists suggested that cottage cheese is as effective as commercial protein shakes and supplements - only much cheaper. 'Cottage cheese is another source of casein, a slow-digesting protein that supports overnight muscle repair, particularly useful if you're very active,' Ruani says. Should I take a banana and warm milk to help me sleep better? It's a combo that was shown in a 2024 study by health scientists in Turkey to improve sleep, regulate appetite hormones and reduce insomnia. Rhiannon Lambert, a registered nutritionist and author of The Science of Plant-Based Nutrition, says bananas and milk both contain tryptophan, an essential amino acid that serves as a precursor to serotonin and melatonin, neurotransmitters that help regulate mood and the sleep-wake cycle. 'Milk also provides calcium, which helps the brain use tryptophan to manufacture melatonin more effectively,' Lambert says. 'Additionally, bananas are rich in magnesium and potassium, minerals that support muscle relaxation.' The Times Read related topics: HealthNutrition