
Tell us: what have you never quite understood about weight loss drugs?
Originally developed for diabetes, these medications are now being prescribed for weight management. But the science, ethics, and long-term effects of these drugs are still being explored.
In a new video series on our It's Complicated Youtube channel, we're investigating the major questions behind some of today's most confusing topics – and weight loss drugs are at the top of that list.
What do these medications actually do to the body? Who should take them, and who decides? Are they reshaping how we think about obesity, health, and personal responsibility? We'll be speaking with experts to better understand the science and the social impact, and we want to make sure we're answering the questions you have.
What have you never quite understood about weight loss drugs? Maybe you're unsure how they work, or you're curious about side effects, access, or stigma. Maybe you've tried them, are thinking about it, or feel overwhelmed by the hype. Whatever your question, we'd love to hear from you. Fill out the form below to share your thoughts. Your questions could help shape our reporting and be featured in the show.
You can tell us what you would like to know about weight-loss drugs by filling in the form below.
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Daily Mail
7 hours ago
- Daily Mail
Weight loss simplified: Shed pounds with the affordable Ozempic alternative that doesn't require insurance (and that actually works)
Daily Mail journalists select and curate the products that feature on our site. If you make a purchase via links on this page we will earn commission - learn more Another day, another effort to shed the pounds. You're used to it by now, possibly depriving yourself of foods you enjoy while attempting to squeeze in a workout. It's not always easy to manage, which is why so many rely on weight loss drugs to help move the scale. If you're interested but concerned about costs and insurance, Hims has an excellent solution using the same active ingredient as Ozempic. Hims Weight Loss Your journey to better health you begins right here. Just fill out a brief profile and a licensed medical provider will evaluate your information. If prescribed, you'll receive a personalized program featuring either an oral medication kit or compounded GLP-1 injections featuring the same active ingredient found in Ozempic. It's affordable, convenient, and incredibly easy to get started! Get Started What sets weight loss from Hims apart from the rest is the company's commitment to you as a whole person. You aren't just one of thousands all in the same boat. And that's because no two situations are exactly alike, especially where important factors like your health and weight goals are concerned. The team at Hims centers your concerns to ensure your treatment plan is tailored precisely to your needs. That's why the entire journey begins with a simple assessment, during which you'll provide information about your health history, your weight goals, your habits, and other factors that could affect your treatment. The companion Hims app is your best friend through this process, providing you with quick access to your program in the palm of your hand Once your profile is complete, you'll receive a personalized weight loss plan if you're approved for treatment. Whether you're prescribed an oral medication kit or compounded GLP-1 injections, it's all about what is right for your body. These treatments feature the same active ingredient found in Ozempic, but Hims makes it easier — no waiting for approval and no worrying about insurance! Plus, everything is handled completely online. You'll use the Hims app through your journey to stay in control of everything. Use it to connect with your provider (regular check-ins are included), adjust medication, track your progress, and even get motivation for workouts and changes to your diet. It's super comprehensive and streamlined, so you'll always feel like you've got someone in your corner during what can otherwise feel like a lonely path. Hims has got you every step of the way! The sparkling reviews from thousands of satisfied men who saw real results really speak for themselves. 'I went from XL shirts to medium! Just amazing,' raved one user. 'It was a wild feeling to never have that urge to snack or want a second helping. The other impact? I have more energy than ever.' 'The treatment has been a game-changer for me,' said another. 'I've noticed a significant increase in my energy levels. The best part was how straightforward and simple the sign-up was.' A third was stunned at the change in his overall lifestyle. 'I absolutely feel a difference in my appetite and energy,' he said. 'The impact has been fantastic.' Why wait to see this kind of change? If you're committed to losing the weight and feeling great, now is the time to get started with Hims. You will never look back! *DISCLAIMER: Not available in all 50 states. Hims Weight Loss is a holistic program that includes nutrition support, technological tools, and custom medication kits or a compounded GLP-1 prescribed based on what your provider determines is medically appropriate and necessary for you. Hims Weight Loss includes compounded products which are not approved or verified for safety or effectiveness by FDA. See website for full details, important safety information, and restrictions, including online provider consultation requirements.


Daily Mail
7 hours ago
- Daily Mail
EXCLUSIVE Urgent Mounjaro warning: Common mistake puts patients at risk of deadly organ damage, expert says
A nurse has warned thousands of patients using the weight loss jab Mounjaro could be at risk of deadly organ failure, because GPs are failing to carry out a vital test. Dubbed the 'King Kong' of weight loss injections, Mounjaro can now be prescribed by NHS GPs in a bid to tackle the ongoing obesity crisis. But the injections often come with side effects ranging from severe dehydration, nausea and even life-threatening pancreatitis––which health professionals say could be avoided with a simple blood test. Rachel Joy, nurse and chief clinical officer at SheMed, a private healthcare provider, said: 'The safest way for people to use these jabs is through mandatory blood screening.' She continued: 'These blood tests help identify any underlying health issues that need to be managed before a patient starts the programme, or if the treatment is entirely unsuitable.' Blood tests can test for liver function, thyroid problems, uncontrolled pre-diabetes and high levels of harmful fats called triglycerides in the blood. These lipids come from foods, including butter, oil and other fats. While a certain level of these fats is essential for good health, high levels can raise the risk of heart disease. Ms Joy warned: 'If someone has really high triglycerides, they may be at higher risk of pancreatitis.' Pancreatitis is the inflammation of the pancreas, a gland located behind the stomach which is used in digestion and blood sugar regulation. While there is a high survival rate for this condition, it can trigger organ failure—which can be fatal. In some cases of severe acute pancreatitis, the pancreas can lose its blood supply and turn necrotic, which can cause deadly sepsis (a blood infection), which can in turn make other major organs fail. Severe acute pancreatitis can also trigger a systemic inflammatory response which causes other organs—like the lungs and kidneys—to fail. Ms Joy continued: 'People who have uncontrolled diabetes are also at an increased risk of becoming severely dehydrated which can be really serious. 'Without a blood test, this could be missed,' she added. Officials are now examining whether jab users affected by pancreatitis have a genetic trait that leaves them at greater risk of side-effects, which Ms Joy said could also be flagged by a simple blood test. 'Sometimes these things are subtle, but can have a massive impact. 'We should be putting these patients at the centre and treating obesity like any other clinical health condition.' She is now urging healthcare officials to reconsider rolling out these jabs without strict guidelines in place, as GPs struggle under time-constraints. As such, SheMed have made blood tests a mandatory part of their programme before prescribing the revolutionary jab. Last month, the UK medicines regulator launched a probe into the safety of fat jabs after hundreds of users developed pancreatitis, leaving ten dead. The Medicines and Healthcare products Regulatory Agency (MHRA) said it has received more than 560 reports of people developing an inflamed pancreas after taking so-called 'GLP-1' injections since they were first launched. The MHRA is now calling for users who are admitted to hospital with pancreatitis to report the side effect to authorities using the regulator's Yellow Card scheme. Healthcare workers can also submit a report on patients' behalf. This involves providing further information and submitting a saliva sample which will be used to explore whether some people are at a higher risk of acute pancreatitis when taking these medicines due to their genetic makeup. Researchers hope this will ultimately enable doctors to use rapid genetic screening tests before prescribing drugs to make the process safer. Side effects continue to be a significant burden on the NHS and studies have shown they account for one in six hospital admissions. The main symptom of pancreatitis is severe pain in the stomach that radiates to the back and does not go away. Anyone who experiences this should seek immediate medical help. Dr Alison Cave, MHRA's chief safety officer, said: 'Evidence shows that almost a third of side effects to medicines could be prevented with the introduction of genetic testing.' It is predicted that adverse drug reactions could cost the NHS more than £2.2 billion a year in hospital stays alone she added. These blockbuster jabs have also been credited with lowering blood sugar levels for people with type 2 diabetes, but Ms Joy warned they are not a silver bullet and can come with a number of serious side effects. Recent estimates suggest that about 1.5 million people in the UK are taking weight loss jabs, many of which are bought privately due to NHS rationing. Most side effects linked to the jabs are gastrointestinal including nausea, constipation and diarrhoea. However Ms Joy warned that Mounjaro can also cause severe dehydration, especially in people with diabetes. It typically causes headaches and dizziness but if not treated quickly can even lead to seizures, kidney failure or prove fatal. There have been further reactions and deaths linked to other side-effects following the use of GLP-1 medicines. The MHRA stresses that it has not been established that the jabs caused the illnesses, but that the patients themselves have reported them as side effects. Professor Matt Brown, chief scientific officer of Genomics England, said: 'GLP-1 medicines like Ozempic and Wegovy have been making headlines, but like all medicines there can be a risk of serious side effects. 'We believe there is real potential to minimise these with many adverse reactions having a genetic cause. 'This next step in our partnership with the MHRA will generate data and evidence for safer and more effective treatment through more personalised approaches to prescription, supporting a shift towards an increasingly prevention-focused healthcare system.'


Daily Mail
7 hours ago
- Daily Mail
EXCLUSIVE Nurse issues urgent Mounjaro warning: Common mistake puts patients at risk of deadly organ damage
A nurse has revealed a potentially life-threatening mistake GPs could be making when prescribing revolutionary weight loss jabs—and putting users at risk of organ failure. Dubbed the 'king kong' of weight loss injections, Mounjaro can now be prescribed by GPs free of charge under NHS guidelines in a bid to tackle the ongoing obesity crisis. But the injections often come with side effects ranging from severe dehydration, nausea and even pancreatitis––which health professionals say could be avoided with a simple blood test. Ms Rachel Joy, the chief clinical officer at SheMed, a private healthcare provider, said: 'The safest way for people to use these jabs is through mandatory metabolic blood screening.' She continued: 'These blood tests help identify any underlying health issues that need to be managed before a patient starts the programme, or if the treatment is entirely unsuitable.' Blood tests can test for liver function, thyroid problems, uncontrolled pre-diabetes and high blood cholesterol, such as triglycerides. This is a type of fat that circulates in the blood. These lipids come from foods, including butter, oil and other fats. Whilst a certain level of these fats is essential for good health, high levels can raise the risk of heart disease. Whilst studies show that semaglutide, the active ingredient in Ozempic and Wegovy can reduce the risk of heart attack and stroke, currently there is little evidence that Mounjaro works in the same way. Ms Joy warned: 'If someone has really high triglycerides, they may be at higher risk of pancreatitis.' Pancreatitis is the inflammation of the pancreas, a gland located behind the stomach which is used in digestion and blood sugar regulation. While there is a high survival rate for this condition, a severe complication can trigger organ failure—which can be fatal. In some cases of severe acute pancreatitis, the pancreas can lose its blood supply and turn necrotic, which can cause deadly sepsis (a blood infection), which can in turn make other major organs fail. Severe acute pancreatitis can also trigger a systemic inflammatory response which causes other organs—like the lungs and kidneys—to fail. Ms Joy continued: 'People who have uncontrolled diabetes are also at an increased risk of becoming severely dehydrated which can be really serious. 'Without a blood test, this could be missed,' she added. Officials are now examining whether those affected had a genetic trait that leaves them at greater risk of side-effects from the likes of Mounjaro, which Ms Joy said could also be flagged by a simple blood test. 'Sometimes these things are subtle, but can have a massive impact. 'We should be putting these patients at the centre and treating obesity like any other clinical health condition.' She is now urging healthcare officials to reconsider rolling out these jabs without strict guidelines in place, which could put users at severe risk of organ damage as GPs struggle under time-constraints. As such, SheMed have made blood tests a mandatory part of their programme before prescribing the revolutionary jab. Last month, the UK medicines regulator launched a probe into the safety of fat jabs after hundreds of users developed pancreatitis, leaving ten dead. The Medicines and Healthcare products Regulatory Agency (MHRA) said it has received more than 560 reports of people developing an inflamed pancreas after taking so-called 'GLP-1' injections since they were first launched. The MHRA is now calling for users who are admitted to hospital with pancreatitis to report the side effect to authorities using the regulator's Yellow Card scheme. Healthcare workers can also submit a report on patients' behalf. This involves providing further information and submitting a saliva sample which will be used to explore whether some people are at a higher risk of acute pancreatitis when taking these medicines due to their genetic makeup. Researchers hope this will ultimately enable doctors to use rapid genetic screening tests before prescribing drugs to make the process safer. Side effects continue to be a significant burden on the NHS and studies have shown they account for one in six hospital admissions. The main symptom of pancreatitis is severe pain in the stomach that radiates to the back and does not go away. Anyone who experiences this should seek immediate medical help. Dr Alison Cave, MHRA's chief safety officer, said: 'Evidence shows that almost a third of side effects to medicines could be prevented with the introduction of genetic testing.' It is predicted that adverse drug reactions could cost the NHS more than £2.2 billion a year in hospital stays alone she added. These blockbuster jabs have also been credited with lowering blood sugar levels for people with type 2 diabetes, but Ms Joy warned they are not a silver bullet and can come with a number of serious side effects. Recent estimates suggest that about 1.5 million people in the UK are taking weight loss jabs, many of which are bought privately due to NHS rationing. Most side effects linked to the jabs are gastrointestinal including nausea, constipation and diarrhoea. However Ms Joy warned that Mounjaro can also cause severe dehydration, especially in people with diabetes. It typically causes headaches and dizziness but if not treated quickly can even lead to seizures, kidney failure or prove fatal. There have been further reactions and deaths linked to other side-effects following the use of GLP-1 medicines. The MHRA stresses that it has not been established that the jabs caused the illnesses, but that the patients themselves have reported them as side effects. Professor Matt Brown, chief scientific officer of Genomics England, said: 'GLP-1 medicines like Ozempic and Wegovy have been making headlines, but like all medicines there can be a risk of serious side effects. 'We believe there is real potential to minimise these with many adverse reactions having a genetic cause. 'This next step in our partnership with the MHRA will generate data and evidence for safer and more effective treatment through more personalised approaches to prescription, supporting a shift towards an increasingly prevention-focused healthcare system.'