Feel Older Overnight? Science Says You Might Be Right: Ageing Jumps At Two Stages
These findings indicate that if you feel like you're aging faster during these stages, it may not be just your imagination. The study highlights how biological aging is not always linear and could involve sharp changes at specific milestones.
According to a news release, researchers assessed many thousands of different molecules in people from age 25 to 75, as well as their microbiomes - the bacteria, viruses and fungi that live inside us and on our skin - and found that the abundance of most molecules and microbes do not shift in a gradual, chronological fashion. Rather, we undergo two periods of rapid change during our life span, averaging around age 44 and age 60. A paper describing these findings was published in the journal Nature Aging in August 2024.
"We're not just changing gradually over time; there are some really dramatic changes," said Michael Snyder, PhD, professor of genetics and the study's senior author. "It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that's true no matter what class of molecules you look at."
According to the researchers, these big changes likely impact our health - the number of molecules related to cardiovascular disease showed significant changes at both time points, and those related to immune function changed in people in their early 60s.
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The Hindu
3 days ago
- The Hindu
Study compares industrialised, indigenous groups, finds inflammation not always linked with ageing
Inflammation may not always be related to ageing and appears to be a consequence of industrialised lifestyles, researchers said, after they found high levels of inflammation in two indigenous populations, which neither increased with age nor led to chronic conditions. The findings, published in the journal Nature Aging, challenge current notions around persistent inflammation related to ageing -- or "inflammaging", the authors said. "These results point to an evolutionary mismatch between our immune systems and the environments we now live in. Inflammaging may not be a direct product of ageing, but rather a response to industrialised conditions," lead author Alan Cohen, associate professor of environmental health sciences at Columbia University, US, said. They added that a holistic approach, looking at culture, environment and lifestyle factors, needs to be taken while studying ageing processes. "In industrialised settings, we see clear links between inflammaging and diseases like chronic kidney disease," Cohen said. "But in populations with high infection rates, inflammation appears more reflective of infectious disease burden than of ageing itself," the lead author said. The researchers looked at four populations -- two industrialised ones from Italy and Singapore and two indigenous, non-industrialised communities, called the 'Tsimane' of the Bolivian Amazon and the 'Orang Asli' of peninsular Malaysia. Inflammation levels due to ageing were found to be similar between the two industrialised populations studied, but did not hold in the indigenous groups, where inflammation was found to be driven largely by infection rather than age. Further, the inflammation seen in the native communities did not increase with age and also did not result in chronic diseases -- such as diabetes, heart disease and Alzheimer's -- a regular feature of modern, industrialised societies, the researchers said. "Infammaging, as measured in this manner in these cohorts, thus appears to be largely a byproduct of industrialised lifestyles, with major variation across environments and populations," the authors wrote. They added that chronic diseases are rare or even absent among native populations, meaning that even when the young in these communities have profiles that look similar on the surface to those of older industrialised adults, they do not lead to disease. "These findings really call into question the idea that inflammation is bad per se. Rather, it appears that inflammation – and perhaps other aging mechanisms too – may be highly context dependent," Cohen said. "On one hand, that's challenging, because there won't be universal answers to scientific questions. On the other, it's promising, because it means we can intervene and change things," the author said. The study analysed a group of 19 cytokines -- proteins created during immune and inflammatory responses -- and found patterns in line with ageing among the Italian and Singaporean individuals, but not among the 'Tsimane' and 'Orang Asli'. The immune systems of the indigenous populations were shaped by persistent infections and distinct environmental exposures, the researchers said.
NDTV
16-06-2025
- NDTV
Feel Older Overnight? Science Says You Might Be Right: Ageing Jumps At Two Stages
While aging is often seen as a slow, steady process, new research suggests it can speed up suddenly at certain points in life. According to a recent study on molecular changes in the human body, scientists have identified two major phases where aging significantly accelerates - around the average ages of 44 and 60. These findings indicate that if you feel like you're aging faster during these stages, it may not be just your imagination. The study highlights how biological aging is not always linear and could involve sharp changes at specific milestones. According to a news release, researchers assessed many thousands of different molecules in people from age 25 to 75, as well as their microbiomes - the bacteria, viruses and fungi that live inside us and on our skin - and found that the abundance of most molecules and microbes do not shift in a gradual, chronological fashion. Rather, we undergo two periods of rapid change during our life span, averaging around age 44 and age 60. A paper describing these findings was published in the journal Nature Aging in August 2024. "We're not just changing gradually over time; there are some really dramatic changes," said Michael Snyder, PhD, professor of genetics and the study's senior author. "It turns out the mid-40s is a time of dramatic change, as is the early 60s. And that's true no matter what class of molecules you look at." According to the researchers, these big changes likely impact our health - the number of molecules related to cardiovascular disease showed significant changes at both time points, and those related to immune function changed in people in their early 60s.
Time of India
08-06-2025
- Time of India
Stanford scientists reveal simple dinner hack to stay slim and it starts with what you eat first
The Experiment That Cracked the Code You Might Also Like: No supplements needed: Longevity doctor shares the one daily nutrient that could add years to your life Not Just for Diabetics—A Smart Move for Everyone The Science Behind the Sequence You Might Also Like: 89 kg weight loss without crash diets or overtraining: Woman shares 5 lifestyle changes you can start today A Small Change, Big Impact In a surprising twist to the ongoing battle against weight gain and blood sugar spikes, Stanford University scientists have found a simple, meal-timing trick that could help you stay slim—without cutting out your favorite foods. The secret? Not avoiding carbs altogether, but delaying to a report from the Daily Mail, in a new study published in Nature Medicine, researchers revealed that eating fiber or protein-rich foods like vegetables or eggs before carbohydrates may significantly blunt the blood sugar spikes typically triggered by carb-heavy meals. These spikes, often followed by crashes, lead to hunger pangs that drive overeating—especially of calorie-laden Michael Snyder, who led the study, explains, 'It's not just what's on your plate—it's the order in which you eat it. Think of it as hacking your metabolism by simply reordering your dinner.'The team studied 55 volunteers, many of whom showed signs of pre-diabetes, a condition that increases the risk of developing type 2 diabetes. On three separate occasions, participants consumed a carb-heavy meal of rice after consuming one of three different food types: a fiber supplement, egg whites (protein), or crème fraîche (fat).Continuous glucose monitors tracked how each dietary combination affected their blood sugar. The results? Eating fiber or egg whites before rice lowered the post-meal blood sugar surge. Eating fat didn't reduce the spike, but interestingly, it did delay the benefits were more pronounced in people with typical blood sugar levels than those with pre-diabetes, the findings highlight an easy and actionable dietary shift for nearly everyone—especially in a world where carbohydrate-rich foods like rice, pasta, and potatoes dominate many recommendation is simple but powerful: Eat your salad or protein before your French are quickly converted into glucose in the blood, fueling the body but also potentially triggering weight gain and metabolic issues when consumed in excess or too quickly absorbed. When you lead your meal with fiber or protein, it slows the digestive process and the absorption of glucose—keeping you fuller longer and your blood sugar more small shift can mean the difference between powering through the day or crashing mid-afternoon and reaching for a 'food order' method doesn't require special diets, supplements, or giving up beloved meals. Just eat your vegetables, eggs, or protein-rich foods first—and let the carbs come you're trying to manage weight, improve energy, or guard against diabetes, this research offers a surprisingly simple way to shift the balance in your favor—one bite at a time.
